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学者姓名:袁祖贻

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MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia. PubMed
期刊论文 | 2019 | Gut
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Gastric intestinal metaplasia (IM) is common in the gastric epithelium of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile acids and following chronic inflammation. But the mechanism underlying how bile acids activate CDX2 in gastric epithelium has not been fully explored.We performed microRNA (miRNA) and messenger RNA (mRNA) profiling using microarray in cells treated with bile acids. Data integration of the miRNA/mRNA profiles with gene ontology (GO) analysis and bioinformatics was performed to detect potential miRNA-mRNA regulatory circuits. Transfection of gastric cancer cell lines with miRNA mimics and inhibitors was used to evaluate their effects on the expression of candidate targets and functions. Immunohistochemistry and in situhybridisation were used to detect the expression of selected miRNAs and their targets in IM tissue microarrays.We demonstrate a bile acids-triggered pathway involving upregulation of miR-92a-1-5p and suppression of its target FOXD1 in gastric cells. We first found that miR-92a-1-5p was increased in IM tissues and induced by bile acids. Moreover, miR-92a-1-5p was found to activate CDX2 and downstream intestinal markers by targeting FOXD1/FOXJ1 axis and modulating activation of nuclear factor kappa B (NF-κB) pathway. Furthermore, these effects were found to be clinical relevant, as high miR-92a-1-5p levels were correlated with low FOXD1 levels and high CDX2 levels in IM tissues.These findings suggest a miR-92a-1-5p/FOXD1/NF-κB/CDX2 regulatory axis plays key roles in the generation of IM phenotype from gastric cells. Suppression of miR-92a-1-5p and restoration of FOXD1 may be a preventive approach for gastric IM in patients with bile regurgitation.

Keyword :

molecular mechanisms gastric pre-cancer gastric inflammation gastric metaplasia bile reflux

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GB/T 7714 Li Ting , Guo Hanqing , Li Hong et al. MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia. [J]. | Gut , 2019 .
MLA Li Ting et al. "MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia." . | Gut (2019) .
APA Li Ting , Guo Hanqing , Li Hong , Jiang Yanzhi , Zhuang Kun , Lei Chao et al. MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia. . | Gut , 2019 .
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Curcumin ameliorates atherosclerosis in apolipoprotein E deficient asthmatic mice by regulating the balance of Th2/Treg cells Scopus PubMed SCIE
期刊论文 | 2019 , 52 , 129-135 | Phytomedicine
WoS CC Cited Count: 1 SCOPUS Cited Count: 3
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© 2018 Elsevier GmbH Background: Allergic asthma and atherosclerosis represent different directions of inflammatory responses of CD4+ T cells, and allergic asthma accelerates atherosclerosis formation. Curcumin could ameliorate the progression of both atherosclerosis and allergic asthma. Purpose: We aimed to investigate the roles of curcumin in asthma-accelerated atherosclerosis plaque formation, and the change of CD4+ T-cell subsets in this process. Methods: Six to eight-week-old apolipoprotein E−/− (apoE−/−) mice were sensitized and challenged by ovalbumin (OVA) to establish an allergic asthma model, and then received curcumin or vehicle treatment for 8 weeks. Results: The accelerated atherosclerosis was induced by allergic asthma accompanied by increased T helper cell (Th)2 and Th17 cells and decreased regulatory T cells (Tregs) in the spleen. After the 8-week treatment with curcumin, the lesion areas in the aortic root in asthmatic mice significantly improved, and the elevated Th2 and Th17 cells significantly decreased, but Tregs markedly increased. Although curcumin treatment markedly reduced the interleukin (IL)-4 and IL-13 in serum and spleen, the elevated IL-17A did not decrease. Moreover, Th1 cells showed no significant change between different groups. The mRNA expression levels of M1 macrophage-related inflammatory factors IL-6, iNOS and IL-1β were markedly elevated in the spleens of asthmatic mice, but significantly decreased after the 8-week treatment with curcumin. Conclusion: Curcumin ameliorated the aggravation of atherosclerotic lesions and stabilised plaque by modulating the balance of Th2/Tregs in asthmatic apoE−/− mice.

