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学者姓名:赵永席

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< Page ,Total 8 >
Self-template synthesis of spherical mesoporous tin dioxide from tin-polyphenol-formaldehyde polymers for conductometric ethanol gas sensing EI SCIE
期刊论文 | 2021 , 341 | SENSORS AND ACTUATORS B-CHEMICAL
WoS CC Cited Count: 1
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Abstract :

Spherical mesoporous tin dioxides are emerging sensing materials for fabrication of gas sensor applied in various fields. However, the synthesis of spherical mesoporous SnO2 with uniform shape and small diameter (i.e., <100 nm) is still challenging. Herein, spherical mesoporous SnO2 materials with tunable diameter (55 110 nm), large pore size (similar to 5.8 nm) and high specific surface area (80.9-185.6 m(2)/g) are synthesized via a self-template strategy by direct thermal decomposition of tin-polyphenol-formaldehyde polymers (TPFPs). Spherical TPFPs are synthesized via a sol-gel process using a low-cost, nontoxic and renewable natural polyphenol (i.e., tannic acid) as a ligand, formaldehyde as a cross-linking agent, tin ions as a metal source in alkaline conditions. Block copolymers can regulate the polymerization process and promote the formation of uniform spheres. The diameter of TPFPs and their derived spherical mesoporous SnO2 can be adjusted by changing the amount of block co-polymers. The gas sensors fabricated from spherical mesoporous SnO2 exhibit excellent sensitivity to ethanol (18.9@50 ppm), fast response and recovery time (4 s / 44 s), good repeatability and long-term stability. This work demonstrates a reliable method for synthesis of spherical mesoporous SnO2, which could be potentially applied in catalysis, sensing and energy storage.

Keyword :

Colloidal sphere Mesoporous material Self-template synthesis Gas sensing Tin dioxide

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GB/T 7714 Feng, Bingxi , Feng, Youyou , Qin, Jing et al. Self-template synthesis of spherical mesoporous tin dioxide from tin-polyphenol-formaldehyde polymers for conductometric ethanol gas sensing [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2021 , 341 .
MLA Feng, Bingxi et al. "Self-template synthesis of spherical mesoporous tin dioxide from tin-polyphenol-formaldehyde polymers for conductometric ethanol gas sensing" . | SENSORS AND ACTUATORS B-CHEMICAL 341 (2021) .
APA Feng, Bingxi , Feng, Youyou , Qin, Jing , Wang, Zheng , Zhang, Yalong , Du, Fei et al. Self-template synthesis of spherical mesoporous tin dioxide from tin-polyphenol-formaldehyde polymers for conductometric ethanol gas sensing . | SENSORS AND ACTUATORS B-CHEMICAL , 2021 , 341 .
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Aptamer-Functionalized Microdevices for Bioanalysis. EI PubMed SCIE
期刊论文 | 2021 , 13 (8) , 9402-9411 | ACS applied materials & interfaces
WoS CC Cited Count: 1
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Abstract :

Aptamers have drawn great attention in the field of biological research and disease diagnosis for the remarkable advantages as recognition elements. They show unique superiority for facile selection, desirable thermal stability, flexible engineering, and low immunogenicity, complementing the use of conventional antibodies. Aptamer-functionalized microdevices offer promising properties for bioanalysis applications because of the compact sizes, minimal reaction volume, high throughput, operational feasibility, and controlled preciseness. In this review, we first introduce the innovative technologies in the selection of aptamers with microdevices and then highlight some advanced applications of aptamer-functionalized microdevices in bioanalysis field for diverse targets. Aptamer-functionalized microfluidic devices, microarrays, and paper-based and other interface-based microdevices are all bioanalysis platforms with huge potential in the near future. Finally, the major challenges of these microdevices applied in bioanalysis are discussed and future perspectives are also envisioned.

