• Complex
  • Title
  • Author
  • Keyword
  • Abstract
  • Scholars
Search
High Impact Results & Cited Count Trend for Year Keyword Cloud and Partner Relationship

Query:

学者姓名:杨铁林

Refining:

Source

Submit Unfold

Co-Author

Submit Unfold

Language

Submit

Clean All

Export Sort by:
Default
  • Default
  • Title
  • Year
  • WOS Cited Count
  • Impact factor
  • Ascending
  • Descending
< Page ,Total 11 >
Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity. PubMed Scopus SCIE
期刊论文 | 2019 , 43 (3) , 450-456 | International journal of obesity
Abstract&Keyword Cite

Abstract :

Genome-wide association studies have identified many susceptibility loci for obesity. However, missing heritability problem is still challenging and ignorance of genetic interactions is believed to be an important cause. Current methods for detecting interactions usually do not consider regulatory elements in non-coding regions. Interaction analyses within chromatin regulatory circuitry may identify new susceptibility loci.We developed a pipeline named interaction analyses within chromatin regulatory circuitry (IACRC), to identify genetic interactions impacting body mass index (BMI). Potential interacting SNP pairs were obtained based on Hi-C datasets, PreSTIGE (Predicting Specific Tissue Interactions of Genes and Enhancers) algorithm, and super enhancer regions. SNP × SNP analyses were next performed in three GWAS datasets, including 2286 unrelated Caucasians from Kansas City, 3062 healthy Caucasians from the Gene Environment Association Studies initiative, and 3164 Hispanic subjects from the Women's Health Initiative.A total of 16,643,227 SNP × SNP analyses were performed. Meta-analyses showed that two SNP pairs, rs6808450-rs9813534 (combined P = 2.39 × 10<sup>-9</sup>) and rs6808450-rs3773306 (combined P = 2.89 × 10<sup>-9</sup>) were associated with BMI after multiple testing corrections. Single-SNP analyses did not detect significant association signals for these three SNPs. In obesity relevant cells, rs6808450 is located in intergenic enhancers, while rs9813534 and rs3773306 are located in the region of strong transcription regions of CAND2 and RPL32, respectively. The expression of CAND2 was significantly downregulated after the differentiation of human Simpson-Golabi-Behmel syndrome (SGBS) preadipocyte cells (P = 0.0241). Functional validation in the International Mouse Phenotyping Consortium database showed that CAND2 was associated with increased lean body mass and decreased total body fat amount.Detecting epistasis within chromatin regulatory circuitry identified CAND2 as a novel obesity susceptibility gene. We hope IACRC could facilitate the interaction analyses for complex diseases and offer new insights into solving the missing heritability problem.

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Dong Shan-Shan , Yao Shi , Chen Yi-Xiao et al. Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity. [J]. | International journal of obesity , 2019 , 43 (3) : 450-456 .
MLA Dong Shan-Shan et al. "Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity." . | International journal of obesity 43 . 3 (2019) : 450-456 .
APA Dong Shan-Shan , Yao Shi , Chen Yi-Xiao , Guo Yan , Zhang Yu-Jie , Niu Hui-Min et al. Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity. . | International journal of obesity , 2019 , 43 (3) , 450-456 .
Export to NoteExpress RIS BibTex
Comprehensive functional annotation of susceptibility SNPs prioritized 10 genes for schizophrenia. PubMed SCIE
期刊论文 | 2019 , 9 , 56 | Translational psychiatry
Abstract&Keyword Cite

Abstract :

Nearly 95% of susceptibility SNPs identified by genome-wide association studies (GWASs) are located in non-coding regions, which causes a lot of difficulty in deciphering their biological functions on disease pathogenesis. Here, we aimed to conduct a comprehensive functional annotation for all the schizophrenia susceptibility loci obtained from GWASs. Considering varieties of epigenomic regulatory elements, we annotated all 22,688 acquired susceptibility SNPs according to their genomic positions to obtain functional SNPs. The comprehensive annotation indicated that these functional SNPs are broadly involved in diverse biological processes. Histone modification enrichment showed that H3K27ac, H3K36me3, H3K4me1, and H3K4me3 were related to the development of schizophrenia. Transcription factors (TFs) prediction, methylation quantitative trait loci (meQTL) analyses, expression quantitative trait loci (eQTL) analyses, and proteomic quantitative trait loci analyses (pQTL) identified 447 target protein-coding genes. Subsequently, differential expression analyses between schizophrenia cases and controls, nervous system phenotypes from mouse models, and protein-protein interaction with known schizophrenia-related pathways and genes were carried out with our target genes. We finaly prioritized 10 target genes for schizophrenia (CACNA1C, CLU, CSNK2B, GABBR1, GRIN2A, MAPK3, NOTCH4, SRR, TNF, and SYNGAP1). Our results may serve as an encyclopedia of schizophrenia susceptibility SNPs and offer holistic guides for post-GWAS functional experiments.

