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< Page ,Total 16 >
Chemerin/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS-sirt1-NF-κB signaling Scopus PubMed SCIE
期刊论文 | 2019 , 120 (4) , 6459-6470 | Journal of Cellular Biochemistry
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Abstract :

© 2018 Wiley Periodicals, Inc. Psoriasis is a chronic disease which carries the emotional and social burden, promotes joint disability and raises comorbidity possibility in patients. Obesity is closely correlated with the occurrence of psoriasis and adipokines produced by adipose tissues were found to be critical culprits. Chemerin is one of them and its expression was increased in patients with psoriatic arthritis. In our hypothesis, chemerin might act on keratinocytes and promote an inflammatory response, which plays an essential role in psoriatic epidermis. To validate our hypothesis, HaCaT cells and primary human keratinocytes were treated with chemerin (5, 10, and 20 ng/mL for 24 hours). Enzyme-linked immunosorbent assay (ELISA) was used to determine the secretion of inflammatory factors. Nuclear factor-κB (NF-κB) activation and p65 acetylation were evaluated by Western blot analysis. The expression and activity of sirtuin 1 (sirt1), a deacetylase act on p65, were also analyzed. The results showed that chemerin prompted inflammatory factors secretion, NF-κB activation and p65 acetylation through chemerin receptor 23 receptor. Chemerin constrained the expression and deacetylase activity of sirt1 through augment of reactive oxygen species (ROS) production. Additionally, chemerin exacerbated psoriasiform dermatitis in imiquimod-treated mice model. In conclusion, chemerin can seduce inflammatory response and promote NF-κB activation through inhibition of sirt1 activity by ROS production.

Keyword :

chemerin inflammatory response keratinocytes p65 acetylation psoriasis sirt1

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GB/T 7714 Wang, Yuan , Huo, Jia , Zhang, Dingwei et al. Chemerin/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS-sirt1-NF-κB signaling [J]. | Journal of Cellular Biochemistry , 2019 , 120 (4) : 6459-6470 .
MLA Wang, Yuan et al. "Chemerin/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS-sirt1-NF-κB signaling" . | Journal of Cellular Biochemistry 120 . 4 (2019) : 6459-6470 .
APA Wang, Yuan , Huo, Jia , Zhang, Dingwei , Hu, Gang , Zhang, Yanfei . Chemerin/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS-sirt1-NF-κB signaling . | Journal of Cellular Biochemistry , 2019 , 120 (4) , 6459-6470 .
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Three-dimensional numerical simulations of barchan dune interactions in unidirectional flow EI Scopus
期刊论文 | 2018 , 1-8 | Particulate Science and Technology
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In this study, a constitutive model based on fluvial hydrodynamics is coupled with a large eddy simulation to better understand barchan dune interactions from the perspective of morphological dynamics. The results show that the developed model can reproduce crescent-shaped dunes, as well as variations in turbulent flow structures above the dune surface. The interactions between two barchan dunes arranged in coaxial and staggered alignments are simulated by changes in their initial mass ratios. A critical moment of fast erosion is observed for the larger of the two coaxial dunes, and the value of this moment converges to a constant with a linear increase in the mass ratio. The interaction pattern of “coalescence” agrees with that of the experiments. These results provide deep insights into the transition of the barchan dune interaction patterns from “coalescence” to “ejection”, which corresponds to a dynamic mass equilibrium state in large dunes. In addition, one elongated horn created from merged barchans after a staggered collision reaffirms that dune collision and influx asymmetry are two potential mechanisms in barchan asymmetry. © 2018 Taylor & Francis

Keyword :

Barchan dunes interaction Interaction pattern Morphological dynamics Potential mechanism Staggered alignment Three-dimensional numerical simulations Unidirectional flow

