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AIPcS(4)-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic (R) F127 nanomicellar drug carriers SCIE PubMed Scopus
期刊论文 | 2018 , 13 , 2017-2036 | INTERNATIONAL JOURNAL OF NANOMEDICINE
WoS CC Cited Count: 2
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Abstract :

Purpose: As a promising photodynamic therapy (PDT) agent, Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) provides deep penetration into tissue, high quantum yields, good photostability, and low photobleaching. However, its low delivery efficiency and high binding affinity to serum albumin cause its low penetration into cancer cells, further limiting its PDT effect on gastric cancer. In order to improve AlPcS4/PDT effect, the AlPcS4 delivery systems with different drug carriers were synthesized and investigated. Materials and methods: Gold nanorods, cationic liposomes, and Pluronic (R) F127 nanomicellars were used to formulate the AlPcS4 delivery systems. The anticancer effect was evaluated by CCK-8 assay and colony formation assay. The delivery efficiency of AlPcS4 and the binding affinity to serum proteins were determined by fluorescence intensity assay. The apoptosis and necrosis ability, reactive oxygen species and singlet oxygen generation, mitochondrial transmembrane potential and ([Ca2+](i)) concentration were further measured to evaluate the mechanism of cell death. Results: The series of synthesized AlPcS4 delivery systems with different drug carriers improve the limited PDT effect in varying degrees. In contrast, AlPcS4 complex with gold nanorods has significant anticancer effects because gold nanorods are not only suitable for AlPcS4 delivery, but also exhibit enhanced singlet oxygen generation effect and photothermal effect to induce cell death directly. Moreover, AlPcS4 complex with cationic liposomes shows the potent inhibition effect because of its optimal AlPcS4 delivery efficiency and ability to block serum albumin. In addition, AlPcS4 complex with Pluronic F127 exhibits inferior PDT effect but presents lower cytotoxicity, slower dissociation rate, and longer retention time of incorporated drugs; thus, F127-AlPcS4 is used for prolonged gastric cancer therapy. Conclusion: The described AlPcS4 drug delivery systems provide promising agents for gastric cancer therapy.

Keyword :

drug delivery carriers cationic liposome gastric cancer therapy gold nanoparticles nanomicelle AlPcS4

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GB/T 7714 Xin, Jing , Wang, Sijia , Wang, Bing et al. AIPcS(4)-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic (R) F127 nanomicellar drug carriers [J]. | INTERNATIONAL JOURNAL OF NANOMEDICINE , 2018 , 13 : 2017-2036 .
MLA Xin, Jing et al. "AIPcS(4)-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic (R) F127 nanomicellar drug carriers" . | INTERNATIONAL JOURNAL OF NANOMEDICINE 13 (2018) : 2017-2036 .
APA Xin, Jing , Wang, Sijia , Wang, Bing , Wang, Jiazhuang , Wang, Jing , Zhang, Luwei et al. AIPcS(4)-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic (R) F127 nanomicellar drug carriers . | INTERNATIONAL JOURNAL OF NANOMEDICINE , 2018 , 13 , 2017-2036 .
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Research Progress on Photodynamic Antimicrobial Chemotherapy Based on Rare Earth Upconversion Nanoplatform EI Scopus CSCD PKU
期刊论文 | 2018 , 45 (2) | Zhongguo Jiguang/Chinese Journal of Lasers
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Abstract :

Rare earth upconversion nanoparticles (UCNPs) can transform near-infrared light into ultraviolet-visible light, which can effectively solve the problems such as a low tissue penetration depth and a low treatment efficiency of photodynamic antimicrobial chemotherapy (PACT). The research progress on the photodynamic antimicrobial chemotherapy based on rare earth upconversion nanoplatforms is reviewed. The development of novel co-antibacterial platform and its clinical applications are prospected. © 2018, Chinese Lasers Press. All right reserved.

