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Three-Dimensional Printing PEEK Implant: A Novel Choice for the Reconstruction of Chest Wall Defect. PubMed SCIE
期刊论文 | 2019 , 107 (3) , 921-928 | The Annals of thoracic surgery
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Abstract :

The purpose of this study is to use 3-dimensional printing (3DP) polyetheretherketone (PEEK) implants for skeletal reconstructions after wide excision of chest wall. 3DP PEEK implants were expected to provide a better physiological simulation than traditional ones because of a closer elastic modulus to cortical bone and similar biomechanical properties.Eighteen patients (mean age 44.5 years), comprising 6 males and 12 females, underwent adequate radical wide excision for tumors and chest wall reconstruction using 3DP PEEK implants. Surgical data, which include patient demographic characteristics, implant preparation parameters, and preoperative and postoperative pulmonary function test results, were collected and analyzed.Ten patients with rib tumors and 8 patients with sternum tumors were selected for the study. The mean chest wall defect size was 173.6 ± 151.5 cm<sup>2</sup> (range, 55 to 625 cm<sup>2</sup>). The mean weight of a single 3DP PEEK rib and sternum was 28 g and 104 g, respectively. The flexural and tensile strength of PEEK implants were 141 ± 7 MPa and 89 ± 3 MPa, respectively. Preoperative and postoperative pulmonary function tests revealed that mean forced vital capacity was from 2.79 ± 0.68 L to 2.40 ± 0.70 L with a reduction of 14.0% (p < 0.001). No side effects were observed 6 to 12 months after the operation.These findings suggest that 3DP PEEK implant is a safe and effective alternative in the reconstruction of chest wall defects. The pulmonary function of the patient may be preserved effectively after surgery.

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GB/T 7714 Wang Lei , Huang Lijun , Li Xiaofei et al. Three-Dimensional Printing PEEK Implant: A Novel Choice for the Reconstruction of Chest Wall Defect. [J]. | The Annals of thoracic surgery , 2019 , 107 (3) : 921-928 .
MLA Wang Lei et al. "Three-Dimensional Printing PEEK Implant: A Novel Choice for the Reconstruction of Chest Wall Defect." . | The Annals of thoracic surgery 107 . 3 (2019) : 921-928 .
APA Wang Lei , Huang Lijun , Li Xiaofei , Zhong Daixing , Li Dichen , Cao Tiesheng et al. Three-Dimensional Printing PEEK Implant: A Novel Choice for the Reconstruction of Chest Wall Defect. . | The Annals of thoracic surgery , 2019 , 107 (3) , 921-928 .
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Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-Healing, Adhesiveness, and 3D Printability for Human Motion Sensing SCIE
期刊论文 | 2019 , 11 (7) , 6796-6808 | ACS APPLIED MATERIALS & INTERFACES
WoS CC Cited Count: 8
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Abstract :

Self-healing, adhesive conductive hydrogels are of great significance in wearable electronic devices, flexible printable electronics, and tissue engineering scaffolds. However, designing self-healing hydrogels with multifunctional properties such as high conductivity, excellent mechanical property, and high sensitivity remains a challenge. In this work, the conductive self-healing nanocomposite hydrogels based on nanoclay (laponite), multi-walled carbon nanotubes (CNTs), and N-isopropyl acrylamide are presented. The presented nanocomposite hydrogels displayed good electrical conductivity, rapid self-healing and adhesive properties, flexible and stretchable mechanical properties, and high sensitivity to near-infrared light and temperature. These excellent properties of the hydrogels are demonstrated by the three-dimensional (3D) bulky pressure-dependent device, human activity monitoring device, and 3D printed gridding scaffolds. Good cytocompatibility of the conductive hydrogels was also evaluated with L929 fibroblast cells. These nanocomposite hydrogels have great potential for applications in stimuli-responsive electrical devices, wearable electronics, and so on.

