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< Page ,Total 26 >
Analysis of Leukocyte Behaviors on Microfluidic Chips. PubMed SCIE
期刊论文 | 2019 , 8 (4) , e1801406 | Advanced healthcare materials
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Abstract :

The orchestration of massive leukocytes in the immune system protects humans from invading pathogens and abnormal cells in the body. So far, researches focusing on leukocyte behaviors are performed based on both in vivo and in vitro models. The in vivo animal models are usually less controllable due to their extreme complexity and nonignorable species issue. Therefore, many researchers turn to in vitro models. With the advances in micro/nanofabrication, the microfluidic chip has emerged as a novel platform for model construction in multiple biomedical research fields. Specifically, the microfluidic chip is used to study leukocyte behaviors, due to its incomparable advantages in high throughput, precise control, and flexible integration. Moreover, the small size of the microstructures on the microfluidic chip can better mimic the native microenvironment of leukocytes, which contributes to a more reliable recapitulation. Herein are reviewed the recent advances in microfluidic chip-based leukocyte behavior analysis to provide an overview of this field. Detailed discussions are specifically focused on host defense against pathogens, immunodiagnosis, and immunotherapy studies on microfluidic chips. Finally, the current technical challenges are discussed, as well as possible innovations in this field to improve the related applications.

Keyword :

microfluidics immunotherapy tissue-on-a-chip host defenses leukocytes immunodiagnosis

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GB/T 7714 Liu Yan , Yang Qingzhen , Cao Lei et al. Analysis of Leukocyte Behaviors on Microfluidic Chips. [J]. | Advanced healthcare materials , 2019 , 8 (4) : e1801406 .
MLA Liu Yan et al. "Analysis of Leukocyte Behaviors on Microfluidic Chips." . | Advanced healthcare materials 8 . 4 (2019) : e1801406 .
APA Liu Yan , Yang Qingzhen , Cao Lei , Xu Feng . Analysis of Leukocyte Behaviors on Microfluidic Chips. . | Advanced healthcare materials , 2019 , 8 (4) , e1801406 .
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Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) SCIE
期刊论文 | 2019 , 11 | NPG ASIA MATERIALS
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GB/T 7714 Zhao, Guoxu , Qing, Huaibin , Huang, Guoyou et al. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) [J]. | NPG ASIA MATERIALS , 2019 , 11 .
MLA Zhao, Guoxu et al. "Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018)" . | NPG ASIA MATERIALS 11 (2019) .
APA Zhao, Guoxu , Qing, Huaibin , Huang, Guoyou , Genin, Guy M. , Lu, Tian Jian , Luo, Zhengtang et al. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) . | NPG ASIA MATERIALS , 2019 , 11 .
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Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. PubMed Scopus SCIE
期刊论文 | 2019 , 120 (4) , 5644-5651 | Journal of cellular biochemistry
WoS CC Cited Count: 3 SCOPUS Cited Count: 2
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Abstract :

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus and is considered as a leading cause of blindness. Oxidative stress and inflammation are significant drivers for the development of DR. Eriodictyol, a flavonoid compound, was proved to possess anti-inflammatory, antioxidative, and antidiabetic activities. However, the role of eriodictyol in DR has not been unveiled. In the current study, we explored the protective effects of eriodictyol on high glucose (HG)-induced rat retinal ganglial cells (RGCs). The results suggested that eriodictyol improved cell viability of HG-induced rat RGC-5 cells in a dose-dependent manner. Eriodictyol reduced the reactive oxygen species production and increased the activities of superoxide dismutase, glutathione peroxidase and catalase in rat RGC-5 cells in response to HG stimulation. The production of proinflammatory cytokines including tumor necrosis factor alpha and interleukin-8 was diminished after eriodictyol treatment. Eriodictyol also suppressed cell apoptosis induced HG in rat RGC-5 cells. Furthermore, eriodictyol enhanced the nuclear translocation of nuclear factor erythroid-2 (E2)-related factor 2 (Nrf2) and elevated the expression of antioxidant enzyme heme-oxygenase-1 (HO-1). These findings suggested that eriodictyol protects the RGC-5 cells from HG-induced oxidative stress, inflammation, and cell apoptosis through regulating the activation of Nrf2/HO-1 pathway.

