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Analysis of Leukocyte Behaviors on Microfluidic Chips. PubMed SCIE
期刊论文 | 2019 , 8 (4) , e1801406 | Advanced healthcare materials
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Abstract :

The orchestration of massive leukocytes in the immune system protects humans from invading pathogens and abnormal cells in the body. So far, researches focusing on leukocyte behaviors are performed based on both in vivo and in vitro models. The in vivo animal models are usually less controllable due to their extreme complexity and nonignorable species issue. Therefore, many researchers turn to in vitro models. With the advances in micro/nanofabrication, the microfluidic chip has emerged as a novel platform for model construction in multiple biomedical research fields. Specifically, the microfluidic chip is used to study leukocyte behaviors, due to its incomparable advantages in high throughput, precise control, and flexible integration. Moreover, the small size of the microstructures on the microfluidic chip can better mimic the native microenvironment of leukocytes, which contributes to a more reliable recapitulation. Herein are reviewed the recent advances in microfluidic chip-based leukocyte behavior analysis to provide an overview of this field. Detailed discussions are specifically focused on host defense against pathogens, immunodiagnosis, and immunotherapy studies on microfluidic chips. Finally, the current technical challenges are discussed, as well as possible innovations in this field to improve the related applications.

Keyword :

microfluidics immunotherapy tissue-on-a-chip host defenses leukocytes immunodiagnosis

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GB/T 7714 Liu Yan , Yang Qingzhen , Cao Lei et al. Analysis of Leukocyte Behaviors on Microfluidic Chips. [J]. | Advanced healthcare materials , 2019 , 8 (4) : e1801406 .
MLA Liu Yan et al. "Analysis of Leukocyte Behaviors on Microfluidic Chips." . | Advanced healthcare materials 8 . 4 (2019) : e1801406 .
APA Liu Yan , Yang Qingzhen , Cao Lei , Xu Feng . Analysis of Leukocyte Behaviors on Microfluidic Chips. . | Advanced healthcare materials , 2019 , 8 (4) , e1801406 .
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A smartphone-based on-site nucleic acid testing platform at point-of-care settings. PubMed CPCI-S SCIE
期刊论文 | 2019 , 40 (6) , 914-921 | Electrophoresis
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Abstract :

We developed a smartphone-based on-site nucleic acid testing (NAT) platform that can image and analyze lateral flow nucleic acid assays at point-of-care settings. An inexpensive add-on was devised to run lateral flow assays while providing homogeneous ambient light for imaging. In addition, an Android app with a user-friendly interface was developed for the result analysis and management. Linear color calibration is implemented inside the app to minimize the colorimetric reaction difference between smartphones. A relationship function between nucleic acid concentration and colorimetric reaction was established and evaluated by leave-one-out cross validation. The predicted concentration and true concentration showed a good agreement with an R-squared value of 0.96. This smartphone-based NAT platform can be used to diagnose infectious diseases and monitor disease progression, and assess treatment efficacy, especially for resource-limited settings.

Keyword :

Lateral flow assay Point-of-care diagnostics Smartphone Nucleic acid testing

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GB/T 7714 Xu Xiayu , Wang Xuemin , Hu Jie et al. A smartphone-based on-site nucleic acid testing platform at point-of-care settings. [J]. | Electrophoresis , 2019 , 40 (6) : 914-921 .
MLA Xu Xiayu et al. "A smartphone-based on-site nucleic acid testing platform at point-of-care settings." . | Electrophoresis 40 . 6 (2019) : 914-921 .
APA Xu Xiayu , Wang Xuemin , Hu Jie , Gong Yang , Wang Lin , Zhou Wan et al. A smartphone-based on-site nucleic acid testing platform at point-of-care settings. . | Electrophoresis , 2019 , 40 (6) , 914-921 .
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Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement EI Scopus CSSCI-E
期刊论文 | 2018 | ACS Biomaterials Science and Engineering
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Abstract :

