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Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting. PubMed SCIE
期刊论文 | 2019 , 37 (2) , 100-107 | Digestive diseases
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Gastroesophageal Reflux Disease Questionnaire (GERDQ) and Quality of Life in Reflux and Dyspepsia Questionnaire (QOLRAD) are reliable tools for evaluation of GERD.We aimed to test validity and reliability of Malay language translations of GERDQ and QOLRAD in a primary care setting.The questionnaires were first translated into the Malay language (GERDQ-M and QOLRAD-M). Patients from primary care clinics with suspected GERD were recruited to complete GERDQ-M, QOLRAD-M, and Malay-translated 36-item short-form health survey (SF-36 or SF-36-M), and underwent endoscopy and 24-h pH-impedance test.A total of 104 (mean age 47.1 years, women 51.9%) participants were enrolled. The sensitivity and specificity for GERDQ-M cut-off score ≥8 were 90.2 and 77.4%, respectively. Based on this cut-off score, 54.7% had a high probability of GERD diagnosis. GERD-M score ≥8 vs. < 8 was associated with erosive esophagitis (p < 0.001), hiatus hernia (p = 0.03), greater DeMeester score (p = 0.001), and Zerbib scores for acid refluxes (p < 0.001) but not non-acid refluxes (p = 0.1). Mean total scores of QOLRAD-M and SF-36-M were correlated (r = 0.74, p < 0.001). GERDQ-M ≥8, erosive esophagitis, and DeMeester ≥14.72 were associated with impaired QOLRAD-M in all domains (all p < 0.02) but this was not seen with SF-36.GERDQ-M and QOLRAD-M are valid and reliable tools applicable in a primary care setting.

Keyword :

Primary care Quality of Life in Reflux and Dyspepsia Questionnaire Malay Gastroesophageal reflux disease Gastroesophageal Reflux Disease Questionnaire

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GB/T 7714 Vadivelu Sangeta , Ma Zheng Feei , Ong Ean Wah et al. Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting. [J]. | Digestive diseases , 2019 , 37 (2) : 100-107 .
MLA Vadivelu Sangeta et al. "Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting." . | Digestive diseases 37 . 2 (2019) : 100-107 .
APA Vadivelu Sangeta , Ma Zheng Feei , Ong Ean Wah , Hassan Norhaliza , Nik Hassan Nik Fariza Husna , Syed Abdul Aziz Syed Hassan et al. Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting. . | Digestive diseases , 2019 , 37 (2) , 100-107 .
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STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction. PubMed SCIE
期刊论文 | 2019 , 33 (1) , 286-300 | FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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Infectious bursal disease virus (IBDV) infection triggers the induction of type I IFN, which is mediated by melanoma differentiation-associated protein 5 recognition of the viral genomic double-stranded RNA (dsRNA). However, the mechanism of IBDV overcoming the type I IFN antiviral response remains poorly characterized. Here, we show that IBDV genomic dsRNA selectively binds to the host cellular RNA binding protein Staufen1 (STAU1) in vitro and in vivo. The viral dsRNA binding region was mapped to the N-terminal moiety of STAU1 (residues 1-468). Down-regulation of STAU1 impaired IBDV replication and enhanced IFN-β transcription in response to IBDV infection, while having little effect on the viral attachment to the host cells and cellular entry. Conversely, overexpression of STAU1 but not the IBDV dsRNA-binding deficient STAU1 mutant (469-702) led to a suppression of IBDV dsRNA-induced IFN-β promoter activity. Moreover, we found that the binding of STAU1 to IBDV dsRNA decreased the association of melanoma differentiation-associated protein 5 but not VP3 with the IBDV dsRNA in vitro. Finally, we showed that STAU1 and VP3 suppressed IFN-β gene transcription in response to IBDV infection in an additive manner. Collectively, these findings provide a novel insight into the evasive strategies used by IBDV to escape the host IFN antiviral response.-Ye, C., Yu, Z., Xiong, Y., Wang, Y., Ruan, Y., Guo, Y., Chen, M., Luan, S., Zhang, E., Liu, H. STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.

