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p38 MAPK signaling pathway activation by phenyl benzoxime in SNU-306 cells causes induction of apoptosis. PubMed SCIE
期刊论文 | 2019 , 126 , 74-78 | Microbial pathogenesis
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Abstract :

The present study was aimed to investigate and understand the mechanism of inhibitory effect of phenyl benzoxime on proliferation of SNU-306 cells. Proliferation of SNU-306 cells transfected with wild-type p53-induced phosphatase 1 (Wip1)-siRNA or treated with phenyl benzoxime was examined by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Induction of apoptosis was examined by flow cytometry using annexin V-fluorescein isothiocyanate/propidium iodide staining. In SNU-306 cells Wip1 mRNA and protein expression was found to be significantly (p < 0.05) higher compared to normal cells. However, Wip1-siRNA transfection significantly (p < 0.02) inhibited the expression of Wip1 at 60 nmol/l. The proliferation of SNU-306 cells was inhibited to 3.7% on transfection with Wip1-siRNA. Phenyl benzoxime reduced proliferation to 92.0, 75.0, 49.0, 19.0 and 4.0% at 1, 2, 4, 8 and 10 μM doses, respectively. The expression of Wip1 was significantly (p < 0.01) suppressed in SNU-306 cells on phenyl benzoxime treatment. Phenyl benzoxime induced apoptosis in 74.73% cells at 10 μM doses compared to 1.34% in control. Treatment with phenyl benzoxime markedly increased the expression of Bax, caspase-3 and p53 and decreased Bcl-2 mRNA. Moreover, addition of SB203580 to cultures of SNU-306 cells significantly (p < 0.01) prevented phenyl benzoxime mediated inhibition of cell proliferation. Phenyl benzoxime induces apoptosis and inhibits SNU-306 cell proliferation by silencing Wip1 expression through p38 MAPK signaling pathway activation. Therefore, phenyl benzoxime can act as an important chemotherapeutic agent for breast cancer treatment.

Keyword :

Signaling Apoptosis Proliferation Estrogen Proto-oncogene

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GB/T 7714 Chen Wei , Tan Yanni , Zhang Yu . p38 MAPK signaling pathway activation by phenyl benzoxime in SNU-306 cells causes induction of apoptosis. [J]. | Microbial pathogenesis , 2019 , 126 : 74-78 .
MLA Chen Wei 等. "p38 MAPK signaling pathway activation by phenyl benzoxime in SNU-306 cells causes induction of apoptosis." . | Microbial pathogenesis 126 (2019) : 74-78 .
APA Chen Wei , Tan Yanni , Zhang Yu . p38 MAPK signaling pathway activation by phenyl benzoxime in SNU-306 cells causes induction of apoptosis. . | Microbial pathogenesis , 2019 , 126 , 74-78 .
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Osteoprotegerin mediate RANK/RANKL signaling inhibition eases asthma inflammatory reaction by affecting the survival and function of dendritic cells. SCIE PubMed Scopus
期刊论文 | 2019 , 47 (2) , 179-184 | Allergologia et immunopathologia
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Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Dendritic cells (DCs) are considered the most important antigen-presenting cell in asthma airway inflammatory reaction. But whether osteoprotegerin (OPG) mediate RANK/RANKL signaling inhibition influences asthma development by affecting the survival and function of DCs remains unclear. In this study, we assessed the effects of OPG on DCs and asthma.BALB/c mice immunized with ovalbumin (OVA) were challenged thrice with an aerosol of OVA every second day for eight days. Dexamethasone (1.0mg/kg) or OPG (50μg/kg) was administered intraperitoneally to OVA-immunized BALB/c mice on day 24 once a day for nine days. Mice were analyzed for effects of OPG on asthma, inflammatory cell infiltration and cytokine levels in lung tissue. The expression of RANK and β-actin was detected by Western Blot. DCs were isolated from mouse bone morrow. Cell survival was assessed by cell counting. The content of IL-12 was detected by ELISA.Results showed that OVA increased the number of inflammatory factors in BALF, elevated lung inflammation scores in mice. OPG reversed the alterations induced by OVA in the asthmatic mice. OPG inhibited the survival and function of DC via inhibition of RANK/RANKL signaling.This research proved inhibition of RANK/RANKL signaling by OPG could ease the inflammatory reaction in asthma, providing new evidence for the application of OPG on asthma.

