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< Page ,Total 41459 >
miR-146a调控脂肪间充质干细胞成骨分化的机制
期刊论文 | 2022 , 26 (1) , 70-75 | 中国组织工程研究
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背景:既往研究表明,miR-146a能影响骨髓间充质干细胞成骨分化,但其在脂肪间充质干细胞成骨分化中的调节功能尚未阐明.目的:探究miR-146a对小鼠脂肪间充质干细胞成骨分化的调控作用.方法:获取雄性C57BL/6小鼠脂肪间充质干细胞,采用倒置显微镜观察细胞形态,流式细胞学方法检测第3代细胞CD29、CD44、CD45的表达,然后用miR-NC、miR-146a mimics和miR-146a inhibitor转染脂肪间充质干细胞并进行成骨诱导分化,成骨诱导第6天,采用碱性磷酸酶染色观察钙化程度,RT-PCR和Western blot检测成骨表型标志物的表达;成骨诱导第12天,采用茜素红染色鉴定细胞表面矿化基质的产生.结果与结论:①培养的细胞为长梭形,呈成纤维样生长,第3代细胞CD29、CD44高表达,CD45低表达;②随着成骨诱导时间的延长,小鼠脂肪间充质干细胞miR-146a的表达逐渐降低(P < 0.05);③与miR-NC组相比,碱性磷酸酶显色及其活性在miR-146a mimic组显著减弱,而在miR-146a inhibitor组显著增强(P < 0.05);④与miR-NC组相比,ALP、Runx2、Akt、PI3K的mRNA和蛋白表达及p-Akt与p-PI3K的蛋白表达在miR-146a mimic组显著降低,而在miR-146a inhibitor组显著升高(P < 0.05);⑤与miR-NC组相比,茜素红染色发现miR-146a mimic组细胞的钙化程度显著降低(P < 0.05),而miR-146a inhibitor组的钙化程度显著升高(P < 0.05);⑥上述结果表明,miR-146a能够通过PI3K/AKT信号通路负向调控脂肪间充质干细胞向成骨细胞分化.

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GB/T 7714 黄涛 , 程志坚 , 贾志强 et al. miR-146a调控脂肪间充质干细胞成骨分化的机制 [J]. | 中国组织工程研究 , 2022 , 26 (1) : 70-75 .
MLA 黄涛 et al. "miR-146a调控脂肪间充质干细胞成骨分化的机制" . | 中国组织工程研究 26 . 1 (2022) : 70-75 .
APA 黄涛 , 程志坚 , 贾志强 , 赵晓光 , 王磊 , 翟文静 et al. miR-146a调控脂肪间充质干细胞成骨分化的机制 . | 中国组织工程研究 , 2022 , 26 (1) , 70-75 .
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Biphasic sensitization effect of NO2 on n-C4H10 auto-ignition EI
期刊论文 | 2022 , 237 | Combustion and Flame
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NOx in the exhaust gas can influence the auto-ignition properties, thus are important for the design and operation of HCCI engines and predicting engine knock in spark ignition engines. More work is clearly required to improve the understanding on fuel/NOx chemistry for both reaction mechanism construction and engine application. In this study, n-C4H10, as a representative hydrocarbon fuel with the negative temperature coefficient (NTC) behavior, was selected for test. Ignition delay times of n-C4H10/air mixtures with varying NO2 addition (0, 500 ppm, 1%, and 5%) have been measured behind reflected shock waves. The sensitization effect of NO2 on n-C4H10 auto-ignition was investigated at engine relevant conditions covering temperatures from 700 to 1200 K, pressure of 20 atm, and equivalence ratios from 1.0 to 2.0. Besides, the mixtures with excessive amounts of NO2 (5% and 10%) were also studied at relatively high temperatures and 10 atm, aiming at highlighting the interactions between NO2 and n-C4H10. Results indicated the effect of NO2 on n-C4H10 oxidation exhibits prominent temperature and NO2 concentration dependences. Trace NO2 addition (500 ppm) promotes low-temperature reactivity of n-C4H10 and reduces the ignition delay times. While higher levels of NO2 no longer promote ignition, instead, it turns gradually to be an inhibiting effect. At high temperatures, NO2 dramatically accelerates the n-C4H10 oxidation, and the promoting effect peaks at around 5% NO2 then saturates with further NO2 addition. In the negative temperature coefficient region, the NTC behavior of n-C4H10 is weakened and even disappears by the introduction of NO2. A preliminary detailed kinetic model was proposed to describe the n-C4H10/NO2 chemistry, and in general, is capable of capturing the NO2 sensitization behaviors under different conditions. Kinetic analyses were then performed to clarify the sensitization mechanisms of NO2 and the chemical interactions between NO2 and n-C4H10. © 2021 The Combustion Institute

