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学者姓名:贺健康

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3D Printing of Layered Gradient Pore Structure of Brain-like Tissue SCIE
期刊论文 | 2021 , 7 (3) , 71-85 | INTERNATIONAL JOURNAL OF BIOPRINTING
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Abstract :

Y YThe pathological research and drug development of brain diseases require appropriate brain models. Given the complex, layered structure of the cerebral cortex, as well as the constraints on the medical ethics and the inaccuracy of animal models, it is necessary to construct a brain-like model in vitro. In this study, we designed and built integrated three-dimensional (3D) printing equipment for cell printing/culture, which can guarantee cell viability in the printing process and provide the equipment foundation for manufacturing the layered structures with gradient distribution of pore size. Based on this printing equipment, to achieve the purpose of printing the layered structures with multiple materials, we conducted research on the performance of bio-inks with different compositions and optimized the printing process. By extruding and stacking materials, we can print the layered structure with the uniform distribution of cells and the gradient distribution of pore sizes. Finally, we can accurately print a structure with 30 layers. The line width (resolution) of the printed monolayer structure was about 478 mu m, the forming accuracy can reach 97.24%, and the viability of cells in the printed structure is as high as 94.5%.

Keyword :

Integrated cell printing/culture equipment 3D bio-printing Layered gradient structure Brain-like model

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GB/T 7714 Pei, Na , Hao, Zhiyan , Wang, Sen et al. 3D Printing of Layered Gradient Pore Structure of Brain-like Tissue [J]. | INTERNATIONAL JOURNAL OF BIOPRINTING , 2021 , 7 (3) : 71-85 .
MLA Pei, Na et al. "3D Printing of Layered Gradient Pore Structure of Brain-like Tissue" . | INTERNATIONAL JOURNAL OF BIOPRINTING 7 . 3 (2021) : 71-85 .
APA Pei, Na , Hao, Zhiyan , Wang, Sen , Pan, Binglei , Fang, Ao , Kang, Jianfeng et al. 3D Printing of Layered Gradient Pore Structure of Brain-like Tissue . | INTERNATIONAL JOURNAL OF BIOPRINTING , 2021 , 7 (3) , 71-85 .
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Development of three-dimensional printed biodegradable external airway splints with native-like shape and mechanical properties for tracheomalacia treatment EI SCIE
期刊论文 | 2021 , 210 | MATERIALS & DESIGN
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Abstract :

3D printed external airway splints derived from degradable biopolymers provide a promising way to treat tracheomalacia (TM). However, most of the splints cannot fully reproduce the lumen shapes and the mechanical properties of native tracheas. In this study, biodegradable external airway splints with native-like lumen geometry and mechanical properties were designed and fabricated. Matchable mechanical properties were realized by the combination of different pore shapes and sizes of the splints. A reliable method for the fabrication of the porous polycaprolactone (PCL) splints was demonstrated via selective laser sintering (SLS). Compression results revealed that the SLS-fabricated PCL splints with the diamond pore shape and an inscribed circle diameter of 3 mm possessed similar mechanical properties to those of native tracheas, before and after implantation in dogs with TM for 12 weeks. These SLSfabricated PCL biodegradable bionic external airway splints might be good candidate for clinical application in future. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keyword :

Selective laser sintering (SLS) Tracheomalacia (TM) 3-dimensional printed (3DP) External airway splint Polycaprolactone (PCL)

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GB/T 7714 Liu, Wenhao , Meng, Zijie , Zheng, Kaifu et al. Development of three-dimensional printed biodegradable external airway splints with native-like shape and mechanical properties for tracheomalacia treatment [J]. | MATERIALS & DESIGN , 2021 , 210 .
MLA Liu, Wenhao et al. "Development of three-dimensional printed biodegradable external airway splints with native-like shape and mechanical properties for tracheomalacia treatment" . | MATERIALS & DESIGN 210 (2021) .
APA Liu, Wenhao , Meng, Zijie , Zheng, Kaifu , Wang, Lei , Zhang, Chenxi , Ji, Jinjie et al. Development of three-dimensional printed biodegradable external airway splints with native-like shape and mechanical properties for tracheomalacia treatment . | MATERIALS & DESIGN , 2021 , 210 .
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Additive manufacturing and large deformation responses of highly-porous polycaprolactone scaffolds with helical architectures for breast tissue engineering SCIE
期刊论文 | 2021 , 16 (3) , 291-305 | VIRTUAL AND PHYSICAL PROTOTYPING
WoS CC Cited Count: 1
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Abstract :