As a layer of soft fibrous tissue, the periodontal ligament (PDL) protects against mechanical shock when transmitting mastication force from tooth to its surrounding alveolar bone. Currently, no quantitative method is available to estimate the shock resistance ability of the PDL. To solve this problem, in the present study we developed a finite element (FE) model of the tooth-PDL-bone complex and analyzed the energy storage and dissipation during the mastication movements. Displacement and Mises stress of tooth-PDL-bone complex show that the PDL is able to protect the alveolar bone from mechanical shock by shielding the transfer of deformation and stress. During mastication, the energy of the PDL is stored up to ∼161.5 J/mm3 at the period of loading and dissipated about one-tenth of the stored energy when unloading. The energy storage is displacement-dependent but time-independent because of the hyperelasticity of PDL. However, the energy dissipation is time- and displacement-dependent because of the viscoelasticity of PDL. The present study helps to understand the periodontal potential and the origin of dental diseases such as tooth concussion and occlusal trauma from the view of energy conversion. © 2018 American Chemical Society.

Keyword :

Deformation and stress Human periodontal ligament Hyper-elasticity Periodontal ligament Quantitative method Shock resistance Time independents tooth

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GB/T 7714 Pei, Dandan , Hu, Xiaoyi , Jin, Changxiong et al. Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement [J]. | ACS Biomaterials Science and Engineering , 2018 .
MLA Pei, Dandan et al. "Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement" . | ACS Biomaterials Science and Engineering (2018) .
APA Pei, Dandan , Hu, Xiaoyi , Jin, Changxiong , Lu, Yi , Liu, Shaobao . Energy Storage and Dissipation of Human Periodontal Ligament during Mastication Movement . | ACS Biomaterials Science and Engineering , 2018 .
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Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing EI Scopus CSCD PKU
期刊论文 | 2018 , 45 (2) | Zhongguo Jiguang/Chinese Journal of Lasers
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Abstract :

Microorganisms, such as bacteria, are always detection objects in point-of-care testing, such as infectious diseases diagnosis, food safety monitoring and environment pollution detection. Optical microscopy is always a tool which is used to detect and analyze these detection objects. Lensless microscopy combines the sample with photodetectors such as charge coupled device (CCD) or complementary metal-oxide semiconductor (CMOS). This technique does not need optical devices, and the samples are imaged directly. The device is significantly simpler, smaller, easier to manipulate and cheaper than that of lens-based conventional microscope, which has been used in microstructure examinations, cell morphological analysis and microorganism detection. The lensless microscopic technology can be divided into three types, such as shadow imaging, fluorescence imaging and digital inline holography according to imaging principle. This paper reviews imaging principle and physical structure of three kinds of lensless microscopic technologies, and summaries the applications of lensless microscopic technologies in point-of-care testing. At last, we discuss the future development of lensless microscopic technologies. © 2018, Chinese Lasers Press. All right reserved.

Keyword :

Complementary metal oxide semiconductors Digital in-line holographies Environment pollution Microorganism detection Microstructure examination Morphological analysis Point-of-care testing Shadow imaging

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GB/T 7714 Li, Conghui , Cao, Ruofan , Xu, Xiayu et al. Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing [J]. | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
MLA Li, Conghui et al. "Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing" . | Zhongguo Jiguang/Chinese Journal of Lasers 45 . 2 (2018) .
APA Li, Conghui , Cao, Ruofan , Xu, Xiayu , Li, Fei , Zhang, Zhenxi , Xu, Feng . Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing . | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
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The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. EI SCIE PubMed Scopus
期刊论文 | 2018 , 88 , 160-169 | Journal of the mechanical behavior of biomedical materials
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Abstract :