Keyword :

Chemical detection Temperature Nitrogen oxides Negative temperature coefficient Ignition Shock waves Mixtures Lasers Masers

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GB/T 7714 Wu, Honghuan , Sun, Wuchuan , Huang, Zuohua et al. Biphasic sensitization effect of NO2 on n-C4H10 auto-ignition [J]. | Combustion and Flame , 2022 , 237 .
MLA Wu, Honghuan et al. "Biphasic sensitization effect of NO2 on n-C4H10 auto-ignition" . | Combustion and Flame 237 (2022) .
APA Wu, Honghuan , Sun, Wuchuan , Huang, Zuohua , Zhang, Yingjia . Biphasic sensitization effect of NO2 on n-C4H10 auto-ignition . | Combustion and Flame , 2022 , 237 .
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Te L-shell X-ray production cross section induced by lower energy H+ and He2+ ions EI
期刊论文 | 2022 , 511 , 42-50 | Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
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The L-shell x-rays of Te have been measured for the impact of protons with energies from 100 to 300 keV, and He2+ ions in the energy range of 300–600 keV. The new experimental data of Te for individual L-subshell and total L x-ray production cross sections were extracted from the thick-target analysis of x-ray yields. This is significant for updating the existing database. The cross sections were also compared with theoretical calculations of BEA, PWBA, ECPSSR and ECUSAR along with various atomic parameter databases and including modification of multiple ionization. On the whole, The ECUSAR-MI predictions using Campbell's atomic parameters present a best agreement to the experimental data. © 2021 Elsevier B.V.

Keyword :

Ions X ray scattering Ionization Atoms X ray production

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GB/T 7714 Wei, Jing , Zhou, Xianming , Cheng, Rui et al. Te L-shell X-ray production cross section induced by lower energy H+ and He2+ ions [J]. | Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms , 2022 , 511 : 42-50 .
MLA Wei, Jing et al. "Te L-shell X-ray production cross section induced by lower energy H+ and He2+ ions" . | Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 511 (2022) : 42-50 .
APA Wei, Jing , Zhou, Xianming , Cheng, Rui , Liang, Changhui , Mei, Cexiang , Zeng, Lixia et al. Te L-shell X-ray production cross section induced by lower energy H+ and He2+ ions . | Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms , 2022 , 511 , 42-50 .
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Thermal optimization of single crystal fiber manufacturing based on heat loss compensation EI
期刊论文 | 2022 , 201 | Applied Thermal Engineering
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Single crystal fiber (SCF) manufacturing, occupying most of the difficulties in the application of next generation high power lasers, has gained significant interest over the years. The thermal optimization of the SCF growth system is imperative to solve the low output laser power and slope efficiency limited by the cracking problem. Using both experimental and simulation approaches that efficiently explore the growth process of sesquioxide crystals in the laser-heated pedestal growth (LHPG) system, the present study explains the reason why the traditional resistance afterheater does not reduce the thermal stress in the SCF from the perspective of the first and second-order derivatives of the temperature field. On the basis, a thermal optimization model based on the idea of thermal compensation is proposed. This form of heat input greatly improves the thermal stress concentration in the crystal and reduces the maximum Von Mises stress by 95%, while perfectly maintaining the uniformity of the overall temperature field. Furthermore, a semi-Gaussian fitting is performed on the optimization model hinting at the possibility of its application in practical engineering. Notably, this thermal compensation idea based on heat loss can be used for reference by other materials and growth systems in the SCF manufacturing field, because heat transfer is always the basis. © 2021 Elsevier Ltd

Keyword :

High power lasers Temperature Manufacture Crystal whiskers Thermal stress Heat transfer Heat losses

