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Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy EI Scopus SCIE
期刊论文 | 2019 , 29 (1) | Advanced Functional Materials
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© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Long blood circulation in vivo remains a challenge to dual-drug-loaded nanocarriers for synergistic chemotherapy. Herein, a novel strategy to prepare lollipop-like dual-drug-loaded nanoparticles (DOX–PDA–gossypol NPs) is developed based on the self-assembly of gossypol, doxorubicin (DOX), and polydopamine (PDA) via π–π stacking. Dopamine polymerizes to PDA and fills the gaps between the gossypol and DOX molecules to form the super compact long-circulating nanoparticles. The DOX–PDA–gossypol NPs show a suitable particle size of 59.6 ± 9.6 nm, high drug loading of 91%, superb stability, high maximum-tolerated dose (MTD) of over 60 mg kg-1, and negligible toxicity. These NPs also exhibit pH-dependent drug release and low combination index (0.23). Notably, they show dramatically ultralong blood circulation (>192 h) with elimination half times 458-fold and 258-fold longer than that of free DOX and free gossypol, respectively. These values are markedly higher than most of the reported results. Therefore, the DOX–PDA–gossypol NPs have a high tumor accumulation of 12% remaining on the 8th day postinjection. This characteristic contributes to the excellent tumor comprehensive synergistic therapeutic efficacy (TIR > 90%) with low administration dosage and is benefitted for widening the drug therapeutic window. Thus, the proposed strategy has remarkable potential for tumor synergistic therapy.

Keyword :

self-assembly synergistic therapy tumor ultralong circulating nanoparticles π–π stacking

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GB/T 7714 Wang, Ya , Wu, Youshen , Li, Ke et al. Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy [J]. | Advanced Functional Materials , 2019 , 29 (1) .
MLA Wang, Ya et al. "Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy" . | Advanced Functional Materials 29 . 1 (2019) .
APA Wang, Ya , Wu, Youshen , Li, Ke , Shen, Shihong , Liu, Zeying , Wu, Daocheng . Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy . | Advanced Functional Materials , 2019 , 29 (1) .
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Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coil Adhesion to Human Renal Tubular Epithelial Cells SCIE PubMed Scopus
期刊论文 | 2018 , 9 | FRONTIERS IN IMMUNOLOGY
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Recent work in a murine model of ascending urinary tract infection has suggested that C5a/C5aR1 interactions play a pathogenic role in the development of renal infection through enhancement of bacterial adhesion/colonization to renal tubular epithelial cells (RTECs). In the present study, we extended these observations to human. We show that renal tubular epithelial C5aR1 signaling is involved in promoting uropathogenic Escherichia coil (UPEC) adhesion/invasion of host cells. Stimulation of primary cultures of RTEC with C5a resulted in significant increases in UPEC adhesion/invasion of the RTEC. This was associated with enhanced expression of terminal oc-mannosyl residues (Man) (a ligand for type 1 fimbriae of E. cols) in the RTEC following C5a stimulation. Mechanism studies revealed that C5aR1-mediated activation of ERK1/2/NF-kappa B and upregulation of proinflammatory cytokine production (i.e., INF-alpha) is at least partly responsible for the upregulation of Man expression and bacterial adhesion. Clinical sample studies showed that C5aR1 and Man were clearly detected in the renal tubular epithelium of normal human kidney biopsies, and UPEC bound to the epithelium in a D-mannose-dependent manner. Additionally, C5a levels were significantly increased in urine of urinary tract infection patients compared with healthy controls. Our data therefore demonstrate that, in agreement with observations in mice, human renal tubular epithelial C5aR1 signaling can upregulate Man expression in RTEC, which enhances UPEC adhesion to and invasion of RTEC. It also suggests the in vivo relevance of upregulation of Man expression in renal tubular epithelium by C5a/C5aR1 interactions and its potential impact on renal infection.

