Objective;　To　study　the　urinary　protein　patterns　of　nephropathy　mice　induced　by　dextran　and　the　effects　of　aquesous　extract　of　Fructus　Corni　(AEFC)　and　Radix　Astragali　(AERA).　Method:　Nephropathy　model　was　established　by　administrated　with　dextran　to　mice.　Some　of　the　dextran　treated　mice　were　given　AERA　(　20　g　·　kg-1　·　d-1)　as　AERA　group,　other　mice　were　given　AEFC　(　10　g　·　kg-1　·　d　-1)　as　AEFC　group.　Some　of　the　dextran　treated　mice　were　given　water　as　model　group,　some　normal　mice　as　normal　control　group.　After　a　12　weeks＇　treatment,　24　hour　urine　of　four　groups　was　collected,　respectively.　Each　urinary　sample　was　divided　into　two　parts,　one　was　non-concentrated　urine　sample,　another　was　used　as　concentrated　urine　sample.　Two　kinds　of　urinary　sample　of　four　groups　were　analyzed　with　microfluidic　chips　on　Agilent　2100　Bioanalyzer　instrument.　Result:　Each　group＇s　urinary　protein　patterns　were　obtained,　more　than　20　proteins　were　were　detected.　Compared　with　normal　group,　about　five　kinds　of　protein　were　found　in　urinary　sample　of　model　group,　among　which　M　＞43　×　103　proteins　were　increased.　Compared　with　model　group,　significant　treated-related　protein＇　s　kind　and　quantitative　changes　in　AERA　treated　group　and　AEFC　group　were　found.　Urinary　protein　kinds　were　reduced,　especially　certain　the　proteins　(　M　＞50　×　103)　were　significantly　decreased　approach　to　normal　patterns.　Non-concentrated　urine　samples＇　protein　pattern　mainly　included　were　proteins　(　M　=　29,　32,　43,　52,　68,　76　×　103)　and　concentrated　urine　samples　mainly　included　the　proteins　(　M　=　22,　24,　32,　46　×　103).　Conclusion:　AERA　and　AEFC　could　reduce　the　urinary　protein　and　made　protein　pattern　different,　which　showed　that　radix　astragali　and　fructus　corni　could　play　an　important　role　in　protecting　renal　function　of　nephropathy　mice　and　finding　the　target　protein　markers　related　to　AERA　and　AEFC　effects　on　nephropathy　mice.