Keyword :

Allergic asthma Apolipoprotein E deficiency Atherosclerosis CD4+ T cells Curcumin

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GB/T 7714 Gao, Shanshan , Zhang, Weiping , Zhao, Qiang et al. Curcumin ameliorates atherosclerosis in apolipoprotein E deficient asthmatic mice by regulating the balance of Th2/Treg cells [J]. | Phytomedicine , 2019 , 52 : 129-135 .
MLA Gao, Shanshan et al. "Curcumin ameliorates atherosclerosis in apolipoprotein E deficient asthmatic mice by regulating the balance of Th2/Treg cells" . | Phytomedicine 52 (2019) : 129-135 .
APA Gao, Shanshan , Zhang, Weiping , Zhao, Qiang , Zhou, Juan , Wu, Yue , Liu, Yan et al. Curcumin ameliorates atherosclerosis in apolipoprotein E deficient asthmatic mice by regulating the balance of Th2/Treg cells . | Phytomedicine , 2019 , 52 , 129-135 .
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Differences in two-year outcomes for patients with non-ST-segment elevation myocardial infarction or unstable angina treated with medication only - findings from the EPICOR Asia study CPCI-S SCIE
会议论文 | 2018 , 72 (16) , C110-C110 | 29th Great Wall International Congress of Cardiology (GW-ICC), China-Heart-Society, and Beijing-Society-of-Cardiology
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GB/T 7714 Zhou, Juan , Huang, Xin , Guo, Ning et al. Differences in two-year outcomes for patients with non-ST-segment elevation myocardial infarction or unstable angina treated with medication only - findings from the EPICOR Asia study [C] . 2018 : C110-C110 .
MLA Zhou, Juan et al. "Differences in two-year outcomes for patients with non-ST-segment elevation myocardial infarction or unstable angina treated with medication only - findings from the EPICOR Asia study" . (2018) : C110-C110 .
APA Zhou, Juan , Huang, Xin , Guo, Ning , Wu, Yue , Yu, Bo , Qiao, Shubin et al. Differences in two-year outcomes for patients with non-ST-segment elevation myocardial infarction or unstable angina treated with medication only - findings from the EPICOR Asia study . (2018) : C110-C110 .
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Combination of the CYP2C19 metabolizer and the GRACE risk score better predicts the long-term major adverse cardiac events in acute coronary syndrome undergoing percutaneous coronary intervention SCIE PubMed Scopus
期刊论文 | 2018 , 170 , 142-147 | THROMBOSIS RESEARCH
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Introduction: Both Global Registry of Acute Coronary Events (GRACE) risk score and CYP2C19 metabolizer status can independently predict major adverse cardiac events (MACEs) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). We investigated whether their combination could better predict MACE occurrence in patients with ACS undergoing PCI. Materials and methods: This retrospective cohort study included 548 consecutive patients with ACS undergoing PCI. A cumulative MACE curve was calculated using the Kaplan-Meier method. Multivariate Cox regression was used to identify MACE predictors. The predictive value of GRACE risk score alone and CYP2C19 metabolizer status was estimated by the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Results: In a median of 28.58 months, 17 patients (3%) were lost to follow-up, and 62 (11.3%) experienced MACEs. Multivariate Cox regression analysis showed that both GRACE score and CYP2C19 metabolizer status were independent MACE predictors (hazard ratio 1.019, 95% CI 1.011-1.027, p < 0.001; hazard ratio 2.383, 95% CI 1.601-3.547, p < 0.001, respectively). Kaplan-Meier analysis showed that CYP2C19 PM increased the MACE risk (log rank test= 10.848, p= 0.004). The GRACE score adjustment by CYP2C19 metabolizer status enhanced the predictive value (AUC increased from 0.682 for GRACE score alone to 0.731 for GRACE score plus CYP2C19 metabolizer). This result was further verified by IDI and NRI. Conclusions: CYP2C19 metabolizer status and GRACE score are readily available predictive approaches for MACEs, and their combination derives a more accurate long-term MACE prediction in clopidogrel-treated patients with ACS undergoing PCI.