Keyword :

eriodictyol oxidative stress diabetic retinopathy (DR) nuclear factor erythroid-2 (E2)-related factor 2/heme-oxygenase-1 (Nrf2/HO-1) pathway inflammation

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GB/T 7714 Lv Peilin , Yu Jingni , Xu Xiayu et al. Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. [J]. | Journal of cellular biochemistry , 2019 , 120 (4) : 5644-5651 .
MLA Lv Peilin et al. "Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells." . | Journal of cellular biochemistry 120 . 4 (2019) : 5644-5651 .
APA Lv Peilin , Yu Jingni , Xu Xiayu , Lu Tianjian , Xu Feng . Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. . | Journal of cellular biochemistry , 2019 , 120 (4) , 5644-5651 .
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Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles SCIE PubMed
期刊论文 | 2019 , 9 (1) , 246-264 | THERANOSTICS
WoS CC Cited Count: 3
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Abstract :

Photodynamic therapy (PDT) has been widely applied in the clinic for the treatment of various types of cancer due to its precise controllability, minimally invasive approach and high spatiotemporal accuracy as compared with conventional chemotherapy. However, the porphyrin-based photosensitizers (PSs) used in clinics generally suffer from aggregation-caused reductions in the generation of reactive oxygen species (ROS) and limited tissue penetration because of visible light activation, which greatly hampers their applications for the treatment of deep-seated tumors. Methods: We present a facile strategy for constructing a NIR-regulated cancer theranostic nanoplatform by encapsulating upconversion nanoparticles (UCNPs) and a luminogen (2-(2,6-bis((E)-4-(phenyl(40-(1,2,2-triphenylvinyl)-[1,10-biphenyl]-4-yl)amino)styryl)-4H-pyran-4-ylidene)malononitrile, TTD) with aggregation-induced emission (AIEgen) characteristics using an amphiphilic polymer, and further conjugating cyclic arginine-glycine-aspartic acid (cRGD) peptide to yield UCNP@TTD-cRGD NPs. We then evaluated the bioimaging and anti-tumor capability of the UCNP@TTD-cRGD NPs under NIR light illumination in an in vitro three-dimensional (3D) cancer spheroid and in a murine tumor model, respectively. Results: With a close match between the UCNP emission and absorption of the AIEgen, the synthesized NPs could efficiently generate ROS, even under excitation through thick tissues. The NIR-regulated UCNP@TTD-cRGD NPs that were developed could selectively light up the targeted cancer cells and significantly inhibit tumor growth during the NIR-regulated PDT treatment as compared with the cells under white light excitation. Conclusion: In summary, the synthesized UCNP@TTD-cRGD NPs showed great potential in NIR light-regulated photodynamic therapy of deep-seated tumors. Our study will inspire further exploration of novel theranostic nanoplatforms that combine UCNPs and various AIEgen PSs for the advancement of deep-seated tumor treatments with potential clinical translations.

Keyword :

aggregation-induced emission (AIE) near infrared light active targeting photodynamic therapy tumor imaging

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GB/T 7714 Jin, Guorui , He, Rongyan , Liu, Qian et al. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles [J]. | THERANOSTICS , 2019 , 9 (1) : 246-264 .
MLA Jin, Guorui et al. "Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles" . | THERANOSTICS 9 . 1 (2019) : 246-264 .
APA Jin, Guorui , He, Rongyan , Liu, Qian , Lin, Min , Dong, Yuqing , Li, Kai et al. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles . | THERANOSTICS , 2019 , 9 (1) , 246-264 .
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A smartphone-based on-site nucleic acid testing platform at point-of-care settings. PubMed CPCI-S SCIE
期刊论文 | 2019 , 40 (6) , 914-921 | Electrophoresis
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Abstract :

We developed a smartphone-based on-site nucleic acid testing (NAT) platform that can image and analyze lateral flow nucleic acid assays at point-of-care settings. An inexpensive add-on was devised to run lateral flow assays while providing homogeneous ambient light for imaging. In addition, an Android app with a user-friendly interface was developed for the result analysis and management. Linear color calibration is implemented inside the app to minimize the colorimetric reaction difference between smartphones. A relationship function between nucleic acid concentration and colorimetric reaction was established and evaluated by leave-one-out cross validation. The predicted concentration and true concentration showed a good agreement with an R-squared value of 0.96. This smartphone-based NAT platform can be used to diagnose infectious diseases and monitor disease progression, and assess treatment efficacy, especially for resource-limited settings.

