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Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives. EI PubMed Scopus
期刊论文 | 2018 , 36 (11) , 1127-1144 | Trends in biotechnology
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Abstract :

Periodontitis has become one of the most universal chronic inflammatory diseases worldwide. Subclinical symptom progression, ultimately leading to permanent damage, calls for early diagnosis and long-term monitoring. However, traditional clinical diagnostic methods are complex and expensive, and cannot meet these requirements. Recently, with more biomarkers and the development of new technologies, various point-of-care testing (POCT) platforms have been developed for periodontitis diagnosis and monitoring. These are easy to perform, rapid, low-cost, and are perfectly suited for high-frequency diagnosis of periodontitis at the point-of-care (POC). We summarize existing biomarkers of different periodontitis stages and recent developed POCT platforms (including lab-on-a-chip, paper-based platforms, and chairside tests), discuss their existing challenges and future potential, and provide some inspiration and guidelines for future POC periodontitis testing.

Keyword :

paper-based test lab-on-a-chip device biomarkers chairside test point-of-care testing periodontitis diagnostics

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GB/T 7714 He Wanghong , You Minli , Wan Wanting et al. Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives. [J]. | Trends in biotechnology , 2018 , 36 (11) : 1127-1144 .
MLA He Wanghong et al. "Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives." . | Trends in biotechnology 36 . 11 (2018) : 1127-1144 .
APA He Wanghong , You Minli , Wan Wanting , Xu Feng , Li Fei , Li Ang . Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives. . | Trends in biotechnology , 2018 , 36 (11) , 1127-1144 .
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Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms. EI PubMed Scopus
期刊论文 | 2018 | Annals of biomedical engineering
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Abstract :

Arteries with 1-mm thick walls can be successfully vitrified by loading cryoprotective agents (CPAs) such as VS55 (8.4 M) or less concentrated DP6 (6 M) and cooling at or beyond their critical cooling rates of 2.5 and 40 °C/min, respectively. Successful warming from this vitrified state, however, can be challenging. For example, convective warming by simple warm-bath immersion achieves 70 °C/min, which is faster than VS55's critical warming rate of 55 °C/min, but remains far below that of DP6 (185 °C/min). Here we present a new method that can dramatically increase the warming rates within either a solution or tissue by inductively warming commercially available metal components placed within solutions or in proximity to tissues with non-invasive radiofrequency fields (360 kHz, 20 kA/m). Directly measured warming rates within solutions exceeded 1000 °C/min with specific absorption rates (W/g) of 100, 450 and 1000 for copper foam, aluminum foil, and nitinol mesh, respectively. As proof of principle, a carotid artery diffusively loaded with VS55 and DP6 CPA was successfully warmed with high viability using aluminum foil, while standard convection failed for the DP6 loaded tissue. Modeling suggests this approach can improve warming in tissues up to 4-mm thick where diffusive loading of CPA may be incomplete. Finally, this technology is not dependent on the size of the system and should therefore scale up where convection cannot.

Keyword :

Skin depth Tissue preservation RF heating Ultrarapid warming Nanowarming Rewarming Vitrification

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GB/T 7714 Manuchehrabadi Navid , Shi Meng , Roy Priyatanu et al. Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms. [J]. | Annals of biomedical engineering , 2018 .
MLA Manuchehrabadi Navid et al. "Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms." . | Annals of biomedical engineering (2018) .
APA Manuchehrabadi Navid , Shi Meng , Roy Priyatanu , Han Zonghu , Qiu Jinbin , Xu Feng et al. Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms. . | Annals of biomedical engineering , 2018 .
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Heterostructured Silk-Nanofiber-Reduced Graphene Oxide Composite Scaffold for SH-SY5Y Cell Alignment and Differentiation. EI PubMed Scopus
期刊论文 | 2018 | ACS applied materials & interfaces
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Abstract :

Stem cell therapy is promising for treating traumatic injuries of the central nervous system, where a major challenge is to effectively differentiate neural stem cells into neurons with uniaxial alignment. Recently, controlling stem cell fate by modulating biophysical cues (e.g., stiffness, conductivity, and patterns) has emerged as an attractive approach. Herein, we report a new heterostructure composite scaffold to induce cell-oriented growth and enhance the neuronal differentiation of SH-SY5Y cells. The scaffold is composed of aligned electrospinning silk nanofibers coated on reduced graphene paper with high conductivity and good biocompatibility. Our experimental results demonstrate that the composite scaffold can effectively induce the oriented growth and enhance neuronal differentiation of SH-SY5Y cells. Our study develops a novel scaffold for enhancing the differentiation of SH-SY5Y cells into neurons, which holds great potential in the treatment of neurological diseases and injuries.