Keyword :

Prognosis Risk factor GRACE score CYP2C19 metabolizer Acute coronary syndrome

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GB/T 7714 Bai, Xiao-Fang , Zhang, Ya-Ping , Zhou, Juan et al. Combination of the CYP2C19 metabolizer and the GRACE risk score better predicts the long-term major adverse cardiac events in acute coronary syndrome undergoing percutaneous coronary intervention [J]. | THROMBOSIS RESEARCH , 2018 , 170 : 142-147 .
MLA Bai, Xiao-Fang et al. "Combination of the CYP2C19 metabolizer and the GRACE risk score better predicts the long-term major adverse cardiac events in acute coronary syndrome undergoing percutaneous coronary intervention" . | THROMBOSIS RESEARCH 170 (2018) : 142-147 .
APA Bai, Xiao-Fang , Zhang, Ya-Ping , Zhou, Juan , Wu, Yue , Li, Rui-Feng , Sun, Li-Zhe et al. Combination of the CYP2C19 metabolizer and the GRACE risk score better predicts the long-term major adverse cardiac events in acute coronary syndrome undergoing percutaneous coronary intervention . | THROMBOSIS RESEARCH , 2018 , 170 , 142-147 .
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Pu-erh Tea Ameliorates Atherosclerosis Associated with Promoting Macrophage Apoptosis by Reducing NF-kappa B Activation in ApoE Knockout Mice SCIE PubMed
期刊论文 | 2018 | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
WoS CC Cited Count: 1
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We explored whether pu-erh tea consumption ameliorates atherosclerosis and the possible mechanism for its effects in apolipoprotein E-deficient (ApoE(-/-)) mice. Our data showed that pu-erh tea consumption markedly reduced early fatty streak formation and the advanced fibrofatty plaque sizes. Additionally, the mean proportion of inflammatory macrophages in the plaque decreased, and the number of apoptotic macrophages increased significantly. NF-kappa B activity in peritoneal macrophages decreased by 75.6% compared to the controls, similar with the levels of IL-6, IL-12, and TNF-alpha expression. The tea extract increased the apoptosis of RAW264.7 cells by decreasing NF-kappa B activation and reducing the inflammatory cytokine expression. In conclusion, pu-erh tea ameliorates atherosclerosis progress by alleviating the chronic inflammatory state by reducing NF-kappa B activation and promoting macrophage apoptosis in atherosclerotic plaques.

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GB/T 7714 Xiao, Yihui , He, Ming , Liang, Xiao et al. Pu-erh Tea Ameliorates Atherosclerosis Associated with Promoting Macrophage Apoptosis by Reducing NF-kappa B Activation in ApoE Knockout Mice [J]. | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY , 2018 .
MLA Xiao, Yihui et al. "Pu-erh Tea Ameliorates Atherosclerosis Associated with Promoting Macrophage Apoptosis by Reducing NF-kappa B Activation in ApoE Knockout Mice" . | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018) .
APA Xiao, Yihui , He, Ming , Liang, Xiao , She, Jianqing , He, Lan , Liu, Yan et al. Pu-erh Tea Ameliorates Atherosclerosis Associated with Promoting Macrophage Apoptosis by Reducing NF-kappa B Activation in ApoE Knockout Mice . | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY , 2018 .
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Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age SCIE PubMed
期刊论文 | 2018 , 29 (12) , 2835-2846 | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
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Background Although high BP is one of the most important factors affecting renal function, whether longitudinal BP trajectories in early life course are associated with renal function damage in later life is unclear. Methods To investigate the correlation between BP trajectories from childhood to adulthood and renal function in middle age, we used group-based trajectory models to identify BP trajectories in 2430 individuals (aged 6-15 years old at baseline) participating in the ongoing Hanzhong Adolescent Hypertension Cohort. We tested the association between these trajectories and subclinical renal damage in middle age, adjusting for several covariates. Results We identified four distinct systolic BP trajectories among 2430 subjects: low stable, moderate stable, high stable, and moderate increasing on the basis of systolic BP levels at baseline and during the 30-year follow-up period. The urinary albumin-to-creatinine ratio (uACR) was higher in moderate stable, high stable, and moderate increasing groups compared with the low stable group. A total of 228 individuals had subclinical renal disease by 2017. Compared with the low stable trajectory group, the other groups had increasingly greater odds of experiencing subclinical renal disease in middle age. These associations were not altered after adjustment for other covariates, except for in the moderate stable group. Analyzed results were similar for the mean arterial pressure and diastolic BP trajectory groups. Conclusions Higher BP trajectories were correlated with higher of uACR levels and risk of subclinical renal disease in middle age. Identifying long-term BP trajectories from early age may assist in predicting individuals' renal function in later life.