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GB/T 7714 Yin, Yuqing , Zhang, Na , Zhang, Jian et al. Thermal optimization of single crystal fiber manufacturing based on heat loss compensation [J]. | Applied Thermal Engineering , 2022 , 201 .
MLA Yin, Yuqing et al. "Thermal optimization of single crystal fiber manufacturing based on heat loss compensation" . | Applied Thermal Engineering 201 (2022) .
APA Yin, Yuqing , Zhang, Na , Zhang, Jian , Li, Zaoyang , Jia, Zhitai . Thermal optimization of single crystal fiber manufacturing based on heat loss compensation . | Applied Thermal Engineering , 2022 , 201 .
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Development and application of TaSNAM 2.0 for advanced pressurized water reactor EI
期刊论文 | 2022 , 166 | Annals of Nuclear Energy
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The Nuclear Thermal-hydraulic Laboratory (NutheL) at Xi'an Jiaotong University developed a Temporal and Spatial Neutronics Analysis Module (TaSNAM) based on the User Defined Function (UDF) and User Define Scalar (UDS) in Fluent. The neutron diffusion equations were solved based on the Finite volume method (FVM). In this paper, the TaSNAM is extended the original function to solve 3D problems and obtain neutron parameters based on the neutron parameters library, and improved to TaSNAM 2.0. The 3D-IAEA benchmark problem was selected and simulated to validate. The calculated results show good agreement with the reference values and the difference from the reference value of keff is 40pcm. A three-dimensional steady-state simulation of the whole core in AP1000 was completed employing the TaSNAM 2.0. The calculated results of important parameters agree well with the design values and the detailed three dimensional distributions of neutron flux and power were achieved. © 2021 Elsevier Ltd

Keyword :

Pressurized water reactors Hydraulic laboratories Finite volume method

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GB/T 7714 Huo, Yuchen , Yu, Hao , Wang, Mingjun et al. Development and application of TaSNAM 2.0 for advanced pressurized water reactor [J]. | Annals of Nuclear Energy , 2022 , 166 .
MLA Huo, Yuchen et al. "Development and application of TaSNAM 2.0 for advanced pressurized water reactor" . | Annals of Nuclear Energy 166 (2022) .
APA Huo, Yuchen , Yu, Hao , Wang, Mingjun , Tian, Wenxi , Qiu, Suizheng , Su, G.H . Development and application of TaSNAM 2.0 for advanced pressurized water reactor . | Annals of Nuclear Energy , 2022 , 166 .
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Assortment optimization with repeated exposures and product-dependent patience cost EI
期刊论文 | 2022 , 50 (1) , 8-15 | Operations Research Letters
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In this paper, we study the assortment optimization problem faced by many online retailers such as Amazon. We develop a cascade multinomial logit model, based on the classic multinomial logit model, to capture the consumers' purchasing behavior across multiple stages. Unlike most of existing studies, our model allows for repeated exposures of a product. In addition, each consumer has a patience budget that is sampled from a known distribution and each product is associated with a patience cost, which is the required amount of the cognitive efforts on browsing that product. We propose an approximation solution to the assortment optimization problem under cascade multinomial logit model. © 2021 Elsevier B.V.

Keyword :

Optimization Budget control Consumer behavior

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GB/T 7714 Tang, Shaojie , Yuan, Jing , Wang, Chenhao et al. Assortment optimization with repeated exposures and product-dependent patience cost [J]. | Operations Research Letters , 2022 , 50 (1) : 8-15 .
MLA Tang, Shaojie et al. "Assortment optimization with repeated exposures and product-dependent patience cost" . | Operations Research Letters 50 . 1 (2022) : 8-15 .
APA Tang, Shaojie , Yuan, Jing , Wang, Chenhao , Wang, Yao , Chen, Luoying . Assortment optimization with repeated exposures and product-dependent patience cost . | Operations Research Letters , 2022 , 50 (1) , 8-15 .
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A void closure model based on hydrostatic integration and the Lode parameter for additive manufacturing AlSi10Mg EI
期刊论文 | 2022 , 73 , 235-247 | Journal of Manufacturing Processes
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The void closure model is urgently needed for the subsequent hot forming process of additive manufacturing (AM) products. The influence of temperature, Lode parameter, and hydrostatic integration (Gm) on void closure was studied by representative volume element (RVE) simulations. The results show that Gm and the Lode parameter significantly influence void closure, and the temperature effect is related to material properties. A new model accounting for Gm and Lode parameter in evaluating void closure was developed using linear regression with an average error of 2.1% in comparison to RVE simulations. X-ray computed tomography (CT) was carried out at different high reductions for the AM cylinder's hot forging experiments. The new and stress-triaxiality-based (STB) models were integrated into the ABAQUS and compared with the CT measurements. Results indicate that the model is more precise than the STB model, suggesting that the model can be appropriately applied to forecast void closure during the hot forging process for AM products. © 2021 The Society of Manufacturing Engineers