Keyword :

nanocomposite hydrogels human motion sensors self-healing conductive hydrogel 3D printing adhesive

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GB/T 7714 Deng, Zexing , Hu, Tianli , Lei, Qi et al. Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-Healing, Adhesiveness, and 3D Printability for Human Motion Sensing [J]. | ACS APPLIED MATERIALS & INTERFACES , 2019 , 11 (7) : 6796-6808 .
MLA Deng, Zexing et al. "Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-Healing, Adhesiveness, and 3D Printability for Human Motion Sensing" . | ACS APPLIED MATERIALS & INTERFACES 11 . 7 (2019) : 6796-6808 .
APA Deng, Zexing , Hu, Tianli , Lei, Qi , He, Jiankang , Ma, Peter X. , Guo, Baolin . Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-Healing, Adhesiveness, and 3D Printability for Human Motion Sensing . | ACS APPLIED MATERIALS & INTERFACES , 2019 , 11 (7) , 6796-6808 .
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Can the sheep model fully represent the human model for the functional evaluation of cervical interbody fusion cages? EI PubMed
期刊论文 | 2018 | Biomechanics and Modeling in Mechanobiology
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Sheep model is the most favourable choice for animal study for functional evaluation of the cervical fusion prostheses before clinical application; however, significantly large differences between sheep and human existed in terms of morphological characteristics and daily-activity motions. Questions should be raised as whether the differences between the two species have influence on the reliability of sheep model. Finite element models (FEM) of the cervical spinal system were built to characterize the differences between the two species with respect to the range of motion (ROM) and biomechanical behaviour, and experimental cadaver tests on both species were employed for validation purposes. Results indicate that sheep model represents the worst-case scenario of the human model with exaggerated stresses (up to 3 times more) and ROM (up to 10 times more). Moreover, sheep model is very sensitive to the variation of prostheses design, whilst human model does not, which denotes that the sheep model provides a rather amplified effect of a certain design for its biomechanical performance. Therefore, caution needs to be taken when sheep models were used as the animal model for functional evaluation over various design, and the FEM built in this study can be employed as an effective methodology for performance evaluation of cage prostheses of cervical spine. © 2018, The Author(s).

Keyword :

Animal studies Biomechanical performance Functional evaluation Interbody fusion cages Morphological characteristic Performance evaluations Range of motions Spinal disc

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GB/T 7714 Wang, Ling , Wang, Yingying , Shi, Lei et al. Can the sheep model fully represent the human model for the functional evaluation of cervical interbody fusion cages? [J]. | Biomechanics and Modeling in Mechanobiology , 2018 .
MLA Wang, Ling et al. "Can the sheep model fully represent the human model for the functional evaluation of cervical interbody fusion cages?" . | Biomechanics and Modeling in Mechanobiology (2018) .
APA Wang, Ling , Wang, Yingying , Shi, Lei , Liu, Peng , Kang, Jianfeng , He, Jiankang et al. Can the sheep model fully represent the human model for the functional evaluation of cervical interbody fusion cages? . | Biomechanics and Modeling in Mechanobiology , 2018 .
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A Method of Accurate Bone Tunnel Placement for Anterior Cruciate Ligament Reconstruction Based on 3-Dimensional Printing Technology: A Cadaveric Study SCIE PubMed Scopus
期刊论文 | 2018 , 34 (2) , 546-556 | ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
WoS CC Cited Count: 3 SCOPUS Cited Count: 5
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Purpose: To explore a method of bone tunnel placement for anterior cruciate ligament (ACL) reconstruction based on 3-dimensional (3D) printing technology and to assess its accuracy. Methods: Twenty human cadaveric knees were scanned by thin-layer computed tomography (CT). To obtain data on bones used to establish a knee joint model by computer software, customized bone anchors were installed before CT. The reference point was determined at the femoral and tibial footprint areas of the ACL. The site and direction of the bone tunnels of the femur and tibia were designed and calibrated on the knee joint model according to the reference point. The resin template was designed and printed by 3D printing. Placement of the bone tunnels was accomplished by use of templates, and the cadaveric knees were scanned again to compare the concordance of the internal opening of the bone tunnels and reference points. Results: The twenty 3D printing templates were designed and printed successfully. CT data analysis between the planned and actual drilled tunnel positions showed mean deviations of 0.57 mm (range, 0-1.5 mm; standard deviation, 0.42 mm) at the femur and 0.58 mm (range, 0-1.5mm; standard deviation, 0.47 mm) at the tibia. Conclusions: The accuracy of bone tunnel placement for ACL reconstruction in cadaveric adult knees based on 3D printing technology is high.

