The　processing　of　high-precision　aerospace　parts　requires　not　only　ultra-precision　machine　tools,　but　also　high-efficiency　processing.　However,　in　order　to　realize　high-efficiency　processing,　besides　optimizing　the　system　and　process　parameters,　some　subversive　research　can　also　be　done　on　the　machine　tool　structure.　In　this　paper,　the　lightweight　research　is　mainly　carried　out　on　the　structure　of　machine　tool　worktable.　The　traditional　workbench　is　very　＇heavy＇　and　＇slowness＇.　If　the　traditional　workbench　is　subverted　and　reformed　to　reduce　the　weight,　the　processing　efficiency　will　be　improved　qualitatively.　Therefore,　this　paper　studies　the　lightweight　worktable　of　CFRP　(carbon　fiber　reinforced　polymer)　in　combination　with　the　biological　＇honeycomb＇　shape.　At　first,　the　tensile,　bending,　compressive　and　laminar　shear　analysis　of　CFRP　were　carried　out,　and　the　comprehensive　parameters　were　obtained.　Simultaneously,　the　theoretical　research　and　the　honeycomb　structure　simulation　and　verification　of　CFRP　worktable　are　carried　out.　The　results　show　that　the　HACT　(honeycomb　arrangement　of　circular　tubes)　is　18.51%　better　than　the　SACT　(straight　arrangement　of　circular　tubes)　and　45.05%　better　than　the　OW　(original　worktable)　by　comparing　and　analyzing　the　weight　of　the　three　modes　(HACT,　SACT　and　OW).　The　actual　weight　of　bionic　honeycomb　lightweight　worktable　is　1100　kg,　while　the　simulation　result　is　1080.25　kg,　with　an　error　of　1.8%.　Meanwhile,　it　is　analyzed　that　the　original　workbench　weight　of　the　five-axis　machining　center　is　2023　kg,　while　the　simulation　result　is　1998.6　kg,　with　an　error　of　1.2%.　The　lightweight　degree　is　reduced　by　45.05%.　However,　the　actual　lightweight　degree　has　been　reduced　by　45.63%.　The　error　between　simulation　and　actual　is　less　than　1.3%.　This　kind　of　structural　transformation　has　brought　forward　cutting-edge　innovations　to　the　machine　tool　processing　industry.　It　provides　a　reference　scheme　for　related　enterprises　in　the　future　equipment　renovation.　©　2020　by　the　authors.　Licensee　MDPI,　Basel,　Switzerland.