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Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes. PubMed Scopus SCIE
期刊论文 | 2019 , 39 (2) , 343-353 | Journal of applied toxicology : JAT
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Deoxynivalenol (DON) and T-2 toxin are prevalent mycotoxin contaminants in the food and feed stuffs worldwide, with non-negligible co-contamination and co-exposure conditions. Meanwhile, they are considerable risk factors for Kashin-Beck disease, a chronic endemic osteochondropathy. The aim of this study was to investigate the individual and combined cytotoxicity of DON and T-2 toxin on proliferating human C-28/I2 and newborn rat primary costal chondrocytes by MTT assay. Four molar concentration combination ratios of DON and T-2 toxin were used, 1:1 for R1 mixture, 10:1 for R10, 100:1 for R100 and 1000:1 for R1000. The toxicological interactions were quantified by the MixLow method. DON, T-2 toxin, and their mixtures all showed a clear dose-dependent toxicity for chondrocytes. The cytotoxicity of T-2 toxin was 285-fold higher than DON was in human chondrocytes, and 22-fold higher in the rat chondrocytes. The combination of DON and T-2 toxin was significantly synergistic at middle and high level concentrations of R10 mixtures in rat chondrocytes, but significantly antagonistic at the low concentrations of R100 mixtures in both cells and at the middle concentrations of R1000 mixtures in rat chondrocytes. These results indicated that the combined toxicity was influenced by the cell sensitivity for toxins, the difference between the combination ratio and equitoxic ratio, the concentrations and other factors.

Keyword :

chondrocyte antagonism T-2 toxin deoxynivalenol synergism combined toxicity

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GB/T 7714 Lin Xialu , Shao Wanzhen , Yu Fangfang et al. Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes. [J]. | Journal of applied toxicology : JAT , 2019 , 39 (2) : 343-353 .
MLA Lin Xialu et al. "Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes." . | Journal of applied toxicology : JAT 39 . 2 (2019) : 343-353 .
APA Lin Xialu , Shao Wanzhen , Yu Fangfang , Xing Ke , Liu Huan , Zhang Feng'e et al. Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes. . | Journal of applied toxicology : JAT , 2019 , 39 (2) , 343-353 .
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Analysis of gene expression and methylation datasets identified ADAMTS9, FKBP5, and PFKBF3 as biomarkers for osteoarthritis. PubMed Scopus SCIE
期刊论文 | 2019 , 234 (6) , 8908-8917 | Journal of cellular physiology
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Osteoarthritis (OA) is a kind of chronic osteoarthropathy and degenerative joint disease. Epigenetic regulation in the gene expression dynamics has become increasingly important in OA. We performed a combined analysis of two types of microarray datasets (gene expression and DNA methylation) to identify methylation-based key biomarkers to provide a better understanding of molecular biological mechanisms of OA.We obtained two expression profiling datasets (GSE55235, GSE55457) and one DNA methylation profiling data set (GSE63695) from the Gene Expression Omnibus. First, differentially expressed genes (DEGs) between patients with OA and controls were identified using the Limma package in R(v3.4.4). Then, function enrichment analysis of DEGs was performed using a DAVID database. For DNA methylation datasets, ChAMP methylation analysis package was used to identify differential methylation genes (DMGs). Finally, a comprehensive analysis of DEGs and DMGs was conducted to identify genes that exhibited differential expression and methylation simultaneously.We identified 112 DEGs and 2,896 DMGs in patients with OA compared with controls. Functional analysis of DEGs obtained that inflammatory responses, immune responses, and positive regulation of apoptosis, tumor necrosis factor (TNF) signaling pathway, and osteoclast differentiation may be involved in the pathogenesis of OA. Cross-analysis revealed 26 genes that exhibited differential expression and methylation in OA. Among them, ADAMTS9, FKBP5, and PFKBF3 were identified as valuable methylation-based biomarkers for OA.In summary, our study identified different molecular features between patients with OA and controls. This may provide new clues for clarifying the pathogenetic mechanisms of OA.