Keyword :

microarray bioanalysis paper strip nanomaterial microfluidics aptamer

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GB/T 7714 Xue Jing , Chen Feng , Bai Min et al. Aptamer-Functionalized Microdevices for Bioanalysis. [J]. | ACS applied materials & interfaces , 2021 , 13 (8) : 9402-9411 .
MLA Xue Jing et al. "Aptamer-Functionalized Microdevices for Bioanalysis." . | ACS applied materials & interfaces 13 . 8 (2021) : 9402-9411 .
APA Xue Jing , Chen Feng , Bai Min , Cao Xiaowen , Fu Wenhao , Zhang Jin et al. Aptamer-Functionalized Microdevices for Bioanalysis. . | ACS applied materials & interfaces , 2021 , 13 (8) , 9402-9411 .
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Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T-1-weighted magnetic resonance imaging SCIE CSCD
期刊论文 | 2021 , 32 (2) , 842-848 | CHINESE CHEMICAL LETTERS
WoS CC Cited Count: 3
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Abstract :

Plant polyphenol-based coordination polymers (CPs) with ultra-small particle size and tailorable compositions are highly desired in biomedical applications, but their synthesis is still challenging due to the sophisticated coordination assembly process and unavoidable self-oxidation polymerization of polyphenol. Herein, a general ligand covalent-modification mediated coordination assembly strategy is proposed for the synthesis of water-dispersible CPs with tunable metal species (e.g., Gd, Cu, Ni, Zn, Fe) and ultra-small diameter (8.6-37.8 nm) using nontoxic plant polyphenol (e.g., tannic acid, gallic acid) as a polymerizable ligand. Polyphenol molecules react with formaldehyde firstly, which can effectively retard the oxidation induced self-polymerization of polyphenol and lead to the formation of metal ions containing CPs colloidal nanoparticles. These ultrafine nanoparticles with stably chelated metal ions are highly water dispersible and thus advantageous for bioimaging. As an example, ultra-small Gd contained CPs exhibit higher longitudinal relaxivity (r(1) = 25.5 L mmol(-1) s(-1)) value with low r(2)/r(1) (1.19) than clinically used Magnevist (Gd-DTPA, r(1) = 3.7 L mmol(-1) s(-1)). Due to the enhanced permeability and retention effect, they can be further used as a positive contrast agent for T-1-weighted MR imaging of tumour. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Keyword :

Nanoparticle Contrast agent Coordination polymer Plant polyphenol Self-assembly

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GB/T 7714 Qin, Jing , Liang, Guohai , Feng, Bingxi et al. Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T-1-weighted magnetic resonance imaging [J]. | CHINESE CHEMICAL LETTERS , 2021 , 32 (2) : 842-848 .
MLA Qin, Jing et al. "Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T-1-weighted magnetic resonance imaging" . | CHINESE CHEMICAL LETTERS 32 . 2 (2021) : 842-848 .
APA Qin, Jing , Liang, Guohai , Feng, Bingxi , Wang, Gen , Wu, Na , Deng, Yonghui et al. Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T-1-weighted magnetic resonance imaging . | CHINESE CHEMICAL LETTERS , 2021 , 32 (2) , 842-848 .
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Construction of a Mesoporous Ceria Hollow Sphere/Enzyme Nanoreactor for Enhanced Cascade Catalytic Antibacterial Therapy EI SCIE PubMed
期刊论文 | 2021 , 13 (34) , 40302-40314 | ACS APPLIED MATERIALS & INTERFACES
WoS CC Cited Count: 1
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Abstract :