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GB/T 7714 Zheng, Wenling , Mu, Jianjun , Chu, Chao et al. Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age [J]. | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY , 2018 , 29 (12) : 2835-2846 .
MLA Zheng, Wenling et al. "Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age" . | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 29 . 12 (2018) : 2835-2846 .
APA Zheng, Wenling , Mu, Jianjun , Chu, Chao , Hu, Jiawen , Yan, Yu , Ma, Qiong et al. Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age . | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY , 2018 , 29 (12) , 2835-2846 .
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Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians SCIE PubMed Scopus
期刊论文 | 2018 , 119 (2) , 228-237 | BRITISH JOURNAL OF NUTRITION
WoS CC Cited Count: 4 SCOPUS Cited Count: 3
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Salt, promoting oxidative stress, contributes to insulin resistance, whereas K, inhibiting oxidative stress, improves insulin sensitivity. Oxidative stress activation of NLRP3 inflammasome is a central player in the induction of insulin resistance. Therefore, we hypothesised that NLRP3 inflammasome may mediate the effects of salt and K on insulin resistance. In all, fifty normotensive subjects were recruited from a rural community of Northern China. The protocol included a low-salt diet for 7 d, then a high-salt diet for 7 d and a high-salt diet with K supplementation for another 7 d. In addition, THP-1 cells were cultured in different levels of Na with and without K. The results showed that salt loading elevated fasting blood glucose, insulin and C-peptide levels, as well as insulin resistance, whereas K supplementation reversed them. Meanwhile, additional K reversed the active effects of high salt on NLRP3 inflammasome in both the subjects and THP-1 cells, and the change of insulin resistance index notably related with the alteration of plasma IL-1 beta, the index of NLRP3 inflammasome activation, during intervention in the subjects. Additional K ameliorated oxidative stress induced by high salt in both the subjects and cultured THP-1 cells, and the change of oxidative stress related with the alteration of plasma IL-1 beta during intervention in the subjects. In vitro, antioxidant N-acetyl-l-cysteine significantly prevented the active effects of high Na or oxidant Rosup on NLRP3 inflammasome, so did K. Our study indicates that oxidative stress modulation of NLRP3 inflammasome may be involved in the impacts of Na and K on insulin resistance.

Keyword :