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Niu Hui-Min , Yang Ping , Chen Huan-Huan et al. Comprehensive functional annotation of susceptibility SNPs prioritized 10 genes for schizophrenia. [J]. | Translational psychiatry , 2019 , 9 : 56 .
MLA Niu Hui-Min et al. "Comprehensive functional annotation of susceptibility SNPs prioritized 10 genes for schizophrenia." . | Translational psychiatry 9 (2019) : 56 .
APA Niu Hui-Min , Yang Ping , Chen Huan-Huan , Hao Ruo-Han , Dong Shan-Shan , Yao Shi et al. Comprehensive functional annotation of susceptibility SNPs prioritized 10 genes for schizophrenia. . | Translational psychiatry , 2019 , 9 , 56 .
Export to NoteExpress RIS BibTex
Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women SCIE PubMed
期刊论文 | 2019 , 19 | CANCER CELL INTERNATIONAL
WoS CC Cited Count: 2
Abstract&Keyword Cite

Abstract :

BackgroundEstrogen exposure is a widely known risk factor for BC. And the interaction of estrogen with estrogen receptor (ER) plays an important role in breast cancer development. This case-control study aims to assess the association of genetic polymorphisms in the estrogen receptor genes with breast cancer (BC) susceptibility in Chinese Han women.MethodsFour polymorphisms (rs2881766, rs9383951, rs9340799 in ESR1 and rs3020449 in ESR2) were genotyped in 459 patients and 549 healthy controls using the Sequenom MassARRAY method. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the associations. False-positive report probability (FPRP) was utilized to examine the noteworthiness of significant findings.ResultsWe observed that rs2881766 was associated with a decreased BC risk (GG vs. TT: OR=0.63, 95% CI=0.44-0.91; GG vs. TT/GT: OR=0.68, 95% CI=0.49-0.95), while rs3020449 was associated with an increased risk of BC (CT vs. TT: OR=1.58, 95% CI=1.21-2.06; CT/CC vs. TT: OR=1.54, 95% CI=1.20-1.98; TT/CC vs. CT: OR=1.48, 95% CI=1.15-1.90). The other two polymorphisms have no relation with BC susceptibility. In addition, rs2881766 was correlated with lymph node metastasis and ER expression, and rs3020449 was related to tumor size, histological grade and ER expression. The values of false-positive report probability indicated that the significant associations of BC risk with both rs2881766 and rs3020449 were noteworthy.ConclusionsOur study suggests that polymorphisms rs2881766 and rs3020449 in estrogen receptor genes were associated with BC susceptibility as well as clinical features in Chinese women. These findings need further validation in a large population.

Keyword :

Polymorphism Breast cancer Estrogen receptor genes Susceptibility

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Dai, Zhijun , Tian, Tian , Wang, Meng et al. Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women [J]. | CANCER CELL INTERNATIONAL , 2019 , 19 .
MLA Dai, Zhijun et al. "Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women" . | CANCER CELL INTERNATIONAL 19 (2019) .
APA Dai, Zhijun , Tian, Tian , Wang, Meng , Yang, Tielin , Li, Hongtao , Lin, Shuai et al. Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women . | CANCER CELL INTERNATIONAL , 2019 , 19 .
Export to NoteExpress RIS BibTex
Integrating regulatory features data for prediction of functional disease-associated SNPs SCIE PubMed
期刊论文 | 2019 , 20 (1) , 26-32 | BRIEFINGS IN BIOINFORMATICS
WoS CC Cited Count: 2
Abstract&Keyword Cite

Abstract :