Nanozyme has been regarded as one of the antibacterial agents to kill bacteria via a Fenton-like reaction in the presence of H2O2. However, it still suffers drawbacks such as insufficient catalytic activity in near-neutral conditions and the requirement of high H2O2 levels, which would minimize the side effects to healthy tissues. Herein, a mesoporous ceria hollow sphere/enzyme nanoreactor is constructed by loading glucose oxidase in the mesoporous ceria hollow sphere nanozyme. Due to the mesoporous framework, large internal voids, and high specific surface area, the obtained nanoreactor can effectively convert the nontoxic glucose into highly toxic hydroxyl radicals via a cascade catalytic reaction. Moreover, the generated glucose acid can decrease the localized pH value, further boosting the peroxidase-like catalytic performance of mesoporous ceria. The generated hydroxyl radicals could damage severely the cell structure of the bacteria and prevent biofilm formation. Moreover, the in vivo experiments demonstrate that the nanoreactor can efficiently eliminate 99.9% of bacteria in the wound tissues and prevent persistent inflammation without damage to normal tissues in mice. This work provides a rational design of a nanoreactor with enhanced catalytic activity, which can covert glucose to hydroxyl radicals and exhibits potential applications in antibacterial therapy.

Keyword :

hollow sphere ceria antibacterial therapy mesoporous material catalysis

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GB/T 7714 Qin, Jing , Feng, Youyou , Cheng, Dong et al. Construction of a Mesoporous Ceria Hollow Sphere/Enzyme Nanoreactor for Enhanced Cascade Catalytic Antibacterial Therapy [J]. | ACS APPLIED MATERIALS & INTERFACES , 2021 , 13 (34) : 40302-40314 .
MLA Qin, Jing et al. "Construction of a Mesoporous Ceria Hollow Sphere/Enzyme Nanoreactor for Enhanced Cascade Catalytic Antibacterial Therapy" . | ACS APPLIED MATERIALS & INTERFACES 13 . 34 (2021) : 40302-40314 .
APA Qin, Jing , Feng, Youyou , Cheng, Dong , Liu, Biwu , Wang, Zheng , Zhao, Yongxi et al. Construction of a Mesoporous Ceria Hollow Sphere/Enzyme Nanoreactor for Enhanced Cascade Catalytic Antibacterial Therapy . | ACS APPLIED MATERIALS & INTERFACES , 2021 , 13 (34) , 40302-40314 .
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Addition-Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling EI SCIE PubMed
期刊论文 | 2021 , 93 (41) , 13974-13980 | ANALYTICAL CHEMISTRY
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Dynamic information of intracellular transcripts is essential to understand their functional roles. Routine RNA-sequencing (RNA-seq) methods only measure RNA species at a steady state and do not provide RNA dynamic information. Here, we develop addition-elimination mechanism-activated nucleotide transition sequencing (AENT-seq) for transcriptome-wide profiling of RNA dynamics. In AENT-seq, nascent transcripts are metabolically labeled with 4-thiouridine (4sU). The total RNA is treated with N2H4 center dot H2O under aqueous conditions. N2H4 center dot H2O is demonstrated to convert 4sU to 4-hydrazino cytosine (C*) based on an addition-elimination chemistry. C* is regarded as cytosine (C) during the DNA extension process. This 4sU-to-C transition marks nascent transcripts, so it enables sequencing analysis of RNA dynamics. We apply our AENT-seq to investigate transcript dynamic information of several genes involved in cancer progression and metastasis. This method uses a simple chemical reaction in aqueous solutions and will be rapidly disseminated with extensive applications.

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GB/T 7714 Su, Li , Chen, Feng , Yu, Huahang et al. Addition-Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling [J]. | ANALYTICAL CHEMISTRY , 2021 , 93 (41) : 13974-13980 .
MLA Su, Li et al. "Addition-Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling" . | ANALYTICAL CHEMISTRY 93 . 41 (2021) : 13974-13980 .
APA Su, Li , Chen, Feng , Yu, Huahang , Yan, Hao , Zhao, Fengjiao , Fan, Chunhai et al. Addition-Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling . | ANALYTICAL CHEMISTRY , 2021 , 93 (41) , 13974-13980 .
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Development of pH-responsive nanocomposites with remarkably synergistic antibiofilm activities based on ultrasmall silver nanoparticles in combination with aminoglycoside antibiotics EI SCIE PubMed
期刊论文 | 2021 , 208 | COLLOIDS AND SURFACES B-BIOINTERFACES
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Abstract :