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GB/T 7714 Zhou, Xiaosi , Wang, Yuan , Yang, Bin . Three-dimensional numerical simulations of barchan dune interactions in unidirectional flow [J]. | Particulate Science and Technology , 2018 : 1-8 .
MLA Zhou, Xiaosi et al. "Three-dimensional numerical simulations of barchan dune interactions in unidirectional flow" . | Particulate Science and Technology (2018) : 1-8 .
APA Zhou, Xiaosi , Wang, Yuan , Yang, Bin . Three-dimensional numerical simulations of barchan dune interactions in unidirectional flow . | Particulate Science and Technology , 2018 , 1-8 .
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MicroRNA-376c-3p facilitates human hepatocellular carcinoma progression via repressing AT-Rich interaction domain 2 Scopus SCIE PubMed
期刊论文 | 2018 , 9 (22) , 4187-4196 | Journal of Cancer
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© Ivyspring International Publisher. Hepatocellular carcinoma (HCC), accounting for approximately 90% of liver cancer, is the most lethal malignant tumors in the world. Large amount of evidence indicate that microRNAs (miRNAs) contribute to the tumorigenesis and progression of HCC. Among them, miR-376c-3p was recently identified as a tumor-related miRNA and is up-regulated in HBV-related HCC. But, the clinical significance of miR-376c-3p and its biological function in HCC progression are still unclear. Here, we confirmed that miR-376c-3p expression level in HCC was markedly higher than that in noncancerous tissues. Up-regulation of miR-376c-3p was detected in four different HCC cell lines. High miR-376c-3p expression correlated with poor prognostic features, such as large tumor size and venous infiltration. Follow-up data indicated that high miR-376c-3p level evidently correlated with poor clinical outcomes of HCC patients. Moreover, knockdown of miR-376c-3p repressed HCC cell growth, migration and invasion in vitro. miR-376c-3p overexpression facilitated these malignant behaviors of Bel-7402 cells. Mechanistically, miR-376c-3p posttranscriptionally repressed ARID2 expression by directly interacting with its 3'-UTR. Furthermore, an obvious negative correlation between miR-376c-3p and ARID2 mRNA expression in HCC tissues was confirmed. Notably, miR-376c-3p knockdown suppressed HCC growth and metastasis in nude mice. Gain-of-function experiments showed that ARID2 inhibited cell growth and mobility of Hep3B cells. Subsequently, ARID2 knockdown rescued miR-376c-3p silencing attenuated Hep3B cell proliferation and mobility. Our results suggest that miR-376c-3p exerts an oncogenic role in HCC progression.

Keyword :

ARID2 Hepatocellular carcinoma Invasion MiR-376c-3p Proliferation

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GB/T 7714 Wang, Yuan , Chang, Weiping , Chang, Wanli et al. MicroRNA-376c-3p facilitates human hepatocellular carcinoma progression via repressing AT-Rich interaction domain 2 [J]. | Journal of Cancer , 2018 , 9 (22) : 4187-4196 .
MLA Wang, Yuan et al. "MicroRNA-376c-3p facilitates human hepatocellular carcinoma progression via repressing AT-Rich interaction domain 2" . | Journal of Cancer 9 . 22 (2018) : 4187-4196 .
APA Wang, Yuan , Chang, Weiping , Chang, Wanli , Chang, Xiaowei , Zhai, Song , Pan, Guoying et al. MicroRNA-376c-3p facilitates human hepatocellular carcinoma progression via repressing AT-Rich interaction domain 2 . | Journal of Cancer , 2018 , 9 (22) , 4187-4196 .
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Measurement of two-phase particle flow based on the characteristics of particle-system scattering EI SCIE Scopus
期刊论文 | 2017 , 28 (2) | MEASUREMENT SCIENCE AND TECHNOLOGY | IF: 1.685
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Precise measurement of the mass of moving particles (MPM) is fundamental to the research on particle flows. In non-intrusive optical measurements, traditional discrete methods obtain the MPM by determining the connected domains on experimental pictures, leading to inevitable errors. In this study, the constitutive relationship between the MPM and the foreground grey scale value of the experimental picture is investigated on the basis of the working principle of digital cameras and the scattering theory of particle systems. This relationship is confirmed to be effective in wind-blown sand particle flow experiments using high-speed photography.

Keyword :

scattering theory particle system optical measurement mass of moving particle particle flow

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GB/T 7714 Li, Min , Zhang, Yang , Wang, Yuan et al. Measurement of two-phase particle flow based on the characteristics of particle-system scattering [J]. | MEASUREMENT SCIENCE AND TECHNOLOGY , 2017 , 28 (2) .
MLA Li, Min et al. "Measurement of two-phase particle flow based on the characteristics of particle-system scattering" . | MEASUREMENT SCIENCE AND TECHNOLOGY 28 . 2 (2017) .
APA Li, Min , Zhang, Yang , Wang, Yuan , Yang, Bin . Measurement of two-phase particle flow based on the characteristics of particle-system scattering . | MEASUREMENT SCIENCE AND TECHNOLOGY , 2017 , 28 (2) .
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近床面风沙输移风洞实验的光学测量研究进展 CSCD
期刊论文 | 2017 , (3) , 43-50 | 科技导报
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Keyword :

