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学者姓名:张彦民

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Ephrin type-B receptor 4 affinity chromatography: An effective and rapid method studying the active compounds targeting Ephrin type-B receptor 4 EI PubMed SCIE
期刊论文 | 2019 , 1586 , 82-90 | Journal of Chromatography A
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Abstract :

Erythropoietin-producing hepatocyte B4 (EphB4) has recently been reported to be an oncogenic factor in many cancers and overexpressed in several types of tumors. Thus, EphB4 has the potential to be a therapeutic target in these malignancies. High-performance affinity chromatography has been a powerful tool to study the interaction between drugs and receptors. In this study, we constructed a novel EphB4 affinity chromatography model to investigate the active compounds which can target EphB4. More than 50 crude extracts of traditional Chinese medicine were screened by this affinity chromatography model. The active ingredients sanguinarine from celandine and macleaya cordata, and berberine from coptis chinensis and phellodendron amurense were found to selectively bind on the EphB4 affinity column. Next biological evaluatation data showed that EphB4 played a critical role in the inhibitory effect of sanguinarine and berberine on cancer cell growth. The results indicated that EphB4 affinity chromatography model constructed in this study can be used to screen the active compounds targeting EphB4 effectively and rapidly, especially in natural products. © 2018 Elsevier B.V.

Keyword :

Berberine EphB4 Erythropoietin (EPO) High-performance affinity chromatography Natural products Sanguinarine Therapeutic targets Traditional Chinese Medicine

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GB/T 7714 Zhu, Man , Cui, Yuxin , Yang, Liu et al. Ephrin type-B receptor 4 affinity chromatography: An effective and rapid method studying the active compounds targeting Ephrin type-B receptor 4 [J]. | Journal of Chromatography A , 2019 , 1586 : 82-90 .
MLA Zhu, Man et al. "Ephrin type-B receptor 4 affinity chromatography: An effective and rapid method studying the active compounds targeting Ephrin type-B receptor 4" . | Journal of Chromatography A 1586 (2019) : 82-90 .
APA Zhu, Man , Cui, Yuxin , Yang, Liu , Yang, Tianfeng , Wang, Hongying , Zhang, Dongdong et al. Ephrin type-B receptor 4 affinity chromatography: An effective and rapid method studying the active compounds targeting Ephrin type-B receptor 4 . | Journal of Chromatography A , 2019 , 1586 , 82-90 .
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PH-sensitive doxorubicin-loaded polymeric nanocomplex based on beta-cyclodextrin for liver cancer-targeted therapy SCIE
期刊论文 | 2019 , 14 , 1997-2010 | INTERNATIONAL JOURNAL OF NANOMEDICINE
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Abstract :

Background: Doxorubicin (DOX) is one of the most effective treatments for hepatocellular carcinoma (HCC), but is restricted by its poor pharmacokinetics. Herein, we exploited efficient targeted drug delivery systems and they have been found to be a worthy strategy for liver cancer therapy. Materials and methods: We investigated polymeric nanoparticles which were synthesized based on host-guest interaction between beta-cyclodextrin and benzimidazole. The properties of nanoparticles with regard to size/shape, encapsulation efficiency, and drug release were investigated using conventional experiments. Cell proliferation assay in vitro, cell uptake assay, and cell apoptosis analysis were used to investigate cytotoxicity, uptake, and mechanism of targeted supramolecular prodrug complexes (TSPCs)-based self-assemblies and supramolecular prodrug complexes (SPCs)-based self-assemblies. Results: The pH-sensitive lactobionic acid (LA)-modified pH-sensitive self-assemblies were synthesized successfully. The results of in vitro released assay showed that the accelerated released of DOX from TSPCs-based self-assemblies with the decrease of pH value. When TSPCs-based self-assemblies were taken up by HepG2 cells, they demonstrated a faster release rate under acidic conditions and proved to have higher cytotoxicity than in the presence of LA. A mechanistic study revealed that TSPCs-based self-assemblies inhibited liver cell proliferation by inducing cell apoptosis. Conclusion: The pH-sensitive nanocomplex, as liver-targeted nanoparticles, facilitated the efficacy of DOX in HepG2 cells, offering an appealing strategy for the treatment of HCC.

