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Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. EI PubMed Scopus
期刊论文 | 2019 , 192 , 248-254 | Talanta
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Abstract :

Radix Salviae Miltiorrhiae (also known as DanShen (DS) in China), a popular herbal drug in traditional Chinese medicine (TCM) for promoting blood circulation and treating blood stasis, has been reported to possess potential anti-tumor effects. The aim of the study was to develop an effective and practical method for screening and identifying bioactive compounds from Radix Salviae Miltiorrhiae. In this work, the epidermal growth factor receptor (EGFR) and fibroblast growth factor receptors 4 (FGFR4) dual-mixed/cell membrane chromatography (CMC) coupled with high performance liquid chromatography-electrospray ionization-ion trap-time of flight-multistage mass spectrum (HPLC-ESI-IT-TOF-MSn) was established and successfully used to identify the active components from Radix Salviae Miltiorrhiae. Salvianolic acid C (SAC), tanshinone I (Tan-I), tanshinone IIA (Tan-IIA), and cryptotanshinone (C-Tan) were identified as bioactive components with EGFR and FGFR4 activities. MTT and kinase assay were performed to investigate inhibitory effects of these compounds against EGFR and FGFR4 cells growth in vitro. Both cell viability and kinase activity showed that cryptotanshinone acting on EGFR receptor and tanshinone IIA acting on FGFR4 receptor. In conclusion, the EGFR & FGFR4 dual-mixed/CMC can simultaneously screen the bioactive components from TCMs that act on both EGFR and FGFR4 receptors, which significantly improve the efficiency of specific bioactive components identification from a complex system.

Keyword :

Epidermal growth factor receptor HPLC-ESI-IT-TOF-MSn Radix Salviae Miltiorrhiaeis Dual-mixed/cell membrane chromatography Fibroblast growth factor receptors 4

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GB/T 7714 Fu Jia , Lv Yanni , Jia Qianqian et al. Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. [J]. | Talanta , 2019 , 192 : 248-254 .
MLA Fu Jia et al. "Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors." . | Talanta 192 (2019) : 248-254 .
APA Fu Jia , Lv Yanni , Jia Qianqian , Lin Yuanyuan , Han Shengli . Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. . | Talanta , 2019 , 192 , 248-254 .
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Lenalidomide acesulfamate: Crystal structure, solid state characterization and dissolution performance EI Scopus
期刊论文 | 2019 , 1175 , 852-857 | Journal of Molecular Structure
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Abstract :

Lenalidomide (LEN) is a first line drug in the treatment of multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma. While, this compound holds poor water solubility, leading to unsatisfied bioavailability. To improve the solubility of LEN, a molecular salt with an artificial sweetener, acesulfame (AH), was obtained in this study. The LEN-AH salt was fully characterized by single-crystal and powder X-ray diffraction (XRD), 13C solid state nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), as well as dynamic vapour sorption (DVS). The crystal structure of LEN-AH clearly reveals the intermolecular proton transfer from NH group of AH to NH2 of LEN. The ionization state of LEN-AH was further confirmed by its feature 13C chemical shifts. The maximum solubility value of LEN was significantly enhanced after salt formation. And the supersaturation state of LEN solution can be maintained at a higher level with the presence of 0.1% PVP-K30. © 2018 Elsevier B.V.

Keyword :

Artificial sweeteners Intermolecular interactions Lenalidomide Myelodysplastic syndromes Single-crystal and powder Solid state characterization Solid-state nuclear magnetic resonance Solubilization

