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陕西地区心血管疾病患者ApoE基因多态性分布及其与血脂水平和冠心病类型的相关性
期刊论文 | 2021 , 42 (3) , 398-401 | 西安交通大学学报(医学版)
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目的 了解陕西地区心血管疾病患者载脂蛋白E(ApoE)基因多态性分布,同时探讨其与血脂水平和冠心病类型的相关性.方法 选取2019年1月至2019年12月于西安交通大学第一附属医院住院的陕西地区汉族心血管疾病患者11533例,采用PCR-荧光探针法检测ApoE基因;进一步选取其中冠心病患者3884例检测空腹血脂水平并进行冠心病分类,采用PCR-RFLP对ApoE基因进行多态性分析.结果 陕西地区汉族人群心血管疾病患者ApoE各基因型E2/E2、E2/E3、E3/E3、E2/E4、E4/E4和E3/E4比例分别为0.69%、11.66%、70.31%、1.17%、0.83% 和15.34%,基因型组合中E3型比例最高,占71.48%,E4型次之,为16.17%;E2型最少,为12.35%.在冠心病与非冠心病心血管疾病患者中ApoE基因分布差异无统计学意义.与E2型相比,E3型、E4型患者的总胆固醇(TC)和低密度脂蛋白(LDL-C)水平升高,差异具有统计学意义(P<0.001);与E3型相比,E2型、E4型的三酰甘油(TG)水平升高,差异有统计学意义(P<0.050).ApoE基因型与冠心病类型具有相关性(P<0.001),其在缺血性心肌病与稳定型心绞痛和不稳定型心绞痛中的基因型分布差异有统计学意义(P<0.001),与急性心肌梗死相比分布无统计学差异(P>0.0083).结论 陕西地区心血管疾病患者ApoE基因多态性以E3型为主,冠心病与其他类型心血管疾病分布无统计学差异;ApoE基因多态性与血脂水平和冠心病具有相关性,但与不同类型冠心病的关系尚待明确.

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冠心病 ApoE基因多态性 血脂水平

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GB/T 7714 肖懿慧 , 舒娟 , 袁祖贻 et al. 陕西地区心血管疾病患者ApoE基因多态性分布及其与血脂水平和冠心病类型的相关性 [J]. | 西安交通大学学报(医学版) , 2021 , 42 (3) : 398-401 .
MLA 肖懿慧 et al. "陕西地区心血管疾病患者ApoE基因多态性分布及其与血脂水平和冠心病类型的相关性" . | 西安交通大学学报(医学版) 42 . 3 (2021) : 398-401 .
APA 肖懿慧 , 舒娟 , 袁祖贻 , 刘睿辰 . 陕西地区心血管疾病患者ApoE基因多态性分布及其与血脂水平和冠心病类型的相关性 . | 西安交通大学学报(医学版) , 2021 , 42 (3) , 398-401 .
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Comparison Between a Novel Sirolimus-Eluting Bioresorbable Scaffold With Everolimus-Eluting Metallic Stent in Patients With Coronary Artery Disease: Three-Year Follow-Up From the NeoVas RCT Study SCIE
期刊论文 | 2021 , 78 (19) , B47-B47 | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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GB/T 7714 Xu, Kai , Xu, Bo , Fu, Guosheng et al. Comparison Between a Novel Sirolimus-Eluting Bioresorbable Scaffold With Everolimus-Eluting Metallic Stent in Patients With Coronary Artery Disease: Three-Year Follow-Up From the NeoVas RCT Study [J]. | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY , 2021 , 78 (19) : B47-B47 .
MLA Xu, Kai et al. "Comparison Between a Novel Sirolimus-Eluting Bioresorbable Scaffold With Everolimus-Eluting Metallic Stent in Patients With Coronary Artery Disease: Three-Year Follow-Up From the NeoVas RCT Study" . | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 78 . 19 (2021) : B47-B47 .
APA Xu, Kai , Xu, Bo , Fu, Guosheng , Wang, Xiaozeng , Tao, Ling , Li, Lang et al. Comparison Between a Novel Sirolimus-Eluting Bioresorbable Scaffold With Everolimus-Eluting Metallic Stent in Patients With Coronary Artery Disease: Three-Year Follow-Up From the NeoVas RCT Study . | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY , 2021 , 78 (19) , B47-B47 .
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Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice SCIE PubMed
期刊论文 | 2021 , 75 (1) , 238-241 | JOURNAL OF HEPATOLOGY
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GB/T 7714 Xu, Liran , Wettschureck, Nina , Bai, Yongping et al. Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice [J]. | JOURNAL OF HEPATOLOGY , 2021 , 75 (1) : 238-241 .
MLA Xu, Liran et al. "Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice" . | JOURNAL OF HEPATOLOGY 75 . 1 (2021) : 238-241 .
APA Xu, Liran , Wettschureck, Nina , Bai, Yongping , Yuan, Zuyi , Wang, Shengpeng . Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice . | JOURNAL OF HEPATOLOGY , 2021 , 75 (1) , 238-241 .
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Circulating lipid and lipoprotein profiles and their correlation to cardiac function and cardiovascular outcomes in patients with acute myocardial infarction SCIE PubMed
期刊论文 | 2021 , 69 (7) , 1310-1317 | JOURNAL OF INVESTIGATIVE MEDICINE
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Recent studies showed that lipoproteins represent major risk factors, both positive and negative, for atherosclerotic cardiovascular disease. The aim of the present study was to describe the relationship between plasma lipid profile and cardiac function and cardiovascular outcomes in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Two independent groups of subjects including a total of 797 patients diagnosed of AMI undergoing PCI admitted to the First Affiliated Hospital of Xi'an Jiaotong University were included in the present study. We performed a cross-sectional study for the correlation between plasma lipid profile and cardiac function based on the first group, including 503 patients with AMI. We further validated the correlation and did the follow-up of 2.4 years of major cardiovascular outcomes on the second group, including 294 patients with AMI. Our results showed that apolipoprotein A-I (ApoA-I) level was significantly reduced, and the high-density lipoprotein cholesterol (HDL-C):ApoA-I ratio was increased in the patients with lower LVEF or higher N-terminal pro-B-type natriuretic peptide levels compared with the control; there was a positive correlation between cardiac function and ApoA-I, and a negative correlation between cardiac function and the HDL-C:ApoA-I ratio. Meanwhile, multivariate Cox analysis showed that ApoA-I was independent predictors of major adverse cardiovascular events (MACEs). Kaplan-Meier survival analysis showed the ApoA-I levels exhibited a significant effect on predicting the incidence of MACEs. In sum, plasma ApoA-I level is positively associated with the cardiac function of patients with AMI after PCI, and ApoA-I is an independent indicator to predict the incidence of MACEs.