Keyword :

doxorubicin pH-sensitive hepatocellular carcinoma drug delivery

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GB/T 7714 Yang, Tianfeng , Du, Guowen , Cui, Yuxin et al. PH-sensitive doxorubicin-loaded polymeric nanocomplex based on beta-cyclodextrin for liver cancer-targeted therapy [J]. | INTERNATIONAL JOURNAL OF NANOMEDICINE , 2019 , 14 : 1997-2010 .
MLA Yang, Tianfeng et al. "PH-sensitive doxorubicin-loaded polymeric nanocomplex based on beta-cyclodextrin for liver cancer-targeted therapy" . | INTERNATIONAL JOURNAL OF NANOMEDICINE 14 (2019) : 1997-2010 .
APA Yang, Tianfeng , Du, Guowen , Cui, Yuxin , Yu, Runze , Hua, Chen , Tian, Wei et al. PH-sensitive doxorubicin-loaded polymeric nanocomplex based on beta-cyclodextrin for liver cancer-targeted therapy . | INTERNATIONAL JOURNAL OF NANOMEDICINE , 2019 , 14 , 1997-2010 .
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Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma. PubMed SCIE
期刊论文 | 2019 , 33 (3) , 745-755 | Phytotherapy research : PTR
WoS CC Cited Count: 1
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Abstract :

Hepatocellular carcinoma (HCC) is a biologically complex disease. Combination chemotherapy is a good strategy after surgery treatment. In this study, we report that berberine combined with HMQ1611 (BCH) had a good synergistic effect on the HCC. Our findings concluded that BCH showed good inhibition on the HCC proliferation and colony formation, which attributed to cell cycle arrest by BCH at G1 phase through impairing the expression of cyclinD1, cyclinE, and cdc2 and downregulated the phosphorylation of Akt, mTOR, and ERK. Moreover, BCH negatively regulated Wnt signaling pathway by upregulating the Axin and inhibiting the nuclear translocation of β-catenin. BCH suppressed the phosphorylation of LRP5/6, GSK3β, the expression of Wnt5a, Frizzled8, CK1, and APC, as well as the nucleus protein included MMP2, MMP3, MMP9, and c-myc. The above data of Wnt signaling regulators contributed to inhibition by BCH on cell migration. In vivo studies, BCH significantly suppressed the growth of SMMC-7721 xenograft tumors through downregulating Ki67 and β-catenin, as well as upregulating Axin and p-β-catenin. In conclusion, the results revealed that BCH exhibited potential antitumor activities against human liver cancer in vitro and in vivo, and the potential mechanism underlying these activities depended on the inhibition of the Wnt/β-catenin signaling pathway.

Keyword :

HCC HMQ1611 Wnt/β-catenin signal cell migration berberine

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GB/T 7714 Dai Bingling , Ma Yujiao , Yang Tianfeng et al. Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma. [J]. | Phytotherapy research : PTR , 2019 , 33 (3) : 745-755 .
MLA Dai Bingling et al. "Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma." . | Phytotherapy research : PTR 33 . 3 (2019) : 745-755 .
APA Dai Bingling , Ma Yujiao , Yang Tianfeng , Fan Mengying , Yu Runze , Su Qi et al. Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma. . | Phytotherapy research : PTR , 2019 , 33 (3) , 745-755 .
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A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer SCIE PubMed Scopus
期刊论文 | 2018 , 40 (2) , 1064-1072 | ONCOLOGY REPORTS
WoS CC Cited Count: 1
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We recently reported that TPD7 suppressed tumor cell proliferation, and inhibited invasion, through the suppression of C-X-C chemokine receptor type 4 (CXCR4). In the present study, we investigated the anticancer effect of TPD7 on apoptosis and invasion of cervical cancer HeLa cells. Cell cycle analysis revealed that TPD7 decreased cyclin-dependent kinase (CDK)1 and cyclin D1 expression, and increased cyclin A expression, following S phase blockade. TPD7 induced chromatin condensation and significantly elevated the number of apoptotic cells, suggesting that its inhibitory effect on HeLa cells was due to the induction of cell cycle blockade and apoptosis. Mechanistically, TPD7 altered the extrinsic apoptosis pathway by upregulating Fas expression, and the intrinsic pathway by modulating Bcl-2 family proteins, p53, and NF-B p65, leading to enhanced apoptosis. TPD7 inhibited HeLa cell invasion by downregulating the expression of matrix metalloproteinase (MMP)-9 and CXCR4 proteins. In vivo experiments revealed that TPD7 inhibited tumor growth in HeLa cell xenografted mice. These findings indicated that TPD7 may be a potential chemoprevention agent for the management of cervical carcinoma.