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GB/T 7714 Chen, Xin , Li, Duanxiu , Wang, Jianming et al. Lenalidomide acesulfamate: Crystal structure, solid state characterization and dissolution performance [J]. | Journal of Molecular Structure , 2019 , 1175 : 852-857 .
MLA Chen, Xin et al. "Lenalidomide acesulfamate: Crystal structure, solid state characterization and dissolution performance" . | Journal of Molecular Structure 1175 (2019) : 852-857 .
APA Chen, Xin , Li, Duanxiu , Wang, Jianming , Deng, Zongwu , Zhang, Hailu . Lenalidomide acesulfamate: Crystal structure, solid state characterization and dissolution performance . | Journal of Molecular Structure , 2019 , 1175 , 852-857 .
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Disparities in out-of-pocket inpatient expenditures in rural Shaanxi Province, western China from 2011 to 2014: a time series analysis SSCI SCIE PubMed Scopus
期刊论文 | 2018 , 23 (6) , 661-667 | TROPICAL MEDICINE & INTERNATIONAL HEALTH
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ObjectiveTo investigate the long-term trend of disparity of monthly average out-of-pocket inpatient expenditures (OOP) between areas with different developing levels since the new healthcare reform. MethodsTime series regression was used to assess the trend of disparities of OOP and monthly average inpatient expenditures (AIE) between areas with different developing levels in rural Shaanxi Province, western China. The data of OOP and AIE in primary health institutions, secondary hospitals, tertiary hospitals and also all levels of the hospital were analysed separately covering the period 2011 through to 2014. ResultsThe disparity of AIE at all levels of hospitals was increasing (coefficient=0.003, P=0.029), and only the disparity of AIE in secondary hospitals was statistical significant (coefficient=0.003, P=0.012) when separately considering different levels of the hospital. The disparity of OOP in all levels of the hospital was increasing (coefficient=0.007, P=0.001), and the OOP in primary hospitals contributed most of the disparity (coefficient=0.019, P=0.000), followed by OOP in secondary (coefficient=0.008, P=0.003) and tertiary hospitals (coefficient=0.004, P=0.091). ConclusionsA statistically significant absolute increase in the trend of disparities of OOP and AIE at all levels of hospital was detected after the new healthcare reform in Shaanxi Province, western China. The increase rate of disparity of OOP was bigger than that of AIE. A modified health insurance plan should be proposed to guarantee equity in the future. Abstract ObjectifsEtudier la tendance a long terme de la disparite dans les depenses directes de la poche (DDP) moyennes mensuelles des patients hospitalises entre les regions ayant des niveaux de developpement differents depuis la nouvelle reforme des soins de sante. MethodesLa regression des series chronologiques a ete utilisee pour evaluer la tendance des disparites des DDP et des depenses moyennes mensuelles des patients hospitalises (DMMPH) entre les regions ayant differents niveaux de developpement dans la province rurale du Shaanxi, dans l'ouest de la Chine. Les donnees des DDP et des DMMPH dans les etablissements de sante primaires, les hopitaux secondaires, les hopitaux tertiaires et a tous les niveaux de l'hopital ont ete analysees separement pour la periode allant de 2011 a 2014. ResultatsLa disparite des DMMPH a tous les niveaux des hopitaux augmentait (coefficient = 0,003; p = 0,029) et seule la disparite des DMMPH dans les hopitaux secondaires etait statistiquement significative (coefficient = 0,003; p = 0,012) lorsqu'on considerait separement differents niveaux de l'hopital. La disparite des DDP a tous les niveaux de l'hopital augmentait (coefficient = 0,007; P = 0.001) et les DDP dans les hopitaux primaires contribuait a la plus grande partie de la disparite (coefficient = 0,019; P = 0,000), suivie des DDP dans les hopitaux secondaires (coefficient = 0,008; p = 0,003) et tertiaires (coefficient = 0,004; p = 0,091). ConclusionsUne augmentation absolue statistiquement significative de la tendance des disparites entre les DDP et les DMMPH a tous les niveaux de l'hopital a ete detectee apres la nouvelle reforme des soins de sante dans la province du Shaanxi, dans l'ouest de la Chine. L'augmentation du taux de disparite des DDP etait plus importante que celle des DMMPH. Un schema d'assurance maladie modifie devrait etre propose pour garantir l'equite a l'avenir.

Keyword :