Keyword :

Combination therapy Medical optics Multidrug resistants Photodynamic antimicrobial chemotherapies Upconversion nanoparticles

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GB/T 7714 Zhao, Yiming , Liu, Chengcheng , Wang, Jing et al. Research Progress on Photodynamic Antimicrobial Chemotherapy Based on Rare Earth Upconversion Nanoplatform [J]. | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
MLA Zhao, Yiming et al. "Research Progress on Photodynamic Antimicrobial Chemotherapy Based on Rare Earth Upconversion Nanoplatform" . | Zhongguo Jiguang/Chinese Journal of Lasers 45 . 2 (2018) .
APA Zhao, Yiming , Liu, Chengcheng , Wang, Jing , Hu, Min . Research Progress on Photodynamic Antimicrobial Chemotherapy Based on Rare Earth Upconversion Nanoplatform . | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
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Preparation of Au@TiO2-HMME and Its Photodynamic Efficiency EI SCIE Scopus CSCD PKU
期刊论文 | 2017 , 37 (12) , 3670-3676 | SPECTROSCOPY AND SPECTRAL ANALYSIS | IF: 0.326
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Abstract :

Photodynamic therapy (PDT) is a potential treatment method that has proven to be an efficient, safe, and minimally invasive technique. The technique mainly depends on photosensitizes to produce reactive oxygen species underthe irradiation of specific wavelengthlight, therefore causing specific killing to tumor cells and tissues. Among them, hematoporphyrinmonomethyl ether (HMME) mediated PDT has been used in clinical treatment of port wine stain (PWS) due to its single component, high yield of singlet oxygen and short light-sensitive period. In order to improve the efficiency of the PDT, we synthesized stable, monodispersecation Au nanospheres with absorption peak of 530 nm based on seed-growth. Poly-(sodium 4-styrenesulfonate) (PSS) was employed to modify Au nanospheres owing to its low toxicity and strong anion electrolytic activation. Then TiOH2+ coming from TiCl3 hydrolysis could be closely attached to negatively charged Au nanospheres through electrostatic attraction and. further oxidation to obtain AuNP@TiOz core-shell nanostructure. The TiO2 shell thickness could be adjusted by changing the NaHCO3 amount, then further mixing AuNP TiOz core-shell and HMME to form the conjugate. The obtained samples were characterized by UV-visible absorption spectroscopy, infrared spectroscopy, laser nanoparticle size analyzer and transmission electron microscope (TEM). The results showed that the core-shell nanostructures were stable and well-distributed. Otherwise, the cell killing experiments were performed with KB cells and LED array of 510 nm light source, and CKK-8 was used to evaluate the cell viability. The results showed that the conjugate improved PDT efficiency about 35% higher than that of HMME alone.

Keyword :

Drug carrier Photodynamic therapy Stable conjugation Nucleus-shell construction

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GB/T 7714 Yao Cui-ping , Wang Jia-zhuang , Wang Jing et al. Preparation of Au@TiO2-HMME and Its Photodynamic Efficiency [J]. | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2017 , 37 (12) : 3670-3676 .
MLA Yao Cui-ping et al. "Preparation of Au@TiO2-HMME and Its Photodynamic Efficiency" . | SPECTROSCOPY AND SPECTRAL ANALYSIS 37 . 12 (2017) : 3670-3676 .
APA Yao Cui-ping , Wang Jia-zhuang , Wang Jing , Zhang Lu-wei , Wang Si-jia , Zhang Zhen-xi . Preparation of Au@TiO2-HMME and Its Photodynamic Efficiency . | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2017 , 37 (12) , 3670-3676 .
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Cancer cell death pathways caused by photothermal and photodynamic effects through gold nanoring induced surface plasmon resonance EI SCIE PubMed Scopus
期刊论文 | 2017 , 28 (27) | NANOTECHNOLOGY | IF: 3.404
WoS CC Cited Count: 1
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Abstract :

The different death pathways of cancer cells under the conditions of the photothermal (PT), effect, photodynamic (PD) effect, and their combination are evaluated. By incubating cells with Au nanoring (NRI) either linked with the photosensitizer, AlPcS, or not, the illumination of a visible continuous laser for exciting the photosensitizer or an infrared femtosecond laser for exciting the localized surface plasmon resonance of Au NRI, leads to various PT and PD conditions for study. Three different staining dyes are used for identifying the cell areas of different damage conditions at different temporal points of observation. The cell death pathways and apoptotic evolution speeds under different cell treatment conditions are evaluated based on the calibration of the threshold laser fluences for causing early-apoptosis (EA) and necrosis (NE) or late-apoptosis (LA). It is found that with the PT effect only, strong cell NE is generated and the transition from EA into LA is faster than that caused by the PD effect when the EA stage is reached within 0.5 h after laser illumination. By combining the PT and PD effects, in the first few hours, the transition speed becomes lower, compared to the case of the PT effect only, when both Au NRIs internalized into cells and adsorbed on cell membrane exist. When the Au NRIs on cell membrane is removed, in the first few hours, the transition speed becomes higher, compared to the case of the PD effect only.