Keyword :

RIG-I–like receptors RNA-binding protein innate antiviral response

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GB/T 7714 Ye Chengjin , Yu Zhaoli , Xiong Yiwei et al. STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction. [J]. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 2019 , 33 (1) : 286-300 .
MLA Ye Chengjin et al. "STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction." . | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 . 1 (2019) : 286-300 .
APA Ye Chengjin , Yu Zhaoli , Xiong Yiwei , Wang Yu , Ruan Yina , Guo Yueping et al. STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction. . | FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 2019 , 33 (1) , 286-300 .
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The optimal treatment for improving the cognitive function in elder people diagnosed with mild cognitive impairment incorporating Bayesian network meta-analysis and systematic review. PubMed SSCI SCIE
期刊论文 | 2019 , 51 , 85-96 | Ageing research reviews
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It's widely acknowledged that, as a neurodegenerative aging disease representing an intermediate stage between cognitive intactness and Alzheimer's disease(AD), Mild cognitive impairment(MCI) poses an excessive burden on patients' well-being, family members, health-care providers as well as the whole society. This study focuses on three cognitive interventions referred from Clare and Woods, that is, Cognitive stimulation(CS), Cognitive training(CT) and Cognitive rehabilitation(CR). Our Network meta-analysis(NMA) is aimed at comparing them with each other for evaluating the optimal cognitive intervention to help elderly adults with MCI to improve their cognitive function. We applied extensive strategies on preliminary literature collection to identify relevant randomized controlled trials (RCTs) which scrupulously compare any of these cognitive interventions with each other or instead with control groups such as with placebo or non-active groups as monotherapy in treatment with elder patients diagnosed primarily with MCI in accordance with the Petersen's criterion. Our NMA of cognitive interventions for patients diagnosed with MCI appraised the relative effectiveness of cognitive interventions across trials simultaneously, our study is attempted to summarize available data to suggest that CS (Mean difference [MD] = 0.95, 95% confidence interval [CI]:0.27, 1.70) and CT (MD = 0.70, [CI]:0.11,1.30) were significantly beneficial to help MCI patients to improve their cognition status while CR gets the lowest rank. There's no previous study which has solved the problem of which cognitive intervention is relatively the best intervention for MCI, our study suggested CS was most likely to be the best treatment for improving the cognitive ability of them.

Keyword :

Systematic review Cognitive intervention Bayesian network meta-analysis Mild cognitive impairment

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GB/T 7714 Liang Jing-Hong , Shen Wan-Ting , Li Jia-Yu et al. The optimal treatment for improving the cognitive function in elder people diagnosed with mild cognitive impairment incorporating Bayesian network meta-analysis and systematic review. [J]. | Ageing research reviews , 2019 , 51 : 85-96 .
MLA Liang Jing-Hong et al. "The optimal treatment for improving the cognitive function in elder people diagnosed with mild cognitive impairment incorporating Bayesian network meta-analysis and systematic review." . | Ageing research reviews 51 (2019) : 85-96 .
APA Liang Jing-Hong , Shen Wan-Ting , Li Jia-Yu , Qu Xin-Yuan , Li Jing , Jia Rui-Xia et al. The optimal treatment for improving the cognitive function in elder people diagnosed with mild cognitive impairment incorporating Bayesian network meta-analysis and systematic review. . | Ageing research reviews , 2019 , 51 , 85-96 .
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The Roles of Power Distance Orientation and Perceived Insider Status in the Subordinates' Moqi with Supervisors and Sustainable Knowledge-Sharing SSCI SCIE
期刊论文 | 2019 , 11 (5) | SUSTAINABILITY
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Although knowledge-sharing, an important facet of knowledge management, has been encouraged for the sustainable development of organizations, this kind of behavior is still not prevalent among group members. To enrich the literature and contribute to its practical usage, this research proposed a model based on the fit theory to examine the roles of perceived insider status (PIS) and power distance orientation in subordinates' Moqi with supervisors (SMS) and knowledge-sharing. Survey data from eight firms in China contained 196 samples and was analyzed by MPLUS software to justify the hypotheses. The results showed that: first, SMS predicted knowledge-sharing and perceived insider status; second, perceived insider status positively mediated the relationship between SMS and knowledge-sharing; third, power distance orientation not only positively moderated the relationship between SMS and perceived insider status, but also positively moderated the relationship between SMS and knowledge-sharing. This study enriched the literature on the antecedents of knowledge-sharing and application of SMS. Additionally, this study proposes a few suggestions to practitioners and researchers for establishing sustainable organizations.