Biocompatible hydrogels with defined mechanical properties are critical to tissue engineering and regenerative medicine. Thiol-acrylate photopolymerized hydrogels have attracted special interest for their degradability and cytocompatibility, and for their tunable mechanical properties through controlling factors that affect reaction kinetics (e.g., photopolymerization, stoichiometry, temperature, and solvent choice). In this study, we hypothesized that the mechanical property of these hydrogels can be tuned by photoinitiators via photobleaching and by thiol-Michael addition reactions. To test this hypothesis, a multiscale mathematical model incorporating both photobleaching and thiol-Michael addition reactions was developed and validated. After validating the model, the effects of thiol concentration, light intensity, and pH values on hydrogel mechanics were investigated. Results revealed that hydrogel stiffness (i) was maximized at a light intensity-specific optimal concentration of thiol groups; (ii) increased with decreasing pH when synthesis occurred at low light intensity; and (iii) increased with decreasing light intensity when synthesis occurred at fixed precursor composition. The multiscale model revealed that the latter was due to higher initiation efficiency at lower light intensity. More broadly, the model provides a framework for predicting mechanical properties of hydrogels based upon the controllable kinetics of thiol-acrylate photopolymerization.

Keyword :

Elastic modulus Eosin Y Hydrogels Thiol-acrylate polymerization Thiol-Michael addition

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GB/T 7714 Zhu Hongyuan , Yang Xiaoxiao , Genin Guy M et al. The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. [J]. | Journal of the mechanical behavior of biomedical materials , 2018 , 88 : 160-169 .
MLA Zhu Hongyuan et al. "The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition." . | Journal of the mechanical behavior of biomedical materials 88 (2018) : 160-169 .
APA Zhu Hongyuan , Yang Xiaoxiao , Genin Guy M , Lu Tian Jian , Xu Feng , Lin Min . The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. . | Journal of the mechanical behavior of biomedical materials , 2018 , 88 , 160-169 .
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Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms. EI SCIE PubMed Scopus
期刊论文 | 2018 , 46 (11) , 1857-1869 | Annals of biomedical engineering
WoS CC Cited Count: 2 SCOPUS Cited Count: 2
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Abstract :

Arteries with 1-mm thick walls can be successfully vitrified by loading cryoprotective agents (CPAs) such as VS55 (8.4 M) or less concentrated DP6 (6 M) and cooling at or beyond their critical cooling rates of 2.5 and 40 °C/min, respectively. Successful warming from this vitrified state, however, can be challenging. For example, convective warming by simple warm-bath immersion achieves 70 °C/min, which is faster than VS55's critical warming rate of 55 °C/min, but remains far below that of DP6 (185 °C/min). Here we present a new method that can dramatically increase the warming rates within either a solution or tissue by inductively warming commercially available metal components placed within solutions or in proximity to tissues with non-invasive radiofrequency fields (360 kHz, 20 kA/m). Directly measured warming rates within solutions exceeded 1000 °C/min with specific absorption rates (W/g) of 100, 450 and 1000 for copper foam, aluminum foil, and nitinol mesh, respectively. As proof of principle, a carotid artery diffusively loaded with VS55 and DP6 CPA was successfully warmed with high viability using aluminum foil, while standard convection failed for the DP6 loaded tissue. Modeling suggests this approach can improve warming in tissues up to 4-mm thick where diffusive loading of CPA may be incomplete. Finally, this technology is not dependent on the size of the system and should therefore scale up where convection cannot.

Keyword :

Nanowarming Rewarming RF heating Skin depth Tissue preservation Ultrarapid warming Vitrification

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GB/T 7714 Manuchehrabadi Navid , Shi Meng , Roy Priyatanu et al. Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms. [J]. | Annals of biomedical engineering , 2018 , 46 (11) : 1857-1869 .
MLA Manuchehrabadi Navid et al. "Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms." . | Annals of biomedical engineering 46 . 11 (2018) : 1857-1869 .
APA Manuchehrabadi Navid , Shi Meng , Roy Priyatanu , Han Zonghu , Qiu Jinbin , Xu Feng et al. Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms. . | Annals of biomedical engineering , 2018 , 46 (11) , 1857-1869 .
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Pen-on-paper strategies for point-of-care testing of human health EI Scopus SCIE
期刊论文 | 2018 , 108 , 50-64 | TrAC - Trends in Analytical Chemistry
WoS CC Cited Count: 8 SCOPUS Cited Count: 7
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Abstract :