Keyword :

cell death pathway photothermal therapy photodynamic therapy photosensitizer surface plasmon resonance Au nanoring

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GB/T 7714 He, Yulu , Hsiao, Jen-Hung , Yu, Jian-He et al. Cancer cell death pathways caused by photothermal and photodynamic effects through gold nanoring induced surface plasmon resonance [J]. | NANOTECHNOLOGY , 2017 , 28 (27) .
MLA He, Yulu et al. "Cancer cell death pathways caused by photothermal and photodynamic effects through gold nanoring induced surface plasmon resonance" . | NANOTECHNOLOGY 28 . 27 (2017) .
APA He, Yulu , Hsiao, Jen-Hung , Yu, Jian-He , Tseng, Po-Hao , Hua, Wei-Hsiang , Low, Meng-Chun et al. Cancer cell death pathways caused by photothermal and photodynamic effects through gold nanoring induced surface plasmon resonance . | NANOTECHNOLOGY , 2017 , 28 (27) .
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Rare-Earth-Based Nanoparticles with Simultaneously Enhanced Near-Infrared (NIR)-Visible (Vis) and NIR-NIR Dual-Conversion Luminescence for Multimodal Imaging EI SCIE PubMed Scopus
期刊论文 | 2016 , 11 (7) , 1050-1058 | CHEMISTRY-AN ASIAN JOURNAL | IF: 4.083
WoS CC Cited Count: 8
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Abstract :

Multifunctional NaGdF4:Yb3+,Er3+,Nd3+@NaGdF4:Nd3+ core-shell nanoparticles (called Gd:Yb3+,Er3+,Nd3+@Gd:Nd3+ NPs) with simultaneously enhanced near-infrared (NIR)-visible (Vis) and NIR-NIR dual-conversion (up and down) luminescence (UCL/DCL) properties were successfully synthesized. The resulting core-shell NPs simultaneously emitted enhanced UCL at 522, 540, and 660nm and DCL at 980 and 1060nm under the excitation of a 793nm laser. The enhanced UCL and DCL can be explained by complex energy-transfer processes, Nd3+Yb3+Er3+ and Nd3+Yb3+, respectively. The effects of Nd3+ concentration and shell thickness on the UCL/DCL properties were systematically investigated. The UCL and DCL properties of NPs were observed under the optimal conditions: a shell Nd3+ content of 20% and a shell thickness of approximately 5nm. Moreover, the Gd:Yb3+,Er3+,Nd3+@Gd:20% Nd3+ NPs exhibited remarkable magnetic resonance imaging (MRI) properties similar to that of a clinical agent, Omniscan. Thus, the core-shell NPs with excellent UCL/DCL/magnetic resonance imaging (MRI) properties have great potential for both in vitro and in vivo multimodal bioimaging.

Keyword :

upconversion imaging agents core-shell structures nanostructures luminescence

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GB/T 7714 Ma, Dandan , Xu, Xiang , Hu, Min et al. Rare-Earth-Based Nanoparticles with Simultaneously Enhanced Near-Infrared (NIR)-Visible (Vis) and NIR-NIR Dual-Conversion Luminescence for Multimodal Imaging [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2016 , 11 (7) : 1050-1058 .
MLA Ma, Dandan et al. "Rare-Earth-Based Nanoparticles with Simultaneously Enhanced Near-Infrared (NIR)-Visible (Vis) and NIR-NIR Dual-Conversion Luminescence for Multimodal Imaging" . | CHEMISTRY-AN ASIAN JOURNAL 11 . 7 (2016) : 1050-1058 .
APA Ma, Dandan , Xu, Xiang , Hu, Min , Wang, Jing , Zhang, Zhenxi , Yang, Jian et al. Rare-Earth-Based Nanoparticles with Simultaneously Enhanced Near-Infrared (NIR)-Visible (Vis) and NIR-NIR Dual-Conversion Luminescence for Multimodal Imaging . | CHEMISTRY-AN ASIAN JOURNAL , 2016 , 11 (7) , 1050-1058 .
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Wavelength dependence of femtosecond laser-induced breakdown in water and implications for laser surgery SCIE Scopus
期刊论文 | 2016 , 94 (2) | PHYSICAL REVIEW B | IF: 3.836
WoS CC Cited Count: 12 SCOPUS Cited Count: 14
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Abstract :