Keyword :

power distance orientation perceived insider status subordinates' Moqi with supervisors knowledge-sharing sustainable organization

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GB/T 7714 Zheng, Xingshan , Li, Lan , Zhang, Fangyu et al. The Roles of Power Distance Orientation and Perceived Insider Status in the Subordinates' Moqi with Supervisors and Sustainable Knowledge-Sharing [J]. | SUSTAINABILITY , 2019 , 11 (5) .
MLA Zheng, Xingshan et al. "The Roles of Power Distance Orientation and Perceived Insider Status in the Subordinates' Moqi with Supervisors and Sustainable Knowledge-Sharing" . | SUSTAINABILITY 11 . 5 (2019) .
APA Zheng, Xingshan , Li, Lan , Zhang, Fangyu , Zhu, Mengyuan . The Roles of Power Distance Orientation and Perceived Insider Status in the Subordinates' Moqi with Supervisors and Sustainable Knowledge-Sharing . | SUSTAINABILITY , 2019 , 11 (5) .
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Pay-it-forward strategy to enhance uptake of dual gonorrhea and chlamydia testing among men who have sex with men in China: a pragmatic, quasi-experimental study SCIE
期刊论文 | 2019 , 19 (1) , 76-82 | LANCET INFECTIOUS DISEASES
WoS CC Cited Count: 1
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Background Chinese men who have sex with men (MSM) rarely receive gonorrhoea and chlamydia testing. The purpose of this pilot study was to evaluate a pay-it-forward strategy to increase uptake of gonorrhoea and chlamydia testing among MSM. Methods We performed a quasi-experimental pragmatic study to compare a pay-it-forward model with standard of care at two HIV testing sites for MSM in Guangzhou, China: an STD clinic for MSM and a local MSM community based organisation. All men who arrived at the STD clinic or the community-based organisation were invited to participate. In the pay-it-forward programme, men were offered free gonorrhoea and chlamydia testing and given the option of donating money toward testing for future participants. In the standard-of-care group, men were offered gonorrhoea and chlamydia testing at the standard patient price of Y150 (about US$21.50). The pay-it-forward programme was implemented for 3 months, after which both sites switched to standard of care offering dual testing for 3 months. The primary outcome for this study was uptake of dual gonorrhoea and chlamydia testing, which we compared using x(2) test and logistic regression, reported as crude odds ratios (cOR) and adjusted odds ratios (aOR), by adjusting for nationality, marital status, income, and site of testing. Findings The pay-it-forward programme took place from Dec 2, 2017, to Feb 3, 2018, and the standard-of-care control took place from March 11, 2018, to May 1, 2018. 408 men were included in this study. 203 men were offered pay-it forward, and 205 were offered standard of care. Overall, 109 (54%) of 203 men in the pay-it-forward group and 12 (6%) of 205 men in the standard-of-care group received gonorrhoea and chlamydia testing (cOR 18.65, 9 78-35 54; p<0.0001; aOR 19.73, 95% CI 10. 02-38. 85; p<0.0001). Of all 121 men who tested, this was the first gonorrhoea test for 97 (80%) men and the first chlamydia test for 104 (86%) men. Five (4%) of these 121 men were diagnosed with gonorrhoea and 15 (12%) were diagnosed with chlamydia. 97 (89%) of 109 men who received testing in the pay-it forward group donated some money toward testing for future participants. Interpretation Pay-it-forward might be a sustainable model for expanding integrated HIV testing services among MSM in China. Copyright (C) 2018 Elsevier Ltd. All rights reserved.