Bacterial biofilms are responsible for many chronic infections because antibacterial agents exhibit poor penetration into the dense matrix barrier and cannot easily reach the internal bacteria. Herein, we reported pHresponsive nanocomposites (PDA@Kana-AgNPs) that could penetrate and disperse biofilms, which were synthesized by the combination of ultrasmall silver nanoparticles (AgNPs) and kanamycin, and then coating with polydopamine. Confocal fluorescence imaging indicated that PDA@Kana-AgNPs could respond to the acidic microenvironment of biofilms, leading to biofilm-triggered on- demand drug release in situ. The zone of inhibition test and Resazurin assay showed that the combination of kanamycin and AgNPs had greater antimicrobial activity against test strains (Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Escherichia coli BL21) than when applied separately. The crystal violet staining test demonstrated that biofilms were effectively dispersed by the proposed nanocomposites. Biocompatibility was also evaluated, which showed that PDA@Kana-AgNPs were non-toxic to mammalian cells. Therefore, the proposed pH-responsive nanocomposites held great potential for efficient antibiotics delivery and showed synergistic antibacterial and antibiofilm activities. This strategy could also be used to encapsulate a variety of antibiotics in combination with other drugs or materials, thereby showing therapeutic potential in preventing biofilm-related infections and realizing fluorescence imaging in situ.

Keyword :

Aminoglycoside antibiotics pH-responsive Antibacterial activity Biofilms dispersion

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GB/T 7714 Li, Xizhe , Li, Bingyu , Liu, Ruirui et al. Development of pH-responsive nanocomposites with remarkably synergistic antibiofilm activities based on ultrasmall silver nanoparticles in combination with aminoglycoside antibiotics [J]. | COLLOIDS AND SURFACES B-BIOINTERFACES , 2021 , 208 .
MLA Li, Xizhe et al. "Development of pH-responsive nanocomposites with remarkably synergistic antibiofilm activities based on ultrasmall silver nanoparticles in combination with aminoglycoside antibiotics" . | COLLOIDS AND SURFACES B-BIOINTERFACES 208 (2021) .
APA Li, Xizhe , Li, Bingyu , Liu, Ruirui , Dong, Yanhua , Zhao, Yongxi , Wu, Yayan . Development of pH-responsive nanocomposites with remarkably synergistic antibiofilm activities based on ultrasmall silver nanoparticles in combination with aminoglycoside antibiotics . | COLLOIDS AND SURFACES B-BIOINTERFACES , 2021 , 208 .
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Bioorthogonal Chemical Signature Enabling Amplified Visualization of Cellular Oxidative Thymines EI SCIE PubMed
期刊论文 | 2021 , 93 (30) , 10495-10501 | ANALYTICAL CHEMISTRY
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Cellular oxidative thymines, 5-hydroxymethyluracil (5hmU) and 5-formyluracil (5fU), are found in the genomes of a diverse range of organisms, the distribution of which profoundly influence biological processes and living systems. However, the distribution of cellular oxidative thymines has not been explored because of lacking both specific bioorthogonal labeling and sensitivity methods for single-cell analysis. Herein, we report a bioorthogonal chemical signature enabling amplified visualization of cellular oxidative thymines in single cells. The synthesized ATP-gamma-alkyne, an ATP analogue with bioorthogonal tag modified on gamma-phosphate can be specifically linked to cellular 5hmU by chemoenzymatic labeling. DNA with 5-alkynephosphomethyluracil were then clicked with azide (N-3)-modified 5hmU-primer. Identification of 5fU is based on selective reduction from 5fU to 5hmU, subsequent chemoenzymatic labeling of the newly generated 5hmU, and cross-linking with N-3-modified 5fU-primer via click chemistry. Then, all of the 5hmU and 5fU sites are encoded with respective circularized barcodes. These barcodes are simultaneously amplified for multiplexed single-molecule imaging. The above two kinds of barcodes can be simultaneously amplified for differentiated visualization of 5hmU and 5fU in single cells. We find these two kinds of cellular oxidative thymines are spatially organized in a cell-type-dependent style with cell-to-cell heterogeneity. We also investigate their multilevel subcellular information and explore their dynamic changes during cell cycles. Further, using DNA sequencing instead of fluorescence imaging, our proposed bioorthogonal chemical signature holds great potential to offer the sequence information of these oxidative thymines in cells and may provide a reliable chemical biology approach for studying the whole-genome oxidative thymines profiles and insights into their functional role and dynamics in biology.