NLRP3 inflammasome Oxidative stress Insulin resistance Potassium Sodium

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GB/T 7714 Wan, Zhaofei , Wen, Wen , Ren, Keyu et al. Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians [J]. | BRITISH JOURNAL OF NUTRITION , 2018 , 119 (2) : 228-237 .
MLA Wan, Zhaofei et al. "Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians" . | BRITISH JOURNAL OF NUTRITION 119 . 2 (2018) : 228-237 .
APA Wan, Zhaofei , Wen, Wen , Ren, Keyu , Zhou, Dong , Liu, Junhui , Wu, Yue et al. Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians . | BRITISH JOURNAL OF NUTRITION , 2018 , 119 (2) , 228-237 .
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AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension SCIE PubMed Scopus
期刊论文 | 2018 , 198 (4) , 509-520 | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
WoS CC Cited Count: 6 SCOPUS Cited Count: 7
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Rationale: Endothelial dysfunction plays an integral role in pulmonary hypertension (PH). AMPK (AMP-activated protein kinase) and ACE2 (angiotensin-converting enzyme 2) are crucial in endothelial homeostasis. The mechanism by which AMPK regulates ACE2 in the pulmonary endothelium and its protective role in PH remain elusive. Objectives: We investigated the role of AMPK phosphorylation of ACE2 Ser680 in ACE2 stability and deciphered the functional consequences of this post-translational modification of ACE2 in endothelial homeostasis and PH. Methods: Bioinformatics prediction, kinase assay, and antibody against phospho-ACE2 Ser680 (p-ACE2 S680) were used to investigate AMPK phosphorylation of ACE2 Ser680 in endothelial cells. Using CRISPR-Cas9 genomic editing, we created gain-of-function ACE2 S680D knock-in and loss-of-function ACE2 knockout (ACE22/2) mouse lines to address the involvement of p-ACE2 S680 and ACE2 in PH. The AMPK-p-ACE2 S680 axis was also validated in lung tissue from humans with idiopathic pulmonary arterial hypertension. Measurements and Main Results: Phosphorylation of ACE2 by AMPK enhanced the stability of ACE2, which increased Ang (angiotensin) 1-7 and endothelial nitric oxide synthase-derived NO bioavailability. ACE2 S680D knock-in mice were resistant to PH as compared with wild-type littermates. In contrast, ACE2-knockout mice exacerbated PH, a similar phenotype found in mice with endothelial cell-specific deletion of AMPK alpha 2. Consistently, the concentrations of phosphorylated AMPK, p-ACE2 S680, and ACE2 were decreased in human lungs with idiopathic pulmonary arterial hypertension. Conclusions: Impaired phosphorylation of ACE2 Ser680 by AMPK in pulmonary endothelium leads to a labile ACE2 and hence is associated with the pathogenesis of PH. Thus, AMPK regulation of the vasoprotective ACE2 is a potential target for PH treatment.

Keyword :

converting enzyme 2 vascular endothelium AMP-activated protein kinase angiotensin pulmonary hypertension

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GB/T 7714 Zhang, Jiao , Dong, Jianjie , Martin, Marcy et al. AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension [J]. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE , 2018 , 198 (4) : 509-520 .
MLA Zhang, Jiao et al. "AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension" . | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 198 . 4 (2018) : 509-520 .
APA Zhang, Jiao , Dong, Jianjie , Martin, Marcy , He, Ming , Gongol, Brendan , Marin, Traci L. et al. AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension . | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE , 2018 , 198 (4) , 509-520 .
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Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents SCIE PubMed Scopus
期刊论文 | 2018 , 31 (2) , 253-260 | AMERICAN JOURNAL OF HYPERTENSION
WoS CC Cited Count: 3 SCOPUS Cited Count: 3
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BACKGROUND Dietary sodium and potassium affect the fluctuation in blood pressure (BP) and renal function. Corin, with its enzymatic activity to convert proatrial natriuretic peptide (pro-ANP) to biologically active ANP, regulates BP, cardiac, and renal functions. We investigated whether corin expression responds to a high-salt (HS) diet to regulate salt and water balance. METHODS Forty-two volunteers followed 3 sequential diets for 7 days each: a low-salt (LS) diet (3.0 g/day NaCl), a HS diet (18.0 g/day NaCl), followed by an HS diet with K+ supplementation (HS + K+) (18.0 g/day NaCl and 4.5 g/day KCl). RESULTS Corin level was higher with the HS diet than the LS and HS + K+ diets and was positively correlated with systolic BP (SBP) and 24-hour urinary Na+ and microalbumin (U-mALB) excretion. In rodents, serum and renal levels of corin were transiently increased with the HS diet and were decreased if the HS diet was continued for up to 7 days. HS loading increased SBP, 24-hour urinary Na+, U-mALB excretion, and the expression of proprotein convertase subtilisin/kexin-6 (PCSK6), a corin activator. Knockdown of PCSK6 or corin in high salt-treated M1-cortical collecting duct (M1-CCD) cells increased the expression of aquaporin 2 (AQP2) and beta-epithelial Na+ channel (beta-ENaC). CONCLUSIONS Short-term HS may induce the PCSK6-corin-ANP-AQP2/beta-ENaC pathway in the kidney. Enhanced serum corin level in humans and rodents is positively correlated with HS-induced SBP and 24-hour urinary Na+ and U-mALB excretion, which suggests that corin is involved in the saltwater balance in response to HS intake.