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GB/T 7714 Li, Katherine T. , Tang, Weiming , Wu, Dan et al. Pay-it-forward strategy to enhance uptake of dual gonorrhea and chlamydia testing among men who have sex with men in China: a pragmatic, quasi-experimental study [J]. | LANCET INFECTIOUS DISEASES , 2019 , 19 (1) : 76-82 .
MLA Li, Katherine T. et al. "Pay-it-forward strategy to enhance uptake of dual gonorrhea and chlamydia testing among men who have sex with men in China: a pragmatic, quasi-experimental study" . | LANCET INFECTIOUS DISEASES 19 . 1 (2019) : 76-82 .
APA Li, Katherine T. , Tang, Weiming , Wu, Dan , Huang, Wenting , Wu, Feng , Lee, Amy et al. Pay-it-forward strategy to enhance uptake of dual gonorrhea and chlamydia testing among men who have sex with men in China: a pragmatic, quasi-experimental study . | LANCET INFECTIOUS DISEASES , 2019 , 19 (1) , 76-82 .
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Special issue on advances in graph algorithm and applications EI SCIE
期刊论文 | 2019 , 336 , 1-2 | Neurocomputing
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GB/T 7714 Liu, Zhi-Yong , Huang, Kai-Zhu , Yang, Xu et al. Special issue on advances in graph algorithm and applications [J]. | Neurocomputing , 2019 , 336 : 1-2 .
MLA Liu, Zhi-Yong et al. "Special issue on advances in graph algorithm and applications" . | Neurocomputing 336 (2019) : 1-2 .
APA Liu, Zhi-Yong , Huang, Kai-Zhu , Yang, Xu , Liu, Cheng-Lin . Special issue on advances in graph algorithm and applications . | Neurocomputing , 2019 , 336 , 1-2 .
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Weather cues associated with masting behavior dampen the negative autocorrelation between past and current reproduction in oaks SCIE PubMed
期刊论文 | 2019 , 106 (1) , 51-60 | AMERICAN JOURNAL OF BOTANY
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Premise of the Study The influence of weather conditions on masting and the ecological advantages of this reproductive behavior have been the subject of much interest. Weather conditions act as cues influencing reproduction of individual plants, and similar responses expressed across many individuals lead to population-level synchrony in reproductive output. In turn, synchrony leads to benefits from economies of scale such as enhanced pollination success and seed predator satiation. However, there may also be individual-level benefits from reproductive responses to weather cues, which may explain the origin of masting in the absence of economies of scale. In a previous study, we found support for a mechanism whereby individual responses to weather cues attenuate the negative autocorrelation between past and current annual seed production-a pattern typically attributed to resource limitation and reproductive tradeoffs among years. Methods Here we provide a follow-up and more robust evaluation of this hypothesis in 12 species of oaks (Quercus spp.), testing for a negative autocorrelation (tradeoff) between past and current reproduction and whether responses to weather cues associated with masting reduce the strength of this negative autocorrelation. Key Results Our results showed a strong negative autocorrelation for 11 of the species, and that species-specific reproductive responses to weather cues dampened this negative autocorrelation in 10 of them. Conclusions This dampening effect presumably reflects a reduction in resource limitation or increased resource use associated with weather conditions, and suggests that responses to weather cues conferring these advantages should be selected for based on individual benefits.

Keyword :

evergreen Quercus acorn production temperature synchrony resource limitation deciduous precipitation

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GB/T 7714 Moreira, Xoaquin , Abdala-Roberts, Luis , Perez-Ramos, Ignacio M. et al. Weather cues associated with masting behavior dampen the negative autocorrelation between past and current reproduction in oaks [J]. | AMERICAN JOURNAL OF BOTANY , 2019 , 106 (1) : 51-60 .
MLA Moreira, Xoaquin et al. "Weather cues associated with masting behavior dampen the negative autocorrelation between past and current reproduction in oaks" . | AMERICAN JOURNAL OF BOTANY 106 . 1 (2019) : 51-60 .
APA Moreira, Xoaquin , Abdala-Roberts, Luis , Perez-Ramos, Ignacio M. , Knops, Johannes M. H. , Pesendorfer, Mario B. , Koenig, Walter D. et al. Weather cues associated with masting behavior dampen the negative autocorrelation between past and current reproduction in oaks . | AMERICAN JOURNAL OF BOTANY , 2019 , 106 (1) , 51-60 .
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Charge specific baryon mass relations with deformed SUq(3) flavor symmetry (vol 52, pg 321, 2016) SCIE
期刊论文 | 2019 , 55 (1) | EUROPEAN PHYSICAL JOURNAL A
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After publication of the paper, the author noticed that the acknowledgement section contained an error. The correction is given in this erratum.

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GB/T 7714 Gresnigt, Niels G. . Charge specific baryon mass relations with deformed SUq(3) flavor symmetry (vol 52, pg 321, 2016) [J]. | EUROPEAN PHYSICAL JOURNAL A , 2019 , 55 (1) .
MLA Gresnigt, Niels G. . "Charge specific baryon mass relations with deformed SUq(3) flavor symmetry (vol 52, pg 321, 2016)" . | EUROPEAN PHYSICAL JOURNAL A 55 . 1 (2019) .
APA Gresnigt, Niels G. . Charge specific baryon mass relations with deformed SUq(3) flavor symmetry (vol 52, pg 321, 2016) . | EUROPEAN PHYSICAL JOURNAL A , 2019 , 55 (1) .
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Effect of micronutrients on algae in different regions of Taihu, a large, spatially diverse, hypereutrophic lake. PubMed SCIE
期刊论文 | 2019 , 151 , 500-514 | Water research
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Eutrophication or excessive nutrient richness is an impairment of many freshwater ecosystems and a prominent cause of harmful algal blooms. It is generally accepted that nitrogen and phosphorus nutrients are the primary causative factor, however, for systems subject to large anthropogenic perturbation, this may no longer be true, and the role of micronutrients is often overlooked. Here we report a study on Lake Tai (Taihu), a large, spatially diverse and hypereutrophic lake in China. We performed small-scale mesocosm nutrient limitation bioassays using boron, iron, cobalt, copper, molybdenum, nitrogen and phosphorus on phytoplankton communities sampled from different locations in Taihu to test the relative effects of micronutrients on in situ algal assemblages. In addition to commonly-used methods of chemical and biological analysis (including algal phytoplankton counting), we used flow cytometry coupled with data-driven analysis to monitor changes to algal assemblages. We found statistically significant effects of limitation or co-limitation for boron, cobalt, copper and iron. For copper at one location chlorophyll-a was over four times higher for amendment with copper, nitrogen and phosphorous than for the latter two alone. Since copper is often proposed as amendment for the environmental management of harmful algal blooms, this result is significant. We have three primary conclusions: first, the strong effects for Cu that we report here are mutually consistent across chlorophyll-a results, count data, and results determined from a data-driven approach to flow cytometry. Given that we cannot rule out a role for a Fe-Cu homeostatic link in causing these effects, future research into MNs and how they interact with N, P, and other MNs should be pursued to explore new interventions for effective management of HABs. Second, in view of the stimulatory effect that Cu exhibited, management of HABs with Cu as an algal biocide may not always be advisable. Third, our approach to flow cytometry offers data confirming our results from chemical and biological analysis, however also holds promise for future development as a high-throughput tool for use in understanding changes in algal assemblages. The results from this study concur with a small and emerging body of literature suggesting that the potential role of micronutrients in eutrophication requires further consideration in environmental management.