disparity out-of-pocket expenditures inpatient expenditure health insurance

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GB/T 7714 Yang, Caijun , Cai, Wenfang , Li, Zongjie et al. Disparities in out-of-pocket inpatient expenditures in rural Shaanxi Province, western China from 2011 to 2014: a time series analysis [J]. | TROPICAL MEDICINE & INTERNATIONAL HEALTH , 2018 , 23 (6) : 661-667 .
MLA Yang, Caijun et al. "Disparities in out-of-pocket inpatient expenditures in rural Shaanxi Province, western China from 2011 to 2014: a time series analysis" . | TROPICAL MEDICINE & INTERNATIONAL HEALTH 23 . 6 (2018) : 661-667 .
APA Yang, Caijun , Cai, Wenfang , Li, Zongjie , Fang, Yu . Disparities in out-of-pocket inpatient expenditures in rural Shaanxi Province, western China from 2011 to 2014: a time series analysis . | TROPICAL MEDICINE & INTERNATIONAL HEALTH , 2018 , 23 (6) , 661-667 .
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Direct and indirect cost of diabetes care among patients with type 2 diabetes in private clinics: a multicenter study in Punjab, Pakistan SSCI SCIE PubMed Scopus
期刊论文 | 2018 , 18 (6) , 647-653 | EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
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Abstract :

Background: Diabetes mellitus (DM) has a very high prevalence and poses a huge financial encumbrance on patients. This study aimed to evaluate the cost of diabetes care among patients with type 2 diabetes in private clinics of southern Punjab, Pakistan. Research design and methods: This was a descriptive, cross-sectional, prevalence-based, cost-of-illness (COI) study conducted in six private clinics of southern Punjab from July to September 2016, using a pretested questionnaire. Study participants were recruited using a random selection method. Continuous variables, including direct and indirect costs, were summarized using descriptive statistics. Inferential statistics were also used to analyze the correlation between the variables and cost. Results: The mean annual direct cost per patient with diabetes was estimated to be 332 USD. Medications accounted for the largest share (60.4%) of this cost. Age, locality, high socioeconomic status, and prolonged disease duration were significantly associated with the direct costs of illness (p<0.05). Moreover, 19% of total earnings among very low-income patients were spent on diabetes care. Conclusions: A substantial proportion of patients' income is spent on diabetes care in Punjab. Our findings support the substantial individual and societal burden caused by diabetes.

Keyword :

Diabetes mellitus Pakistan indirect cost direct cost on diabetes

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GB/T 7714 Gillani, Ali Hassan , Aziz, Muhammad Majid , Masood, Imran et al. Direct and indirect cost of diabetes care among patients with type 2 diabetes in private clinics: a multicenter study in Punjab, Pakistan [J]. | EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH , 2018 , 18 (6) : 647-653 .
MLA Gillani, Ali Hassan et al. "Direct and indirect cost of diabetes care among patients with type 2 diabetes in private clinics: a multicenter study in Punjab, Pakistan" . | EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH 18 . 6 (2018) : 647-653 .
APA Gillani, Ali Hassan , Aziz, Muhammad Majid , Masood, Imran , Saqib, Anum , Yang, Caijun , Chang, Jie et al. Direct and indirect cost of diabetes care among patients with type 2 diabetes in private clinics: a multicenter study in Punjab, Pakistan . | EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH , 2018 , 18 (6) , 647-653 .
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Knowledge, Attitudes and Practices Regarding Diabetes in the General Population: A Cross-Sectional Study from Pakistan SSCI SCIE PubMed Scopus
期刊论文 | 2018 , 15 (9) | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
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Background: Low knowledge about diabetes risk factors coupled with high disease prevalence is common in low-resource countries. This study evaluated diabetes-related knowledge, attitudes, and practices in the general population in Punjab (Pakistan). Methods: A cross-sectional study was conducted in five districts in Punjab from January to March 2017. Data were collected from 2019 adults aged 18-90 years through face-to-face interviews using a semi-structured questionnaire. The total knowledge score ranged from 0-9; a score 6 was considered adequate diabetes awareness. Descriptive statistics, chi-square tests, and linear and binary logistic regression were used for the analyses. Results: Respondents' mean age was 32.92 +/- 11.4 years. In total, 85.9% of respondents had heard of diabetes, and 30.1% knew about the glucose tolerance test. We found 2.3% of respondents scored zero for diabetes knowledge, 11.3% scored 9, and 47.4% scored 6 (adequate awareness). Being female ( = 0.37, 95% confidence interval [CI]: 0.16, 0.05; p = 0.001), socioeconomic status ( = 0.24, 95% CI: 0.12, 0.36; p < 0.001), being diabetic ( = 0.82, 95% CI: 0.53, 1.10; p < 0.001), and higher education ( = 0.25, 95% CI: 0.17, 0.33; p < 0.001) were significantly associated with knowledge score. Respondents with high socioeconomic status showed significantly higher positive attitudes compared with those with low socioeconomic status (adjusted odds ratio 1.57, 95% CI: 1.12, 2.24). Only 8.7% (30/343) of those diagnosed with diabetes had never undergone blood glucose screening since diagnosis. Conclusions: Knowledge of diabetes risk factors, management, and care is low in Pakistan's general population. Targeted public education programs should be instigated at a national level to increase understanding of diabetes prevention and treatment.

