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< Page ,Total 27 >
Whether to Delay the Release of eBooks or Not? An Analysis of Optimal Publishing Strategies for Book Publishers SSCI
期刊论文 | 2019 , 14 (2) , 124-137 | JOURNAL OF THEORETICAL AND APPLIED ELECTRONIC COMMERCE RESEARCH
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Abstract :

The eBooks market has been growing rapidly in recent years. At the same time, evidence shows that eBooks are cannibalizing the market for physical books. To alleviate the cannibalization effect between eBooks and physical books, publishers may choose to delay the release of eBooks or physical books for a period of time. Adopting a stylized two-period model, this paper investigates three publishing strategies for a monopolistic publisher: delaying the release of eBooks, delaying the release of physical books, and releasing them simultaneously. We find that the publisher should delay the format that has significantly less market potential. Furthermore, the one that has greater market potential should be priced higher. In addition, a stronger substitution effect between eBooks and physical books favors delaying strategies. Finally, the smaller marginal cost for eBooks than physical books renders the strategy to delay the release of physical books more popular.

Keyword :

Substitution effect eBook Pricing strategies Publishing strategies Cannibalization

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GB/T 7714 Li, Fan , Li, Shengli , Gu, Jiarong . Whether to Delay the Release of eBooks or Not? An Analysis of Optimal Publishing Strategies for Book Publishers [J]. | JOURNAL OF THEORETICAL AND APPLIED ELECTRONIC COMMERCE RESEARCH , 2019 , 14 (2) : 124-137 .
MLA Li, Fan 等. "Whether to Delay the Release of eBooks or Not? An Analysis of Optimal Publishing Strategies for Book Publishers" . | JOURNAL OF THEORETICAL AND APPLIED ELECTRONIC COMMERCE RESEARCH 14 . 2 (2019) : 124-137 .
APA Li, Fan , Li, Shengli , Gu, Jiarong . Whether to Delay the Release of eBooks or Not? An Analysis of Optimal Publishing Strategies for Book Publishers . | JOURNAL OF THEORETICAL AND APPLIED ELECTRONIC COMMERCE RESEARCH , 2019 , 14 (2) , 124-137 .
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Controlled Deposition of ZnS Nanoparticles on CuS Nanoplates for Visible-Light-Driven Photocatalytic H₂ Production. PubMed Scopus
期刊论文 | 2019 , 19 (1) , 414-421 | Journal of nanoscience and nanotechnology
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Abstract :

With giving property to guide and control charge carries at the nanoscale, fabrication of heterostructure photocatalyst with desirable spatial distribution has been significantly valued. In this study, by using CuS nanoplates as seeds, CuS@ZnS core-shell heterojunction photocatalysts with diverse morphologies were developed via controlled synthesis kinetics. Kinetic control was completed through manipulation of the injection rate of Zn<sup>2+</sup> precursor with a syringe pump as well as the reaction temperature. It is found that the growth is determined by the deposition rate relative to the diffusion rate of the ZnS growth monomers. Specifically, at a high injection rate and a relatively low reaction temperature, ZnS monomers on the surface of the CuS nanoplate will be in a localized manner and tend to form island nanoparticles. On the contrary, when surface diffusion is facilitated at a lower injection rate and a higher reaction temperature, the morphology of the ZnS nanocrystals can be switched to flat ZnS layers covering the surface of CuS. In addition, the heterostructures have found with shape-dependent photocatalytic performance toward H₂ evolution under visiblelight irradiation. The CuS@ZnS core-shell composites that possess ZnS islands exhibit the highest photocatalytic activity. The corresponding H₂ generation rate reaches 6.3 <i>μ</i>mol h<sup>-1</sup> g<sup>-1</sup>, which is 37.9 times of that for CuS@ZnS core-shell nanostructure with flat surface. This work thus provides a powerful means for the rational design and synthesis of heterojunctions with spatially controlled distribution of the component.