The wavelength dependence of the threshold for femtosecond optical breakdown in water provides information on the interplay of multiphoton, tunneling, and avalanche ionization and is of interest for parameter selection in laser surgery. We measured the bubble threshold from ultraviolet to near-infrared wavelengths and found a continuous decrease of the irradiance threshold with increasing wavelength lambda. Results are compared to the predictions of a numerical model that assumes a band gap of 9.5 eV and considers the existence of a separate initiation channel via excitation of valence band electrons into a solvated state followed by rapid upconversion into the conduction band. Fits to experimental data yield an electron collision time of approximate to 1 fs and an estimate for the capacity of the initiation channel. Using that collision time, the breakdown dynamics were explored up to lambda = 2 mu m. The irradiance threshold first continues to decrease but levels out for wavelengths longer than 1.3 mu m. This opens promising perspectives for laser surgery at wavelengths around 1.3 and 1.7 mu m, which are attractive because of their large penetration depth into scattering tissues.

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GB/T 7714 Linz, Norbert , Freidank, Sebastian , Liang, Xiao-Xuan et al. Wavelength dependence of femtosecond laser-induced breakdown in water and implications for laser surgery [J]. | PHYSICAL REVIEW B , 2016 , 94 (2) .
MLA Linz, Norbert et al. "Wavelength dependence of femtosecond laser-induced breakdown in water and implications for laser surgery" . | PHYSICAL REVIEW B 94 . 2 (2016) .
APA Linz, Norbert , Freidank, Sebastian , Liang, Xiao-Xuan , Vogel, Alfred . Wavelength dependence of femtosecond laser-induced breakdown in water and implications for laser surgery . | PHYSICAL REVIEW B , 2016 , 94 (2) .
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Model-based segmentation of the left atrium in CT and MRI scans EI Scopus
会议论文 | 2014 , 8330 LNCS , 31-41 | 4th International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2013, Held in Conjunction with MICCAI 2013
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Abstract :

Ablation is a minimal invasive interventional method used in cardiac electrophysiology. It is one option for the treatment of patients suffering from paroxysmal or persistent atrial fibrillation through pulmonary vein isolation. During the intervention endocardial surface potentials from a tracked mapping catheter are recorded with respect to a static patient specific surface geometry. The purpose of the presented work is to compare two different automatic segmentation methods working on both CT and MRI volumes. Segmentation of the left atrium is challenging because the shape variability is high. The use of statistical shape models initialized by means of affine image registration was explored as first method. The second method was non-parametric and based on atlas registration and statistical region growing. Segmentation results were validated and compared using a leave-one-out cross validation on the volumes provided with segmentation results achieved manually by experts. The Dice's coefficient was used as error measure. The method based on statistical region growing performed better than statistical shape models. A Dice's coefficient of 0.87 was achieved on both imaging modalities. © Springer-Verlag Berlin Heidelberg 2014.

Keyword :

Automatic segmentations Cardiac electrophysiology Endocardial surfaces Leave-one-out cross validations Model-based segmentation Segmentation results Shape variabilities Statistical shape model

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GB/T 7714 Stender, Birgit , Blanck, Oliver , Wang, Bo et al. Model-based segmentation of the left atrium in CT and MRI scans [C] . 2014 : 31-41 .
MLA Stender, Birgit et al. "Model-based segmentation of the left atrium in CT and MRI scans" . (2014) : 31-41 .
APA Stender, Birgit , Blanck, Oliver , Wang, Bo , Schlaefer, Alexander . Model-based segmentation of the left atrium in CT and MRI scans . (2014) : 31-41 .
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Motion compensation of optical mapping signals from isolated beating rat hearts EI CPCI-S Scopus
会议论文 | 2013 , 8856 | Conference on Applications of Digital Image Processing XXXVI
WoS CC Cited Count: 1
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Abstract :

Optical mapping is a well established technique for recording monophasic action potential traces on the epicardial surface of isolated hearts. This measuring technique offers a high spatial resolution but it is sensitive towards myocardial motion. Motion artifacts occur because the mapping between a certain tissue portion sending out fluorescent light and a pixel of the photo detector changes over time. So far this problem has been addressed by suppressing the motion or ratiometric imaging. We developed a different approach to compensate the motion artifacts based on image registration. We could demonstrate how an image deformation field temporally changing with the heart motion could be determined. Using these deformation field time series for image transformation motion signals could be generated for each image pixel which were then successfully applied to remove baseline shift and compensate motion artifacts potentially leading to errors within maps of the first arrival time. The investigation was based on five different rat hearts stained with Di-4-ANEPPS.