Keyword :

apoptosis Bcl-2 TPD7 cervical cancer Fas

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GB/T 7714 Zhan, Yingzhuan , Zhang, Han , Dai, Bingling et al. A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer [J]. | ONCOLOGY REPORTS , 2018 , 40 (2) : 1064-1072 .
MLA Zhan, Yingzhuan et al. "A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer" . | ONCOLOGY REPORTS 40 . 2 (2018) : 1064-1072 .
APA Zhan, Yingzhuan , Zhang, Han , Dai, Bingling , Zhang, Yanmin , Zhang, Jie , He, Langchong . A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer . | ONCOLOGY REPORTS , 2018 , 40 (2) , 1064-1072 .
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Analysis of genotype-phenotype correlation for a novel MYH7-D554Y mutation identified in an ethnic han Chinese pedigree affected with hypertrophic cardiomyopathy Scopus CSCD PKU
期刊论文 | 2018 , 35 (5) , 667-671 | Chinese Journal of Medical Genetics
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Abstract :

© 2018 West China University of Medical Sciences. All rights reserved. Objective: To explore the genotype-phenotype correlation of a MYH7-D554Y mutation identified in an ethnic Han Chinese pedigree affected with hypertrophic cardiomyopathy. Methods: Ninety six cardiovascular disease-related genes were detected in the proband by exonic amplification and highthroughput sequencing. Suspected mutations were verified by Sanger sequencing among 300 healthy controls as well as family members of the proband. The pathogenicity and conservation of the detected mutations were analyzed with ClustalX, MutationTaster, PolyPhen-2, Provean and SIFT software. Results: Four of the 5 first-degree relatives of the proband were diagnosed with hypertrophic cardiomyopathy. The proband has featured extremely hypertrophic left ventricular wall with a maximal thickness of 35 mm. Genetic testing showed that four of them have carried a heterozygous c. 1660G>T (p. Asp554Tyr) mutation of the MYH7 gene, who the remaining one was phenotypically normal and did not carry the mutation. The mutation has not been recorded by the Human Gene Mutation Database (HGMD) and other databases. Bioinformatics analysis suggested that the mutation site is highly conserved and that the mutation is pathogenic. Conclusion: The p. Asp554Tyr mutation of the MYH7 gene probably underlies the hypertrophic cardiomyopathy in this pedigree.

Keyword :

Genotype Hypertrophic cardiomyopathy MYH7-D554Y mutation Phenotype

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GB/T 7714 Yang, Qianli , Wang, Bo , Wang, Jing et al. Analysis of genotype-phenotype correlation for a novel MYH7-D554Y mutation identified in an ethnic han Chinese pedigree affected with hypertrophic cardiomyopathy [J]. | Chinese Journal of Medical Genetics , 2018 , 35 (5) : 667-671 .
MLA Yang, Qianli et al. "Analysis of genotype-phenotype correlation for a novel MYH7-D554Y mutation identified in an ethnic han Chinese pedigree affected with hypertrophic cardiomyopathy" . | Chinese Journal of Medical Genetics 35 . 5 (2018) : 667-671 .
APA Yang, Qianli , Wang, Bo , Wang, Jing , Sun, Chao , Ma, Zhiling , Zuo, Lei et al. Analysis of genotype-phenotype correlation for a novel MYH7-D554Y mutation identified in an ethnic han Chinese pedigree affected with hypertrophic cardiomyopathy . | Chinese Journal of Medical Genetics , 2018 , 35 (5) , 667-671 .
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HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway Scopus SCIE PubMed
期刊论文 | 2018 , 22 (11) , 5231-5243 | Journal of Cellular and Molecular Medicine
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. Hepatocellular carcinoma (HCC) is a highly prevalent cancer worldwide and it is necessary to discover and develop novel preventive strategies and therapeutic approaches for HCC. Herein, we report that EphrinB2 expression is correlated with liver cancer progression. Moreover, by using phosphorylated proteomics array, we reveal a pro-apoptosis protein whose phosphorylation and activation levels are up-regulated upon EphrinB2 knockdown. These results suggest that EphrinB2 may act as an anti-apoptotic protein in liver cancer cells. We also explored the therapeutic potential of HMQ-T-B10 (B10), which was designed and synthesized in our laboratory, for HCC and its underlying mechanisms in vitro and in vivo. Our data demonstrate that B10 could bind EphrinB2 and show inhibitory activity on human liver cancer cells. Moreover, induction of human liver cancer cell apoptosis by B10 could be augmented upon EphrinB2 knockdown. B10 inhibited HCC cell growth and induced HCC cell apoptosis by repressing the EphrinB2 and VEGFR2 signalling pathway. Growth of xenograft tumours derived from Hep3B in nude mice was also significantly inhibited by B10. Collectively, these findings highlight the potential molecular mechanisms of B10 and its potential as an effective antitumour agent for HCC.