Keyword :

DNA methylation osteoarthritis (OA) gene expression bioinformatics

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GB/T 7714 Li ZhaoFang , Zhang RongQiang , Yang XiaoLi et al. Analysis of gene expression and methylation datasets identified ADAMTS9, FKBP5, and PFKBF3 as biomarkers for osteoarthritis. [J]. | Journal of cellular physiology , 2019 , 234 (6) : 8908-8917 .
MLA Li ZhaoFang et al. "Analysis of gene expression and methylation datasets identified ADAMTS9, FKBP5, and PFKBF3 as biomarkers for osteoarthritis." . | Journal of cellular physiology 234 . 6 (2019) : 8908-8917 .
APA Li ZhaoFang , Zhang RongQiang , Yang XiaoLi , Zhang DanDan , Li BaoRong , Zhang Di et al. Analysis of gene expression and methylation datasets identified ADAMTS9, FKBP5, and PFKBF3 as biomarkers for osteoarthritis. . | Journal of cellular physiology , 2019 , 234 (6) , 8908-8917 .
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Genome-Wide Association Study and Identification of Chromosomal Enhancer Maps in Multiple Brain Regions Related to Autism Spectrum Disorder. PubMed Scopus SSCI SCIE
期刊论文 | 2019 , 12 (1) , 26-32 | Autism research : official journal of the International Society for Autism Research
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Autism spectrum disorder (ASD) is a complex developmental disorder with strong genetic components involved. Recent studies have demonstrated the importance of non-coding regulatory variants for complex diseases. To explore the roles of chromosomal enhancer regions in the pathogenesis of ASD, we conducted an integrative analysis of genome-wide association study (GWAS) and brain region related enhancer-gene networks for ASD. The GWAS data of ASD were driven from a published study, involving 7,387 ASD cases and 8,567 controls. The enhancer-gene networks of eight brain regions were used here. The GWAS of ASD was first merged respectively with the enhancer datasets of eight brain regions. Pathway enrichment analysis was then performed to detect ASD associated pathways based on the enhancer-related single nucleotide polymorphism (SNPs) of each brain region. We detected multiple genes with brain region specific or common association signals, such as PGM3 (P value = 1.93 × 10<sup>-5</sup> ) and RWDD2A (P value = 1.93 × 10<sup>-5</sup> ) for hippocampus middle, and ENPP4 (all P values <0.05), and ENPP5 (all P values <0.05) for seven brain regions. By comparing the pathway enrichment analysis results of various brain regions, several cross brain regions pathways were detected for ASD, such as REACTOME_POTASSIUM_CHANNELS (all P values <0.05) for six brain regions and KEGG_CELL_ADHESION_MOLECULES_CAMS (all P values <0.05) for seven brain regions. In addition, several pathways were also identified for specific brain regions, such as REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING (P value = 4.00 × 10<sup>-3</sup> ) for angular gyrus, REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR (P value = 2.22 × 10<sup>-3</sup> ) for anterior caudate, and KEGG_PRION_DISEASES (P value = 1.00 × 10<sup>-4</sup> ) for germinal matrix. Our results provide novel clues for understanding the genetic basis of ASD.ASD is a complex developmental disorder with strong genetic components, but the pathogenesis of ASD is still unclear. Using the latest GWAS data and enhancer map, we explored the brain region related biological pathways associated with ASD. Our results provide novel clues for revealing the functional relevance of enhancer variants with ASD and understanding the genetic basis of ASD.

Keyword :