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GB/T 7714 Fu Wenlong , Xue Fei , Liu Maochang et al. Controlled Deposition of ZnS Nanoparticles on CuS Nanoplates for Visible-Light-Driven Photocatalytic H₂ Production. [J]. | Journal of nanoscience and nanotechnology , 2019 , 19 (1) : 414-421 .
MLA Fu Wenlong et al. "Controlled Deposition of ZnS Nanoparticles on CuS Nanoplates for Visible-Light-Driven Photocatalytic H₂ Production." . | Journal of nanoscience and nanotechnology 19 . 1 (2019) : 414-421 .
APA Fu Wenlong , Xue Fei , Liu Maochang , Guo Liejin . Controlled Deposition of ZnS Nanoparticles on CuS Nanoplates for Visible-Light-Driven Photocatalytic H₂ Production. . | Journal of nanoscience and nanotechnology , 2019 , 19 (1) , 414-421 .
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Construction of three-dimensional ordered porous carbon bulk networks for high performance lithium-sulfur batteries. EI PubMed Scopus
期刊论文 | 2019 , 533 , 445-451 | Journal of colloid and interface science
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Abstract :

In order to suppress the shuttling of soluble lithium polysulfides in Li-S batteries and increase the conductivity of the sulfur cathode, here we report the design and synthesis of three-dimensional (3D) highly ordered porous carbon bulk network (PCBNs), using silica (SiO2) nanospheres as removable hard templates and soluble starch as carbon source. After carbonization and template removal, the as-prepared PCBNs composed of interconnected hollow carbon balls exhibit large surface area (447.4 m<sup>2</sup>/g) and large pore volume (1.567 cm<sup>3</sup>/g), high graphitization degree and robust framework. Serving as an efficient sulfur host, PCBNs supported sulfur cathode (S@PCBNs with sulfur content of 72 wt%) delivers a high discharge capacity of 760 mA h/g after 150 cycles at 0.1 C and 455 mA h/g after 400 cycles at 1 C. The superior lithium storage properties is attributed to the novel hierarchical microstructure of the PCBNs, in which the large hollow space not only allows high loading of sulfur but also efficiently accommodates the large volumetric expansion. Moreover, the interconnected PCBNs with high conductivity can spatially confine the shuttling of soluble polysulfides and enhance the redox reaction kinetics.

Keyword :

Silica nanosphere template Porous carbon bulk networks Li-S batteries Superior electrochemical properties Spatial confinement

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GB/T 7714 Gu Hangyu , Zhang Rong , Wang Ping et al. Construction of three-dimensional ordered porous carbon bulk networks for high performance lithium-sulfur batteries. [J]. | Journal of colloid and interface science , 2019 , 533 : 445-451 .
MLA Gu Hangyu et al. "Construction of three-dimensional ordered porous carbon bulk networks for high performance lithium-sulfur batteries." . | Journal of colloid and interface science 533 (2019) : 445-451 .
APA Gu Hangyu , Zhang Rong , Wang Ping , Xie Sanmu , Niu Chunming , Wang Hongkang . Construction of three-dimensional ordered porous carbon bulk networks for high performance lithium-sulfur batteries. . | Journal of colloid and interface science , 2019 , 533 , 445-451 .
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Single-Molecule Fluorescence Measurement of SNARE-Mediated Vesicle Fusion. PubMed Scopus
期刊论文 | 2019 , 1860 , 335-344 | Methods in molecular biology
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Abstract :

This chapter expounds the single vesicle-vesicle fluorescence resonance energy transfer (FRET) measurement to study the membrane fusion mediated by SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins. The formation of a four-α-helix bundle of SNARE proteins can drive two membranes to a close proximity for fusion. Through single-molecule FRET-based microscopy, the lipid-mixing process at the single-vesicle level can be tracked in real time. This reconstitution system is applicable to study the molecular mechanism of SNAREs during different membrane fusion stages, such as docking, hemifusion, and full fusion. Four main parts are described in this chapter, including SNARE reconstitution, imaging preparation, data collection, and analysis.