Keyword :

renal tubular epithelial cell mannosyl residues C5aR1 uropathogenic Escherichia coli bacterial adhesion/invasion

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GB/T 7714 Song, Yun , Wu, Kun-Yi , Wu, Weiju et al. Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coil Adhesion to Human Renal Tubular Epithelial Cells [J]. | FRONTIERS IN IMMUNOLOGY , 2018 , 9 .
MLA Song, Yun et al. "Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coil Adhesion to Human Renal Tubular Epithelial Cells" . | FRONTIERS IN IMMUNOLOGY 9 (2018) .
APA Song, Yun , Wu, Kun-Yi , Wu, Weiju , Duan, Zhao-Yang , Gao, Ya-Feng , Zhang, Liang-Dong et al. Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coil Adhesion to Human Renal Tubular Epithelial Cells . | FRONTIERS IN IMMUNOLOGY , 2018 , 9 .
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Study of Wavelength Temperature Stability of Multifunctional Integrated Optical Chips Applied on Fiber Optic Gyroscopes EI Scopus SCIE
期刊论文 | 2018 , 36 (23) , 5528-5535 | Journal of Lightwave Technology
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© 1983-2012 IEEE. In this paper, we theoretically analyze the wavelength temperature stability of multifunctional integrated optical chips (MIOCs) applied on fiber optic gyroscopes (FOGs). This study is critical for improving the temperature stability of the FOG scale factor, which is a significant parameter used to evaluate the dynamic characteristics of FOGs. Analytical and multiphysics simulations uncover two significant new predictions. First, changes in environmental temperature can lead to misalignment of the coupling structure between the chip and fiber, which is the main reason for the deterioration of the MIOC wavelength temperature stability. Second, misalignment caused by temperature changes is related to the initial alignment parameters of the coupling structure. Therefore, we can effectively improve the wavelength temperature stability of an MIOC by correctly choosing the initial alignment state of the coupling structure. Space coupling experiments are also presented to verify these predictions, and the experimental and simulation results are in good agreement.

Keyword :

Fiber optic gyroscope (FOG) LiNbO3 waveguide multifunctional integrated optical chip (MIOC)

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GB/T 7714 Yao, Junjie , Li, Ke , Li, Bei et al. Study of Wavelength Temperature Stability of Multifunctional Integrated Optical Chips Applied on Fiber Optic Gyroscopes [J]. | Journal of Lightwave Technology , 2018 , 36 (23) : 5528-5535 .
MLA Yao, Junjie et al. "Study of Wavelength Temperature Stability of Multifunctional Integrated Optical Chips Applied on Fiber Optic Gyroscopes" . | Journal of Lightwave Technology 36 . 23 (2018) : 5528-5535 .
APA Yao, Junjie , Li, Ke , Li, Bei , Wang, Chenge , Kan, Chen , She, Xuan et al. Study of Wavelength Temperature Stability of Multifunctional Integrated Optical Chips Applied on Fiber Optic Gyroscopes . | Journal of Lightwave Technology , 2018 , 36 (23) , 5528-5535 .
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The Controversial C5a Receptor C5aR2: Its Role in Health and Disease SCIE PubMed Scopus
期刊论文 | 2017 | JOURNAL OF IMMUNOLOGY RESEARCH | IF: 3.298
WoS CC Cited Count: 2
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After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des-arginine form. As a heptahelical G protein-coupled receptor but devoid of the intracellular G alpha signal, C5aR2 is special and confusing. Ramifications and controversies about C5aR2 are under debate since its identification, from putative ligands and cellular localization to intracellular signals and pathological roles in inflammation and immunity. The ruleless and even conflicting pro- or anti-inflammatory role of C5aR2 in animal models of diverse diseases makes one bewildered. This review summarizes reports on C5aR2, tries to clear up available evidence on these four controversial aspects, and delineates C5aR2 function(s). It also summarizes available toolboxes for C5aR2 study.