Keyword :

apoptosis EphrinB2 HMQ-T-B10 liver cancer cell

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GB/T 7714 Dai, Bingling , Shi, Xianpeng , Ma, Nan et al. HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway [J]. | Journal of Cellular and Molecular Medicine , 2018 , 22 (11) : 5231-5243 .
MLA Dai, Bingling et al. "HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway" . | Journal of Cellular and Molecular Medicine 22 . 11 (2018) : 5231-5243 .
APA Dai, Bingling , Shi, Xianpeng , Ma, Nan , Ma, Weina , Zhang, Yanmin , Yang, Tianfeng et al. HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway . | Journal of Cellular and Molecular Medicine , 2018 , 22 (11) , 5231-5243 .
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Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway SCIE PubMed Scopus
期刊论文 | 2018 , 315 (2) , F254-F262 | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
WoS CC Cited Count: 2 SCOPUS Cited Count: 4
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Abstract :

Salvianolic acid A (Sal A) has been shown to prevent and treat ischemic cardiovascular, as well as cerebral vascular diseases. However, little is known about Sal A in renal ischemia/reperfusion (I/R) injury. In this study, a renal I/R injury model in rats and a hypoxia/reoxygenation (H/R) model to damage proximal renal tubular cells (HK-2) were used to assess whether Sal A halts the development and progression of renal I/R injury. As compared with vehicle treatment, Sal A significantly attenuated kidney injury after renal I/R injury, accompanied by decreases in plasma creatinine, blood urea nitrogen levels, the number of apoptosis-positive tubular cells, and kidney oxidative stress. Sal A also activated phosphorylated protein kinase B (p-Akt) and phosphorylated-mammalian target of rapamycin (p-mTOR) compared with vehicle-treated I/R injury rats. In H/R-injured HK-2 cells. Sal A can reduce the levels of reactive oxygen species in a dose-related manner. Similar to the results from in vivo experiments, in vitro Sal A also increased the protein expression of phosphorylated-eukaryotic initiation factor 4E binding protein 1 (p-4EBP1) compared with vehicle. Furthermore. the cytoprotective activity of Sal A was inhibited by LY294002 and rapamycin. These findings indicate that Sal A can ameliorate renal I/R injury and promote tubular cell survival partly via the Akt/mTOR/4EBP1pathway. Sal A could be a candidate compound to prevent ischemic tissue damage.

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GB/T 7714 Song, Ying , Liu, Weihai , Ding, Yi et al. Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway [J]. | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY , 2018 , 315 (2) : F254-F262 .
MLA Song, Ying et al. "Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway" . | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 315 . 2 (2018) : F254-F262 .
APA Song, Ying , Liu, Weihai , Ding, Yi , Jia, Yanyan , Zhao, Jinyi , Wang, Fan et al. Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway . | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY , 2018 , 315 (2) , F254-F262 .
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HMQ-T-F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells SCIE PubMed Scopus
期刊论文 | 2018 , 22 (5) , 2955-2959 | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
WoS CC Cited Count: 2 SCOPUS Cited Count: 2
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Abstract :

Looking for novel, effective and less toxic therapies for cervical cancer is of significant importance. In this study, we reported that HMQ-T-F2(F2) significantly inhibited cell proliferation and transplantable tumour growth. Mechanistically, HMQ-T-F2 inhibited HeLa cell growth through repressing the expression and nuclear translocation of beta-catenin, enhancing Axin expression, as well as downregulating the Wnt downstream targeted proteins. Knock-down of a checkpoint beta-catenin by siRNA significantly attenuated HeLa cell proliferation. Furthermore, XAV939, an inhibitor of beta-catenin, was used to treat HeLa cells and the results demonstrated that HMQ-T-F2 inhibited proliferation and migration via the inhibition of the Wnt/beta-catenin pathway.