Keyword :

lipoproteins lipids cardiovascular diseases biomarkers HDL apolipoprotein A-I

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GB/T 7714 Wu, Haoyu , Wang, Chen , Tuerhongjiang, Gulinigaer et al. Circulating lipid and lipoprotein profiles and their correlation to cardiac function and cardiovascular outcomes in patients with acute myocardial infarction [J]. | JOURNAL OF INVESTIGATIVE MEDICINE , 2021 , 69 (7) : 1310-1317 .
MLA Wu, Haoyu et al. "Circulating lipid and lipoprotein profiles and their correlation to cardiac function and cardiovascular outcomes in patients with acute myocardial infarction" . | JOURNAL OF INVESTIGATIVE MEDICINE 69 . 7 (2021) : 1310-1317 .
APA Wu, Haoyu , Wang, Chen , Tuerhongjiang, Gulinigaer , Qiao, Xiangrui , Hua, Yiming , She, Jianqing et al. Circulating lipid and lipoprotein profiles and their correlation to cardiac function and cardiovascular outcomes in patients with acute myocardial infarction . | JOURNAL OF INVESTIGATIVE MEDICINE , 2021 , 69 (7) , 1310-1317 .
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An Optimized Model of Hypertrophic Preconditioning Confers Cardioprotection in the Mouse SCIE PubMed
期刊论文 | 2021 , 264 , 544-552 | JOURNAL OF SURGICAL RESEARCH
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Background: Conventional models of hypertrophic preconditioning (C-HP) can be established surgically through transverse aortic constriction (TAC) -> deconstriction (De-TAC) -> reconstriction (Re-TAC) characterized by dynamic afterload while it exerts technical difficulty on operators and poses high mortality during perioperative period in mice. Weaimed to introduce an optimized method for obtaining a hypertrophic preconditioning (O-HP) model for further study on cardiac hypertrophy. Methods: Ninety mice were divided into four groups: sham, TAC, C-HP, and O-HP. The sham group was exerted on three-time thoracotomies. The TAC group experienced twice thoracotomies and one TAC operation. C-HP and O-HP groups were given TAC, De-TAC, and Re-TAC operation at day 0, day 3, and day 7 in conventional and optimized method, respectively. We optimized the operating procedure in O-HP mice compared with the C-HP group by (1) leaving a w3-cm suture fixed in the subcutaneous layer after aortic constriction in TAC surgery (2) using two small forceps to untie the constriction knot instead of cutting it in the De-TAC operation. Ultrasound biomicroscopy was used for hemodynamics and cardiac function detection. Four weeks after the third surgery, all mice were sacrificed and pathology was analyzed among four groups. Results: Four weeks after Re-TAC, the survival of O-HP mice was 63.3% while that of C-HP was 26.7%. Ultrasound biomicroscopy showed a successful establishment of HP models. C-HP and O-HP mice had improved cardiac structure and function indicated by left ventricular end-systolic diameter, left ventricular end-systolic posterior wall thickness, left ventricular ejection fraction, and left ventricular fractional shortening than the TAC group. Pathological analysis showed O-HP as well as C-HP had less hypertrophy than the TAC mice. Conclusions: Our results provide a rapid, safe, efficient, and reproducible method for optimized establishment of the HP model, which will facilitate studies for early intervention and prevention of left ventricular hypertrophy and heart failure. (C) 2020 Elsevier Inc. All rights reserved.