Keyword :

Optical mapping motion compensation non-rigid registration motion artifacts

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GB/T 7714 Stender, B. , Ernst, F. , Wang, B. et al. Motion compensation of optical mapping signals from isolated beating rat hearts [C] . 2013 .
MLA Stender, B. et al. "Motion compensation of optical mapping signals from isolated beating rat hearts" . (2013) .
APA Stender, B. , Ernst, F. , Wang, B. , Zhang, Z. X. , Schlaefer, A. . Motion compensation of optical mapping signals from isolated beating rat hearts . (2013) .
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An approach to validate ultrasound surface segmentation of the heart EI Scopus
期刊论文 | 2013 , 58 (SUPPL.1) | Biomedizinische Technik | IF: 1.227
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Abstract :

Cardiac ultrasound can be used to estimate the patient specific geometry of the heart, e.g., to model the inverse ECG problem. However, segmentation of the surface is complicated by artifacts, e.g., speckle noise, and segmentation methods are typically validated against manually drawn contours. This requires considerable expert knowledge and is time consuming. Hence, we have developed a setup that allows studying the accuracy of image segmentation from cardiac ultrasound. Using a three-dimensional mold constructed from a CT-data set, we have studied whether the actual geometry can be reconstructed from ultrasound images. We illustrate the use of our approach in quantifying the segmentation result for a three-dimensional region-based active contour algorithm. © 2013 by Walter de Gruyter.

Keyword :

Cardiac ultrasound Expert knowledge Region based active contours Segmentation methods Segmentation results Surface segmentation Ultrasound images Validation

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GB/T 7714 Wang, B. , Stender, B. , Long, T. et al. An approach to validate ultrasound surface segmentation of the heart [J]. | Biomedizinische Technik , 2013 , 58 (SUPPL.1) .
MLA Wang, B. et al. "An approach to validate ultrasound surface segmentation of the heart" . | Biomedizinische Technik 58 . SUPPL.1 (2013) .
APA Wang, B. , Stender, B. , Long, T. , Zhang, Z. , Schlaefer, A. . An approach to validate ultrasound surface segmentation of the heart . | Biomedizinische Technik , 2013 , 58 (SUPPL.1) .
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Synthesis of Folate Receptor-Targeted Nanoprobe for Detection of Cancer Cells and Its Spectral Analysis EI SCIE Scopus CSCD PKU
期刊论文 | 2013 , 33 (5) , 1299-1303 | SPECTROSCOPY AND SPECTRAL ANALYSIS | IF: 0.27
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Folate receptor (FR) is particularly upregulated in many epithelial cancer cells membrane and limited distribution is found in normal tissues. In the present work, the folic acid protected gold nanoparticles (FA-GNPs) were synthesized by a simple and quick method, in which chloroauric acid (HAuCl4) was reduced by sodium borohydride (NaBH4) in the presence of FA is used as stabilizer. UV-Visible spectroscopy and transmission electron microscopy (TEM) were used to characterize the shape and size distribution of the produced FA-GNPs. X-ray photoelectron spectroscopy and cell experiment were employed to confirm the immobilization of FA and GNPs. The results showed that FA-GNPs have a good size distribution in the 3 similar to 5 rim diameter range. Moreover, it is very stable even in solution with high concentration of salt (up to 3.5% NaCl), and even high speed centrifuges of 25 000 r . min(-1) could not cause aggregation. The nanoparticles could be used to detect cancer cells.

Keyword :

Spectral analysis Cancer cell Folate receptor Gold nanoparticles

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GB/T 7714 Yao Cui-ping , Wang Jing , Yang Yang et al. Synthesis of Folate Receptor-Targeted Nanoprobe for Detection of Cancer Cells and Its Spectral Analysis [J]. | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2013 , 33 (5) : 1299-1303 .
MLA Yao Cui-ping et al. "Synthesis of Folate Receptor-Targeted Nanoprobe for Detection of Cancer Cells and Its Spectral Analysis" . | SPECTROSCOPY AND SPECTRAL ANALYSIS 33 . 5 (2013) : 1299-1303 .
APA Yao Cui-ping , Wang Jing , Yang Yang , Dong Yan-hua , Xue Yang , Mei Jian-sheng et al. Synthesis of Folate Receptor-Targeted Nanoprobe for Detection of Cancer Cells and Its Spectral Analysis . | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2013 , 33 (5) , 1299-1303 .
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