Keyword :

Pakistan knowledge practice general population attitude diabetes mellitus

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GB/T 7714 Gillani, Ali Hassan , Islam, Fakir Mohammad Amirul , Hayat, Khezar et al. Knowledge, Attitudes and Practices Regarding Diabetes in the General Population: A Cross-Sectional Study from Pakistan [J]. | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH , 2018 , 15 (9) .
MLA Gillani, Ali Hassan et al. "Knowledge, Attitudes and Practices Regarding Diabetes in the General Population: A Cross-Sectional Study from Pakistan" . | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 15 . 9 (2018) .
APA Gillani, Ali Hassan , Islam, Fakir Mohammad Amirul , Hayat, Khezar , Atif, Naveel , Yang, Caijun , Chang, Jie et al. Knowledge, Attitudes and Practices Regarding Diabetes in the General Population: A Cross-Sectional Study from Pakistan . | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH , 2018 , 15 (9) .
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A School-Based Educational Intervention for School-Aged Children and Caregivers about Rational Use of Antibiotics in Urban Areas of Shaanxi Province: A Study Protocol for a Randomized Controlled Research SSCI SCIE Scopus
期刊论文 | 2018 , 15 (9) | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
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(1) Background: Antibiotic resistance is an imperative public health issue globally. Major factors that are resulting in this trend are the irrational and excessive use of antibiotics. Children account for a greater population of antibiotics use, therefore, an educational intervention on the rational use of antibiotics for children and caregivers will be beneficial. (2) Methods: A randomized controlled and parallel group study of fifth grade children and their caregivers will be evaluated in four primary schools in Baoji and Weinan of the Shaanxi Province. Two primary schools will be randomly selected for the educational intervention and two schools will serve as a control group. In the intervention arm, educational interventions will be conducted among caregivers and their children. The intervention measures include interactive training sessions, booklets, and printed or electronic educational materials that will be given to the caregivers or the school-aged children. In the control arm, no interventions will be implemented. Baseline data collected from June, 2018 and the intervention will last for three months. Knowledge-Attitude-Practice (KAP) questionnaires will be used to evaluate the caregivers' knowledge, their attitude, and their practice. Knowledge-Retention questionnaires will be used to assess the children's knowledge about microbes, antibiotics, and hygiene. (3) Discussion: This study is a unique comprehensive intervention targeting both children and their caregivers. We hypothesize a decrease in the irrational use of antibiotics among the studied population. Hence, this result would provide evidence for policy makers and educational departments for the implementation of similar interventions on the rational use of antibiotics.

Keyword :

antibiotics resistance caregivers educational intervention upper respiratory tract infection children rational antibiotic use