enhancer biological pathways autism brain regions

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GB/T 7714 Zhang Lu , Liu Li , Wen Yan et al. Genome-Wide Association Study and Identification of Chromosomal Enhancer Maps in Multiple Brain Regions Related to Autism Spectrum Disorder. [J]. | Autism research : official journal of the International Society for Autism Research , 2019 , 12 (1) : 26-32 .
MLA Zhang Lu et al. "Genome-Wide Association Study and Identification of Chromosomal Enhancer Maps in Multiple Brain Regions Related to Autism Spectrum Disorder." . | Autism research : official journal of the International Society for Autism Research 12 . 1 (2019) : 26-32 .
APA Zhang Lu , Liu Li , Wen Yan , Ma Mei , Cheng Shiqiang , Yang Jian et al. Genome-Wide Association Study and Identification of Chromosomal Enhancer Maps in Multiple Brain Regions Related to Autism Spectrum Disorder. . | Autism research : official journal of the International Society for Autism Research , 2019 , 12 (1) , 26-32 .
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Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China SCIE PubMed
期刊论文 | 2019 | DISEASE MARKERS
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Clinical variables contribute to the severity of Kashin-Beck disease (KBD). However, it is unclear if there is a correlation between gene expression and clinical variables. Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expressed genes in KBD. Correlation analysis and multiple logistic regression analysis were performed using gene expression and clinical parameters. Immunohistochemistry (IHC) was used to detect the expression of related proteins in articular cartilage tissues. Thirty-nine differentially expressed genes were identified in patients with KBD. Nine differentially expressed genes were correlated with the metacarpal length/metacarpal breadth index. FZD1 was identified as having statistical significance in establishing the regression model of clinical parameters and gene expression. FZD1 expression levels were remarkably reduced in patients with KBD. Our results indicate that FZD1 could be involved in the pathological process of phalanges tuberositas and brachydactylia and may provide new insight into the pathogenesis of articular cartilage destruction observed in patients with KBD.

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GB/T 7714 Wang, Xi , Ning, Yujie , Zhang, Pan et al. Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China [J]. | DISEASE MARKERS , 2019 .
MLA Wang, Xi et al. "Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China" . | DISEASE MARKERS (2019) .
APA Wang, Xi , Ning, Yujie , Zhang, Pan , Yang, Lei , Li, Cheng , Zhou, Rong et al. Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China . | DISEASE MARKERS , 2019 .
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Epidemic pattern of hand-foot-and-mouth disease in Xi'an, China from 2008 through 2015 SCIE PubMed
期刊论文 | 2019 , 19 | BMC INFECTIOUS DISEASES
WoS CC Cited Count: 1
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BackgroundHand, foot and mouth disease (HFMD) is an infectious disease caused by enteroviruses that has a severely impair for those high incidence countries such as China.The current study aimed to investigate the epidemic pattern of HFMD by time and region in Northwestern China.MethodsAll reported HFMD cases from 2008 to 2015 were collected from local Disease Control and Prevention.The HFMD was diagnosed in accordance with the guidebook provided by the National Health and Family Planning Commission of the People's Republic of China.ResultsA total of 154,869 cases of probable HFMD were reported. The overall incidence of HFMD has been increased from 91.68 per 100/000 in 2008 to 335.64 per 100/000 in 2015.The case mortality is decreased from 0.014 per100/000 to 0.011 per 100/000 during the time period. Most HFMD (93.82%) occurred in children younger than 5years. The seasonal peak of HFMD infections occurred in April-July and September-November and Central regions of Xi'an city were the major locations of the clusters (incidence rate 245.75/100,000; relative risk 1.19, P<0.01). EVA71 was the predominant enterovirus serotype, accounting for 50.0% of all reported HFMD cases since 2011.The most susceptible group infected by HFMD was children younger than 5years, especially boys.ConclusionsIncidence of HFMD has been increasing in the past few years, however, the case fatality is decreasing. Season and region shall be considered as influence factors in the prevention of HFMD.

Keyword :