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GB/T 7714 Ni, Jianlong , Li, Dichen , Mao, Mao et al. A Method of Accurate Bone Tunnel Placement for Anterior Cruciate Ligament Reconstruction Based on 3-Dimensional Printing Technology: A Cadaveric Study [J]. | ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY , 2018 , 34 (2) : 546-556 .
MLA Ni, Jianlong et al. "A Method of Accurate Bone Tunnel Placement for Anterior Cruciate Ligament Reconstruction Based on 3-Dimensional Printing Technology: A Cadaveric Study" . | ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY 34 . 2 (2018) : 546-556 .
APA Ni, Jianlong , Li, Dichen , Mao, Mao , Dang, Xiaoqian , Wang, Kunzheng , He, Jiankang et al. A Method of Accurate Bone Tunnel Placement for Anterior Cruciate Ligament Reconstruction Based on 3-Dimensional Printing Technology: A Cadaveric Study . | ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY , 2018 , 34 (2) , 546-556 .
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Novel Application of Cell Penetrating R11 Peptide for Diagnosis of Bladder Cancer EI SCIE Scopus
期刊论文 | 2018 , 14 (1) , 161-167 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
WoS CC Cited Count: 4 SCOPUS Cited Count: 4
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Abstract :

Objective: As a novel cell-permeable peptide, polyarginine (R11) showed great potential as contrast agent to target bladder cancer (BCa) for therapeutic applications. However, its diagnostic ability and uptake efficiency between BCa and normal bladder tissues is unknown. In this study, we investigated the feasibility of R11 conjugated with fluorescein isothiocyanate (FITC-R11) for detecting BCa in clinical practice. Method: FITC-R11 was synthesized and incubated with BCa cell lines (T24, 5637, RT4), normal immortalized human bladder epithelial cell line (SVHUC) and clinical specimens from BCa and benign prostate hyperplasia patients. The uptake efficiency was determined by the mean values of relative FITC intensity. Furthermore, FITC-R11 was intravesically injected into the athymic nude mice bearing orthotopic T24-t tumors and pulmonary metastasis of bladder tumor mice models, the fluorescence intensity of bladder tumors and normal bladder tissues was examined, as well as lung tissues. Result: After incubation with FITC-R11, the fluorescence intensity of T24, 5637, RT4 and SVHUC cell line was 64678.56 +/- 9699.27, 46456.22 +/- 2588.06, 33802.02 +/- 429.72 and 17785.01 +/- 1704.36, respectively (P < 0.05). In the athymic nude mice bearing orthotopic T24-t tumors, FITC-R11 showed elevated accumulation in the bladder tumors compared with normal bladder tissues, FITC-R11 was also accumulated in the lung of pulmonary metastasis mice. Moreover, the uptake efficiency of FITC-R11 in patients' BCa tissues was much higher than in normal bladder tissues (6441.95 vs. 1196.92, P < 0.05), as well as the urine samples of BCa patients and benign prostate hyperplasia patients (30250.37 vs. 4948.42, P < 0.05). Conclusion: As compared with normal bladder tissue, FITC-R11 is a more specific molecular probe for BCa, and has the potential application in clinical practice.