Keyword :

Vesicle Membrane fusion Reconstitution Lipid mixing SNARE FRET

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GB/T 7714 Hu Yachong , Tian Zhiqi , Diao Jiajie . Single-Molecule Fluorescence Measurement of SNARE-Mediated Vesicle Fusion. [J]. | Methods in molecular biology , 2019 , 1860 : 335-344 .
MLA Hu Yachong et al. "Single-Molecule Fluorescence Measurement of SNARE-Mediated Vesicle Fusion." . | Methods in molecular biology 1860 (2019) : 335-344 .
APA Hu Yachong , Tian Zhiqi , Diao Jiajie . Single-Molecule Fluorescence Measurement of SNARE-Mediated Vesicle Fusion. . | Methods in molecular biology , 2019 , 1860 , 335-344 .
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Weighted gene co-expression network analysis and connectivity map identifies lovastatin as a treatment option of gastric cancer by inhibiting HDAC2. PubMed Scopus
期刊论文 | 2019 , 681 , 15-25 | Gene
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Abstract :

This study aimed to identifying and validating therapeutic compounds which might have positive effects on patients with gastric cancer (GC) based on weighted gene co-expression network analysis (WGCNA) and connectivity map (CMap).We performed WGCNA to gain insights into the molecular aspects of GC. Raw microarray datasets (including 132 samples) were downloaded from the Gene Expression Omnibus (GEO) website. We utilized the WGCNA to identify the coexpressed genes (modules) and modular hub genes after non-specific filtering. Furthermore, these differentially expressed genes were submitted to CMap analysis to identify candidate therapeutic compounds for GC. In experimental part, cell growth inhibition was evaluated by Cell Counting Kit-8 (CCK-8) and colony formation assays. Tumor growth was assessed using nude mice with xenografts established in vivo. QRT-PCR and western blot were used for determination of HDAC2 expression level and immunohistochemistry was performed to quantify HDAC2 in gastric tumor samples.Through WGCNA and CMap analysis, we found two potential therapeutic compounds, the valproic acid (VPA), which is the histone deacetylase (HDAC) inhibitor and lovastatin. HDAC2 was overexpressed in gastric cancer cell lines including AGS, BGC-823, NCI-N87 and MKN28. Dose-dependent inhibition of gastric cancer cells by VPA and lovastatin was verified in vitro. Apoptosis of GC cells was induced after treatment with VPA and lovastatin through suppressing HDAC2 expression. Furthermore, the inhibition of VPA with cisplatin and lovastatin with cisplatin were also dose-dependent and cisplatin exhibited synergistic effects. In the xenografts, similar results were found.WGCNA was able to identify significant groups of genes associated with cancer prognosis. Moreover, analysis of gene expression signature using CMap is a powerful way to explore potential therapeutics for human diseases. For treating GC, lovastatin may be a potential drug.

Keyword :

Valproic acid Gastric cancer CMap WGCNA Lovastatin

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GB/T 7714 Zhang Li , Kang Wenquan , Lu Xiaolan et al. Weighted gene co-expression network analysis and connectivity map identifies lovastatin as a treatment option of gastric cancer by inhibiting HDAC2. [J]. | Gene , 2019 , 681 : 15-25 .
MLA Zhang Li et al. "Weighted gene co-expression network analysis and connectivity map identifies lovastatin as a treatment option of gastric cancer by inhibiting HDAC2." . | Gene 681 (2019) : 15-25 .
APA Zhang Li , Kang Wenquan , Lu Xiaolan , Ma Shiyang , Dong Lei , Zou Baicang . Weighted gene co-expression network analysis and connectivity map identifies lovastatin as a treatment option of gastric cancer by inhibiting HDAC2. . | Gene , 2019 , 681 , 15-25 .
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Co-pyrolysis behavior of microalgae biomass and low-rank coal: Kinetic analysis of the main volatile products. PubMed Scopus
期刊论文 | 2019 , 271 , 202-209 | Bioresource technology
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Abstract :