Keyword :

Asthma Dendritic cells Osteoprotegerin RANK/RANKL

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GB/T 7714 Yang X , Wang X , Chi M et al. Osteoprotegerin mediate RANK/RANKL signaling inhibition eases asthma inflammatory reaction by affecting the survival and function of dendritic cells. [J]. | Allergologia et immunopathologia , 2019 , 47 (2) : 179-184 .
MLA Yang X et al. "Osteoprotegerin mediate RANK/RANKL signaling inhibition eases asthma inflammatory reaction by affecting the survival and function of dendritic cells." . | Allergologia et immunopathologia 47 . 2 (2019) : 179-184 .
APA Yang X , Wang X , Chi M , Zhang M , Shan H , Zhang Q-H et al. Osteoprotegerin mediate RANK/RANKL signaling inhibition eases asthma inflammatory reaction by affecting the survival and function of dendritic cells. . | Allergologia et immunopathologia , 2019 , 47 (2) , 179-184 .
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Pay-it-forward strategy to enhance uptake of dual gonorrhea and chlamydia testing among men who have sex with men in China: a pragmatic, quasi-experimental study SCIE
期刊论文 | 2019 , 19 (1) , 76-82 | LANCET INFECTIOUS DISEASES
WoS CC Cited Count: 1
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Background Chinese men who have sex with men (MSM) rarely receive gonorrhoea and chlamydia testing. The purpose of this pilot study was to evaluate a pay-it-forward strategy to increase uptake of gonorrhoea and chlamydia testing among MSM. Methods We performed a quasi-experimental pragmatic study to compare a pay-it-forward model with standard of care at two HIV testing sites for MSM in Guangzhou, China: an STD clinic for MSM and a local MSM community based organisation. All men who arrived at the STD clinic or the community-based organisation were invited to participate. In the pay-it-forward programme, men were offered free gonorrhoea and chlamydia testing and given the option of donating money toward testing for future participants. In the standard-of-care group, men were offered gonorrhoea and chlamydia testing at the standard patient price of Y150 (about US$21.50). The pay-it-forward programme was implemented for 3 months, after which both sites switched to standard of care offering dual testing for 3 months. The primary outcome for this study was uptake of dual gonorrhoea and chlamydia testing, which we compared using x(2) test and logistic regression, reported as crude odds ratios (cOR) and adjusted odds ratios (aOR), by adjusting for nationality, marital status, income, and site of testing. Findings The pay-it-forward programme took place from Dec 2, 2017, to Feb 3, 2018, and the standard-of-care control took place from March 11, 2018, to May 1, 2018. 408 men were included in this study. 203 men were offered pay-it forward, and 205 were offered standard of care. Overall, 109 (54%) of 203 men in the pay-it-forward group and 12 (6%) of 205 men in the standard-of-care group received gonorrhoea and chlamydia testing (cOR 18.65, 9 78-35 54; p<0.0001; aOR 19.73, 95% CI 10. 02-38. 85; p<0.0001). Of all 121 men who tested, this was the first gonorrhoea test for 97 (80%) men and the first chlamydia test for 104 (86%) men. Five (4%) of these 121 men were diagnosed with gonorrhoea and 15 (12%) were diagnosed with chlamydia. 97 (89%) of 109 men who received testing in the pay-it forward group donated some money toward testing for future participants. Interpretation Pay-it-forward might be a sustainable model for expanding integrated HIV testing services among MSM in China. Copyright (C) 2018 Elsevier Ltd. All rights reserved.