Keyword :

blood pressure potassium PCSK6 corin hypertension high-salt diet

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GB/T 7714 Zhang, Jiao , Yin, Yanjun , Chen, Lili et al. Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents [J]. | AMERICAN JOURNAL OF HYPERTENSION , 2018 , 31 (2) : 253-260 .
MLA Zhang, Jiao et al. "Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents" . | AMERICAN JOURNAL OF HYPERTENSION 31 . 2 (2018) : 253-260 .
APA Zhang, Jiao , Yin, Yanjun , Chen, Lili , Chu, Chao , Wang, Yang , Lv, Yongbo et al. Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents . | AMERICAN JOURNAL OF HYPERTENSION , 2018 , 31 (2) , 253-260 .
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Prognostic significance and dynamic change of plasma macrophage migration inhibitory factor in patients with acute ST-elevation myocardial infarction Scopus SCIE PubMed
期刊论文 | 2018 , 97 (43) | Medicine
WoS CC Cited Count: 2 SCOPUS Cited Count: 1
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Macrophage migration inhibitory factor (MIF) has been reported as an inflammatory cytokine in many inflammatory diseases, including rheumatoid arthritis and ischemic diseases. However, dynamic changes of MIF within the first 24 hours on admission and potential prognostic significance following ST-elevation myocardial infarction (STEMI) have been little known. In this study, we examined the dynamic change of MIF level and its potential diagnostic and prognostic value after the onset of STEMI. Plasma MIF levels were evaluated in symptomatic subjects who received coronary angiogram with a median 27 months follow-up for the development of major adverse cardiovascular events (MACEs).Of all 993 subjects, patients with STEMI showed a significantly higher MIF levels than in patients with non-ST elevation acute coronary syndrome, stable angina, and normal coronary artery, respectively (P < .01). Plasma MIF levels elevated as early as 12 hours post-onset of STEMI and peaked rapidly within 24 hours, and remained elevated from about day 5 till day 9 during hospitalization. In multivariate analysis, MIF was associated with a decreased risk of MACEs occurrence in STEMI patients after adjustment for traditional cardiovascular risk factors [hazard ratio 0.81, (0.72-0.90), P < .001]. The ROC curve for MACEs was 0.72 (95% CI 0.62-0.80, P < .001) and 0.85 (95% CI 0.80-0.90, P < .001) using Framingham risk factors only and combined with MIF, individually.Measurement of MIF adds potential information for the early diagnosis of acute STEMI and significantly improves risk prediction of MACEs when added to a prognostic model with traditional Framingham risk factors.

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GB/T 7714 Deng, Fuxue , Zhao, Qiang , Deng, Yangyang et al. Prognostic significance and dynamic change of plasma macrophage migration inhibitory factor in patients with acute ST-elevation myocardial infarction [J]. | Medicine , 2018 , 97 (43) .
MLA Deng, Fuxue et al. "Prognostic significance and dynamic change of plasma macrophage migration inhibitory factor in patients with acute ST-elevation myocardial infarction" . | Medicine 97 . 43 (2018) .
APA Deng, Fuxue , Zhao, Qiang , Deng, Yangyang , Wu, Yue , Zhou, Dong , Liu, Weimin et al. Prognostic significance and dynamic change of plasma macrophage migration inhibitory factor in patients with acute ST-elevation myocardial infarction . | Medicine , 2018 , 97 (43) .
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