风洞实验 光学测量 风沙输移 高速摄影 激光测速

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GB/T 7714 周晓斯 , 张洋 , 王元 et al. 近床面风沙输移风洞实验的光学测量研究进展 [J]. | 科技导报 , 2017 , (3) : 43-50 .
MLA 周晓斯 et al. "近床面风沙输移风洞实验的光学测量研究进展" . | 科技导报 3 (2017) : 43-50 .
APA 周晓斯 , 张洋 , 王元 , 李敏 . 近床面风沙输移风洞实验的光学测量研究进展 . | 科技导报 , 2017 , (3) , 43-50 .
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Evolution of crescent-shaped sand dune under the influence of injected sand flux: scaling law and wind tunnel experiment SCIE Scopus CSCD
期刊论文 | 2017 , 9 (2) , 270-277 | JOURNAL OF ARID LAND | IF: 1.444
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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Abstract :

This paper studies the evolution of crescent-shaped dune under the influence of injected flux. A scaling law and a wind tunnel experiment are carried out for comparison. The experiment incorporates a novel image processing algorithm to recover the evolutionary process. The theoretical and experimental results agree well in the middle stage of dune evolution, but deviate from each other in the initial and final stages, suggesting that the crescent-shaped dune evolution is intrinsically scale-variant and that the crescent shape breaks down under unsaturated condition.

Keyword :

crescent-shaped sand dune scale-invariant model image processing wind tunnel experiment

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GB/T 7714 Zhang Yang , Wang Yuan , Zhou Xiaosi et al. Evolution of crescent-shaped sand dune under the influence of injected sand flux: scaling law and wind tunnel experiment [J]. | JOURNAL OF ARID LAND , 2017 , 9 (2) : 270-277 .
MLA Zhang Yang et al. "Evolution of crescent-shaped sand dune under the influence of injected sand flux: scaling law and wind tunnel experiment" . | JOURNAL OF ARID LAND 9 . 2 (2017) : 270-277 .
APA Zhang Yang , Wang Yuan , Zhou Xiaosi , Yang Bin . Evolution of crescent-shaped sand dune under the influence of injected sand flux: scaling law and wind tunnel experiment . | JOURNAL OF ARID LAND , 2017 , 9 (2) , 270-277 .
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3D numerical simulation of the evolutionary process of aeolian downsized crescent-shaped dunes SCIE Scopus
期刊论文 | 2016 , 21 , 45-52 | AEOLIAN RESEARCH | IF: 2.298
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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Abstract :

A dune constitutive model was coupled with a large eddy simulation (LES) with the Smagorinsky subgrid-scale (SGS) model to accurately describe the evolutionary process of dunes from the macroscopic perspective of morphological dynamics. A 3D numerical simulation of the evolution of aeolian downsized crescent-shaped dunes was then performed. The evolution of the 3D structure of Gaussian-shaped dunes was simulated under the influence of gravity modulation, which was the same with the vertical oscillation of the sand bed to adjust the threshold of sand grain liftoff in wind tunnel experiments under the same wind speed. The influence of gravity modulation intensity on the characteristic scale parameter of the dune was discussed. Results indicated that the crescent shape of the dune was reproduced with the action of gravity during regulation of the saturation of wind-sand flow at specific times. The crescent shape was not dynamically maintained as time passed, and the dunes dwindled until they reached final decomposition because of wind erosion. The height of the dunes decreased over time, and the height time curve converged as the intensity of modulation increased linearly. The results qualitatively agreed with those obtained from wind tunnel experiments. (C) 2016 Elsevier B.V. All rights reserved.

Keyword :

Downsized Numerical stimulation Modulation of gravity Crescent-shaped dune

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GB/T 7714 Zhou, Xiaosi , Zhang, Yang , Wang, Yuan et al. 3D numerical simulation of the evolutionary process of aeolian downsized crescent-shaped dunes [J]. | AEOLIAN RESEARCH , 2016 , 21 : 45-52 .
MLA Zhou, Xiaosi et al. "3D numerical simulation of the evolutionary process of aeolian downsized crescent-shaped dunes" . | AEOLIAN RESEARCH 21 (2016) : 45-52 .
APA Zhou, Xiaosi , Zhang, Yang , Wang, Yuan , Li, Min . 3D numerical simulation of the evolutionary process of aeolian downsized crescent-shaped dunes . | AEOLIAN RESEARCH , 2016 , 21 , 45-52 .
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Measurement of sand creep on a flat sand bed using a high-speed digital camera: Mesoscopic features of creeping grains EI SCIE Scopus
期刊论文 | 2016 , 63 (3) , 629-644 | SEDIMENTOLOGY | IF: 3.638
WoS CC Cited Count: 2 SCOPUS Cited Count: 2
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Abstract :

The characterization of aeolian sand creep motion remains incomplete. In this study, a top-view imaging system was constructed in a wind tunnel experiment to record sand creep motion on a flat sand bed. In addition, a set of 'mesoscopic' parameters was defined based on the creep trajectory that was reconstructed by a particle tracking algorithm. Statistical results show that the parameters representing the lifespan of the creep motion follow a lognormal distribution, whereas those representing the sideways grain motion deviate from the lognormal distribution. As the wind velocity increases, the sideways motion is strengthened and the lifespan of the creep motion is shortened, indicating a stronger transition from creep to saltation. Furthermore, under a 'pure rolling' hypothesis, the creep trajectory can be transformed into two numbers of rolling cycles from the perspectives of space and time. The ratio of the two numbers is useful in identifying the specific mode of the creep motion.