Distribution Serotype Epidemic Hand-foot-and-mouth disease

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GB/T 7714 Liu, JiFeng , Xiang, XiaoMei , Pu, ZhongShu et al. Epidemic pattern of hand-foot-and-mouth disease in Xi'an, China from 2008 through 2015 [J]. | BMC INFECTIOUS DISEASES , 2019 , 19 .
MLA Liu, JiFeng et al. "Epidemic pattern of hand-foot-and-mouth disease in Xi'an, China from 2008 through 2015" . | BMC INFECTIOUS DISEASES 19 (2019) .
APA Liu, JiFeng , Xiang, XiaoMei , Pu, ZhongShu , Long, Yong , Xiao, Dan , Zhang, WeiLu et al. Epidemic pattern of hand-foot-and-mouth disease in Xi'an, China from 2008 through 2015 . | BMC INFECTIOUS DISEASES , 2019 , 19 .
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Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome-wide gene expression profiling analysis SCIE PubMed
期刊论文 | 2019 , 19 (1) , 30-40 | MOLECULAR MEDICINE REPORTS
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The present study aimed to identify potential novel biomarkers in synovial tissue obtained from patients with Rheumatoid Arthritis (RA) and Osteoarthritis (OA) for differential diagnosis. The genome-wide expression profiling datasets of synovial tissues from RA and OA cohorts, including GSE55235, GSE55457 and GSE55584 datasets, were retrieved and used to identify differentially expressed genes (DEGs; P<0.05; false discovery rate <0.05 and Fold Change >2) between RA and OA using R software. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of DEGs were performed to determine molecular and biochemical pathways associated with the identified DEGs, and a protein-protein interaction (PPI) network of the DEGs was constructed using Cytoscape software. Significant modules in the PPI network and candidate driver genes were screened using the Molecular Complex Detection Algorithm. Potential biomarkers were evaluated by receiver operating characteristic and logistic regression analyses. Large numbers of DEGs were detected, including 273, 205 and 179 DEGs in the GSE55235, GSE55457 and GSE55584 datasets, respectively. Among them, 80 DEGs exhibited identical expression trends in all the three datasets, including 49 upregulated and 31 downregulated genes in patients with RA. DEGs in patients suffering from RA compared with patients suffering from OA were predominantly associated with the primary immunodeficiency pathway, including interleukin 7 receptor (IL7R) and signal transducer activator of transcription 1 (STAT1). The sensitivity of IL7R + STAT1 to differentiate RA from OA was 93.94% with a specificity of 80.77%. The results generated from analyses of the GSE36700 dataset were closely associated with results generated from analyses of GSE55235, GSE55457 and GSE55584 datasets, which further verified the reliability of the aforementioned results. The results of the present study suggested that increased expression of IL7R and STAT1 in synovial tissue as well as in the primary immunodeficiency may be associated with RA occurrence. These identified novel biomarkers may be used to predict disease occurrence and clinically differentiate RA from OA.

Keyword :

rheumatoid arthritis sensitivity protein-protein interaction osteoarthritis specificity pathway

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GB/T 7714 Zhang, Rongqiang , Yang, Xiaoli , Wang, Jing et al. Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome-wide gene expression profiling analysis [J]. | MOLECULAR MEDICINE REPORTS , 2019 , 19 (1) : 30-40 .
MLA Zhang, Rongqiang et al. "Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome-wide gene expression profiling analysis" . | MOLECULAR MEDICINE REPORTS 19 . 1 (2019) : 30-40 .
APA Zhang, Rongqiang , Yang, Xiaoli , Wang, Jing , Han, Lixin , Yang, Aimin , Zhang, Jie et al. Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome-wide gene expression profiling analysis . | MOLECULAR MEDICINE REPORTS , 2019 , 19 (1) , 30-40 .
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Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis. PubMed Scopus SCIE
期刊论文 | 2019 , 43 (2) , 323-331 | International orthopaedics
WoS CC Cited Count: 1
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Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and the severe knee pain and functional limitations were seriously affecting the quality of life in patients with end-stage KBD. We retrospectively evaluated the clinical outcomes and the quality of life in KBD patients with total knee arthroplasty (TKA).A total of 22 subjects (25 knees) suffered KBD with severe knee pain and underwent primary TKA. Knee pain was measured by visual analogue scale (VAS), and the knee function was evaluated by Knee Society Clinical Rating System Score (KSS). KBD Quality of Life (KBDQOL) was used to evaluate the quality of life in KBD patients before and after TKA.There were no major complications after TKA. The levels of VAS score were obviously deceased in post-operation than that in pre-operation. The levels of KSS score were increased in one year after TKA compared with the pre-operative values, and it maintained a higher level on three years after TKA. The average KBDQOL score level of each domain in pre-operation and one and three years after TKA was increased accordingly. The average scores of physical function, activity limitation, support of society, mental health, and general health in one year after TKA were significantly higher than those in pre-operation.TKA can reduce knee pain, improve knee function, and improve the quality life in KBD patients. KBDQOL questionnaire may be a promising instrument for assessing the quality life in KBD patients.