Keyword :

tissue engineering stem cell graphene oxide silk nanofibers cell microenvironment electrospinning

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GB/T 7714 Qing Huaibin , Jin Guorui , Zhao Guoxu et al. Heterostructured Silk-Nanofiber-Reduced Graphene Oxide Composite Scaffold for SH-SY5Y Cell Alignment and Differentiation. [J]. | ACS applied materials & interfaces , 2018 .
MLA Qing Huaibin et al. "Heterostructured Silk-Nanofiber-Reduced Graphene Oxide Composite Scaffold for SH-SY5Y Cell Alignment and Differentiation." . | ACS applied materials & interfaces (2018) .
APA Qing Huaibin , Jin Guorui , Zhao Guoxu , Huang Guoyou , Ma Yufei , Zhang Xiaohui et al. Heterostructured Silk-Nanofiber-Reduced Graphene Oxide Composite Scaffold for SH-SY5Y Cell Alignment and Differentiation. . | ACS applied materials & interfaces , 2018 .
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The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. EI PubMed Scopus
期刊论文 | 2018 , 88 , 160-169 | Journal of the mechanical behavior of biomedical materials
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Abstract :

Biocompatible hydrogels with defined mechanical properties are critical to tissue engineering and regenerative medicine. Thiol-acrylate photopolymerized hydrogels have attracted special interest for their degradability and cytocompatibility, and for their tunable mechanical properties through controlling factors that affect reaction kinetics (e.g., photopolymerization, stoichiometry, temperature, and solvent choice). In this study, we hypothesized that the mechanical property of these hydrogels can be tuned by photoinitiators via photobleaching and by thiol-Michael addition reactions. To test this hypothesis, a multiscale mathematical model incorporating both photobleaching and thiol-Michael addition reactions was developed and validated. After validating the model, the effects of thiol concentration, light intensity, and pH values on hydrogel mechanics were investigated. Results revealed that hydrogel stiffness (i) was maximized at a light intensity-specific optimal concentration of thiol groups; (ii) increased with decreasing pH when synthesis occurred at low light intensity; and (iii) increased with decreasing light intensity when synthesis occurred at fixed precursor composition. The multiscale model revealed that the latter was due to higher initiation efficiency at lower light intensity. More broadly, the model provides a framework for predicting mechanical properties of hydrogels based upon the controllable kinetics of thiol-acrylate photopolymerization.

Keyword :

Eosin Y Hydrogels Elastic modulus Thiol-Michael addition Thiol-acrylate polymerization

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GB/T 7714 Zhu Hongyuan , Yang Xiaoxiao , Genin Guy M et al. The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. [J]. | Journal of the mechanical behavior of biomedical materials , 2018 , 88 : 160-169 .
MLA Zhu Hongyuan et al. "The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition." . | Journal of the mechanical behavior of biomedical materials 88 (2018) : 160-169 .
APA Zhu Hongyuan , Yang Xiaoxiao , Genin Guy M , Lu Tian Jian , Xu Feng , Lin Min . The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. . | Journal of the mechanical behavior of biomedical materials , 2018 , 88 , 160-169 .
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Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing EI Scopus CSCD PKU
期刊论文 | 2018 , 45 (2) | Zhongguo Jiguang/Chinese Journal of Lasers
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Abstract :

Microorganisms, such as bacteria, are always detection objects in point-of-care testing, such as infectious diseases diagnosis, food safety monitoring and environment pollution detection. Optical microscopy is always a tool which is used to detect and analyze these detection objects. Lensless microscopy combines the sample with photodetectors such as charge coupled device (CCD) or complementary metal-oxide semiconductor (CMOS). This technique does not need optical devices, and the samples are imaged directly. The device is significantly simpler, smaller, easier to manipulate and cheaper than that of lens-based conventional microscope, which has been used in microstructure examinations, cell morphological analysis and microorganism detection. The lensless microscopic technology can be divided into three types, such as shadow imaging, fluorescence imaging and digital inline holography according to imaging principle. This paper reviews imaging principle and physical structure of three kinds of lensless microscopic technologies, and summaries the applications of lensless microscopic technologies in point-of-care testing. At last, we discuss the future development of lensless microscopic technologies. © 2018, Chinese Lasers Press. All right reserved.