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GB/T 7714 Li, Katherine T. , Tang, Weiming , Wu, Dan et al. Pay-it-forward strategy to enhance uptake of dual gonorrhea and chlamydia testing among men who have sex with men in China: a pragmatic, quasi-experimental study [J]. | LANCET INFECTIOUS DISEASES , 2019 , 19 (1) : 76-82 .
MLA Li, Katherine T. et al. "Pay-it-forward strategy to enhance uptake of dual gonorrhea and chlamydia testing among men who have sex with men in China: a pragmatic, quasi-experimental study" . | LANCET INFECTIOUS DISEASES 19 . 1 (2019) : 76-82 .
APA Li, Katherine T. , Tang, Weiming , Wu, Dan , Huang, Wenting , Wu, Feng , Lee, Amy et al. Pay-it-forward strategy to enhance uptake of dual gonorrhea and chlamydia testing among men who have sex with men in China: a pragmatic, quasi-experimental study . | LANCET INFECTIOUS DISEASES , 2019 , 19 (1) , 76-82 .
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LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture SCIE
期刊论文 | 2019 , 16 | JOURNAL OF INFLAMMATION-LONDON
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Background: Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe sepsis and septic shock. We hypothesized that LDK378 can improve micro- and macro-circulation of septic rats, therefore improving the outcome of survival via blocking the ALK-STING pathway to attenuate inflammatory injuries. Methods: A septic rat model was established by the cecal ligation and puncture (CLP) method. A total of 60 rats were randomized into three groups: a sham group, CLP group, and CLP + LDK378 group (n = 20 in each group). Five rats were randomly selected from each group for the mechanism study; the remaining 15 rats in each group were involved in a survival curve examination. A sidestream dark field video microscope was used to record sublingual microcirculation and mean arterial pressure (MAP) and levels of inflammatory cytokine secretion were examined at 6 h, 30 h, and 54 h after CLP surgery. Expressions of TANK binding kinase 1 (TBK1) and its downstream targets were determined, and histological alterations to the heart, lungs, and kidneys were examined at 54 h after CLP surgery. Results: We found the group that received LDK378 treatment showed increased MAP levels compared to the CLP group at 30 h and 54 h. Meanwhile, LDK378 ameliorated the perfused small vessel density and microvascular flow index, decreased the expression of TNF-a and IL-6, and upregulated the expression of IL-10 in comparison with the CLP group. LDK378 injections also downregulated the expression of TBK1 and its downstream targets. Furthermore, LDK378 treatment significantly reduced sepsis-induced organ injuries, therefore improving survival rates. Conclusions: These findings demonstrate that LDK378 treatment can improve microcirculation and reduce organ injuries in CLP-induced septic rats via the regulation of inflammatory cytokine secretion and the downstream signaling components of the ALK-STING pathway.

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Sepsis Inflammation LDK378 ALK-STING pathway

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GB/T 7714 Ge, Weiwei , Hu, Qiaohua , Fang, Xiangshao et al. LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture [J]. | JOURNAL OF INFLAMMATION-LONDON , 2019 , 16 .
MLA Ge, Weiwei et al. "LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture" . | JOURNAL OF INFLAMMATION-LONDON 16 (2019) .
APA Ge, Weiwei , Hu, Qiaohua , Fang, Xiangshao , Liu, Juanhua , Xu, Jing , Hu, Juntao et al. LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture . | JOURNAL OF INFLAMMATION-LONDON , 2019 , 16 .
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Phenylethanoid glycosides of Phlomis younghusbandii Mukerjee ameliorate acute hypobaric hypoxia-induced brain impairment in rats SCIE
期刊论文 | 2019 , 108 , 81-88 | MOLECULAR IMMUNOLOGY
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High altitude cerebral edema (HACE), whose development process is associated with oxidative stress and inflammatory response, is a life-threatening condition caused by rapid ascent speed to high altitudes. Phenylethanoid glycosides (PhGCs) are primary active constituents isolated from Phlomis younghusbandii Mukerjee that reportedly exhibit potent anti-oxidant and anti-inflammatory activities. The present study aims to investigate the protective effect of phenylethanoid glycosides (PhGCs) from P. younghusbandii in acute hypobaric hypoxia (AHH) stimulated HACE rats and its underlying mechanisms. The expression of pro-inflammatory cytokine levels (IL-1 beta, TNF-alpha, and IL-6) was detected by RT-PCR and ELISA at mRNA and protein levels in brain tissues. Western blotting was carried out to measure the major protein levels (IL-1 beta, TNF-alpha, and NF-kappa B) in brain tissues. The oxidative stress biomarkers (MDA, SOD, and GSH) were evaluated using kits. Results demonstrate that PhGCs significantly improved pathological changes in brain tissues, reduced the brain's water content, and attenuated the production and mRNA expression of pro-inflammatory cytoldnes. Furthermore, the increased oxidative stress and the decrease in anti-oxidant stress system under the AHH condition were also abrogated reversely through PhGCs treatment by elevating the levels of SOD and GSH and suppressing the accumulation of MDA. Simultaneously, there was also a significant reduction in NF-kappa 3, IL-1 beta, and TNF-alpha protein expression levels in brain tissues, suggesting that blocking the NF-kappa B signaling pathway activation prevented the production of pro-inflammatory cytokines. Taken together, these findings indicate that PhGCs may afford a protectively intervene in HACE through the suppression of oxidative stress and inflammatory response via the inhibition of the NF-xB signaling pathway, indicating that PhGCs are promising agents for the treatment of acute HACE.

