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Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) SCIE
期刊论文 | 2019 , 11 | NPG ASIA MATERIALS
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GB/T 7714 Zhao, Guoxu , Qing, Huaibin , Huang, Guoyou et al. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) [J]. | NPG ASIA MATERIALS , 2019 , 11 .
MLA Zhao, Guoxu et al. "Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018)" . | NPG ASIA MATERIALS 11 (2019) .
APA Zhao, Guoxu , Qing, Huaibin , Huang, Guoyou , Genin, Guy M. , Lu, Tian Jian , Luo, Zhengtang et al. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) . | NPG ASIA MATERIALS , 2019 , 11 .
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Analysis of Leukocyte Behaviors on Microfluidic Chips. PubMed SCIE
期刊论文 | 2019 , e1801406 | Advanced healthcare materials
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Abstract :

The orchestration of massive leukocytes in the immune system protects humans from invading pathogens and abnormal cells in the body. So far, researches focusing on leukocyte behaviors are performed based on both in vivo and in vitro models. The in vivo animal models are usually less controllable due to their extreme complexity and nonignorable species issue. Therefore, many researchers turn to in vitro models. With the advances in micro/nanofabrication, the microfluidic chip has emerged as a novel platform for model construction in multiple biomedical research fields. Specifically, the microfluidic chip is used to study leukocyte behaviors, due to its incomparable advantages in high throughput, precise control, and flexible integration. Moreover, the small size of the microstructures on the microfluidic chip can better mimic the native microenvironment of leukocytes, which contributes to a more reliable recapitulation. Herein are reviewed the recent advances in microfluidic chip-based leukocyte behavior analysis to provide an overview of this field. Detailed discussions are specifically focused on host defense against pathogens, immunodiagnosis, and immunotherapy studies on microfluidic chips. Finally, the current technical challenges are discussed, as well as possible innovations in this field to improve the related applications.

Keyword :

microfluidics immunotherapy tissue-on-a-chip host defenses leukocytes immunodiagnosis

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GB/T 7714 Liu Yan , Yang Qingzhen , Cao Lei et al. Analysis of Leukocyte Behaviors on Microfluidic Chips. [J]. | Advanced healthcare materials , 2019 : e1801406 .
MLA Liu Yan et al. "Analysis of Leukocyte Behaviors on Microfluidic Chips." . | Advanced healthcare materials (2019) : e1801406 .
APA Liu Yan , Yang Qingzhen , Cao Lei , Xu Feng . Analysis of Leukocyte Behaviors on Microfluidic Chips. . | Advanced healthcare materials , 2019 , e1801406 .
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Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. PubMed Scopus SCIE
期刊论文 | 2019 , 120 (4) , 5644-5651 | Journal of cellular biochemistry
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Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus and is considered as a leading cause of blindness. Oxidative stress and inflammation are significant drivers for the development of DR. Eriodictyol, a flavonoid compound, was proved to possess anti-inflammatory, antioxidative, and antidiabetic activities. However, the role of eriodictyol in DR has not been unveiled. In the current study, we explored the protective effects of eriodictyol on high glucose (HG)-induced rat retinal ganglial cells (RGCs). The results suggested that eriodictyol improved cell viability of HG-induced rat RGC-5 cells in a dose-dependent manner. Eriodictyol reduced the reactive oxygen species production and increased the activities of superoxide dismutase, glutathione peroxidase and catalase in rat RGC-5 cells in response to HG stimulation. The production of proinflammatory cytokines including tumor necrosis factor alpha and interleukin-8 was diminished after eriodictyol treatment. Eriodictyol also suppressed cell apoptosis induced HG in rat RGC-5 cells. Furthermore, eriodictyol enhanced the nuclear translocation of nuclear factor erythroid-2 (E2)-related factor 2 (Nrf2) and elevated the expression of antioxidant enzyme heme-oxygenase-1 (HO-1). These findings suggested that eriodictyol protects the RGC-5 cells from HG-induced oxidative stress, inflammation, and cell apoptosis through regulating the activation of Nrf2/HO-1 pathway.