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GB/T 7714 Zhang, Ting , Garstka, Malgorzata A. , Li, Ke . The Controversial C5a Receptor C5aR2: Its Role in Health and Disease [J]. | JOURNAL OF IMMUNOLOGY RESEARCH , 2017 .
MLA Zhang, Ting et al. "The Controversial C5a Receptor C5aR2: Its Role in Health and Disease" . | JOURNAL OF IMMUNOLOGY RESEARCH (2017) .
APA Zhang, Ting , Garstka, Malgorzata A. , Li, Ke . The Controversial C5a Receptor C5aR2: Its Role in Health and Disease . | JOURNAL OF IMMUNOLOGY RESEARCH , 2017 .
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The Controversial C5a Receptor C5aR2: Its Role in Health and Disease (vol 2017, 8193932, 2017) SCIE PubMed
期刊论文 | 2017 | JOURNAL OF IMMUNOLOGY RESEARCH | IF: 3.298
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GB/T 7714 Zhang, Ting , Garstka, Malgorzata A. , Li, Ke . The Controversial C5a Receptor C5aR2: Its Role in Health and Disease (vol 2017, 8193932, 2017) [J]. | JOURNAL OF IMMUNOLOGY RESEARCH , 2017 .
MLA Zhang, Ting et al. "The Controversial C5a Receptor C5aR2: Its Role in Health and Disease (vol 2017, 8193932, 2017)" . | JOURNAL OF IMMUNOLOGY RESEARCH (2017) .
APA Zhang, Ting , Garstka, Malgorzata A. , Li, Ke . The Controversial C5a Receptor C5aR2: Its Role in Health and Disease (vol 2017, 8193932, 2017) . | JOURNAL OF IMMUNOLOGY RESEARCH , 2017 .
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Anti-Double-Stranded DNA IgG Participates in Renal Fibrosis through Suppressing the Suppressor of Cytokine Signaling 1 Signals SCIE PubMed Scopus
期刊论文 | 2017 , 8 | FRONTIERS IN IMMUNOLOGY | IF: 5.511
WoS CC Cited Count: 4 SCOPUS Cited Count: 4
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Suppressor of cytokine signaling 1 (SOCS1) participates in renal fibrosis by downregulating Janus kinase 2 (JAK2)/signal transducer and activator of transcription 1 (STAT1)-mediated cytokine signaling. Recently, it was found that anti-double-stranded DNA (dsDNA) IgG induces the synthesis of profibrotic cytokines by renal cells. To explore the potential effect of anti-dsDNA IgG on SOCS1-mediated renal fibrosis, kidney tissues were collected from patients with lupus nephritis (LN) as well as MRL/lpr lupus-prone mice. The SOCS1 expression was evaluated in tissue samples. In addition, SCID mice were injected with anti-dsDNA IgG, followed by evaluation of SOCS1 levels. Renal resident cells were cultured in vitro, receiving the stimulation of anti-dsDNA IgG and then the measurement of SOCS1, JAK2, STAT1 alpha, and profibrotic cytokines. Moreover, the binding of anti-dsDNA IgG to SOCS1 kinase inhibitory region (KIR) peptide was analyzed by surface plasmon resonance. We found that SOCS1 expression was inhibited, but JAK2/STAT1 activation was prominent in the kidney tissues of patients with LN, MRL/lpr mice, or anti-dsDNA IgG-injected SCID mice. The cultured renal cells also showed SOCS1 downregulation, JAK2/STAT1 activation, and profibrotic cytokine promotion upon anti-dsDNA IgG stimulation. Surprisingly, anti-dsDNA IgG showed high affinity to KIR peptide and competed with JAK2 loop for KIR. Additionally, a DNA-mimicking peptide (ALW) blocked the binding of anti-dsDNA IgG to KIR, and even partially abrogated the activation of JAK2/STAT1 alpha signals and the expression of profibrotic cytokines in SCID mice. In conclusion, anti-dsDNA IgG downregulates SOCS1 expression, activates JAK2/STAT1 signals, and contributes to renal fibrosis; its peptide blockade may restore the SOCS1 inhibitory effect on the production of profibrotic cytokine, and finally ameliorate renal fibrosis in LN.

Keyword :

suppressor of cytokine signaling 1 peptide lupus nephritis signal transducer and activator of transcription 1 anti-double-stranded DNA IgG Janus kinase 2 renal fibrosis