Nowadays, point-of-care testing (POCT) techniques have achieved flourishing development in human health monitoring, where paper-based POCT platforms have exhibited superior properties of low cost, easy accessibility and eco-friendliness. For fabrication of paper-based POCT platforms, the pen-on-paper (PoP) strategies through directly writing desired functional materials on paper have been creatively developed in recent years. The PoP strategies are characterized by simplicity, rapid prototyping and do-it-yourself capability, and are also likely to realize scalable manufacturing through integration with software-controlled plotter. In this review, we firstly introduce various kinds of papers and pens employed in the PoP strategies, and then summarize the state-of-art advances of PoP strategies for making paper-based POCT platforms. Subsequently, we discuss the representative applications of PoP strategies for human health monitoring. Conclusions, current challenges and future perspectives of the PoP strategies for human health related POCT uses are finally given. © 2018 Elsevier B.V.

Keyword :

Do it yourself Future perspectives Human health Low costs Point-of-care testing

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GB/T 7714 Li, Zedong , Liu, Hao , He, Xiaocong et al. Pen-on-paper strategies for point-of-care testing of human health [J]. | TrAC - Trends in Analytical Chemistry , 2018 , 108 : 50-64 .
MLA Li, Zedong et al. "Pen-on-paper strategies for point-of-care testing of human health" . | TrAC - Trends in Analytical Chemistry 108 (2018) : 50-64 .
APA Li, Zedong , Liu, Hao , He, Xiaocong , Xu, Feng , Li, Fei . Pen-on-paper strategies for point-of-care testing of human health . | TrAC - Trends in Analytical Chemistry , 2018 , 108 , 50-64 .
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Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues EI Scopus SCIE
期刊论文 | 2018 , 10 , 982-994 | NPG Asia Materials
WoS CC Cited Count: 6 SCOPUS Cited Count: 5
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Abstract :

Tissue engineering has provided an alternative strategy for the regeneration of functional tissues for drug screening and disease intervention. The central challenge in the development of mature and functional excitable tissues is to design and construct advanced conductive biomaterials that can guide cells to form electrically interconnected networks. The objective of this study was to develop reduced graphene oxide modified silk nanofibrous biomaterials with controllable surface deposition on the nanoscale. A vacuum filtration system was applied to attain reduced graphene oxide nanolayer deposition. The results demonstrate that with this method, a uniform and compact reduced graphene oxide nanolayer was formed, and the conductivity and nanofibrous morphology of the materials was well controlled. The composite nanofibrous scaffolds were applied for the engineering of cardiac tissues and demonstrated a great ability to promote tissue formation and functions, including the expression of cardiac-specific proteins, the formation of sarcomeric structures and gap junctions, and tissue contraction. External electrical stimulation further enhanced the maturation level of cardiac tissues cultured on these conductive scaffolds. All these results demonstrated the great potential of reduced graphene oxide functionalized silk biomaterials fabricated using our method for recapitulating electrical microenvironments for the regeneration of functional excitable tissues. © 2018, The Author(s).