Keyword :

eriodictyol oxidative stress diabetic retinopathy (DR) nuclear factor erythroid-2 (E2)-related factor 2/heme-oxygenase-1 (Nrf2/HO-1) pathway inflammation

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GB/T 7714 Lv Peilin , Yu Jingni , Xu Xiayu et al. Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. [J]. | Journal of cellular biochemistry , 2019 , 120 (4) : 5644-5651 .
MLA Lv Peilin et al. "Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells." . | Journal of cellular biochemistry 120 . 4 (2019) : 5644-5651 .
APA Lv Peilin , Yu Jingni , Xu Xiayu , Lu Tianjian , Xu Feng . Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. . | Journal of cellular biochemistry , 2019 , 120 (4) , 5644-5651 .
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Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles SCIE PubMed
期刊论文 | 2019 , 9 (1) , 246-264 | THERANOSTICS
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Photodynamic therapy (PDT) has been widely applied in the clinic for the treatment of various types of cancer due to its precise controllability, minimally invasive approach and high spatiotemporal accuracy as compared with conventional chemotherapy. However, the porphyrin-based photosensitizers (PSs) used in clinics generally suffer from aggregation-caused reductions in the generation of reactive oxygen species (ROS) and limited tissue penetration because of visible light activation, which greatly hampers their applications for the treatment of deep-seated tumors. Methods: We present a facile strategy for constructing a NIR-regulated cancer theranostic nanoplatform by encapsulating upconversion nanoparticles (UCNPs) and a luminogen (2-(2,6-bis((E)-4-(phenyl(40-(1,2,2-triphenylvinyl)-[1,10-biphenyl]-4-yl)amino)styryl)-4H-pyran-4-ylidene)malononitrile, TTD) with aggregation-induced emission (AIEgen) characteristics using an amphiphilic polymer, and further conjugating cyclic arginine-glycine-aspartic acid (cRGD) peptide to yield UCNP@TTD-cRGD NPs. We then evaluated the bioimaging and anti-tumor capability of the UCNP@TTD-cRGD NPs under NIR light illumination in an in vitro three-dimensional (3D) cancer spheroid and in a murine tumor model, respectively. Results: With a close match between the UCNP emission and absorption of the AIEgen, the synthesized NPs could efficiently generate ROS, even under excitation through thick tissues. The NIR-regulated UCNP@TTD-cRGD NPs that were developed could selectively light up the targeted cancer cells and significantly inhibit tumor growth during the NIR-regulated PDT treatment as compared with the cells under white light excitation. Conclusion: In summary, the synthesized UCNP@TTD-cRGD NPs showed great potential in NIR light-regulated photodynamic therapy of deep-seated tumors. Our study will inspire further exploration of novel theranostic nanoplatforms that combine UCNPs and various AIEgen PSs for the advancement of deep-seated tumor treatments with potential clinical translations.

Keyword :

aggregation-induced emission (AIE) near infrared light active targeting photodynamic therapy tumor imaging

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GB/T 7714 Jin, Guorui , He, Rongyan , Liu, Qian et al. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles [J]. | THERANOSTICS , 2019 , 9 (1) : 246-264 .
MLA Jin, Guorui et al. "Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles" . | THERANOSTICS 9 . 1 (2019) : 246-264 .
APA Jin, Guorui , He, Rongyan , Liu, Qian , Lin, Min , Dong, Yuqing , Li, Kai et al. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles . | THERANOSTICS , 2019 , 9 (1) , 246-264 .
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Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing EI Scopus CSCD PKU
期刊论文 | 2018 , 45 (2) | Zhongguo Jiguang/Chinese Journal of Lasers
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Microorganisms, such as bacteria, are always detection objects in point-of-care testing, such as infectious diseases diagnosis, food safety monitoring and environment pollution detection. Optical microscopy is always a tool which is used to detect and analyze these detection objects. Lensless microscopy combines the sample with photodetectors such as charge coupled device (CCD) or complementary metal-oxide semiconductor (CMOS). This technique does not need optical devices, and the samples are imaged directly. The device is significantly simpler, smaller, easier to manipulate and cheaper than that of lens-based conventional microscope, which has been used in microstructure examinations, cell morphological analysis and microorganism detection. The lensless microscopic technology can be divided into three types, such as shadow imaging, fluorescence imaging and digital inline holography according to imaging principle. This paper reviews imaging principle and physical structure of three kinds of lensless microscopic technologies, and summaries the applications of lensless microscopic technologies in point-of-care testing. At last, we discuss the future development of lensless microscopic technologies. © 2018, Chinese Lasers Press. All right reserved.