Genome-wide association studies (GWASs) are an effective strategy to identify susceptibility loci for human complex diseases. However, missing heritability is still a big problem. Most GWASs single-nucleotide polymorphisms (SNPs) are located in noncoding regions, which has been considered to be the unexplored territory of the genome. Recently, data from the Encyclopedia of DNA Elements (ENCODE) and Roadmap Epigenomics projects have shown that many GWASs SNPs in the noncoding regions fall within regulatory elements. In this study, we developed a pipeline named functional disease-associated SNPs prediction (FDSP), to identify novel susceptibility loci for complex diseases based on the interpretation of the functional features for known disease-associated variants with machine learning. We applied our pipeline to predict novel susceptibility SNPs for type 2 diabetes (T2D) and hypertension. The predicted SNPs could explain heritability beyond that explained by GWAS-associated SNPs. Functional annotation by expression quantitative trait loci analyses showed that the target genes of the predicted SNPs were significantly enriched in T2D or hypertension-related pathways in multiple tissues. Our results suggest that combining GWASs and regulatory features data could identify additional functional susceptibility SNPs for complex diseases. We hope FDSP could help to identify novel susceptibility loci for complex diseases and solve the missing heritability problem.

Keyword :

FDSP SNPs regulatory feature data machine learning complex diseases missing heritability

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Dong, Shan-Shan , Guo, Yan , Yao, Shi et al. Integrating regulatory features data for prediction of functional disease-associated SNPs [J]. | BRIEFINGS IN BIOINFORMATICS , 2019 , 20 (1) : 26-32 .
MLA Dong, Shan-Shan et al. "Integrating regulatory features data for prediction of functional disease-associated SNPs" . | BRIEFINGS IN BIOINFORMATICS 20 . 1 (2019) : 26-32 .
APA Dong, Shan-Shan , Guo, Yan , Yao, Shi , Chen, Yi-Xiao , He, Mo-Nan , Zhang, Yu-Jie et al. Integrating regulatory features data for prediction of functional disease-associated SNPs . | BRIEFINGS IN BIOINFORMATICS , 2019 , 20 (1) , 26-32 .
Export to NoteExpress RIS BibTex
DETECTING EPISTASIS WITHIN CHROMATIN REGULATORY CIRCUITRY REVEALS FRRS1L AS A NOVEL SUSCEPTIBILITY GENE FOR OSTEOPOROSIS CPCI-S SCIE
会议论文 | 2018 , 29 , S389-S390 | WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases
Abstract&Keyword Cite

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Yang, B. , Yao, S. , Dong, S. -S. et al. DETECTING EPISTASIS WITHIN CHROMATIN REGULATORY CIRCUITRY REVEALS FRRS1L AS A NOVEL SUSCEPTIBILITY GENE FOR OSTEOPOROSIS [C] . 2018 : S389-S390 .
MLA Yang, B. et al. "DETECTING EPISTASIS WITHIN CHROMATIN REGULATORY CIRCUITRY REVEALS FRRS1L AS A NOVEL SUSCEPTIBILITY GENE FOR OSTEOPOROSIS" . (2018) : S389-S390 .
APA Yang, B. , Yao, S. , Dong, S. -S. , Guo, Y. , Yang, T. -L. . DETECTING EPISTASIS WITHIN CHROMATIN REGULATORY CIRCUITRY REVEALS FRRS1L AS A NOVEL SUSCEPTIBILITY GENE FOR OSTEOPOROSIS . (2018) : S389-S390 .
Export to NoteExpress RIS BibTex
MODULATION OF LONG NONCODING RNAS BY RISK SNPS UNDERLYING GENETIC PREDISPOSITIONS TO OSTEOARTHRITIS CPCI-S SCIE
会议论文 | 2018 , 29 , S368-S368 | WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases
Abstract&Keyword Cite

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Yang, B. , Yao, S. , Zhang, Y. -J. et al. MODULATION OF LONG NONCODING RNAS BY RISK SNPS UNDERLYING GENETIC PREDISPOSITIONS TO OSTEOARTHRITIS [C] . 2018 : S368-S368 .
MLA Yang, B. et al. "MODULATION OF LONG NONCODING RNAS BY RISK SNPS UNDERLYING GENETIC PREDISPOSITIONS TO OSTEOARTHRITIS" . (2018) : S368-S368 .
APA Yang, B. , Yao, S. , Zhang, Y. -J. , Dong, S. -S. , Guo, Y. , Yang, T. -L. . MODULATION OF LONG NONCODING RNAS BY RISK SNPS UNDERLYING GENETIC PREDISPOSITIONS TO OSTEOARTHRITIS . (2018) : S368-S368 .
Export to NoteExpress RIS BibTex
Polymorphisms in HIFs and breast cancer sutarsceptibility in Chinese women: a case-control study. PubMed Scopus SCIE
期刊论文 | 2018 , 38 | Bioscience reports
Abstract&Keyword Cite