Keyword :

Eutrophication Copper Flow cytometry Lake Harmful algal bloom Micronutrient limitation

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GB/T 7714 Zhang Xiaokai , Li Boling , Xu Hai et al. Effect of micronutrients on algae in different regions of Taihu, a large, spatially diverse, hypereutrophic lake. [J]. | Water research , 2019 , 151 : 500-514 .
MLA Zhang Xiaokai et al. "Effect of micronutrients on algae in different regions of Taihu, a large, spatially diverse, hypereutrophic lake." . | Water research 151 (2019) : 500-514 .
APA Zhang Xiaokai , Li Boling , Xu Hai , Wells Mona , Tefsen Boris , Qin Boqiang . Effect of micronutrients on algae in different regions of Taihu, a large, spatially diverse, hypereutrophic lake. . | Water research , 2019 , 151 , 500-514 .
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Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy. PubMed SCIE
期刊论文 | 2019 , 24 (2) | Molecules
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Renal carcinoma cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP, MMP-14) to degrade extracellular matrix components and a range of bioactive molecules to allow metastasis and cell proliferation. The activity of MT1-MMP is modulated by the endogenous inhibitors, Tissue Inhibitor of Metalloproteinases (TIMPs). In this study, we describe a novel strategy that would enable a "designer" TIMP-1 tailored specifically for MT1-MMP inhibition (V4A/P6V/T98L; <i>K</i>i<sup>app</sup> 1.66 nM) to be targeted to the plasma membrane for more effective MT1-MMP inhibition. To achieve this, we fuse the designer TIMP-1 to the glycosyl-phosphatidyl inositol (GPI) anchor of the prion protein to create a membrane-tethered, high-affinity TIMP variant named "T1<sup>Pr αMT1</sup>" that is predominantly located on the cell surface and co-localised with MT1-MMP. Confocal microscopy shows that T1<sup>Pr αMT1</sup> is found throughout the cell surface in particular the membrane ruffles where MT1-MMP is most abundant. Expression of T1<sup>Pr αMT1</sup> brings about a complete abrogation of the gelatinolytic activity of cellular MT1-MMP in HT1080 fibrosarcoma cells whilst in renal carcinoma cells CaKi-1, the GPI-TIMP causes a disruption in MMP-mediated proteolysis of ECM components such as fibronectin, collagen I and laminin that consequently triggers a downstream senescence response. Moreover, the transduced cells also suffer from an impairment in proliferation and survival in vitro as well as in NOD/SCID mouse xenograft. Taken together, our findings demonstrate that the GPI anchor of prion could be exploited as a targeting device in TIMP engineering for MT1-MMP inhibition with a potential in renal carcinoma therapy.

Keyword :

TIMP protein engineering MT1-MMP prion renal carcinoma GPI anchor cancer therapy

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GB/T 7714 Jiang Bingjie , Liu Jian , Lee Meng Huee . Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy. [J]. | Molecules , 2019 , 24 (2) .
MLA Jiang Bingjie et al. "Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy." . | Molecules 24 . 2 (2019) .
APA Jiang Bingjie , Liu Jian , Lee Meng Huee . Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy. . | Molecules , 2019 , 24 (2) .
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