Keyword :

particle tracking sand creep motion mesoscopic parameter wind tunnel experiment Creep trajectory

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GB/T 7714 Zhang, Yang , Wang, Yuan , Yang, Bin et al. Measurement of sand creep on a flat sand bed using a high-speed digital camera: Mesoscopic features of creeping grains [J]. | SEDIMENTOLOGY , 2016 , 63 (3) : 629-644 .
MLA Zhang, Yang et al. "Measurement of sand creep on a flat sand bed using a high-speed digital camera: Mesoscopic features of creeping grains" . | SEDIMENTOLOGY 63 . 3 (2016) : 629-644 .
APA Zhang, Yang , Wang, Yuan , Yang, Bin , Jia, Pan . Measurement of sand creep on a flat sand bed using a high-speed digital camera: Mesoscopic features of creeping grains . | SEDIMENTOLOGY , 2016 , 63 (3) , 629-644 .
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Experimental study on an indoor scale solar chimney setup in an artificial environment simulation laboratory EI SCIE Scopus
期刊论文 | 2016 , 107 , 818-826 | APPLIED THERMAL ENGINEERING | IF: 3.444
WoS CC Cited Count: 13 SCOPUS Cited Count: 14
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Abstract :

An artificial environment simulation laboratory (AESL) was built and successfully applied to the experimental study of a solar chimney setup for the first time. A solar simulator and a temperature control system are included in the laboratory to achieve active control of environmental parameters. An indoor scale solar chimney setup with a collector diameter of 1.22 m and chimney height of 1 m was constructed in the testing area of the AESL. The airflow temperature and updraft velocity were measured for the solar chimney setup with varying radiation intensities and chimney heights. The measured data were used to validate a thermal model for the collector. The thermal characteristics of the solar collector were investigated through the temperature field in the collector. The upper limitations on the collector radius and chimney height were discussed based on experimental results. The experimental work on the basic solar chimney setup performance helped in understanding the thermodynamic characteristics of the solar chimney power plant (SCPP), thereby serving as the basis for the design of large-scale commercial SCPPs. (C) 2016 Elsevier Ltd. All rights reserved.

Keyword :

Collector thermal model Solar chimney power plant Artificial environment simulation Experimental study

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GB/T 7714 Guo, Penghua , Wang, Yuan , Meng, Qinglong et al. Experimental study on an indoor scale solar chimney setup in an artificial environment simulation laboratory [J]. | APPLIED THERMAL ENGINEERING , 2016 , 107 : 818-826 .
MLA Guo, Penghua et al. "Experimental study on an indoor scale solar chimney setup in an artificial environment simulation laboratory" . | APPLIED THERMAL ENGINEERING 107 (2016) : 818-826 .
APA Guo, Penghua , Wang, Yuan , Meng, Qinglong , Li, Jingyin . Experimental study on an indoor scale solar chimney setup in an artificial environment simulation laboratory . | APPLIED THERMAL ENGINEERING , 2016 , 107 , 818-826 .
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微气候多参数综合环境模拟实验平台建设
期刊论文 | 2015 , (4) , 244-250 | 实验技术与管理
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设计并建立了近地层微气候环境模拟实验平台.分析了实验室围护结构的构造特性,完成了实验室的温度模拟系统、日光模拟系统、风速模拟系统、计算机控制系统及围护结构的硬件建设.以典型环境参数为例,给出部分模拟结果.从模拟结果可以看出,该实验室设计达到了预期目标.该实验室的建成,为发生在近地层中各类物理现象的可控模拟提供了全新的实验平台.

Keyword :

多参数 微气候 环境模拟实验平台

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GB/T 7714 孟庆龙 , 丁帅 , 王元 et al. 微气候多参数综合环境模拟实验平台建设 [J]. | 实验技术与管理 , 2015 , (4) : 244-250 .
MLA 孟庆龙 et al. "微气候多参数综合环境模拟实验平台建设" . | 实验技术与管理 4 (2015) : 244-250 .
APA 孟庆龙 , 丁帅 , 王元 , 李彦鹏 , 赵凡 , 韩文生 . 微气候多参数综合环境模拟实验平台建设 . | 实验技术与管理 , 2015 , (4) , 244-250 .
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