This work studied the kinetic characteristics of volatile products from co-pyrolysis of microalgae and low-rank coal. Iso-conversional method was applied to calculate the reaction order, activation energy and pre-exponential factor of gaseous products (H2, CO, CH4, and CO2) and benzene. The results indicated the activation energy of H2 generating from both individual and mixing samples was the highest, meaning H2 was the hardest to generate during the pyrolysis process. The values of activation energy from the formation of CO and benzene from low-rank coal and green algae were 31.11, 32.44, 18.21 and 24.31 kJ·mol<sup>-1</sup>, respectively. The formation of benzene and CO were easier than other volatile products due to the lower activation energy. Synergistic effects were observed from the formation of CO2, the addition of green algae decreased the activation energy. The order of the activation energy was in agreement with that of the releasing sequence of main volatile products.

Keyword :

Kinetic analysis Low-rank coal Microalgae biomass Co-pyrolysis Synergistic effects

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GB/T 7714 Wu Zhiqiang , Li Yaowu , Zhang Bo et al. Co-pyrolysis behavior of microalgae biomass and low-rank coal: Kinetic analysis of the main volatile products. [J]. | Bioresource technology , 2019 , 271 : 202-209 .
MLA Wu Zhiqiang et al. "Co-pyrolysis behavior of microalgae biomass and low-rank coal: Kinetic analysis of the main volatile products." . | Bioresource technology 271 (2019) : 202-209 .
APA Wu Zhiqiang , Li Yaowu , Zhang Bo , Yang Wangcai , Yang Bolun . Co-pyrolysis behavior of microalgae biomass and low-rank coal: Kinetic analysis of the main volatile products. . | Bioresource technology , 2019 , 271 , 202-209 .
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5-HTT, BMPR2, EDN1, ENG, KCNA5 gene polymorphisms and susceptibility to pulmonary arterial hypertension: A meta-analysis. PubMed Scopus
期刊论文 | 2019 , 680 , 34-42 | Gene
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The influence of 5-HTT, BMPR2, EDN1, ENG, KCNA5 genes polymorphisms on susceptibility of pulmonary arterial hypertension remains uncertain. This meta-analysis is conducted for further study.We conducted a literature search on PubMed and ISI web of science databases for searching relevant articles until November 2017. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. A total of 17 articles with 2631 PAH subjects and 5139 controls were included in the final meta-analysis. Statistical software Stata13.0 was used for data-analysis.A significant relationship was found between the 5-HTT L/S polymorphism and PAH in all the genetic models [LL vs. SS: OR = 1.60, 95% CI, 1.11-2.32; LS vs. SS: OR = 1.55, 95% CI, 1.10-2.21; (LS + LL) vs. SS: OR = 1.56, 95% CI, 1.13-2.17; L vs. S: OR = 1.32, 95% CI, 1.08-1.62]. There were also associations of the SERT L/S polymorphism with IPAH and PAH in COPD [IPAH L/S: OR = 1.26, 95% CI, 1.01-1.57; PAH in COPD L/S: OR = 1.42, 95% CI, 1.04-1.94]. In addition, the results showed a statistically significant association between EDN1 rs5370 polymorphism and the risk of PAH in all the genetic models [TT vs. GG: OR = 3.32, 95% CI, 1.30-8.51; TG vs. GG: OR = 2.68, 95% CI, 1.54-4.66; (TG + TT) vs. GG: OR = 2.82, 95% CI, 1.69-4.71; T vs. G: OR = 2.43, 95% CI, 1.60-3.68]. However, the significant association was not found between BMPR2 rs1061157, KCNA5 rs10744676, ENG rs3739817 polymorphisms and the risk of PAH (all p > 0.05).5-HTT L/S polymorphism and END1 rs5370 polymorphism were correlated with significantly increased risk of PAH. Moreover, L allele in 5-HTT gene increased susceptibility to IPAH and PAH in COPD.