Helical architectures were designed for the additive manufacturing of highly flexible polycaprolactone (PCL) scaffolds for engineering soft tissues, which commonly require high flexibility and predominantly function under large deformation conditions. It was found that the design parameters like revolution and radius of helical architectures highly affected the filament fusion or bonding during the fabrication process. The bonding-induced interlaced helical architectures resulted in a more uniform deformation pattern and a lower modulus. mu CT-based finite element method was established to predict the large deformation responses of the scaffolds with helical architectures and patient-specific scaffold potentially for breast reconstruction, which showed well agreement with the experimental results. The fabricated scaffolds exhibited good shape recovery capability even under cyclical compression at a strain of about 20% for 10000 times. This exploration offers a promising way to predict the mechanical responses of flexible scaffolds with complex helical architectures under large deformation conditions.

Keyword :

large deformation response Additive manufacturing helical architectures breast tissue engineering

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GB/T 7714 Meng, Zijie , He, Jiankang , Li, Dichen . Additive manufacturing and large deformation responses of highly-porous polycaprolactone scaffolds with helical architectures for breast tissue engineering [J]. | VIRTUAL AND PHYSICAL PROTOTYPING , 2021 , 16 (3) : 291-305 .
MLA Meng, Zijie et al. "Additive manufacturing and large deformation responses of highly-porous polycaprolactone scaffolds with helical architectures for breast tissue engineering" . | VIRTUAL AND PHYSICAL PROTOTYPING 16 . 3 (2021) : 291-305 .
APA Meng, Zijie , He, Jiankang , Li, Dichen . Additive manufacturing and large deformation responses of highly-porous polycaprolactone scaffolds with helical architectures for breast tissue engineering . | VIRTUAL AND PHYSICAL PROTOTYPING , 2021 , 16 (3) , 291-305 .
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Bioprinting of 3D Functional Tissue Constructs SCIE PubMed
期刊论文 | 2021 , 7 (3) , 1-2 | INTERNATIONAL JOURNAL OF BIOPRINTING
WoS CC Cited Count: 1
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GB/T 7714 He, Jiankang , Mao, Mao , Li, Xiao et al. Bioprinting of 3D Functional Tissue Constructs [J]. | INTERNATIONAL JOURNAL OF BIOPRINTING , 2021 , 7 (3) : 1-2 .
MLA He, Jiankang et al. "Bioprinting of 3D Functional Tissue Constructs" . | INTERNATIONAL JOURNAL OF BIOPRINTING 7 . 3 (2021) : 1-2 .
APA He, Jiankang , Mao, Mao , Li, Xiao , Chua, Chee Kai . Bioprinting of 3D Functional Tissue Constructs . | INTERNATIONAL JOURNAL OF BIOPRINTING , 2021 , 7 (3) , 1-2 .
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Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into SCIE PubMed
期刊论文 | 2021 , 14 (16) | MATERIALS
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Abstract :

Implantable nerve electrodes, as a bridge between the brain and external devices, have been widely used in areas such as brain function exploration, neurological disease treatment and human-computer interaction. However, the mechanical properties mismatch between the electrode material and the brain tissue seriously affects the stability of electrode signal acquisition and the effectiveness of long-term service in vivo. In this study, a modified neuroelectrode was developed with conductive biomaterials. The electrode has good biocompatibility and a gradient microstructure suitable for cell growth. Compared with metal electrodes, bioelectrodes not only greatly reduced the elastic modulus (<10 kpa) but also increased the conductivity of the electrode by 200 times. Through acute electrophysiological analysis and a 12-week chronic in vivo experiment, the bioelectrode clearly recorded the rat's brain electrical signals, effectively avoided the generation of glial scars and induced neurons to move closer to the electrode. The new conductive biomaterial electrodes developed in this research make long-term implantation of cortical nerve electrodes possible.