Keyword :

High altitude cerebral edema Acute hypobaric hypoxia Phenylethanoid glycosides Oxidative stress Inflammation

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GB/T 7714 Luan, Fei , Li, Maoxing , Han, Keqing et al. Phenylethanoid glycosides of Phlomis younghusbandii Mukerjee ameliorate acute hypobaric hypoxia-induced brain impairment in rats [J]. | MOLECULAR IMMUNOLOGY , 2019 , 108 : 81-88 .
MLA Luan, Fei et al. "Phenylethanoid glycosides of Phlomis younghusbandii Mukerjee ameliorate acute hypobaric hypoxia-induced brain impairment in rats" . | MOLECULAR IMMUNOLOGY 108 (2019) : 81-88 .
APA Luan, Fei , Li, Maoxing , Han, Keqing , Ma, Qiang , Wang, Jian , Qiu, Yan et al. Phenylethanoid glycosides of Phlomis younghusbandii Mukerjee ameliorate acute hypobaric hypoxia-induced brain impairment in rats . | MOLECULAR IMMUNOLOGY , 2019 , 108 , 81-88 .
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PM2.5 Exposure Induced Autophagy Activation via the ROS/AMPK/mTOR/ULK1 Signaling Axis in Macrophages CPCI-S SCIE
会议论文 | 2019 , 143 (2) , AB230-AB230 | Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI)
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GB/T 7714 Liu, Lu , Liu, Qun , Wen, Dongqing et al. PM2.5 Exposure Induced Autophagy Activation via the ROS/AMPK/mTOR/ULK1 Signaling Axis in Macrophages [C] . 2019 : AB230-AB230 .
MLA Liu, Lu et al. "PM2.5 Exposure Induced Autophagy Activation via the ROS/AMPK/mTOR/ULK1 Signaling Axis in Macrophages" . (2019) : AB230-AB230 .
APA Liu, Lu , Liu, Qun , Wen, Dongqing , Rule, Ana , Koehler, Kirsten , Li, Manxiang et al. PM2.5 Exposure Induced Autophagy Activation via the ROS/AMPK/mTOR/ULK1 Signaling Axis in Macrophages . (2019) : AB230-AB230 .
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Comparison of clinical characteristics and outcomes of pyogenic liver abscess patients < 65years of age versus65years of age SCIE
期刊论文 | 2019 , 19 | BMC INFECTIOUS DISEASES
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BackgroundPyogenic liver abscess (PLA) in the elderly is insufficiently elucidated. A few studies attempted to investigate the role of age in PLA have yielded controversial results. The purpose of this study was to explore the possible differences in the comorbidity, microbiological characteristics and clinical course between elderly and young PLA patients.MethodsThe clinical data of 332 adult PLA patients who received treatment at our hospital from January 2010 to December 2016 were collected. The demographic data, etiologies, comorbidities, clinical features, laboratory results, imaging findings, microbiological characteristics, choices of treatment and clinical outcomes were analyzed.ResultsEighty-two (24.7%) patients were older than 65years. Comorbidities including hypertension, diabetes mellitus, and cholelithiasis were more frequently found in older patients. Elderly PLA patients were more likely to present with atypical symptoms and signs on admission. The laboratory abnormalities and imaging findings were similar between the two groups. Klebsiella pneumonia was the most common pathogen on pus culture in both groups. There were no statistically significant differences in choices of treatment, PLA-related complications and length of in-hospital stay between the two groups. And there was no in-hospital mortality.ConclusionsThe clinical characteristics were similar in young and elderly PLA patients. However, elderly PLA patients were more likely to have underlying diseases and tended to have atypical presentations. Physicians need to be vigilant when encounter possible elderly patients with PLA. However, older PLA patients had comparable outcomes as their younger counterparts. With effective treatment, both elderly and young PLA patients can be cured.