Keyword :

Bladder Cancer Cell Penetrating Peptide Diagnosis FITC-R11

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GB/T 7714 Du, Yiqing , Wang, Lei , Wang, Weiyi et al. Novel Application of Cell Penetrating R11 Peptide for Diagnosis of Bladder Cancer [J]. | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY , 2018 , 14 (1) : 161-167 .
MLA Du, Yiqing et al. "Novel Application of Cell Penetrating R11 Peptide for Diagnosis of Bladder Cancer" . | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 14 . 1 (2018) : 161-167 .
APA Du, Yiqing , Wang, Lei , Wang, Weiyi , Guo, Ting , Zhang, Mengzhao , Zhang, Pu et al. Novel Application of Cell Penetrating R11 Peptide for Diagnosis of Bladder Cancer . | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY , 2018 , 14 (1) , 161-167 .
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一种镁合金-聚合物复合可降解生物支架的3D打印方法
专利 | 2018-03-22 | CN201810240983.4
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一种镁合金‑聚合物复合可降解生物支架的3D打印方法,首先将可降解镁合金材料制作成不同力学性能的不同直径的可降解镁合金纤维,并将可降解镁合金纤维穿过同轴式3D打印喷头的喷嘴;然后在同轴式3D打印喷头的内侧热熔腔中加入可降解聚合物材料,可降解聚合物在熔融后,将可降解镁合金纤维和熔融后的可降解聚合物共同从喷嘴挤出,从而形成可降解镁合金‑聚合物复合增强纤维;最后在3D打印系统的控制下根据个性化设计的支架结构进行3D打印,从而得到镁合金‑聚合物复合增强的可降解生物支架;本发明通过在可降解镁合金纤维外表面低温复合聚合物的方式,增强了所打印出的可降解生物支架的力学和结构性能,有效控制了镁合金的降解时间。

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GB/T 7714 贺健康 , 田小永 , 李涤尘 et al. 一种镁合金-聚合物复合可降解生物支架的3D打印方法 : CN201810240983.4[P]. | 2018-03-22 .
MLA 贺健康 et al. "一种镁合金-聚合物复合可降解生物支架的3D打印方法" : CN201810240983.4. | 2018-03-22 .
APA 贺健康 , 田小永 , 李涤尘 , 仝站国 . 一种镁合金-聚合物复合可降解生物支架的3D打印方法 : CN201810240983.4. | 2018-03-22 .
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Treatment of bronchomalacia using three-dimensional printed polycaprolactone scaffold in a pediatric patient. PubMed
期刊论文 | 2018 | The Journal of thoracic and cardiovascular surgery
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GB/T 7714 Wang Lei , Liu Wenhao , He Jiankang et al. Treatment of bronchomalacia using three-dimensional printed polycaprolactone scaffold in a pediatric patient. [J]. | The Journal of thoracic and cardiovascular surgery , 2018 .
MLA Wang Lei et al. "Treatment of bronchomalacia using three-dimensional printed polycaprolactone scaffold in a pediatric patient." . | The Journal of thoracic and cardiovascular surgery (2018) .
APA Wang Lei , Liu Wenhao , He Jiankang , Li Xiaofei , Huang Lijun . Treatment of bronchomalacia using three-dimensional printed polycaprolactone scaffold in a pediatric patient. . | The Journal of thoracic and cardiovascular surgery , 2018 .
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A study of cryogenic tissue-engineered liver slices in calcium alginate gel for drug testing SCIE PubMed Scopus
期刊论文 | 2018 , 82 , 1-7 | CRYOBIOLOGY
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To address issues such as transportation and the time-consuming nature of tissue-engineered liver for use as an effective drug metabolism and toxicity testing model, "ready-to-use" cryogenic tissue-engineered liver needs to be studied. The research developed a cryogenic tissue-engineered liver slice (TELS), which comprised of HepG2 cells and calcium alginate gel. Cell viability and liver-specific functions were examined after different cryopreservation and recovery culture times. Then, cryogenic TELSs were used as a drug-testing model and treated with Gefitinib. Cryogenic TELSs were stored at -80 degrees C to ensure high cell viability. During recovery in culture, the cells in the cryogenic TELS were evenly distributed, massively proliferated, and then formed spheroid-like aggregates from day 1 to day 13. The liver-specific functions in the cryogenic TELS were closely related to cryopreservation time and cell proliferation. As a reproducible drug-testing model, the cryogenic TELS showed an obvious drug reaction after treatment with the Gefitinib. The present study shows that the cryopreservation techniques can be used in drug-testing models.