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GB/T 7714 Wang, Ping , Yang, Jie , Tong, Fang et al. Anti-Double-Stranded DNA IgG Participates in Renal Fibrosis through Suppressing the Suppressor of Cytokine Signaling 1 Signals [J]. | FRONTIERS IN IMMUNOLOGY , 2017 , 8 .
MLA Wang, Ping et al. "Anti-Double-Stranded DNA IgG Participates in Renal Fibrosis through Suppressing the Suppressor of Cytokine Signaling 1 Signals" . | FRONTIERS IN IMMUNOLOGY 8 (2017) .
APA Wang, Ping , Yang, Jie , Tong, Fang , Duan, Zhaoyang , Liu, Xingyin , Xia, Linlin et al. Anti-Double-Stranded DNA IgG Participates in Renal Fibrosis through Suppressing the Suppressor of Cytokine Signaling 1 Signals . | FRONTIERS IN IMMUNOLOGY , 2017 , 8 .
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Complement Receptor 3 Has Negative Impact on Tumor Surveillance Through Suppression of Natural Killer Cell Function SCIE PubMed Scopus
期刊论文 | 2017 , 8 | FRONTIERS IN IMMUNOLOGY | IF: 5.511
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Complement receptor 3 (CR3) is expressed abundantly on natural killer (NK) cells; however, whether it plays roles in NK cell-dependent tumor surveillance is largely unknown. Here, we show that CR3 is an important negative regulator of NK cell function, which has negative impact on tumor surveillance. Mice deficient in CR3 (CD11b(-/-) mice) exhibited a more activated NK phenotype and had enhanced NK-dependent tumor killing. In a B16-luc melanoma-induced lung tumor growth and metastasis model, mice deficient in CR3 had reduced tumor growth and metastases, compared with WT mice. In addition, adaptive transfer of NK cells lacking CR3 (into NK-deficient mice) mediated more efficient suppression of tumor growth and metastases, compared with the transfer of CR3 sufficient NK cells, suggesting that CR3 can impair tumor surveillance through suppression of NK cell function. In vitro analyses showed that engagement of CR3 with iC3b (classical CR3 ligand) on NK cells negatively regulated NK cell activity and effector functions (i.e. direct tumor cell killing, antibody-dependent NK-mediated tumor killing). Cell signaling analyses showed that iC3b stimulation caused activation of Src homology 2 domain-containing inositol-5-phosphatase-1 (SHIP-1) and JNK, and suppression of ERK in NK cells, supporting that iC3b mediates negative regulation of NK cell function through its effects on SHIP-1, JNK, and ERK signal transduction pathways. Thus, our findings demonstrate a previously unknown role for CR3 in dysregulation of NK-dependent tumor surveillance and suggest that the iC3b/CR3 signaling is a critical negative regulator of NK cell function and may represent a new target for preserving NK cell function in cancer patients and improving NK cell-based therapy.

Keyword :

natural killer cell function complement receptor 3 Melanoma tumor surveillance iC3b

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GB/T 7714 Liu, Cheng-Fei , Min, Xiao-Yun , Wang, Naiyin et al. Complement Receptor 3 Has Negative Impact on Tumor Surveillance Through Suppression of Natural Killer Cell Function [J]. | FRONTIERS IN IMMUNOLOGY , 2017 , 8 .
MLA Liu, Cheng-Fei et al. "Complement Receptor 3 Has Negative Impact on Tumor Surveillance Through Suppression of Natural Killer Cell Function" . | FRONTIERS IN IMMUNOLOGY 8 (2017) .
APA Liu, Cheng-Fei , Min, Xiao-Yun , Wang, Naiyin , Wang, Jia-Xing , Ma, Ning , Dong, Xia et al. Complement Receptor 3 Has Negative Impact on Tumor Surveillance Through Suppression of Natural Killer Cell Function . | FRONTIERS IN IMMUNOLOGY , 2017 , 8 .
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Complement and Glycosylation SCIE Scopus CSCD PKU
期刊论文 | 2017 , 44 (10) , 888-897 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | IF: 0.288
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Complement system is an essential part of the innate immunity which serves as a bridge between innate and adaptive immunity. The complement system comprises of over 30 different proteins, most of which are glycoproteins. The recent researches have shown that complement system plays important roles in defense against the evading microbes and maintaining the cellular hemostasis. However, the complement system requires firm controls. Either insufficient activation or over-activation of complement would cause diseases. In this review, we summarize the recent advances in understanding the activation, regulation and the function of complement system and for the first time review the complement system by its glycosylation: we summarize the glycan structures of the complement proteins and analyze the glycosylation impact on the function of the proteins.