Keyword :

Prognosis Comorbidities Elderly Pyogenic liver abscess Treatment

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GB/T 7714 Zhang, Jia , Du, Zhaoqing , Bi, Jianbin et al. Comparison of clinical characteristics and outcomes of pyogenic liver abscess patients < 65years of age versus65years of age [J]. | BMC INFECTIOUS DISEASES , 2019 , 19 .
MLA Zhang, Jia et al. "Comparison of clinical characteristics and outcomes of pyogenic liver abscess patients < 65years of age versus65years of age" . | BMC INFECTIOUS DISEASES 19 (2019) .
APA Zhang, Jia , Du, Zhaoqing , Bi, Jianbin , Wu, Zheng , Lv, Yi , Zhang, Xufeng et al. Comparison of clinical characteristics and outcomes of pyogenic liver abscess patients < 65years of age versus65years of age . | BMC INFECTIOUS DISEASES , 2019 , 19 .
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Epidemiology and risk factors for nosocomial infection in the respiratory intensive care unit of a teaching hospital in China: A prospective surveillance during 2013 and 2015. PubMed SCIE
期刊论文 | 2019 , 19 , 145 | BMC infectious diseases
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To determine the epidemiology and risk factors for nosocomial infection (NI) in the Respiratory Intensive Care Unit (RICU) of a teaching hospital in Northwest China.An observational, prospective surveillance was conducted in the RICU from 2013 to 2015. The overall infection rate, distribution of infection sites, device-associated infections and pathogen in the RICU were investigated. Then, the logistic regression analysis was used to test the risk factors for RICU infection.In this study, 102 out of 1347 patients experienced NI. Among them, 87 were device-associated infection. The overall prevalence of NI was 7.57% with varied rates from 7.19 to 7.73% over the 3 years. The lower respiratory tract (43.1%), urinary tract (26.5%) and bloodstream (20.6%) infections accounted for the majority of infections. The device-associated infection rates of urinary catheter, central catheter and ventilator were 9.8, 7.4 and 7.4 per 1000 days, respectively.The most frequently isolated pathogens were Staphylococcus aureus (20.9%), Klebsiella pneumoniae (16.4%) and Pseudomonas aeruginosa (10.7%). Multivariate analysis showed that the categories D or E of Average Severity of Illness Score (ASIS), length of stay (10-30, 30-60, ≥60 days), immunosuppressive therapy and ventilator use are the independent risk factors for RICU infection with an adjusted odds ratio (OR) of 1.65 (95% CI: 1.15~2.37), 5.22 (95% CI: 2.63~10.38)), 2.32 (95% CI: 1.19~4.65), 8.93 (95% CI: 3.17~21.23), 31.25 (95% CI: 11.80~63.65)) and 2.70 (95% CI: 1.33~5.35), respectively.A relatively low and stable rate of NI was observed in our RICU through year 2013-2015. The ASIS-D、E, stay ≥10 days, immunosuppressive therapy and ventilator use are the independent risk factors for RICU infection.