Keyword :

Forging Volume measurement Additives 3D printers Integration Hydraulics Computerized tomography

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GB/T 7714 Niu, Liqun , Zhang, Qi . A void closure model based on hydrostatic integration and the Lode parameter for additive manufacturing AlSi10Mg [J]. | Journal of Manufacturing Processes , 2022 , 73 : 235-247 .
MLA Niu, Liqun et al. "A void closure model based on hydrostatic integration and the Lode parameter for additive manufacturing AlSi10Mg" . | Journal of Manufacturing Processes 73 (2022) : 235-247 .
APA Niu, Liqun , Zhang, Qi . A void closure model based on hydrostatic integration and the Lode parameter for additive manufacturing AlSi10Mg . | Journal of Manufacturing Processes , 2022 , 73 , 235-247 .
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Thermal Energy Storage Air-conditioning Demand Response Control Using Elman Neural Network Prediction Model EI
期刊论文 | 2022 , 76 | Sustainable Cities and Society
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Load forecasting plays a vital role in the effort to solve the imbalance between supply and demand in smart grids. In buildings, a large part of electricity load comes from heating, ventilation, and air-conditioning (HVAC), which has been deemed as effective DR resource, especially in system with thermal energy storage (TES). However, it is difficult to define the optimal charging and discharging period for TES in real DR events. Meanwhile, few studies have combined load forecasting with suitable demand response strategy for TES systems in field tests. Thus, this study develops an Elman neural network (ENN) prediction model for both load and TES. Based on this prediction model, a control strategy for DR is proposed in an office building. To get historical data, a TRNSYS simulation model was established. The ENN model was adopted by comparing with four other machine learning algorithms and then coupled with particle swarm optimization for optimizing load forecasting. Experimental results show that the ENN prediction model gains great fitness in the actual load curve and the storage-release time of the energy storage tank. Furthermore, case studies indicate that the proposed strategy can effectively reduce energy use and operation costs without comprising thermal comfort. © 2021

Keyword :

Electric power plant loads Heat storage Air conditioning Energy utilization Thermal energy Deterioration Digital storage Economics Learning algorithms Machine learning Electric load management Forecasting Curve fitting Office buildings Particle swarm optimization (PSO) Electric energy storage

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GB/T 7714 Meng, Qinglong , Xi, Yuan , Ren, Xiaoxiao et al. Thermal Energy Storage Air-conditioning Demand Response Control Using Elman Neural Network Prediction Model [J]. | Sustainable Cities and Society , 2022 , 76 .
MLA Meng, Qinglong et al. "Thermal Energy Storage Air-conditioning Demand Response Control Using Elman Neural Network Prediction Model" . | Sustainable Cities and Society 76 (2022) .
APA Meng, Qinglong , Xi, Yuan , Ren, Xiaoxiao , Li, Hui , Jiang, Le , Yang, Li . Thermal Energy Storage Air-conditioning Demand Response Control Using Elman Neural Network Prediction Model . | Sustainable Cities and Society , 2022 , 76 .
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The SES-based difference of adolescents’ digital skills and usages: An explanation from family cultural capital EI
期刊论文 | 2022 , 177 | Computers and Education
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Drawing on Pierre Bourdieu's framework of cultural capital, the study explored whether family cultural capital contributed to adolescents' digital inequality regarding both digital skills and usages of digital media and could further explain the relationship between social origins and youth's digital diversity. Cultural capital was operationalized as family cultural resources, cultural practices and media-related parenting activities (i.e., active and restrictive mediation). We tested the proposed hypotheses using data collected from 1119 middle school students in China. The results showed that cultural resources, cultural practices and active parental mediation were significant predictors of adolescents' general digital skill, creative skill and educational use of Internet, whereas leisure use of Internet was not explained by family cultural capital. The results also suggested a relatively complex pattern of relationships between restrictive parental mediation and different dimensions of digital inequality. The path analysis further revealed that cultural resources, cultural practices and active mediation were mechanisms underlying the effects of family SES on adolescents' digital practices. The role of family cultural capital in teenagers' digital practices was discussed in the context of media education. © 2021 Elsevier Ltd