Keyword :

Knee Osteoarthritis Quality of life Arthroplasty Kashin-Beck disease

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GB/T 7714 Jin Zhan-Kui , Yang Ying , Xu Cui-Xiang et al. Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis. [J]. | International orthopaedics , 2019 , 43 (2) : 323-331 .
MLA Jin Zhan-Kui et al. "Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis." . | International orthopaedics 43 . 2 (2019) : 323-331 .
APA Jin Zhan-Kui , Yang Ying , Xu Cui-Xiang , Yang Bo , Lammi Mikko J , Chang Yan-Hai et al. Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis. . | International orthopaedics , 2019 , 43 (2) , 323-331 .
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The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. PubMed Scopus SCIE
期刊论文 | 2019 , 120 , 239-245 | Bone
WoS CC Cited Count: 1 SCOPUS Cited Count: 2
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The aim of the study was to investigate the association between rs5859 in Sep15, rs1139793 in TrxR2 polymorphisms with the risks of KBD and to detect the expression of AP-1 pathway in KBD subjects and in vitro. 208 KBD and 206 control subjects were included. PCR-Restriction Fragment Length Polymorphism (RFLP), Amplification Refractory Mutation Specific-PCR (ARMS-PCR) and Western Blotting were conducted. The results showed the minor A-allele frequency of rs5859 in KBD was statistically significantly higher than that in the control group (P < 0.05). The cases carrying A-allele had a 2-fold (95%CI: 1.064-3.956) increased risk of developing KBD compared with the G-allele carriers. There was no significant difference in genotype and allele distribution of rs1139793 between KBD patients and controls (P > 0.05). The frequency of the minor A allele of rs5859 was significantly different in Chinese healthy population compared with European, African and American. The frequency of the minor A allele of rs1139793 showed significant difference when compared with African and American. The levels of JunB, JunD, P65 proteins in KBD group were higher than those in control group (P < 0.0001). The expression of JunB, JunD, P65 proteins all increased in tBHP-induced C28/I2 oxidative damage model compared with control group (P < 0.05) and decreased after Se supplementation. Our finding indicated Sep15 is a possible candidate susceptibility gene for KBD. Combined with the in vitro study, our studies reveal novel insights into the mechanism of Se supplementation as an antioxidant via inhibiting the AP-1 signaling pathway in patients with KBD.

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Thioredoxin reductase 2(TrxR2) Polymorphism The 15-kDa selenoprotein (Sep15) Kashin-Beck disease

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GB/T 7714 Wu RuiPeng , Zhang RongQiang , Xiong YongMin et al. The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. [J]. | Bone , 2019 , 120 : 239-245 .
MLA Wu RuiPeng et al. "The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease." . | Bone 120 (2019) : 239-245 .
APA Wu RuiPeng , Zhang RongQiang , Xiong YongMin , Sun WenYan , Li YuanYuan , Yang XiaoLi et al. The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. . | Bone , 2019 , 120 , 239-245 .
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Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis. PubMed Scopus SCIE
期刊论文 | 2019 , 104 (2) , 171-181 | Calcified tissue international
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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Osteoporosis is a common metabolic bone disease. The impact of global blood plasma proteins on the risk of osteoporosis remains elusive now. We performed a large-scale polygenic risk score (PRS) analysis to evaluate the potential effects of blood plasma proteins on the development of osteoporosis in 2286 Caucasians, including 558 males and 1728 females. Bone mineral density (BMD) and bone areas at ulna & radius, hip, and spine were measured using Hologic 4500W DXA. BMD/bone areas values were adjusted for age, sex, height, and weight as covariates. Genome-wide SNP genotyping of 2286 Caucasian subjects was performed using Affymetrix Human SNP Array 6.0. The 267 blood plasma proteins-associated SNP loci and their genetic effects were obtained from recently published genome-wide association study (GWAS) using a highly multiplexed aptamer-based affinity proteomics platform. The polygenetic risk score (PRS) of study subjects for each blood plasma protein was calculated from the genotypes data of the 2286 Caucasian subjects by PLINK software. Pearson correlation analysis of individual PRS values and BMD/bone area value was performed using R. Additionally, gender-specific analysis also was performed by Pearson correlation analysis. 267 blood plasma proteins were analyzed in this study. For BMD, we observed association signals between 41 proteins and BMD, mainly including whole body total BMD versus Factor H (p value = 9.00 × 10<sup>-3</sup>), whole body total BMD versus BGH3 (p value = 1.40 × 10<sup>-2</sup>), spine total BMD versus IGF-I (p value = 2.15 × 10<sup>-2</sup>), and spine total BMD versus SAP (p value = 3.90 × 10<sup>-2</sup>). As for bone areas, association evidence was observed between 45 blood plasma proteins and bone areas, such as ferritin versus spine area (p value = 1.90 × 10<sup>-2</sup>), C4 versus hip area (p value = 1.25 × 10<sup>-2</sup>), and hemoglobin versus right ulna and radius area (p value = 2.70 × 10<sup>-2</sup>). Our study results suggest the modest impact of blood plasma proteins on the variations of BMD/bone areas, and identify several candidate blood plasma proteins for osteoporosis.