Keyword :

Complementary metal oxide semiconductors Digital in-line holographies Environment pollution Microorganism detection Microstructure examination Morphological analysis Point-of-care testing Shadow imaging

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GB/T 7714 Li, Conghui , Cao, Ruofan , Xu, Xiayu et al. Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing [J]. | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
MLA Li, Conghui et al. "Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing" . | Zhongguo Jiguang/Chinese Journal of Lasers 45 . 2 (2018) .
APA Li, Conghui , Cao, Ruofan , Xu, Xiayu , Li, Fei , Zhang, Zhenxi , Xu, Feng . Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing . | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
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Pen-on-paper strategies for point-of-care testing of human health EI Scopus
期刊论文 | 2018 , 108 , 50-64 | TrAC - Trends in Analytical Chemistry
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Abstract :

Nowadays, point-of-care testing (POCT) techniques have achieved flourishing development in human health monitoring, where paper-based POCT platforms have exhibited superior properties of low cost, easy accessibility and eco-friendliness. For fabrication of paper-based POCT platforms, the pen-on-paper (PoP) strategies through directly writing desired functional materials on paper have been creatively developed in recent years. The PoP strategies are characterized by simplicity, rapid prototyping and do-it-yourself capability, and are also likely to realize scalable manufacturing through integration with software-controlled plotter. In this review, we firstly introduce various kinds of papers and pens employed in the PoP strategies, and then summarize the state-of-art advances of PoP strategies for making paper-based POCT platforms. Subsequently, we discuss the representative applications of PoP strategies for human health monitoring. Conclusions, current challenges and future perspectives of the PoP strategies for human health related POCT uses are finally given. © 2018 Elsevier B.V.

Keyword :

Do it yourself Future perspectives Human health Low costs Point-of-care testing

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GB/T 7714 Li, Zedong , Liu, Hao , He, Xiaocong et al. Pen-on-paper strategies for point-of-care testing of human health [J]. | TrAC - Trends in Analytical Chemistry , 2018 , 108 : 50-64 .
MLA Li, Zedong et al. "Pen-on-paper strategies for point-of-care testing of human health" . | TrAC - Trends in Analytical Chemistry 108 (2018) : 50-64 .
APA Li, Zedong , Liu, Hao , He, Xiaocong , Xu, Feng , Li, Fei . Pen-on-paper strategies for point-of-care testing of human health . | TrAC - Trends in Analytical Chemistry , 2018 , 108 , 50-64 .
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The elastic fields of a compressible liquid inclusion EI Scopus CSSCI-E
期刊论文 | 2018 , 22 , 122-130 | Extreme Mechanics Letters
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Abstract :

Elastic composites containing liquid inclusions exist widely in rocks, food, tissues and hydrogels. We investigate a single ellipsoidal compressible liquid inclusion embedded in an infinite elastic matrix, such as an isolated cell embedded in an extracellular matrix or an oil or gas pocket embedded within shale. We first derive the displacement and stress fields in the matrix under far field loading. For the special case of a spherical inclusion, we arrive at simple, explicit expressions for these fields. We next focus on the shape evolution of the liquid inclusion and the stress concentration in the matrix, from which we identify when the effect of liquid compressibility is most significant. Finally, we classify common examples of liquid inclusions in nature and engineering. According to our theoretical results, we estimate the importance of liquid compressibility in these examples and provide guidelines for further application of the theory of liquid inclusions in practical situations. © 2018

Keyword :

Compressible liquid Displacement and stress fields Elastic composites Extracellular matrices Liquid inclusion Liquid interactions Spherical inclusion Theory of liquids

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GB/T 7714 Chen, Xin , Li, Moxiao , Yang, Mao et al. The elastic fields of a compressible liquid inclusion [J]. | Extreme Mechanics Letters , 2018 , 22 : 122-130 .
MLA Chen, Xin et al. "The elastic fields of a compressible liquid inclusion" . | Extreme Mechanics Letters 22 (2018) : 122-130 .
APA Chen, Xin , Li, Moxiao , Yang, Mao , Liu, Shaobao , Genin, Guy M. , Xu, Feng et al. The elastic fields of a compressible liquid inclusion . | Extreme Mechanics Letters , 2018 , 22 , 122-130 .
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Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement EI Scopus CSSCI-E
期刊论文 | 2018 | ACS Biomaterials Science and Engineering
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Abstract :

As a layer of soft fibrous tissue, the periodontal ligament (PDL) protects against mechanical shock when transmitting mastication force from tooth to its surrounding alveolar bone. Currently, no quantitative method is available to estimate the shock resistance ability of the PDL. To solve this problem, in the present study we developed a finite element (FE) model of the tooth-PDL-bone complex and analyzed the energy storage and dissipation during the mastication movements. Displacement and Mises stress of tooth-PDL-bone complex show that the PDL is able to protect the alveolar bone from mechanical shock by shielding the transfer of deformation and stress. During mastication, the energy of the PDL is stored up to ∼161.5 J/mm3 at the period of loading and dissipated about one-tenth of the stored energy when unloading. The energy storage is displacement-dependent but time-independent because of the hyperelasticity of PDL. However, the energy dissipation is time- and displacement-dependent because of the viscoelasticity of PDL. The present study helps to understand the periodontal potential and the origin of dental diseases such as tooth concussion and occlusal trauma from the view of energy conversion. © 2018 American Chemical Society.