Keyword :

Optimized model Hypertrophic preconditioning Ultrasound biomicroscopy Cardiac hypertrophy Transverse aortic constriction

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GB/T 7714 Cai, Xiaojie , Tian, Yuling , Wu, Yue et al. An Optimized Model of Hypertrophic Preconditioning Confers Cardioprotection in the Mouse [J]. | JOURNAL OF SURGICAL RESEARCH , 2021 , 264 : 544-552 .
MLA Cai, Xiaojie et al. "An Optimized Model of Hypertrophic Preconditioning Confers Cardioprotection in the Mouse" . | JOURNAL OF SURGICAL RESEARCH 264 (2021) : 544-552 .
APA Cai, Xiaojie , Tian, Yuling , Wu, Yue , Bonner, Michael Y. , Zhuo, Xiaozhen , Yuan, Zuyi . An Optimized Model of Hypertrophic Preconditioning Confers Cardioprotection in the Mouse . | JOURNAL OF SURGICAL RESEARCH , 2021 , 264 , 544-552 .
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The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention. PubMed
期刊论文 | 2021 , 8 , 731261 | Frontiers in cardiovascular medicine
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Inflammation and nutrition as main factors can affect the prognosis of patients with chronic total coronary occlusion (CTO) undergoing percutaneous coronary intervention (PCI). The C-reactive protein to albumin ratio (CAR) can clarify the inflammation and nutrition status, which are highly related to clinical outcomes. This study aims to investigate the association between CAR and adverse cardiovascular events in patients with CTO undergoing PCI. For this study, 664 patients were divided into three groups based on the tertiles of CAR. The primary endpoint was all-cause mortality and the secondary endpoint was major adverse cardiovascular events (MACE). Over a median follow-up of 33.7 months, the primary endpoint occurred in 64 patients (9.6%) and the secondary endpoint occurred in 170 patients (25.6%). The patients with higher CAR represented a worse prognosis with all-cause death and cardiovascular death after the adjustment for the baseline risk factors. Adding the CAR values raised the predictive value for the incidence of the all-cause death and cardiovascular death but not MACE. The capacity of prognosis prediction was improved after the addition of the CAR value to the traditional prediction model.

Keyword :

percutaneous coronary intervention c-reactive protein to albumin ratio chronic coronary total occlusion prognostic indicator adverse cardiovascular events

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GB/T 7714 Cheng Lele , Meng Zixuan , Wang Qi et al. The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention. [J]. | Frontiers in cardiovascular medicine , 2021 , 8 : 731261 .
MLA Cheng Lele et al. "The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention." . | Frontiers in cardiovascular medicine 8 (2021) : 731261 .
APA Cheng Lele , Meng Zixuan , Wang Qi , Jian Zhijie , Fan Pengcheng , Feng Xinxin et al. The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention. . | Frontiers in cardiovascular medicine , 2021 , 8 , 731261 .
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Interplay Between Gut Microbiota and Amino Acid Metabolism in Heart Failure SCIE PubMed
期刊论文 | 2021 , 8 | FRONTIERS IN CARDIOVASCULAR MEDICINE
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Heart failure (HF) is a complex clinical syndrome of which the incidence is on the rise worldwide. Cardiometabolic disorders are associated with the deterioration of cardiac function and progression of HF. Recently, there has been renewed interest in gut microbiota (GM) and its metabolites in the cardiovascular disease. HF-caused hypoperfusion could increase intestinal permeability, and a "leaky" bowel leads to bacterial translocation and make its metabolites more easily enter the circulation. Considerable evidence shows that the composition of microbiota and amino acids (AAs) has been altered in HF patients, and AAs could serve as a diagnostic and prognostic biomarker in HF. The findings indicate that the gut-amino acid-HF axis may play a key role in the progression of HF. In this paper, we focus on the interrelationship between the AA metabolism and GM alterations during the development of heart failure. We also discuss the potential prognostic and therapeutic value of the gut-amino acid-HF axis in the cortex of HF.