Keyword :

Meta-analysis ENG BMPR2 EDN1 Pulmonary arterial hypertension 5-HTT KCNA5

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GB/T 7714 Jiao Yu-Rui , Wang Wei , Lei Peng-Cheng et al. 5-HTT, BMPR2, EDN1, ENG, KCNA5 gene polymorphisms and susceptibility to pulmonary arterial hypertension: A meta-analysis. [J]. | Gene , 2019 , 680 : 34-42 .
MLA Jiao Yu-Rui et al. "5-HTT, BMPR2, EDN1, ENG, KCNA5 gene polymorphisms and susceptibility to pulmonary arterial hypertension: A meta-analysis." . | Gene 680 (2019) : 34-42 .
APA Jiao Yu-Rui , Wang Wei , Lei Peng-Cheng , Jia Hui-Ping , Dong Jie , Gou Yun-Qian et al. 5-HTT, BMPR2, EDN1, ENG, KCNA5 gene polymorphisms and susceptibility to pulmonary arterial hypertension: A meta-analysis. . | Gene , 2019 , 680 , 34-42 .
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Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. EI PubMed Scopus
期刊论文 | 2019 , 192 , 248-254 | Talanta
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Radix Salviae Miltiorrhiae (also known as DanShen (DS) in China), a popular herbal drug in traditional Chinese medicine (TCM) for promoting blood circulation and treating blood stasis, has been reported to possess potential anti-tumor effects. The aim of the study was to develop an effective and practical method for screening and identifying bioactive compounds from Radix Salviae Miltiorrhiae. In this work, the epidermal growth factor receptor (EGFR) and fibroblast growth factor receptors 4 (FGFR4) dual-mixed/cell membrane chromatography (CMC) coupled with high performance liquid chromatography-electrospray ionization-ion trap-time of flight-multistage mass spectrum (HPLC-ESI-IT-TOF-MSn) was established and successfully used to identify the active components from Radix Salviae Miltiorrhiae. Salvianolic acid C (SAC), tanshinone I (Tan-I), tanshinone IIA (Tan-IIA), and cryptotanshinone (C-Tan) were identified as bioactive components with EGFR and FGFR4 activities. MTT and kinase assay were performed to investigate inhibitory effects of these compounds against EGFR and FGFR4 cells growth in vitro. Both cell viability and kinase activity showed that cryptotanshinone acting on EGFR receptor and tanshinone IIA acting on FGFR4 receptor. In conclusion, the EGFR & FGFR4 dual-mixed/CMC can simultaneously screen the bioactive components from TCMs that act on both EGFR and FGFR4 receptors, which significantly improve the efficiency of specific bioactive components identification from a complex system.

Keyword :

Epidermal growth factor receptor HPLC-ESI-IT-TOF-MSn Radix Salviae Miltiorrhiaeis Dual-mixed/cell membrane chromatography Fibroblast growth factor receptors 4

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GB/T 7714 Fu Jia , Lv Yanni , Jia Qianqian et al. Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. [J]. | Talanta , 2019 , 192 : 248-254 .
MLA Fu Jia et al. "Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors." . | Talanta 192 (2019) : 248-254 .
APA Fu Jia , Lv Yanni , Jia Qianqian , Lin Yuanyuan , Han Shengli . Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. . | Talanta , 2019 , 192 , 248-254 .
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An Electrooptothermal-Coupled Circuit-Level Model for VCSELs Under Pulsed Condition EI SCIE Scopus
期刊论文 | 2019 , 66 (2) , 1315-1324 | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
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In this paper, a circuit-level model for accurately calculating vertical-cavity surface-emitting laser's (VCSEL) response under pulsed working condition is implemented in the advanced design system computer-aided design environment. New normalization method and thermal leakage current expression are proposed to rate equation to improve numerical convergence of the model's output part, which is critical for pulsed working condition. A self-consistent decoupling method is applied to include the self-heating effects in both input and output parts of the model for getting the accurate waveforms of input current and output light power under pulsed driving conditions. The model's input part is similar to standard SPICE model for p-n junction diode, and is convenient for extracting model parameters to match the device's input impedance profile. A real device's model parameters are extracted, and its voltage-current-light power (V-I-P) curves, small-signal transfer function, and transient response under pulsed drive condition are calculated to demonstrate the model's calculation capability. The proposed model is well applicable for designing a high-power electromagnetic sensor including VCSEL and other high-frequency devices.