Keyword :

External electrical stimulations Interconnected network Microenvironments Nanofibrous scaffolds Nanofibrous silk fibroin Reduced graphene oxides Surface deposition Vacuum filtration

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GB/T 7714 Zhao, Guoxu , Qing, Huaibin , Huang, Guoyou et al. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues [J]. | NPG Asia Materials , 2018 , 10 : 982-994 .
MLA Zhao, Guoxu et al. "Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues" . | NPG Asia Materials 10 (2018) : 982-994 .
APA Zhao, Guoxu , Qing, Huaibin , Huang, Guoyou , Genin, Guy M. , Lu, Tian Jian , Luo, Zhengtang et al. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues . | NPG Asia Materials , 2018 , 10 , 982-994 .
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An improved U-net architecture for simultaneous arteriole and venule segmentation in fundus image EI Scopus
会议论文 | 2018 , 894 , 333-340 | 22nd Conference on Medical Image Understanding and Analysis, MIUA 2018
SCOPUS Cited Count: 1
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Abstract :

The segmentation and classification of retinal arterioles and venules play an important role in the diagnosis of various eye diseases and systemic diseases. The major challenges include complicated vessel structure, inhomogeneous illumination, and large background variation across subjects. In this study, we proposed an improved fully convolutional network that simultaneously segment arterioles and venules directly from the retinal image. To simultaneously segment retinal arterioles and venules, we configured the fully convolutional network to allow true color image as input and multiple labels as output. A domain-specific loss function is designed to improve the performance. The proposed method was assessed extensively on public datasets and compared with the state-of-the-art methods in literatures. The sensitivity and specificity of overall vessel segmentation on DRIVE is 0.870 and 0.980 with a misclassification rate of 23.7% and 9.8% for arteriole and venule, respectively. The proposed method outperforms the state-of-the-art methods and avoided possible error-propagation as in the segmentation-classification strategy. The proposed method holds great potential for the diagnostics and screening of various eye diseases and systemic diseases. © Springer Nature Switzerland AG 2018.

Keyword :

Arteriole Background variation Convolutional networks Misclassification rates Retinal vessels Sensitivity and specificity State-of-the-art methods Venule

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GB/T 7714 Xu, Xiayu , Tan, Tao , Xu, Feng . An improved U-net architecture for simultaneous arteriole and venule segmentation in fundus image [C] . 2018 : 333-340 .
MLA Xu, Xiayu et al. "An improved U-net architecture for simultaneous arteriole and venule segmentation in fundus image" . (2018) : 333-340 .
APA Xu, Xiayu , Tan, Tao , Xu, Feng . An improved U-net architecture for simultaneous arteriole and venule segmentation in fundus image . (2018) : 333-340 .
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Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives. EI PubMed Scopus SCIE
期刊论文 | 2018 , 36 (11) , 1127-1144 | Trends in biotechnology
WoS CC Cited Count: 5 SCOPUS Cited Count: 3
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Abstract :

Periodontitis has become one of the most universal chronic inflammatory diseases worldwide. Subclinical symptom progression, ultimately leading to permanent damage, calls for early diagnosis and long-term monitoring. However, traditional clinical diagnostic methods are complex and expensive, and cannot meet these requirements. Recently, with more biomarkers and the development of new technologies, various point-of-care testing (POCT) platforms have been developed for periodontitis diagnosis and monitoring. These are easy to perform, rapid, low-cost, and are perfectly suited for high-frequency diagnosis of periodontitis at the point-of-care (POC). We summarize existing biomarkers of different periodontitis stages and recent developed POCT platforms (including lab-on-a-chip, paper-based platforms, and chairside tests), discuss their existing challenges and future potential, and provide some inspiration and guidelines for future POC periodontitis testing.

Keyword :

paper-based test lab-on-a-chip device biomarkers chairside test point-of-care testing periodontitis diagnostics

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GB/T 7714 He Wanghong , You Minli , Wan Wanting et al. Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives. [J]. | Trends in biotechnology , 2018 , 36 (11) : 1127-1144 .
MLA He Wanghong et al. "Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives." . | Trends in biotechnology 36 . 11 (2018) : 1127-1144 .
APA He Wanghong , You Minli , Wan Wanting , Xu Feng , Li Fei , Li Ang . Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives. . | Trends in biotechnology , 2018 , 36 (11) , 1127-1144 .
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