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GB/T 7714 Bai, Min , Cao, Xiaowen , Chen, Feng et al. Bioorthogonal Chemical Signature Enabling Amplified Visualization of Cellular Oxidative Thymines [J]. | ANALYTICAL CHEMISTRY , 2021 , 93 (30) : 10495-10501 .
MLA Bai, Min et al. "Bioorthogonal Chemical Signature Enabling Amplified Visualization of Cellular Oxidative Thymines" . | ANALYTICAL CHEMISTRY 93 . 30 (2021) : 10495-10501 .
APA Bai, Min , Cao, Xiaowen , Chen, Feng , Xue, Jing , Zhao, Yue , Zhao, Yongxi . Bioorthogonal Chemical Signature Enabling Amplified Visualization of Cellular Oxidative Thymines . | ANALYTICAL CHEMISTRY , 2021 , 93 (30) , 10495-10501 .
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Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications SCIE PubMed
期刊论文 | 2021 , 12 (1) | NATURE COMMUNICATIONS
WoS CC Cited Count: 1
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Exploring spatial organization and relationship of diverse biomolecules within cellular nanoenvironments is important to elucidate the fundamental processes of life. However, it remains methodologically challenging. Herein, we report a molecular recognition mechanism cellular macromolecules-tethered DNA walking indexing (Cell-TALKING) to probe the nanoenvironments containing diverse chromatin modifications. As an example, we characterize the nanoenvironments of three DNA modifications around one histone posttranslational modification (PTM). These DNA modifications in fixed cells are labeled with respective DNA barcoding probes, and then the PTM site is tethered with a DNA walking probe. Cell-TALKING can continuously produce cleavage records of any barcoding probes nearby the walking probe. New 3'-OH ends are generated on the cleaved barcoding probes to induce DNA amplification for downstream detections. Combining fluorescence imaging, we identify various combinatorial chromatin modifications and investigate their dynamic changes during cell cycles. We also explore the nanoenvironments in different cancer cell lines and clinical specimens. In principle, using high-throughput sequencing instead of fluorescence imaging may allow the detection of complex cellular nanoenvironments containing tens of biomolecules such as transcription factors. Investigation of spatial organization and relationships of biomolecules in cellular nanoenvironments is necessary to understand essential biological processes, but methodologically challenging. Here, the authors report cellular macromolecules-tethered DNA walking indexing (Cell-TALKING) to probe the nanoenvironments of DNA modifications around histone post-translational modifications, and explore the nanoenvironments in different cancer cell lines and clinical specimens.

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GB/T 7714 Chen, Feng , Bai, Min , Cao, Xiaowen et al. Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications [J]. | NATURE COMMUNICATIONS , 2021 , 12 (1) .
MLA Chen, Feng et al. "Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications" . | NATURE COMMUNICATIONS 12 . 1 (2021) .
APA Chen, Feng , Bai, Min , Cao, Xiaowen , Xue, Jing , Zhao, Yue , Wu, Na et al. Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications . | NATURE COMMUNICATIONS , 2021 , 12 (1) .
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Controllable synthesis of iron-polyphenol colloidal nanoparticles with composition-dependent photothermal performance EI SCIE PubMed
期刊论文 | 2021 , 593 , 172-181 | Journal of Colloid and Interface Science
WoS CC Cited Count: 1
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Abstract :