Keyword :

Complementary metal oxide semiconductors Digital in-line holographies Environment pollution Microorganism detection Microstructure examination Morphological analysis Point-of-care testing Shadow imaging

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GB/T 7714 Li, Conghui , Cao, Ruofan , Xu, Xiayu et al. Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing [J]. | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
MLA Li, Conghui et al. "Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing" . | Zhongguo Jiguang/Chinese Journal of Lasers 45 . 2 (2018) .
APA Li, Conghui , Cao, Ruofan , Xu, Xiayu , Li, Fei , Zhang, Zhenxi , Xu, Feng . Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing . | Zhongguo Jiguang/Chinese Journal of Lasers , 2018 , 45 (2) .
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An improved U-net architecture for simultaneous arteriole and venule segmentation in fundus image EI Scopus
会议论文 | 2018 , 894 , 333-340 | 22nd Conference on Medical Image Understanding and Analysis, MIUA 2018
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The segmentation and classification of retinal arterioles and venules play an important role in the diagnosis of various eye diseases and systemic diseases. The major challenges include complicated vessel structure, inhomogeneous illumination, and large background variation across subjects. In this study, we proposed an improved fully convolutional network that simultaneously segment arterioles and venules directly from the retinal image. To simultaneously segment retinal arterioles and venules, we configured the fully convolutional network to allow true color image as input and multiple labels as output. A domain-specific loss function is designed to improve the performance. The proposed method was assessed extensively on public datasets and compared with the state-of-the-art methods in literatures. The sensitivity and specificity of overall vessel segmentation on DRIVE is 0.870 and 0.980 with a misclassification rate of 23.7% and 9.8% for arteriole and venule, respectively. The proposed method outperforms the state-of-the-art methods and avoided possible error-propagation as in the segmentation-classification strategy. The proposed method holds great potential for the diagnostics and screening of various eye diseases and systemic diseases. © Springer Nature Switzerland AG 2018.

Keyword :

Arteriole Background variation Convolutional networks Misclassification rates Retinal vessels Sensitivity and specificity State-of-the-art methods Venule

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GB/T 7714 Xu, Xiayu , Tan, Tao , Xu, Feng . An improved U-net architecture for simultaneous arteriole and venule segmentation in fundus image [C] . 2018 : 333-340 .
MLA Xu, Xiayu et al. "An improved U-net architecture for simultaneous arteriole and venule segmentation in fundus image" . (2018) : 333-340 .
APA Xu, Xiayu , Tan, Tao , Xu, Feng . An improved U-net architecture for simultaneous arteriole and venule segmentation in fundus image . (2018) : 333-340 .
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基于先进生物材料的心肌细胞力-电微环境体外构建 CSCD PKU
期刊论文 | 2018 , (1) , 320-359 | 力学进展
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心血管疾病是当前全球范围内导致人类死亡的首要原因,心肌组织工程的发展为心血管疾病的治疗,尤其是心肌组织再生修复提供了最有潜力的解决方案.心血管疾病的发生发展与细胞力-电微环境的变化密切相关.近十几年,随着先进生物材料和微纳生物制造技术的发展,越来越多的研究表明,细胞力-电微环境的调控对工程化心肌组织的成熟和功能化以及心肌组织再生修复具有重要意义.本文首先阐明了在体心肌细胞所处力学微环境的生物学基础以及电信号的传导过程,包括正常和疾病状态下心肌细胞所处的力-电微环境.其次调研了用于心肌组织工程的先进生物材料的研究现状.最后总结用于基底硬度与应力应变细胞微环境以及细胞电学微环境的构建和调控,以及细胞对力-电微环境的生物学响应.

Keyword :

细胞电学微环境 细胞力学微环境 生物材料 心肌组织工程

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GB/T 7714 徐峰 , 张晓慧 , 鲍雪娇 et al. 基于先进生物材料的心肌细胞力-电微环境体外构建 [J]. | 力学进展 , 2018 , (1) : 320-359 .
MLA 徐峰 et al. "基于先进生物材料的心肌细胞力-电微环境体外构建" . | 力学进展 1 (2018) : 320-359 .
APA 徐峰 , 张晓慧 , 鲍雪娇 , 赵国旭 , 刘付生 , 黄国友 et al. 基于先进生物材料的心肌细胞力-电微环境体外构建 . | 力学进展 , 2018 , (1) , 320-359 .
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对分课堂教学模式在医学细胞生物学教学中的效果
期刊论文 | 2018 , (18) , 2247-2249 | 广西医学
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目的 探讨对分课堂教学模式在医学细胞生物学教学中的应用效果.方法 选择<em>西安</em>医学院2016级检验本科专业的114名学生为对照组,2017级检验本科专业的120名学生为教改组.对照组采用传统教学模式授课,教改组采用对分课堂教学模式授课.对照组通过期末考试、绘制知识点框架图、调查问卷3种方式进行教学效果评价.教改组在对照组评价内容的基础上,增加随堂测验和随堂作业两项过程性评价指标,比较两组教学效果及教改组各次随堂测验和随堂作业标准化得分.结果 教改组期末成绩、框架图中标记的知识点数目、问卷调查中的学习方法培养、解决问题能力提高、对课程认可度以及与其他课程相关性的得分均高于对照组(均P<0.05).教改组第2、3、4、5次的随堂测验标准化得分和随堂作业标准化得分均分别高于第1次得分(均P<0.05).结论 与传统教学相比,对分课堂能提升学生的期末考试成绩,培养良好的学习方法,锻炼学以致用的实践能力,促进学生对知识的内在化吸收,保障学生进行自主性学习.