Keyword :

glycoprotein complement regulation glycosylation factor H

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GB/T 7714 Zhao Fei , Dang Liu-Yi , Zhao Xuan et al. Complement and Glycosylation [J]. | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS , 2017 , 44 (10) : 888-897 .
MLA Zhao Fei et al. "Complement and Glycosylation" . | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 44 . 10 (2017) : 888-897 .
APA Zhao Fei , Dang Liu-Yi , Zhao Xuan , Li Ke . Complement and Glycosylation . | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS , 2017 , 44 (10) , 888-897 .
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基于CLP败血症小鼠中补体C5a与白细胞介素-6相关性研究
期刊论文 | 2017 , (2) , 148-150 | 蚌埠医学院学报
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目的:探讨败血症发病机制中炎症介质C5a与细胞因子白细胞介素-6(IL-6)的关系.方法:利用经典盲肠结扎穿孔术(CLP)建立败血症动物模型,在败血症活动期,取不同时间段建模组和假手术组小鼠的腹腔灌洗液,检测补体C5a和IL-6的表达.结果:建模组小鼠的腹腔灌洗液中补体C5a和IL-6水平在建模后第4、6、12、24 h均明显高于假手术组(P<0.01);伴随病变恢复,2组实验动物体内补体C5a和IL-6的表达水平逐渐趋于正常.结论:CLP败血症小鼠发病机制中,炎症介质C5a与细胞因子IL-6的调节有一定的线性相关趋势.

Keyword :

败血症 盲肠结肠穿孔术 白细胞介素-6 小鼠 C5a

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GB/T 7714 周亚妮 , 李可 , 刘丹 . 基于CLP败血症小鼠中补体C5a与白细胞介素-6相关性研究 [J]. | 蚌埠医学院学报 , 2017 , (2) : 148-150 .
MLA 周亚妮 et al. "基于CLP败血症小鼠中补体C5a与白细胞介素-6相关性研究" . | 蚌埠医学院学报 2 (2017) : 148-150 .
APA 周亚妮 , 李可 , 刘丹 . 基于CLP败血症小鼠中补体C5a与白细胞介素-6相关性研究 . | 蚌埠医学院学报 , 2017 , (2) , 148-150 .
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Activation of Endogenous Anti-Inflammatory Mediator Cyclic AMP Attenuates Acute Pyelonephritis in Mice Induced by Uropathogenic Escherichia coli SCIE PubMed Scopus
期刊论文 | 2015 , 185 (2) , 472-484 | AMERICAN JOURNAL OF PATHOLOGY | IF: 4.206
WoS CC Cited Count: 5
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The pathogenesis of pyelonephritis caused by uropathogenic Escherichia coli (UPEC) is not well understood. Here, we show that besides UPEC virulence, the severity of the host innate immune response and invasion of renal epithelial cells are important pathogenic factors. Activation of endogenous anti-inflammatory mediator cAMP significantly attenuated acute pyelonephritis in mice induced by UPEC. Administration of forskolin (a potent elevator of intracellular cAMP) reduced kidney infection (ie, bacterial load, tissue destruction); this was associated with attenuated Local inflammation, as evidenced by the reduction of renal production of proinflammatory mediators, renal infiltration of inflammatory cells, and renal myeloperoxidase activity. In primary cell culture systems, forskolin not only down-regulated UPEC-stimulated production of proinflammatory mediators by renal tubular epithelial cells and inflammatory cells (eg, monocyte/macrophages) but also reduced bacterial internalization by renal tubular epithelial cells. Our findings clearly indicate that activation of endogenous anti-inflammatory mediator cAMP is beneficial for controlling UPEC-mediated acute pyelonephritis in mice. The beneficial effect can be explained at least in part by Limiting excessive inflammatory responses through acting on both renal tubular epithelial cells and inflammatory cells and by inhibiting bacteria invasion of renal tubular epithelial cells.

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GB/T 7714 Wei, Yang , Li, Ke , Wang, Na et al. Activation of Endogenous Anti-Inflammatory Mediator Cyclic AMP Attenuates Acute Pyelonephritis in Mice Induced by Uropathogenic Escherichia coli [J]. | AMERICAN JOURNAL OF PATHOLOGY , 2015 , 185 (2) : 472-484 .
MLA Wei, Yang et al. "Activation of Endogenous Anti-Inflammatory Mediator Cyclic AMP Attenuates Acute Pyelonephritis in Mice Induced by Uropathogenic Escherichia coli" . | AMERICAN JOURNAL OF PATHOLOGY 185 . 2 (2015) : 472-484 .
APA Wei, Yang , Li, Ke , Wang, Na , Cai, Gui-Dong , Zhang, Ting , Lin, Yan et al. Activation of Endogenous Anti-Inflammatory Mediator Cyclic AMP Attenuates Acute Pyelonephritis in Mice Induced by Uropathogenic Escherichia coli . | AMERICAN JOURNAL OF PATHOLOGY , 2015 , 185 (2) , 472-484 .
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