Axially　chiral　compounds　are　valuable　chiral　compounds　used　as　core　skeleton　of　natural　products,　pharmaceutical　intermediates　and　chiral　ligands.　Compared　to　asymmetric　couplings　catalyzed　by　metal　catalysts　or　other　asymmetric　chemical　methods,　biocatalytic　methods　are　mild,　environmental　friendly　and　highly　selective.　With　the　fast　development　of　enzyme　engineering　and　directed　evolution,　biocatalytic　asymmetric　synthesis　of　axially　chiral　compounds　has　attracted　increasing　research　interest.　This　article　reviews　major　progress　in　the　area　of　biocatalytic　synthesis　of　axially　chiral　compounds　starting　from　different　synthetic　methods　kinetic　resolution　(KR),　dynamic　kinetic　resolution　(DKR)　and　desymmetrization,　and　discusses　the　prospects　of　applications　and　existing　problems　of　this　area.　©　2021,　Editorial　Board　of　＇Journal　of　Chemical　Engineering　of　Chinese　Universities＇.　All　right　reserved.