Iron-polyphenol nanoparticles are usually prepared with nontoxic plant polyphenols as a main building block, which are an emerging photothermal agent for photothermal therapy. However, till now, few works have been made on the controllable synthesis of iron-polyphenol nanoparticles with tunable composition, as well as investigation of the relationship between material composition and photothermal property. In the present study, iron-polyphenol colloidal nanoparticles with tunable diameter (21–303 nm) and ion content (9.2–97.6 mg/g), as well as high colloidal stability are successfully synthesized using different polyphenols (such as tannic acid, epigallocatechin gallate, gallic acid, epicatechin and proanthocyanidin) as a ligand. In addition, photothermal performance is highly dependent on the organic ligand, iron content and particle size. Higher iron content and smaller diameter can contribute to higher photothermal performance. The iron-polyphenol nanoparticles with the optimal iron content and particle size are selected as a photothermal agent. They can effectively inhibit the tumour growth in vivo. The current work demonstrates a general synthesis strategy for iron-polyphenol colloidal nanoparticles with tailorable composition and clarifies the relationship between material composition and photothermal performance. Moreover, it is conductive to the rational design of polyphenol-based photothermal agents for theranostic applications. © 2021 Elsevier Inc.

Keyword :

Flavonoids Particle size Synthesis (chemical) Iron Ligands Theranostics Nanoparticles

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GB/T 7714 Qin, Jing , Liang, Guohai , Cheng, Dong et al. Controllable synthesis of iron-polyphenol colloidal nanoparticles with composition-dependent photothermal performance [J]. | Journal of Colloid and Interface Science , 2021 , 593 : 172-181 .
MLA Qin, Jing et al. "Controllable synthesis of iron-polyphenol colloidal nanoparticles with composition-dependent photothermal performance" . | Journal of Colloid and Interface Science 593 (2021) : 172-181 .
APA Qin, Jing , Liang, Guohai , Cheng, Dong , Liu, Yining , Cheng, Xiaoran , Yang, Pengkun et al. Controllable synthesis of iron-polyphenol colloidal nanoparticles with composition-dependent photothermal performance . | Journal of Colloid and Interface Science , 2021 , 593 , 172-181 .
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DNA Nanostructures as Drug Carriers for Cellular Delivery SCIE CSCD
期刊论文 | 2020 , 36 (2) , 177-184 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
WoS CC Cited Count: 1
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Drug delivery systems have been widely developed for enhancing target activity and improving drug functions. Liposomes, high-molecular polymer, gold nanoparticles and carbon nanomaterials, etc., are all the candidates of drug carriers. However, immunotoxicity, heterogeneity and low solubility generally exist and hamper their applications. As a kind of biological materials, DNA has its unique advantages in biomedical applications, including excellent biological compatibility and programmability. DNA nanostructures have been proved to possess high cellular uptake efficiency, which sheds new light on DNA-based drug delivery system. In this review, we summarize the influence factors of DNA nanostructure internalization efficiency, including cell lines, and the size and the shape of DNA nanoparticles. Uniformity of DNA nanostructures in appearance and properties ensures the stability in research, which makes DNA carriers stand out from other nanomaterials. Next, we focus on the functionalization of DNA carriers, which endows DNA nanostructures with the potential to construct integrated drug delivery platforms. We also discuss the internalization pathways of DNA nanostructures and their fate in cells. The deeply understanding about the endocytic pathways provides new sight for the further design strategy on changing the transportation routes of DNA carriers in cells. Finally, the challenges in further applications are discussed, and suggestions are proposed.

Keyword :

Internalization pathway DNA-based drug carrier DNA nanostructure Drug delivery Cellular uptake

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GB/T 7714 Wu Na , Zhao Yongxi . DNA Nanostructures as Drug Carriers for Cellular Delivery [J]. | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES , 2020 , 36 (2) : 177-184 .
MLA Wu Na et al. "DNA Nanostructures as Drug Carriers for Cellular Delivery" . | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 36 . 2 (2020) : 177-184 .
APA Wu Na , Zhao Yongxi . DNA Nanostructures as Drug Carriers for Cellular Delivery . | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES , 2020 , 36 (2) , 177-184 .
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