Keyword :

Leisure E-learning Regression analysis Digital storage

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GB/T 7714 Ren, Wei , Zhu, Xiaowen , Yang, Jianghua . The SES-based difference of adolescents’ digital skills and usages: An explanation from family cultural capital [J]. | Computers and Education , 2022 , 177 .
MLA Ren, Wei et al. "The SES-based difference of adolescents’ digital skills and usages: An explanation from family cultural capital" . | Computers and Education 177 (2022) .
APA Ren, Wei , Zhu, Xiaowen , Yang, Jianghua . The SES-based difference of adolescents’ digital skills and usages: An explanation from family cultural capital . | Computers and Education , 2022 , 177 .
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Acoustofluidic Patterning inside Capillary Tubes Using Standing Surface Acoustic Waves EI
期刊论文 | 2022 , 214 | International Journal of Mechanical Sciences
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Acoustofluidic platforms have great potentials to integrate capillary tubes for controlling and manipulating microparticles and biological cells in both non-flowing and continuous-flow settings. In order to effectively manipulate microparticles/cells inside capillary tubes, it is essential to fully understand and control the patterns generated inside the capillary tubes with different cross-sections, and to investigate the influences of configuration and position arrangement of electrodes along with the capillary tubes. This paper aims to systematically investigate the patterning and alignment of microparticles inside glass capillary tubes using thin film surface acoustic wave (SAW) devices. Through both experimental studies and numerical modelling, effects of various cross-section geometries of the capillary tubes and their positioning with respect to the direction of interdigital transducers (IDTs) of the SAW device in both a stationary fluid and a continuous flow fluid were studied. Results showed that for the rectangular glass capillary tubes, the patterned lines of particles are parallel to the tube's side walls, irrelevant to the tube positions along with the IDTs, which is mainly caused by the standing wave field generated inside the rectangular glass tube. Whereas for the circular glass capillary tubes, alignment patterns of particles are quite different along the tube's height. At the bottom of the circular tube, particles are patterned into lines parallel to the tube direction, because the acoustic waves propagate into the water and form a standing wave along the direction of the circular tube. Whereas at the middle height of the tube, the particles are patterned into lines perpendicular to the tube direction, because the formed standing waves also propagate around the circular cross-section of the tube and are perpendicular to the tube direction. For the cases with a continuous liquid flow, under the agitation of acoustic waves, particles are patterned in lines parallel to the flow directions for both the rectangular and circular glass tubes, and the fluid flow enhances and smoothens the patterned lines of the particles. © 2021 The Author(s)

Keyword :

Tubes (components) Thin films Ultrasonic transducers Acoustic waves Glass Capillary tubes Numerical models Acoustic surface wave devices Acoustic wave propagation

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GB/T 7714 Maramizonouz, Sadaf , Jia, Changfeng , Rahmati, Mohammad et al. Acoustofluidic Patterning inside Capillary Tubes Using Standing Surface Acoustic Waves [J]. | International Journal of Mechanical Sciences , 2022 , 214 .
MLA Maramizonouz, Sadaf et al. "Acoustofluidic Patterning inside Capillary Tubes Using Standing Surface Acoustic Waves" . | International Journal of Mechanical Sciences 214 (2022) .
APA Maramizonouz, Sadaf , Jia, Changfeng , Rahmati, Mohammad , Zheng, Tengfei , Liu, Qiang , Torun, Hamdi et al. Acoustofluidic Patterning inside Capillary Tubes Using Standing Surface Acoustic Waves . | International Journal of Mechanical Sciences , 2022 , 214 .
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