Keyword :

Lateral flow assay Point-of-care diagnostics Smartphone Nucleic acid testing

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GB/T 7714 Xu Xiayu , Wang Xuemin , Hu Jie et al. A smartphone-based on-site nucleic acid testing platform at point-of-care settings. [J]. | Electrophoresis , 2019 , 40 (6) : 914-921 .
MLA Xu Xiayu et al. "A smartphone-based on-site nucleic acid testing platform at point-of-care settings." . | Electrophoresis 40 . 6 (2019) : 914-921 .
APA Xu Xiayu , Wang Xuemin , Hu Jie , Gong Yang , Wang Lin , Zhou Wan et al. A smartphone-based on-site nucleic acid testing platform at point-of-care settings. . | Electrophoresis , 2019 , 40 (6) , 914-921 .
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Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing EI Scopus CSCD PKU
期刊论文 | 2018 , 45 (2) | Zhongguo Jiguang/Chinese Journal of Lasers
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Abstract :

Microorganisms, such as bacteria, are always detection objects in point-of-care testing, such as infectious diseases diagnosis, food safety monitoring and environment pollution detection. Optical microscopy is always a tool which is used to detect and analyze these detection objects. Lensless microscopy combines the sample with photodetectors such as charge coupled device (CCD) or complementary metal-oxide semiconductor (CMOS). This technique does not need optical devices, and the samples are imaged directly. The device is significantly simpler, smaller, easier to manipulate and cheaper than that of lens-based conventional microscope, which has been used in microstructure examinations, cell morphological analysis and microorganism detection. The lensless microscopic technology can be divided into three types, such as shadow imaging, fluorescence imaging and digital inline holography according to imaging principle. This paper reviews imaging principle and physical structure of three kinds of lensless microscopic technologies, and summaries the applications of lensless microscopic technologies in point-of-care testing. At last, we discuss the future development of lensless microscopic technologies. © 2018, Chinese Lasers Press. All right reserved.

Keyword :

Complementary metal oxide semiconductors Digital in-line holographies Environment pollution Microorganism detection Microstructure examination Morphological analysis Point-of-care testing Shadow imaging

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GB/T 7714 Li, Conghui , Cao, Ruofan , Xu, Xiayu et al. Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing [J]. | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
MLA Li, Conghui et al. "Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing" . | Zhongguo Jiguang/Chinese Journal of Lasers 45 . 2 (2018) .
APA Li, Conghui , Cao, Ruofan , Xu, Xiayu , Li, Fei , Zhang, Zhenxi , Xu, Feng . Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing . | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
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The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury SCIE PubMed Scopus
期刊论文 | 2018 , 211 , 51-62 | LIFE SCIENCES
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Abstract :

Aims: Prevention and treatment of myocardial ischemia-reperfusion (I/R) injury has for many years been a hot topic in treating ischemic heart disease. As one of the most well-known methods of complementary and alternative medicine, acupuncture has attracted increasing interest in preventing myocardial I/R injury due to its remarkable effectiveness and minimal side effect. However, traditional acupuncture approaches are limited by cumbersome execution, high labor costs and inevitable pain caused by frequent stimulation. Therefore, in this work, we aimed to develop a novel acupoint gel embedding approach and investigated its role in protecting against myocardial I/R injury in rats. Main methods: Gels were embedded at bilateral Neiguan (PC6) points of rats and their protective effects against myocardial I/R injury evaluated in terms of changes in histomorphology, myocardial enzymology, antioxidant capacity, anti-inflammatory response, and anti-apoptosis of cells. Key findings: We found that the approach of acupoint gel embedding could significantly reduce myocardial infarcted size, repair pathological changes, mitigate oxidative stress damage and inflammatory response, as well as inhibit apoptosis of cardiomyocytes. Such cardioprotective effects were found to be associated with Notch-1/Jagged-1 signaling pathway. Significance: The proposed approach of acupoint gel embedding has advantages in continuous acupoint stimulation, dosing controls, and no side effects in the course of treatment, as well as in reducing the pain caused by frequent acupuncture. It can form an alternative therapy to not only protect against myocardial I/R injury but also hold great potential in treating other diseases in the future.

Keyword :

Acupuncture Cardioprotective effect Injectable gel In vivo microenvironment Myocardial ischemia-reperfusion injury

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GB/T 7714 Ji, Changchun , Song, Fan , Huang, Guoyou et al. The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury [J]. | LIFE SCIENCES , 2018 , 211 : 51-62 .
MLA Ji, Changchun et al. "The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury" . | LIFE SCIENCES 211 (2018) : 51-62 .
APA Ji, Changchun , Song, Fan , Huang, Guoyou , Wang, Siwang , Liu, Han , Wang, Shaobao et al. The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury . | LIFE SCIENCES , 2018 , 211 , 51-62 .
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The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. EI SCIE PubMed Scopus
期刊论文 | 2018 , 88 , 160-169 | Journal of the mechanical behavior of biomedical materials
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Abstract :