Keyword :

amino acids heart failure cardiometabolic disorders gut microbiota metabolism

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GB/T 7714 Tuerhongjiang, Gulinigaer , Guo, Manyun , Qiao, Xiangrui et al. Interplay Between Gut Microbiota and Amino Acid Metabolism in Heart Failure [J]. | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2021 , 8 .
MLA Tuerhongjiang, Gulinigaer et al. "Interplay Between Gut Microbiota and Amino Acid Metabolism in Heart Failure" . | FRONTIERS IN CARDIOVASCULAR MEDICINE 8 (2021) .
APA Tuerhongjiang, Gulinigaer , Guo, Manyun , Qiao, Xiangrui , Lou, Bowen , Wang, Chen , Wu, Haoyu et al. Interplay Between Gut Microbiota and Amino Acid Metabolism in Heart Failure . | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2021 , 8 .
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Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress SCIE PubMed
期刊论文 | 2021 , 135 (14) , 1689-1706 | CLINICAL SCIENCE
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Recent studies reveal that bile acid metabolite composition and its metabolism are changed in metabolic disorders, such as obesity, type 2 diabetes and metabolic associated fatty liver disease (MAFLD), yet its role and the mechanism remain largely unknown. In the present study, metabolomic analysis of 163 serum and stool samples of our metabolic disease cohort was performed, and we identified glycoursodeoxycholic acid (GUDCA), glycine-conjugated bile acid produced from intestinal bacteria, was decreased in both serum and stool samples from patients with hyperglycemia. RNA-sequencing and quantitative PCR results indicated that GUDCA alleviated endoplasmic reticulum (ER) stress in livers of high fat diet (HFD)-fed mice without alteration of liver metabolism. In vitro, GUDCA reduced palmitic acid induced-ER stress and -apoptosis, as well as stabilized calcium homeostasis. In vivo, GUDCA exerted effects on amelioration of HFD-induced insulin resistance and hepatic steatosis. In parallel, ER stress and apoptosis were decreased in GUDCA-treated mice as compared with vehicle-treated mice in liver. These findings demonstrate that reduced GUDCA is an indicator of hyperglycemia. Supplementation of GUDCA could be an option for the treatment of diet-induced metabolic disorders, including insulin resistance and hepatic steatosis, with inhibiting ER stress.

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GB/T 7714 Cheng, Lele , Chen, Tao , Guo, Manyun et al. Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress [J]. | CLINICAL SCIENCE , 2021 , 135 (14) : 1689-1706 .
MLA Cheng, Lele et al. "Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress" . | CLINICAL SCIENCE 135 . 14 (2021) : 1689-1706 .
APA Cheng, Lele , Chen, Tao , Guo, Manyun , Liu, Peining , Qiao, Xiangrui , Wei, Yuanyuan et al. Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress . | CLINICAL SCIENCE , 2021 , 135 (14) , 1689-1706 .
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ARNI versus ACEI/ARB in Reducing Cardiovascular Outcomes after Myocardial Infarction SCIE PubMed
期刊论文 | 2021 | ESC HEART FAILURE
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Aims This study aimed to compare the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) therapy with angiotensin converting enzyme inhibitor or angiotensin receptor blocker (ACEI/ARB) therapy for cardiovascular outcomes in patients with acute myocardial infarction (AMI). Methods and results Data were collected from the Biobank of the First Affiliated Hospital of Xi'an Jiaotong University between January 2016 and December 2020. A total of 7556 AMI patients were screened for eligibility. Propensity score matching based on age, sex, blood pressure, kidney function, baseline left ventricular ejection fraction (LVEF), and cardiovascular medication were conducted, resulting in 291 patients with AMI being assigned to ARNI, ACEI, and ARB group, respectively. Patients receiving ARNI had significantly lower rates of the composite cardiovascular outcome than ACEI {hazard ratio [HR] 0.51, [95% confidence interval (CI), 0.27-0.95], P = 0.02}, and ARB users [HR 0.47, (95%CI, 0.24-0.90), P = 0.02]. Patients receiving ARNI showed lower rates of cardiovascular death than ACEI [HR 0.37, (95%CI, 0.18-0.79), P = 0.01] and ARB users [HR 0.41, (95%CI, 0.18-0.95), P = 0.04]. Subgroup analysis indicated that patients with LVEF no more than 40% tend to benefit more from ARNI as compared with ACEI [HR 0.30, (95%CI, 0.11-0.86), P = 0.01] or ARB [HR 0.21, (95%CI, 0.04-1.1), P = 0.05]. Patients aged no more than 60 years exhibited reduced composite endpoints [HR for ARNI vs. ARB: 0.11, (95%CI, 0.03-0.46), P = 0.002]. Conclusions In patients with AMI, ARNI was superior to ACEI/ARB in reducing the long-term adverse cardiovascular outcomes. Subgroup analysis further indicates that ARNI is more likely to benefit patients with LVEF less than 40% and aged less than 60 years.