Abstract :

Hypoxia-inducible factors (HIFs) play a crucial role in cancer progression. Several epidemiological studies have demonstrated that HIFs polymorphisms can influence the susceptibility of multiple cancers. However, the relationship of HIFs polymorphisms (rs11549467 and rs17039192) and breast cancer (BC) risk was still unknown. Thus, we performed a case-control study based on 560 BC patients and 583 healthy controls to explore the association between them. Our results indicated a boardline connection between HIF-1 rs11549467 and BC risk (AG compared with GG: OR = 1.61, 95% CI = 1.05-2.49, <i>P</i>=0.03; AG + AA compared with GG: OR = 1.64, 95% CI = 1.08-2.51, <i>P</i>=0.02; AG compared with GG + AA: OR = 1.61, 95% CI = 1.04-2.48, <i>P</i>=0.03; OR = 1.64, 95% CI = 1.09-2.45, <i>P</i>=0.02), while HIF-2 rs17039192 had no influence on breast cancer. Considered the comparison of sample size and potential heterogeneity of previous case-control studies, we concluded that HIF-1 rs11549467 has a marginal effect on BC risk. Further well-designed studies with larger sample size were required.

Keyword :

HIFs case-control study breast cancer polymorphism

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Shan Changyou , Zheng Yi , Wang Meng et al. Polymorphisms in HIFs and breast cancer sutarsceptibility in Chinese women: a case-control study. [J]. | Bioscience reports , 2018 , 38 .
MLA Shan Changyou et al. "Polymorphisms in HIFs and breast cancer sutarsceptibility in Chinese women: a case-control study." . | Bioscience reports 38 (2018) .
APA Shan Changyou , Zheng Yi , Wang Meng , Lin Shuai , Tian Tian , Deng Yujiao et al. Polymorphisms in HIFs and breast cancer sutarsceptibility in Chinese women: a case-control study. . | Bioscience reports , 2018 , 38 .
Export to NoteExpress RIS BibTex
Prognostic values of LAPTM4B-35 in human cancer: A Meta-analysis Scopus SCIE PubMed
期刊论文 | 2018 , 9 (23) , 4355-4362 | Journal of Cancer
Abstract&Keyword Cite

Abstract :

© Ivyspring International Publisher. Background: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors. However, the prognostic value of LAPTM4B-35 remains controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers. Methods: The relevant publications were obtained by systematically searching the PubMed, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated for the prognosis value of LAPTM4B-35 for cancer patient. Results: Our result suggest that LAPTM4B-35 overexpression is significantly associated with poor overall survival (OS) (HR = 2.49, 95% CI = 1.87-3.32, p < 0.001), disease-free survival (DFS) (HR = 2.43, 95% CI = 1.35-4.35, p = 0.003), and progression-free survival (PFS) (HR = 4.12, 95% CI = 2.30-7.37, p < 0.001). Moreover, subgroup analysis revealed significant association with poor OS in lung (HR = 2.05, 95% CI = 1.37-3.06, p < 0.001), gastric carcinoma (HR = 1.88, 95% CI = 1.01-3.50, p < 0.047) and ovarian cancer (HR = 4.94, 95% CI = 1.44-16.94, p = 0.011). Conclusion: LAPTM4B-35 may be a novel predictive biomarker and a potential target for treatment.

Keyword :

Cancer LAPTM4B-35 Meta-analysis Prognosis

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Zhou, Linghui , Dai, Cong , Tian, Tian et al. Prognostic values of LAPTM4B-35 in human cancer: A Meta-analysis [J]. | Journal of Cancer , 2018 , 9 (23) : 4355-4362 .
MLA Zhou, Linghui et al. "Prognostic values of LAPTM4B-35 in human cancer: A Meta-analysis" . | Journal of Cancer 9 . 23 (2018) : 4355-4362 .
APA Zhou, Linghui , Dai, Cong , Tian, Tian , Wang, Meng , Lin, Shuai , Deng, Yujiao et al. Prognostic values of LAPTM4B-35 in human cancer: A Meta-analysis . | Journal of Cancer , 2018 , 9 (23) , 4355-4362 .
Export to NoteExpress RIS BibTex
Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females Scopus SCIE PubMed
期刊论文 | 2018 , 9 (21) , 3858-3866 | Journal of Cancer
Abstract&Keyword Cite

Abstract :