Keyword :

Deformation and stress Human periodontal ligament Hyper-elasticity Periodontal ligament Quantitative method Shock resistance Time independents tooth

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GB/T 7714 Pei, Dandan , Hu, Xiaoyi , Jin, Changxiong et al. Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement [J]. | ACS Biomaterials Science and Engineering , 2018 .
MLA Pei, Dandan et al. "Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement" . | ACS Biomaterials Science and Engineering (2018) .
APA Pei, Dandan , Hu, Xiaoyi , Jin, Changxiong , Lu, Yi , Liu, Shaobao . Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement . | ACS Biomaterials Science and Engineering , 2018 .
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Liquid wicking behavior in paper-like materials: mathematical models and their emerging biomedical applications Scopus
期刊论文 | 2018 , 22 (11) | Microfluidics and Nanofluidics
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© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Paper-like materials have found widespread applications in various fields, especially recently emerging applications in biomedicine as paper-based devices, where liquid wicking behavior plays a significant role. Although tremendous experimental evidence has indicated that fluid control is a key technology to improve the performance of these paper-based devices, the underlying mechanisms of liquid wicking behavior in paper-like materials remain unclear. Numerical and mathematical techniques provide effective strategy and great potential in understanding the liquid flowing process in the complex fibrous structure of paper-like materials. In this review, we first present the basic physical process and key factors of liquid wicking behavior in paper-like materials. Furthermore, we review various macroscopic and mesoscopic mathematical models on fluid flow in porous materials, focusing on each model’s advantages and challenges, and summarize their related biomedical applications. The aims are to better understand the underlying mechanisms of liquid wicking behavior in paper-like materials through mathematical models and to provide guidance in the design and optimization of paper-based biomedical devices.

Keyword :

Biomedical devices Liquid wicking behavior Mathematical model Paper-like material

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GB/T 7714 Liu, Zhi , He, Xiaocong , Han, Jiaxiu et al. Liquid wicking behavior in paper-like materials: mathematical models and their emerging biomedical applications [J]. | Microfluidics and Nanofluidics , 2018 , 22 (11) .
MLA Liu, Zhi et al. "Liquid wicking behavior in paper-like materials: mathematical models and their emerging biomedical applications" . | Microfluidics and Nanofluidics 22 . 11 (2018) .
APA Liu, Zhi , He, Xiaocong , Han, Jiaxiu , Zhang, Xiuhai , Li, Fei , Li, Ang et al. Liquid wicking behavior in paper-like materials: mathematical models and their emerging biomedical applications . | Microfluidics and Nanofluidics , 2018 , 22 (11) .
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3D Spatiotemporal Mechanical Microenvironment: A Hydrogel-Based Platform for Guiding Stem Cell Fate. EI PubMed Scopus
期刊论文 | 2018 , e1705911 | Advanced materials
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Abstract :

Stem cells hold great promise for widespread biomedical applications, for which stem cell fate needs to be well tailored. Besides biochemical cues, accumulating evidence has demonstrated that spatiotemporal biophysical cues (especially mechanical cues) imposed by cell microenvironments also critically impact on the stem cell fate. As such, various biomaterials, especially hydrogels due to their tunable physicochemical properties and advanced fabrication approaches, are developed to spatiotemporally manipulate biophysical cues in vitro so as to recapitulate the 3D mechanical microenvironment where stem cells reside in vivo. Here, the main mechanical cues that stem cells experience in their native microenvironment are summarized. Then, recent advances in the design of hydrogel materials with spatiotemporally tunable mechanical properties for engineering 3D the spatiotemporal mechanical microenvironment of stem cells are highlighted. These in vitro engineered spatiotemporal mechanical microenvironments are crucial for guiding stem cell fate and their potential biomedical applications are subsequently discussed. Finally, the challenges and future perspectives are presented.

Keyword :

hydrogels mechanical cues cell microenvironments spatiotemporal control polymeric design

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GB/T 7714 Ma Yufei , Lin Min , Huang Guoyou et al. 3D Spatiotemporal Mechanical Microenvironment: A Hydrogel-Based Platform for Guiding Stem Cell Fate. [J]. | Advanced materials , 2018 : e1705911 .
MLA Ma Yufei et al. "3D Spatiotemporal Mechanical Microenvironment: A Hydrogel-Based Platform for Guiding Stem Cell Fate." . | Advanced materials (2018) : e1705911 .
APA Ma Yufei , Lin Min , Huang Guoyou , Li Yuhui , Wang Shuqi , Bai Guiqin et al. 3D Spatiotemporal Mechanical Microenvironment: A Hydrogel-Based Platform for Guiding Stem Cell Fate. . | Advanced materials , 2018 , e1705911 .
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