Keyword :

Laser modeling normalization method vertical-cavity surface-emitting laser (VCSEL) self-heating effect

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GB/T 7714 Yan, Junkai , Wang, Jianguo , Tang, Chuanxiang et al. An Electrooptothermal-Coupled Circuit-Level Model for VCSELs Under Pulsed Condition [J]. | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS , 2019 , 66 (2) : 1315-1324 .
MLA Yan, Junkai et al. "An Electrooptothermal-Coupled Circuit-Level Model for VCSELs Under Pulsed Condition" . | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS 66 . 2 (2019) : 1315-1324 .
APA Yan, Junkai , Wang, Jianguo , Tang, Chuanxiang , Liu, Xiaolong , Zhang, Gengqing , He, Yanyang . An Electrooptothermal-Coupled Circuit-Level Model for VCSELs Under Pulsed Condition . | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS , 2019 , 66 (2) , 1315-1324 .
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Optimal design of a piezo-actuated 2-DOF millimeter-range monolithic flexure mechanism with a pseudo-static model EI SCIE Scopus
期刊论文 | 2019 , 115 , 120-131 | MECHANICAL SYSTEMS AND SIGNAL PROCESSING
SCOPUS Cited Count: 1
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Flexure-based displacement amplifiers are frequently used to magnify the small stroke of piezoelectric actuators. In this paper, a hybrid rhombus-lever multistage displacement amplifier with an improved boundary constraint is proposed to develop a parallel millimeter-range XY monolithic mechanism while retaining a relatively high dynamic frequency. A concise pseudo-static model developed by the authors is utilized to analyze the kinetostatic and dynamic performances of the designed flexure mechanism and then the geometric parameters are optimized in terms of both kinetostatics and dynamics. Different from the previous Lagrange-based dynamic methods for compliant mechanisms, cumbersome calculations of the kinetic and elastic energies as well as adopting Lagrange's equation are all avoided. With the proposed pseudo-static model, the kinetostatics and dynamics of the flexure mechanism can be analyzed concurrently in a programmed statics-similar way, suggesting its superiority for fast performance prediction and parameter optimization during the early stage of design. Finally, a prototype of the XY monolithic mechanism is manufactured and experimentally tested for evaluating its performances. Experimental results show that the designed flexure mechanism has a motion range in excess of 1.2 mm x 1.2 mm with a resonance frequency of 128 Hz. The cross-coupling error is measured to be less than 2%, indicating an acceptable decoupling performance. (C) 2018 Elsevier Ltd. All rights reserved.

Keyword :

Displacement amplifier Compliant mechanisms Flexure hinge Precision positioning stage Piezoelectric actuator

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GB/T 7714 Ling, Mingxiang , Cao, Junyi , Jiang, Zhou et al. Optimal design of a piezo-actuated 2-DOF millimeter-range monolithic flexure mechanism with a pseudo-static model [J]. | MECHANICAL SYSTEMS AND SIGNAL PROCESSING , 2019 , 115 : 120-131 .
MLA Ling, Mingxiang et al. "Optimal design of a piezo-actuated 2-DOF millimeter-range monolithic flexure mechanism with a pseudo-static model" . | MECHANICAL SYSTEMS AND SIGNAL PROCESSING 115 (2019) : 120-131 .
APA Ling, Mingxiang , Cao, Junyi , Jiang, Zhou , Zeng, Minghua , Li, Qisheng . Optimal design of a piezo-actuated 2-DOF millimeter-range monolithic flexure mechanism with a pseudo-static model . | MECHANICAL SYSTEMS AND SIGNAL PROCESSING , 2019 , 115 , 120-131 .
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