Keyword :

Angiotensin converting enzyme inhibitor (ACEI) Acute myocardial infarction Angiotensin receptor blockers (ARB) Sacubitril/valsartan (LCZ696)

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GB/T 7714 She, Jianqing , Lou, Bowen , Liu, Hui et al. ARNI versus ACEI/ARB in Reducing Cardiovascular Outcomes after Myocardial Infarction [J]. | ESC HEART FAILURE , 2021 .
MLA She, Jianqing et al. "ARNI versus ACEI/ARB in Reducing Cardiovascular Outcomes after Myocardial Infarction" . | ESC HEART FAILURE (2021) .
APA She, Jianqing , Lou, Bowen , Liu, Hui , Zhou, Bo , Jiang, Gulinigaer Tuerhong , Luo, Yongbai et al. ARNI versus ACEI/ARB in Reducing Cardiovascular Outcomes after Myocardial Infarction . | ESC HEART FAILURE , 2021 .
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The effect of Sacubitril/Valsartan on cardiac function and cardiac remodeling in patients with heart failure with reduced ejection fraction SCIE PubMed
期刊论文 | 2021 , 10 (8) , 8684-8691 | ANNALS OF PALLIATIVE MEDICINE
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Background: The aim of this study was to observe the effect of Sacubitril/Valsartan on cardiac function and remodeling in patients with heart failure with reduced ejection fraction (HFrEF). Methods: A total of 120 patients with HFrEF were selected and given standard heart failure treatment according to the 2017 ACC/AHA/HFSA guidelines. Regardless of whether patients had taken AngiotensinConverting Enzyme Inhibitors/Angiotensin Receptor Blockers (ACEI/ARB) medications previously, after admission they were treated with the minimum effective dose of Sacubitril/Valsartan according to their blood pressure reading. Baseline clinical data were recorded and patients were followed up at 1, 3, 6, 9, and 12 months post discharge, during which time the dose of Sacubitril/Valsartan was gradually increased to the maximum tolerated dose (dose range 25-200 mg/twice daily). During follow-up, N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), and left atrium diameter (LAD) were monitored; a 6-minute walking test and Kansas City Cardiomyopathy Questionnaire (KCCQ) scores were recorded; and adverse reactions were collected. Results: Over the course of the 12-month follow-up, the plasma concentrations of NT-proBNP were significantly reduced compared with the baseline, and the longer the follow-up time, the lower the NT-proBNP levels were (P<0.05). Similarly, LVEDD, LVESD and LAD were significantly smaller at 12 months than at baseline, and the longer the follow-up time, the smaller the internal diameter was (P<0.05). The LVEF, 6-minute walking distance and KCCQ scores increased significantly from baseline (P<0.05), whereas eGFR and serum potassium levels showed no significant change compared with the baseline. Conclusions: Sacubitril/Valsartan demonstrated a remarkable ability to improve cardiac function and to control cardiac remodeling with a high degree of safety in patients with HFrEF.

Keyword :

cardiac remodeling heart failure with reduced ejection fraction (HFrEF) Sacubitril/Valsartan

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GB/T 7714 Chen, Fangyuan , Tian, Gang , Bai, Xiaojun et al. The effect of Sacubitril/Valsartan on cardiac function and cardiac remodeling in patients with heart failure with reduced ejection fraction [J]. | ANNALS OF PALLIATIVE MEDICINE , 2021 , 10 (8) : 8684-8691 .
MLA Chen, Fangyuan et al. "The effect of Sacubitril/Valsartan on cardiac function and cardiac remodeling in patients with heart failure with reduced ejection fraction" . | ANNALS OF PALLIATIVE MEDICINE 10 . 8 (2021) : 8684-8691 .
APA Chen, Fangyuan , Tian, Gang , Bai, Xiaojun , Li, Juanli , Yuan, Zuyi . The effect of Sacubitril/Valsartan on cardiac function and cardiac remodeling in patients with heart failure with reduced ejection fraction . | ANNALS OF PALLIATIVE MEDICINE , 2021 , 10 (8) , 8684-8691 .
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