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GB/T 7714 Zhang, Yu , Kabba, John , Chang, Jie et al. A School-Based Educational Intervention for School-Aged Children and Caregivers about Rational Use of Antibiotics in Urban Areas of Shaanxi Province: A Study Protocol for a Randomized Controlled Research [J]. | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH , 2018 , 15 (9) .
MLA Zhang, Yu et al. "A School-Based Educational Intervention for School-Aged Children and Caregivers about Rational Use of Antibiotics in Urban Areas of Shaanxi Province: A Study Protocol for a Randomized Controlled Research" . | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 15 . 9 (2018) .
APA Zhang, Yu , Kabba, John , Chang, Jie , Ji, Wenjing , Zhu, Shan , Yu, Jiale et al. A School-Based Educational Intervention for School-Aged Children and Caregivers about Rational Use of Antibiotics in Urban Areas of Shaanxi Province: A Study Protocol for a Randomized Controlled Research . | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH , 2018 , 15 (9) .
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miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells. PubMed Scopus
期刊论文 | 2018 , 661 , 1-9 | Archives of biochemistry and biophysics
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The Warburg effect, characterized by energy production through a high rate of aerobic glycolysis, is a metabolic hallmark of cancer cells. We previously found that ginsenoside 20(S)-Rg3 upregulated miR-603 and impaired the malignancy of ovarian cancer cells by inhibiting the Warburg effect. However, the precise functional role of miR-603 in ovarian cancer progression remains poorly defined. Here, we report that the level of miR-603 in ovarian cancer tissues is significantly lower than that in para-tumor tissues. Overexpression of miR-603 in ovarian cancer cells inhibits the Warburg effect as evidenced by a decrease in glucose consumption, lactate production and hexokinase-2 (HK2) expression, reduces cell proliferation in vitro, and weakens their migration and invasion. Further, miR-603 directly targets HK2 as indicated in a luciferase reporter assay. In contrast to agomiR-NC, agomiR-603 treatment significantly inhibits tumor growth in vivo and the Warburg effect, which is illustrated by a decreased uptake of <sup>18</sup>F-FDG in subcutaneous xenografts and HK2 downregulation. Finally, miR-603 is negatively regulated by DNMT3A-mediated DNA methylation in the promoter region of its precursor gene, suggesting that 20(S)-Rg3 antagonizes DNMT3A-mediated DNA methylation to impair growth, migration and invasion of ovarian cancer cells. In conclusion, miR-603 is a tumor suppressor targeting HK2 in ovarian cancer and its low level may result from DNMT3A-mediated methylation.

Keyword :

Ovarian cancer Warburg effect MicroRNA Methylation

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GB/T 7714 Lu Jiaojiao , Wang Lijie , Chen Wei et al. miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells. [J]. | Archives of biochemistry and biophysics , 2018 , 661 : 1-9 .
MLA Lu Jiaojiao et al. "miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells." . | Archives of biochemistry and biophysics 661 (2018) : 1-9 .
APA Lu Jiaojiao , Wang Lijie , Chen Wei , Wang Yueling , Zhen Shuai , Chen Hong et al. miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells. . | Archives of biochemistry and biophysics , 2018 , 661 , 1-9 .
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Prices, availability and affordability of insulin products: a cross-sectional survey in Shaanxi Province, western China. PubMed Scopus
期刊论文 | 2018 | Tropical medicine & international health : TM & IH
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To evaluate price, availability and affordability of insulin products in Shaanxi Province, western China.We used a simplified and adapted WHO/Health Action International method to obtain the availability and prices of insulin products and 5 oral anti-diabetic medicines as comparators in public general hospitals and private retail outlets. In addition, we investigated the price components of 8 selected insulin products by tracing the supply chain.All three kinds of insulin products, prandial, basal and premixed insulin, are 100% available in public hospitals, and have fairly high availability in the private sector (62.5% to 68.8%). The prices of most insulin products were higher than international reference prices in both sectors (ranging from 0.95 times to 2.33 times). All insulin products were unaffordable as they would cost 3.5 to 17.1 days' wage of the lowest-paid government workers in Shaanxi. The manufacturer's markup (selling price), which comprised more than 60% of the final price of all insulin products surveyed, was the largest price component.Although availability of insulin products was high in public general hospitals and private retail pharmacies, their high price made them unaffordable to diabetes patients, especially low-income patients. The government should increase insurance compensation for those who need these life-saving medicines or decrease the cost of insulin products through negotiation with suppliers. This article is protected by copyright. All rights reserved.

Keyword :