Biocompatible hydrogels with defined mechanical properties are critical to tissue engineering and regenerative medicine. Thiol-acrylate photopolymerized hydrogels have attracted special interest for their degradability and cytocompatibility, and for their tunable mechanical properties through controlling factors that affect reaction kinetics (e.g., photopolymerization, stoichiometry, temperature, and solvent choice). In this study, we hypothesized that the mechanical property of these hydrogels can be tuned by photoinitiators via photobleaching and by thiol-Michael addition reactions. To test this hypothesis, a multiscale mathematical model incorporating both photobleaching and thiol-Michael addition reactions was developed and validated. After validating the model, the effects of thiol concentration, light intensity, and pH values on hydrogel mechanics were investigated. Results revealed that hydrogel stiffness (i) was maximized at a light intensity-specific optimal concentration of thiol groups; (ii) increased with decreasing pH when synthesis occurred at low light intensity; and (iii) increased with decreasing light intensity when synthesis occurred at fixed precursor composition. The multiscale model revealed that the latter was due to higher initiation efficiency at lower light intensity. More broadly, the model provides a framework for predicting mechanical properties of hydrogels based upon the controllable kinetics of thiol-acrylate photopolymerization.

Keyword :

Elastic modulus Eosin Y Hydrogels Thiol-acrylate polymerization Thiol-Michael addition

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GB/T 7714 Zhu Hongyuan , Yang Xiaoxiao , Genin Guy M et al. The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. [J]. | Journal of the mechanical behavior of biomedical materials , 2018 , 88 : 160-169 .
MLA Zhu Hongyuan et al. "The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition." . | Journal of the mechanical behavior of biomedical materials 88 (2018) : 160-169 .
APA Zhu Hongyuan , Yang Xiaoxiao , Genin Guy M , Lu Tian Jian , Xu Feng , Lin Min . The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. . | Journal of the mechanical behavior of biomedical materials , 2018 , 88 , 160-169 .
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Engineering Cell Mechanical Microenvironment and its Application in Cancer Research SCIE
期刊论文 | 2018 , 109 , 825-825 | CANCER SCIENCE
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Keyword :

tissue engineering cancer biology 3D microenvironment

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GB/T 7714 Xu, Feng . Engineering Cell Mechanical Microenvironment and its Application in Cancer Research [J]. | CANCER SCIENCE , 2018 , 109 : 825-825 .
MLA Xu, Feng . "Engineering Cell Mechanical Microenvironment and its Application in Cancer Research" . | CANCER SCIENCE 109 (2018) : 825-825 .
APA Xu, Feng . Engineering Cell Mechanical Microenvironment and its Application in Cancer Research . | CANCER SCIENCE , 2018 , 109 , 825-825 .
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Droplet based vitrification for cell aggregates: Numerical analysis EI SCIE PubMed Scopus
期刊论文 | 2018 , 82 , 383-393 | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
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Cell aggregates represent the main format of cells existing in vivo and have been widely used as tissue and disease models in vitro. Nevertheless, the preservation of cell aggregates while maintaining their functionalities for off the -shelf applications is still challenging. Among various preservation methods, droplet-based vitrification exhibits superior advantages for the cryopreservation of cell aggregates; however, the physical mechanisms underlying droplet-based vitrification of cell aggregate using this method remain elusive. To address this issue, we proposed a voronoi model to construct two-dimensional geometric morphologies of cell aggregates and established a coupled physical model to describe the diffusion, heat transfer and crystallization processes during vitrification. Based on these models, we performed a numerical study on the variation and distribution of cryoprotectant (CPA) concentration, temperature and crystallization in cell aggregates during droplet-based vitrification. The results show that although cell membrane is not an obvious barrier in heat transfer, it affects the diffusion of CPA remarkably as a biologic film and thus the following crystallization in cell aggregates. The effective protection of CPA during vitrification occurs during the initial stage of CPA diffusion, thus a longer CPA loading time does not necessarily lead to significant decrease in crystallization, but rather may induce more toxicity to cells.

Keyword :

Cell aggregates Cell membrane Simulation Vitrification

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GB/T 7714 Shi, Meng , Feng, Shangsheng , Zhang, Xiaohui et al. Droplet based vitrification for cell aggregates: Numerical analysis [J]. | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS , 2018 , 82 : 383-393 .
MLA Shi, Meng et al. "Droplet based vitrification for cell aggregates: Numerical analysis" . | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS 82 (2018) : 383-393 .
APA Shi, Meng , Feng, Shangsheng , Zhang, Xiaohui , Ji, Changchun , Xu, Feng , Lu, Tian Jian . Droplet based vitrification for cell aggregates: Numerical analysis . | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS , 2018 , 82 , 383-393 .
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