Keyword :

Calcium alginate gel Cryopreservation Drug-testing model HepG2 cell Tissue-engineered liver slice

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GB/T 7714 Chen, Ruomeng , Wang, Bo , Liu, Yaxiong et al. A study of cryogenic tissue-engineered liver slices in calcium alginate gel for drug testing [J]. | CRYOBIOLOGY , 2018 , 82 : 1-7 .
MLA Chen, Ruomeng et al. "A study of cryogenic tissue-engineered liver slices in calcium alginate gel for drug testing" . | CRYOBIOLOGY 82 (2018) : 1-7 .
APA Chen, Ruomeng , Wang, Bo , Liu, Yaxiong , Lin, Rong , He, Jiankang , Li, Dichen . A study of cryogenic tissue-engineered liver slices in calcium alginate gel for drug testing . | CRYOBIOLOGY , 2018 , 82 , 1-7 .
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一种曲面分层熔融沉积成型的5轴3D打印装置及方法
专利 | 2018-05-22 | CN201810495540.X
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一种曲面分层熔融沉积成型的5轴3D打印装置及方法,装置包括动平台,3D打印头以及挤丝机,塑料丝经由挤丝机送入3D打印头中,3D打印头的下方设有动平台,动平台通过平台伸出轴、万向节和支撑杆连接,支撑杆和升降装置连接,动平台的边缘通过球轴承和三个推杆上端连接,推杆下端通过皮带夹紧件以及球面副球心和滑块连接,滑块和固定在固定机架上的竖直导轨配合,使滑块沿导轨直线上下运动,滑块由电机通过皮带控制;根据零件三维模型的特征对三维模型曲面切层,并得到每个切层曲面的路径规划数据,通过数学推导得到动平台、3D打印头和电机的运动学参数,经由计算机程序控制进行零件加工;本发明具有精度高,且打印范围大的优点。

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GB/T 7714 刘亚雄 , 冯晓静 , 崔滨 et al. 一种曲面分层熔融沉积成型的5轴3D打印装置及方法 : CN201810495540.X[P]. | 2018-05-22 .
MLA 刘亚雄 et al. "一种曲面分层熔融沉积成型的5轴3D打印装置及方法" : CN201810495540.X. | 2018-05-22 .
APA 刘亚雄 , 冯晓静 , 崔滨 , 任辉 , 贺健康 , 王玲 et al. 一种曲面分层熔融沉积成型的5轴3D打印装置及方法 : CN201810495540.X. | 2018-05-22 .
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一种矫治阴道畸形用3D打印可降解支架及其制造方法
专利 | 2018-03-22 | CN201810240996.1
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一种矫治阴道畸形用3D打印可降解支架及其制造方法,可降解支架包括根据患者的影像数据设计的支架主体,支架主体为两端敞口的中空管道,支架主体的表面设有孔洞,支架主体两端敞口位置设置有凸缘;支架主体的一侧设置有凹槽,制造方法是先对患者病患部位进行医学影像扫描;然后在计算机中进行三维重建和个性化多孔支架的设计,再将设计好后的支架用3D打印切片软件进行处理,得到各个截面层的信息;然后将切片后各个截面层的信息导入3D打印机中,用可降解生物活性材料打印得到支架;本发明可以减小对患者的创伤,并且随着时间的推移自体细胞可以长入支架,形成自然腔道,同时支架自然降解,避免了二次手术的风险和损伤。

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GB/T 7714 贺健康 , 仝站国 , 曹铁生 et al. 一种矫治阴道畸形用3D打印可降解支架及其制造方法 : CN201810240996.1[P]. | 2018-03-22 .
MLA 贺健康 et al. "一种矫治阴道畸形用3D打印可降解支架及其制造方法" : CN201810240996.1. | 2018-03-22 .
APA 贺健康 , 仝站国 , 曹铁生 , 梁嘉赫 , 李涤尘 . 一种矫治阴道畸形用3D打印可降解支架及其制造方法 : CN201810240996.1. | 2018-03-22 .
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