Keyword :

Risk factors Respiratory intensive care unit Nosocomial infection

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GB/T 7714 Wang Linchuan , Zhou Kai-Ha , Chen Wei et al. Epidemiology and risk factors for nosocomial infection in the respiratory intensive care unit of a teaching hospital in China: A prospective surveillance during 2013 and 2015. [J]. | BMC infectious diseases , 2019 , 19 : 145 .
MLA Wang Linchuan et al. "Epidemiology and risk factors for nosocomial infection in the respiratory intensive care unit of a teaching hospital in China: A prospective surveillance during 2013 and 2015." . | BMC infectious diseases 19 (2019) : 145 .
APA Wang Linchuan , Zhou Kai-Ha , Chen Wei , Yu Yan , Feng Si-Fang . Epidemiology and risk factors for nosocomial infection in the respiratory intensive care unit of a teaching hospital in China: A prospective surveillance during 2013 and 2015. . | BMC infectious diseases , 2019 , 19 , 145 .
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Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus. PubMed
期刊论文 | 2019 | Microbes and infection
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Hantaviruses is the major causative agents of hemorrhagic fever with renal syndrome (HFRS) in humans, which is characterized by increased capillary permeability. Dentin matrix protein 1 (DMP1) has been shown to degrade components of the basal membrane and interendothelial junctions via matrix metalloproteinase-9. To study the changes of serum DMP1 in HFRS, we determined the concentration of DMP1 using sandwich enzyme-linked immunosorbent assay. We found that serum DMP1 concentrations increased significantly, and reached peak value during the oliguric phase and in the critical group in HFRS patients. Moreover, serum DMP1 concentrations were closely related to blood urea nitrogen, creatinine, cystatin C, and vascular endothelial growth factor (VEGF). We further explored the role of DMP1 in HTNV-infected human umbilical vein endothelial cells (HUVECs) model. Data from immunocytochemistry showed that VEGF and tumor necrosis factor-α (TNF-α) promote expression of DMP1 on HTNV-infected HUVECs. Results from transwell assays demonstrated that the permeability of HUVECs increases significantly after HTNV infection with the addition of DMP1, VEGF, and TNF-α. This study suggests that elevated DMP1 concentrations may be associated with disease stage, severity, and the degree of acute kidney injury. DMP1 is involved in the regulation of capillary permeability in HFRS caused by hantavirus infection.

Keyword :

hyper-permeability vascular endothelial growth factor hantavirus dentin matrix protein 1 tumor necrosis factor-α hemorrhagic fever with renal syndrome

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GB/T 7714 Shi Dongsha , Dong Yanying , Dai Pengfei et al. Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus. [J]. | Microbes and infection , 2019 .
MLA Shi Dongsha et al. "Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus." . | Microbes and infection (2019) .
APA Shi Dongsha , Dong Yanying , Dai Pengfei , Gao Juan , Yin Jingjing , Xie Ming . Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus. . | Microbes and infection , 2019 .
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Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release. PubMed
期刊论文 | 2019 | Inflammation
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Acute brain dysfunction and the following neurological manifestation are common complications in septic patients, which are associated with increased morbidity and mortality. However, the therapeutic strategy of this disorder remains a major challenge. Given the emerging role of a clinically approved drug, probenecid (PRB) has been recently identified as an inhibitor of pannexin 1 (PANX1) channel, which restrains extracellular ATP release-induced purinergic pathway activation and inflammatory response contributing to diverse pathological processes. In this study, we explored whether PRB administration attenuated neuroinflammatory response and cognitive impairment during sepsis. In mice suffered from cecal ligation and puncture (CLP)-induced sepsis, treatment with PRB improved memory retention and lessened behavioral deficits. This neuroprotective effect was coupled with restricted overproduction of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and interleukin (IL)-1β in the hippocampus. Since this damped neuroinflammation was replicated by inhibition of ATP release, it suggested that PANX1 channel modulates a purinergic-related pathway contributing to the neurohistological damage. Therefore, we identified PRB could be a promising therapeutic approach for the therapy of cerebral dysfunction of sepsis.

Keyword :

pannexin 1 neuroinflammation cecal ligation and puncture cognitive impairment probenecid

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GB/T 7714 Zhang Zhanqin , Lei Yi , Yan Chaoying et al. Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release. [J]. | Inflammation , 2019 .
MLA Zhang Zhanqin et al. "Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release." . | Inflammation (2019) .
APA Zhang Zhanqin , Lei Yi , Yan Chaoying , Mei Xiaopeng , Jiang Tao , Ma Zhi et al. Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release. . | Inflammation , 2019 .
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