In　this　study,　a　three-dimensional　(3D)　fluid-solid　coupling　simulation　with　the　full　consideration　of　irradiation　effects　for　plate-type　nuclear　fuel　assemblies　was　conducted.　Mechanical　models　of　radiation-induced　deformations　in　solid　domain　and　thermo-hydraulic　models　in　fluid　domain　were　established　based　on　ABAQUS　and　FLUENT,　respectively.　By　use　of　MpCCI,　the　capability　of　fluid-solid　coupling　simulation　was　developed　through　the　real-time　parameter　exchange　of　different　physical　fields　at　fluid-solid　boundary　interfaces.　The　accuracy　and　reliability　of　fluid-solid　coupling　methodology　by　FLUENT-MpCCI-ABAQUS　was　validated　through　benchmark　with　simulation　in　public　reference.　The　influence　of　radiation　swelling　and　bending　deformation　on　fluid　thermal-hydraulic　characteristics　was　investigated　based　on　the　developed　coupling　analysis　method.　In　addition,　the　sensitivity　study　of　heterogeneous　swelling　and　flow　channel　width　was　carried　out.　The　simulation　result　shows　that　radiation　swelling　and　bending　deformation　exerted　substantial　influence　on　flow　distribution　and　outlet　temperature.　©　2020　Elsevier　Ltd