The　aim　of　the　present　study　is　to　explore　the　frequency　of　small　intestinal　bacterial　overgrowth　(SIBO)　and　orocecal　transit　time　(OCTT)　in　patients　with　nonalcoholic　fatty　liver　disease　(NAFLD).103　patients　with　NAFLD　and　49　healthy　controls　were　enrolled.　Clinical　indicators　such　as　BMI,　liver　function,　blood　lipids,　homeostasis　model　assessment-insulin　resistance　(HOMA-IR),　serum　endotoxin　of　NAFLD　patients　were　collected　and　examined.　FibroTouch　was　used　to　detect　the　controlled　attenuation　parameter　(CAP)　and　liver　stiffness　measurement　(LSM).　SIBO　and　OCTT　were　measured　by　the　lactulose　hydrogen　breath　test.The　incidence　of　SIBO　in　NAFLD　patients　(58.3%)　was　significantly　higher　than　that　in　healthy　controls　(26.5%).　The　level　of　serum　endotoxin　in　NAFLD　patients　was　higher　than　that　in　healthy　controls.　The　levels　of　CAP,　LSM,　serum　endotoxin,　alanine　transaminase,　asperate　aminotransferase　and　HOMA-IR　in　SBIO-positive　NAFLD　patients　were　higher　than　those　in　SIBO-negative　patients.　There　was　no　significant　difference　in　glutamyl　transpeptidase　triglyceride,　low　density　lipoprotein　and　BMI　between　the　two　groups.　OCTT　in　NAFLD　patients　was　longer　than　that　in　healthy　controls.　It　was　also　observed　that　OCTT　in　SIBO-positive　NAFLD　patients　was　significantly　delayed　compared　with　SIBO-negative　NAFLD　patients.Patients　with　NAFLD　exhibit　the　increased　incidence　rate　of　SIBO　and　prolonged　OCTT;　SIBO　in　NAFLD　patients　maybe　a　contributing　factor　to　the　elevated　transaminase,　hepatic　steatosis,　progression　of　liver　fibrosis　and　prolonged　OCTT.