Keyword :

Genome-wide association study Osteoporosis Polygenic risk score analysis Blood plasma proteins

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GB/T 7714 Liang Xiao , Du Yanan , Wen Yan et al. Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis. [J]. | Calcified tissue international , 2019 , 104 (2) : 171-181 .
MLA Liang Xiao et al. "Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis." . | Calcified tissue international 104 . 2 (2019) : 171-181 .
APA Liang Xiao , Du Yanan , Wen Yan , Liu Li , Li Ping , Zhao Yan et al. Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis. . | Calcified tissue international , 2019 , 104 (2) , 171-181 .
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The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016 SCIE
期刊论文 | 2019 , 20 | BMC MUSCULOSKELETAL DISORDERS
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Kashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease. However, quantitative syntheses of X-ray detective rate studies for KBD are rare. We performed an initial systematic review and meta-analysis to assess the X-ray detective rate of KBD in China. For this systematic review and meta-analysis, we searched five databases (PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WanFang Data and the China Science and Technology Journal Database (VIP))using a comprehensive search strategy to identify studies of KBD X-ray detective rate in China that were published from database inception to January 13, 2018. The X-ray detective rate of KBD was determined via an analysis of published studies using a random effect meta-analysis with the proportions approach. Subgroup analysis and meta-regression were used to explore heterogeneity, and study quality was assessed using the risk of bias tool. A total of 53 studies involving 14,039 samples with X-ray detective rate in 163,340 observations in total were included in this meta-analysis. These studies were geographically diverse (3 endemic areas). The pooled overall X-ray detective rate for KBD was 11% (95%CI,8-15%;Z = 13.14; p < 0.001). The pooled X-ray detective rate estimates were 11% (95%CI, 6-17%; Z = 7.06; p < 0.001) for northeast endemic areas, 13% (95%CI, 7-20%; Z = 7.45; p < 0.001) for northwest endemic areas, and 8% (95%CI, 5-12%; Z = 7.90; p < 0.001) for southwest endemic areas. There was a significant relationship between the survey year and the X-ray detective rate of KBD. Our systematic review found that the summary estimate of the X-ray detective rate of KBD was 11% and, that KBD X-ray positive rate ranged from 8.00 to 15.00% depending on the study. Further research is required to identify effective strategies for preventing and treating KBD.

Keyword :

X-ray detective rate Meta-analysis Kashin-Beck disease Correlation analysis

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GB/T 7714 Wang, Xi , Ning, Yujie , Liu, Amin et al. The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016 [J]. | BMC MUSCULOSKELETAL DISORDERS , 2019 , 20 .
MLA Wang, Xi et al. "The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016" . | BMC MUSCULOSKELETAL DISORDERS 20 (2019) .
APA Wang, Xi , Ning, Yujie , Liu, Amin , Qi, Xin , Liu, Meidan , Zhang, Pan et al. The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016 . | BMC MUSCULOSKELETAL DISORDERS , 2019 , 20 .
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