The　PINK1　gene　encodes　a　serine/threonine　protein　kinase　that　localizes　to　mitochondria　and　has　usually　been　considered　to　protect　cells　from　stress-induced　mitochondrial　dysfunction.　PINK1　mutations　have　been　observed　to　lead　to　autosomal　recessive　Parkinson＇s　disease.　However,　the　immunological　and　prognostic　roles　of　PINK1　across　cancers　remain　unclear.In　the　current　study,　we　used　multiple　databases,　including　Oncomine,　PrognoScan,　Kaplan-Meier　Plotter,　GEPIA,　TIMER,　and　cBioportal,　to　investigate　the　PINK1　expression　distribution　and　its　immunological　and　prognostic　role　across　cancers.Bioinformatics　data　revealed　that　the　mRNA　expression　of　PINK1　was　downregulated　in　most　tumors.　Although　there　was　a　significant　prognostic　value　of　PINK1　expression　across　cancers,　PINK1　played　a　protective　or　detrimental　role　in　different　kinds　of　cancers.　Liver　hepatocellular　carcinoma　and　lung　squamous　cell　carcinoma　were　selected　as　representative　cancer　types　for　further　exploration.　We　found　that　PINK1　always　played　a　protective　role　in　liver　hepatocellular　carcinoma　patients　in　the　stratified　prognostic　analyses　of　clinicopathological　characteristics.　There　were　contradictory　results　between　liver　hepatocellular　carcinoma　and　lung　squamous　cell　carcinoma　in　the　correlations　of　PINK1　expression　with　immune　infiltration,　including　infiltration　of　B　cells,　CD8+　T　cells,　CD4+　T　cells,　macrophages,　neutrophils,　and　dendritic　cells.　Furthermore,　specific　markers　of　B　cells　and　CD8+　T　cells　also　exhibited　different　PINK1-related　immune　infiltration　patterns.　In　addition,　there　was　a　significant　association　between　PINK1　copy　number　variations　and　immune　infiltrates　across　cancers.The　mitophagy-related　protein　PINK1　can　work　as　a　biomarker　for　prognosis　and　the　immune　response　across　cancers.