Keyword :

医学细胞生物学 对分课堂 自主学习 教学 过程性评价

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GB/T 7714 沙保勇 , 李昱辉 , 徐峰 et al. 对分课堂教学模式在医学细胞生物学教学中的效果 [J]. | 广西医学 , 2018 , (18) : 2247-2249 .
MLA 沙保勇 et al. "对分课堂教学模式在医学细胞生物学教学中的效果" . | 广西医学 18 (2018) : 2247-2249 .
APA 沙保勇 , 李昱辉 , 徐峰 , 靳国瑞 , 杨清振 , 景晓红 et al. 对分课堂教学模式在医学细胞生物学教学中的效果 . | 广西医学 , 2018 , (18) , 2247-2249 .
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A smartphone-based on-site nucleic acid testing platform at point-of-care settings. PubMed
期刊论文 | 2018 | Electrophoresis
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We developed a smartphone-based on-site nucleic acid testing (NAT) platform that can image and analyze lateral flow nucleic acid assays at point-of-care settings. An inexpensive add-on was devised to run lateral flow assays while providing homogeneous ambient light for imaging. In addition, an Android app with a user-friendly interface was developed for the result analysis and management. Linear color calibration is implemented inside the app to minimize the colorimetric reaction difference between smartphones. A relationship function between nucleic acid concentration and colorimetric reaction was established and evaluated by leave-one-out cross validation. The predicted concentration and true concentration showed a good agreement with an R-squared value of 0.96. This smartphone-based NAT platform can be used to diagnose infectious diseases and monitor disease progression, and assess treatment efficacy, especially for resource-limited settings.

Keyword :

Lateral flow assay Point-of-care diagnostics Smartphone Nucleic acid testing

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GB/T 7714 Xu Xiayu , Wang Xuemin , Hu Jie et al. A smartphone-based on-site nucleic acid testing platform at point-of-care settings. [J]. | Electrophoresis , 2018 .
MLA Xu Xiayu et al. "A smartphone-based on-site nucleic acid testing platform at point-of-care settings." . | Electrophoresis (2018) .
APA Xu Xiayu , Wang Xuemin , Hu Jie , Gong Yang , Wang Lin , Zhou Wan et al. A smartphone-based on-site nucleic acid testing platform at point-of-care settings. . | Electrophoresis , 2018 .
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Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture EI SCIE PubMed Scopus
期刊论文 | 2018 , 6 (4) , 885-892 | BIOMATERIALS SCIENCE
WoS CC Cited Count: 2 SCOPUS Cited Count: 2
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Hydrogel particles that can be engineered to compartmentally culture cells in a three-dimensional (3D) and high-throughput manner have attracted increasing interest in the biomedical area. However, the ability to generate hydrogel particles with specially designed structures and their potential biomedical applications need to be further explored. This work introduces a method for fabricating hydrogel particles in an ellipsoidal cap-like shape (i.e., ellipsoidal cap-like hydrogel particles) by employing an open-pore anodic aluminum oxide membrane. Hydrogel particles of different sizes are fabricated. The ability to produce ellipsoidal cap-like magnetic hydrogel particles with controlled distribution of magnetic nanoparticles is demonstrated. Encapsulated cells show high viability, indicating the potential for using these hydrogel particles as structure-and remote-controllable building blocks for tissue engineering application. Moreover, the hydrogel particles are also used as sacrificial templates for fabricating ellipsoidal cap-like concave wells, which are further applied for producing size controllable cell aggregates. The results are beneficial for the development of hydrogel particles and their applications in 3D cell culture.

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GB/T 7714 Zhang, Weiwei , Huang, Guoyou , Ng, Kelvin et al. Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture [J]. | BIOMATERIALS SCIENCE , 2018 , 6 (4) : 885-892 .
MLA Zhang, Weiwei et al. "Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture" . | BIOMATERIALS SCIENCE 6 . 4 (2018) : 885-892 .
APA Zhang, Weiwei , Huang, Guoyou , Ng, Kelvin , Ji, Yuan , Gao, Bin , Huang, Liqing et al. Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture . | BIOMATERIALS SCIENCE , 2018 , 6 (4) , 885-892 .
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