Keyword :

cervical HeLa cells proliferation Wnt/beta-catenin signal HMQ-T-F2

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GB/T 7714 Dai, Bingling , Yang, Tianfeng , Ma, Yujiao et al. HMQ-T-F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells [J]. | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE , 2018 , 22 (5) : 2955-2959 .
MLA Dai, Bingling et al. "HMQ-T-F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells" . | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 22 . 5 (2018) : 2955-2959 .
APA Dai, Bingling , Yang, Tianfeng , Ma, Yujiao , Ma, Nan , Shi, Xianpeng , Zhang, Dongdong et al. HMQ-T-F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells . | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE , 2018 , 22 (5) , 2955-2959 .
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Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology SCIE CSCD
期刊论文 | 2018 , 16 (4) , 302-312 | CHINESE JOURNAL OF NATURAL MEDICINES
WoS CC Cited Count: 1
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Abstract :

Guanxinshutong capsule (GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases (CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms of action involved in the treatment of CVDs are still unclear. In the present study, we used a systems pharmacology approach to identify the active ingredients of GXSTC and their corresponding targets in the calcium signaling pathway with respect to the treatment of CVDs. This method integrated chromatographic techniques, prediction of absorption, distribution, metabolism, and excretion, analysis using Kyoto Encyclopedia of Genes and Genomes, network construction, and pharmacological experiments. 12 active compounds and 33 targets were found to have a role in the treatment of CVDs, and four main active ingredients, including protocatechuic acid, cryptotanshinone, eugenol, and bomeol were selected to verify the effect of (GXSTC) on calcium signaling system in cardiomyocyte injury induced by hypoxia and reoxygenation. The results from the present study revealed the active components and targets of GXSTC in the treatment of CVDs, providing a new perspective to enhance the understanding of the role of the calcium signaling pathway in the therapeutic effect of GXSTC.

Keyword :

Mass spectrum Systems pharmacology Calcium signaling pathway Cardiovascular diseases Guanxinshutong capsule

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GB/T 7714 Liu Feng , Du Xia , Liu Pei-Rong et al. Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology [J]. | CHINESE JOURNAL OF NATURAL MEDICINES , 2018 , 16 (4) : 302-312 .
MLA Liu Feng et al. "Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology" . | CHINESE JOURNAL OF NATURAL MEDICINES 16 . 4 (2018) : 302-312 .
APA Liu Feng , Du Xia , Liu Pei-Rong , Sun Yu-Hong , Zhang Yan-Min . Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology . | CHINESE JOURNAL OF NATURAL MEDICINES , 2018 , 16 (4) , 302-312 .
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Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells SCIE PubMed Scopus
期刊论文 | 2018 , 46 , 85-92 | PHYTOMEDICINE
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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Background: Colorectal cancer remains the third most common malignancies and migration is one of the main factors for its high mortality rate. Brucine, a natural plant alkaloid, has been proved to possess a variety of pharmacological functions including anti-tumor activities. Purpose: The aim of this study was to investigate the inhibitory effect of brucine on the colorectal cancer and the underlying mechanism. Methods: In this study, colony formation assay and transwell assay were used to investigate the effect of brucine on LoVo cells viability and migration. Immunofluorescence assay, western blot assay and Gelatin zymography assay were used to study the mechanism of brucine. Xenograft model in nude mice was induced to investigate the in vivo effect of brucine on LoVo cells. Results: Brucine could significantly decrease the viability, inhibit the colony formation and induce the apoptosis of LoVo cells. Brucine could also suppress the migration of LoVo cells in a dose-dependent manner. Western blot analysis elucidated that the inhibition of migration was associated with the decreasing expression of matrix metalloproteinases including MMP2, MMP3 and MMP9. Moreover, we found that treatment of brucine could downregulate the expression of Frizzled-8, Wnt5a, APC and GSNK1A1, and increase the expression of AXIN1. Meanwhile, brucine also decreased the phosphorylation level of LRP5/6 and GSK3 beta, and increased the level of p-beta-catenin. Xenografted model in nude mice study also revealed that oral administration of brucine could inhibit the growth and migration of LoVo cells by activating the expression of AXIN1 and p-beta-catenin. Conclusion: Brucine could suppress the migration of the colorectal cancer in vitro and in vivo and the effect was associated with the inhibition of the WM/beta-catenin signaling pathway.

Keyword :

Migration Signaling pathway Wnt/beta-catenin Brucine Colorectal cancer

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GB/T 7714 Shi Xianpeng , Zhu Man , Kang Yuan et al. Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells [J]. | PHYTOMEDICINE , 2018 , 46 : 85-92 .
MLA Shi Xianpeng et al. "Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells" . | PHYTOMEDICINE 46 (2018) : 85-92 .
APA Shi Xianpeng , Zhu Man , Kang Yuan , Yang Tianfeng , Chen Xia , Zhang Yanmin . Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells . | PHYTOMEDICINE , 2018 , 46 , 85-92 .
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