© Ivyspring International Publisher. Although genome-wide association studies (GWASs) have identified some risk single-nucleotide polymorphisms in East Asian never-smoking females, the unexplained missing heritability is still required to be investigated. Runs of homozygosity (ROHs) are thought to be a type of genetic variation acting on human complex traits and diseases. We detected ROHs in 8,881 East Asian never-smoking women. The summed ROHs were used to fit a logistic regression model which noteworthily revealed a significant association between ROHs and the decreased risk of lung cancer (P < 0.05). We identified 4 common ROHs regions located at 2p22.1, which were significantly associated with decreased risk of lung cancer (P = 2.00 × 10-4 - 1.35 × 10-4). Functional annotation was conducted to investigate the regulatory function of ROHs. The common ROHs were overlapped with potential regulatory elements, such as active epigenome elements and chromatin states in lung-derived cell lines. SOS1 and ARHGEF33 were significantly up-regulated as the putative target genes of the identified ROHs in lung cancer samples according to the analysis of differently expressed genes. Our results suggest that ROHs could act as recessive contributing factors and regulatory elements to influence the risk of lung cancer in never-smoking East Asian females.

Keyword :

Genetic risk factors GWASs Lung cancer Regulatory elements Runs of homozygosity

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Chen, Yi-Xiao , Guo, Yan , Dong, Shan-Shan et al. Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females [J]. | Journal of Cancer , 2018 , 9 (21) : 3858-3866 .
MLA Chen, Yi-Xiao et al. "Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females" . | Journal of Cancer 9 . 21 (2018) : 3858-3866 .
APA Chen, Yi-Xiao , Guo, Yan , Dong, Shan-Shan , Chen, Xiao-Feng , Chen, Jia-Bin , Zhang, Yu-Jie et al. Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females . | Journal of Cancer , 2018 , 9 (21) , 3858-3866 .
Export to NoteExpress RIS BibTex
V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis SCIE PubMed
期刊论文 | 2018 , 8 (19) , 5379-5399 | THERANOSTICS
Abstract&Keyword Cite

Abstract :

Vacuolar ATPases (V-ATPases) play a critical role in regulating extracellular acidification of osteoclasts and bone resorption. The deficiencies of subunit a3 and d2 of V-ATPases result in increased bone density in humans and mice. One of the traditional drug design strategies in treating osteoporosis is the use of subunit a3 inhibitor. Recent findings connect subunits H and G1 with decreased bone density. Given the controversial effects of ATPase subunits on bone density, there is a critical need to review the subunits of V-ATPase in osteoclasts and their functions in regulating osteoclasts and bone remodeling. In this review, we comprehensively address the following areas: information about all V-ATPase subunits and their isoforms; summary of V-ATPase subunits associated with human genetic diseases; V-ATPase subunits and osteopetrosis/osteoporosis; screening of all V-ATPase subunits variants in GEFOS data and in-house data; spectrum of V-ATPase subunits during osteoclastogenesis; direct and indirect roles of subunits of V-ATPases in osteoclasts; V-ATPase-associated signaling pathways in osteoclasts; interactions among V-ATPase subunits in osteoclasts; osteoclast-specific V-ATPase inhibitors; perspective of future inhibitors or activators targeting V-ATPase subunits in the treatment of osteoporosis.

Keyword :

osteoclasts osteopetrosis signaling pathways pH inhibitor V-ATPase osteoporosis

Cite:

Copy from the list or Export to your reference management。

GB/T 7714 Duan, Xiaohong , Yang, Shaoqing , Zhang, Lei et al. V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis [J]. | THERANOSTICS , 2018 , 8 (19) : 5379-5399 .
MLA Duan, Xiaohong et al. "V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis" . | THERANOSTICS 8 . 19 (2018) : 5379-5399 .
APA Duan, Xiaohong , Yang, Shaoqing , Zhang, Lei , Yang, Tielin . V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis . | THERANOSTICS , 2018 , 8 (19) , 5379-5399 .
Export to NoteExpress RIS BibTex
10| 20| 50 per page
< Page ,Total 11 >

Export

Results:

Selected

to

Format:
FAQ| About| Online/Total:2843/65830230
Address:XI'AN JIAOTONG UNIVERSITY LIBRARY(No.28, Xianning West Road, Xi'an, Shaanxi Post Code:710049) Contact Us:029-82667865
Copyright:XI'AN JIAOTONG UNIVERSITY LIBRARY Technical Support:Beijing Aegean Software Co., Ltd.