price components insulin China affordability availability

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GB/T 7714 Li Zongjie , Feng Qinqin , Kabba John Alimamy et al. Prices, availability and affordability of insulin products: a cross-sectional survey in Shaanxi Province, western China. [J]. | Tropical medicine & international health : TM & IH , 2018 .
MLA Li Zongjie et al. "Prices, availability and affordability of insulin products: a cross-sectional survey in Shaanxi Province, western China." . | Tropical medicine & international health : TM & IH (2018) .
APA Li Zongjie , Feng Qinqin , Kabba John Alimamy , Yang Caijun , Chang Jie , Jiang Minghuan et al. Prices, availability and affordability of insulin products: a cross-sectional survey in Shaanxi Province, western China. . | Tropical medicine & international health : TM & IH , 2018 .
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Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor. PubMed Scopus
期刊论文 | 2018 , 10 (20) , 2445-2455 | Future medicinal chemistry
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The discovery and development of novel agents simultaneously targeting PI3K/AKT/mammalian target of rapamycin and Ras/RAF/MEK, two signaling pathways, are urgent to improve the curative effect of kinase inhibitors and overcome acquired resistance.In the present study, 2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6-(N-cyclopropyl-N- (1-benzoylpiperidin-4-yl))triazines/pyrimidines were designed as PI3K and BRAF dual inhibitors. The synthesized 20 compounds exhibited potent antiproliferative effects in vitro against HCT116, A375, MCF-7, Colo205, A549 and LOVO cancer cell lines. The tested compounds A6, A7, A9 and A11 remarkably displayed inhibitory activities toward both PI3Kα and BRAF<sup>V600E</sup>.These results indicated that our design compounds can serve as potent PI3Kα and BRAF<sup>V600E</sup> dual inhibitors and effective antiproliferative agents, which can be further optimized to discover more potent PI3Kα and BRAF<sup>V600E</sup> dual inhibitors.

Keyword :

BRAF inhibitor drug design PI3K inhibitor antiproliferative effects PI3K and BRAF dual inhibitor

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GB/T 7714 Wang Hui-Yan , Shen Ying , Zhang Hao et al. Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor. [J]. | Future medicinal chemistry , 2018 , 10 (20) : 2445-2455 .
MLA Wang Hui-Yan et al. "Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor." . | Future medicinal chemistry 10 . 20 (2018) : 2445-2455 .
APA Wang Hui-Yan , Shen Ying , Zhang Hao , Hei Yuan-Yuan , Zhao Hong-Yi , Xin Minhang et al. Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor. . | Future medicinal chemistry , 2018 , 10 (20) , 2445-2455 .
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Association between loss of heterozygosity of chromosome 16q and survival in Wilms' tumor: A meta-analysis. PubMed Scopus
期刊论文 | 2018 , 214 (11) , 1772-1777 | Pathology, research and practice
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Wilms' tumor (WT) is the most common pediatric renal tumor. Despite its high survival rate, the potential prognostic factors should further be studied to reduce the intensity of the treatment. A few studies have found LOH of 16q is associated with worse survival in patients with WT, but it is still contradictory. This study aimed to performed a meta-analysis to clarify this.Databases including the Wanfang, PubMed, Chinese National Knowledge Infrastructure, Embase, and Cochrane Library databases were searched July 2018. The meta-analysis was done using Stata (version 14.0). Publication bias was evaluated by funnel plots, Begg's test, and Egger's test. The trim-and-fill method was applied if significant publication bias existed. Sensitivity analysis was performed to evaluate the stability of the results.This meta-analysis identified 9 cohort studies encompassing 3266 cases. The pooled relative risk when comparing LOH of 16q groups with control groups was 2.22 [95% confidence interval (CI) = 1.64-3.00, P < 0.001], and the pooled hazard ratio was 1.92 (95%CI = 1.32-2.80, P = 0.001). The results were stable after correcting for publication bias and performing a leave-one-out sensitivity analysis.This meta-analysis indicated that LOH of 16q was significantly associated with worse survival in WT. Further studies need to identify this conclusion because the overall quality of the included studies is not high, investigate the impact of LOH of 16q on the survival of WT patients in different subgroups and identify better treatments for WT patients with LOH of 16q in order to lengthen their survival.

Keyword :

LOH of 16q Wilms’ tumor Survival Meta-analysis

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GB/T 7714 Bu Qingting , He Hairong , Fan Di et al. Association between loss of heterozygosity of chromosome 16q and survival in Wilms' tumor: A meta-analysis. [J]. | Pathology, research and practice , 2018 , 214 (11) : 1772-1777 .
MLA Bu Qingting et al. "Association between loss of heterozygosity of chromosome 16q and survival in Wilms' tumor: A meta-analysis." . | Pathology, research and practice 214 . 11 (2018) : 1772-1777 .
APA Bu Qingting , He Hairong , Fan Di , Lyu Jun , Pan Zhenyu , You Haisheng . Association between loss of heterozygosity of chromosome 16q and survival in Wilms' tumor: A meta-analysis. . | Pathology, research and practice , 2018 , 214 (11) , 1772-1777 .
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