Polyethylene　wear　is　a　great　concern　in　total　joint　replacement.　It　is　now　considered　a　major　limiting　factor　to　the　long　life　of　such　prostheses.　Cross-linking　has　been　introduced　to　reduce　the　wear　of　ultra-high-molecular-weight　polyethylene　(UHMWPE).　Computational　models　have　been　used　extensively　for　wear　prediction　and　optimization　of　artificial　knee　designs.　However,　in　order　to　be　independent　and　have　general　applicability　and　predictability,　computational　wear　models　should　be　based　on　inputs　from　independent　experimentally　determined　wear　parameters　(wear　factors　or　wear　coefficients).　The　objective　of　this　study　was　to　investigate　moderately　cross-linked　UHMWPE,　using　a　multidirectional　pin-on-plate　wear　test　machine,　under　a　wide　range　of　applied　nominal　contact　pressure　(from　1　to　11　MPa)　and　under　five　different　kinematic　inputs,　varying　from　a　purely　linear　track　to　a　maximum　rotation　of　+/-　55　degrees.　A　computational　model,　based　on　a　direct　simulation　of　the　multidirectional　pin-on-plate　wear　tester,　was　developed　to　quantify　the　degree　of　cross-shear　(CS)　of　the　polyethylene　pins　articulating　against　the　metallic　plates.　The　moderately　cross-linked　UHMWPE　showed　wear　factors　less　than　half　of　that　reported　in　the　literature　for　the　conventional　UHMWPE,　under　the　same　loading　and　kinematic　inputs.　In　addition,　under　high　applied　nominal　contact　stress,　the　moderately　crosslinked　UHMWPE　wear　showed　lower　dependence　on　the　degree　of　CS　compared　to　that　under　low　applied　nominal　contact　stress.　The　calculated　wear　coefficients　were　found　to　be　independent　of　the　applied　nominal　contact　stress,　in　contrast　to　the　wear　factors　that　were　shown　to　be　highly　pressure　dependent.　This　study　provided　independent　wear　data　for　inputs　into　computational　models　for　moderately　cross-linked　polyethylene　and　supported　the　application　of　wear　coefficient-based　computational　wear　models.