Keyword :

polyaniline glial response conductive biomaterial neural electrode

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GB/T 7714 Hao, Zhiyan , Wang, Sen , Zhang, Kun et al. Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into [J]. | MATERIALS , 2021 , 14 (16) .
MLA Hao, Zhiyan et al. "Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into" . | MATERIALS 14 . 16 (2021) .
APA Hao, Zhiyan , Wang, Sen , Zhang, Kun , Zhou, Jiajia , Li, Dichen , He, Jiankang et al. Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into . | MATERIALS , 2021 , 14 (16) .
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Electrohydrodynamic 3D printing of orderly carbon/nickel composite network as supercapacitor electrodes EI SCIE
期刊论文 | 2021 , 82 , 135-143 | Journal of Materials Science and Technology
WoS CC Cited Count: 2
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Abstract :

Electrohydrodynamic (EHD) 3D printing of carbon-based materials in the form of orderly networks can have various applications. In this work, microscale carbon/nickel (C-Ni) composite electrodes with controlled porosity have been utilized in electrochemical energy storage of supercapacitors. Polyacrylonitrile (PAN) was chosen as the basic material for its excellent carbonization performance and EHD printing property. Nickel nitrate (Ni(NO3)2) was incorporated to form Ni nanoparticles which can improve the conductivity and the capacitance performance of the electrode. Well-aligned PAN-Ni(NO3)2 composite structures have been fabricated and carbonized as C-Ni electrodes with the typical diameter of 9.2±2.1 μm. The porosity of the as-prepared C-Ni electrode can be controlled during the EHD process. Electrochemical results show the C-Ni network electrode has achieved a 2.3 times higher areal specific capacitance and 1.7 times higher mass specific capacitance than those of a spin-coated electrode. As such, this process offers a facile and scalable strategy for the fabrication of orderly carbon-based conductive structures for various applications such as energy storage devices and printable electronics. © 2021

Keyword :

Porosity 3D printers Carbon Coated wire electrodes Capacitance Energy storage Process control Composite structures Nickel compounds Electrohydrodynamics Supercapacitor Carbonization

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GB/T 7714 Zhang, Bing , He, Jiankang , Zheng, Gaofeng et al. Electrohydrodynamic 3D printing of orderly carbon/nickel composite network as supercapacitor electrodes [J]. | Journal of Materials Science and Technology , 2021 , 82 : 135-143 .
MLA Zhang, Bing et al. "Electrohydrodynamic 3D printing of orderly carbon/nickel composite network as supercapacitor electrodes" . | Journal of Materials Science and Technology 82 (2021) : 135-143 .
APA Zhang, Bing , He, Jiankang , Zheng, Gaofeng , Huang, Yuanyuan , Wang, Chaohung , He, Peisheng et al. Electrohydrodynamic 3D printing of orderly carbon/nickel composite network as supercapacitor electrodes . | Journal of Materials Science and Technology , 2021 , 82 , 135-143 .
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Coaxial Electrohydrodynamic Bioprinting of Pre-vascularized Cell-laden Constructs for Tissue Engineering SCIE PubMed
期刊论文 | 2021 , 7 (3) , 86-96 | INTERNATIONAL JOURNAL OF BIOPRINTING
WoS CC Cited Count: 1
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Recapitulating the vascular networks that maintain the delivery of nutrition, oxygen, and byproducts for the living cells within the three-dimensional (3D) tissue constructs is a challenging issue in the tissue-engineering area. Here, a novel coaxial electrohydrodynamic (EHD) bioprinting strategy is presented to fabricate thick pre-vascularized cell-laden constructs. The alginate and collagen/calcium chloride solution were utilized as the outer-layer and inner-layer bioink, respectively, in the coaxial printing nozzle to produce the core-sheath hydrogel filaments. The effect of process parameters (the feeding rate of alginate and collagen and the moving speed of the printing stage) on the size of core and sheath lines within the printed filaments was investigated. The core-sheath filaments were printed in the predefined pattern to fabricate lattice hydrogel with perfusable lumen structures. Endothelialized lumen structures were fabricated by culturing the core-sheath filaments with endothelial cells laden in the core collagen hydrogel. Multilayer core-sheath filaments were successfully printed into 3D porous hydrogel constructs with a thickness of more than 3 mm. Finally, 3D pre-vascularized cardiac constructs were successfully generated, indicating the efficacy of our strategy to engineer living tissues with complex vascular structures.

Keyword :

Coaxial bioprinting Vascularized tissues Biofabrication Electrohydrodynamic bioprinting Core-sheath filaments

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GB/T 7714 Mao, Mao , Liang, Hongtao , He, Jiankang et al. Coaxial Electrohydrodynamic Bioprinting of Pre-vascularized Cell-laden Constructs for Tissue Engineering [J]. | INTERNATIONAL JOURNAL OF BIOPRINTING , 2021 , 7 (3) : 86-96 .
MLA Mao, Mao et al. "Coaxial Electrohydrodynamic Bioprinting of Pre-vascularized Cell-laden Constructs for Tissue Engineering" . | INTERNATIONAL JOURNAL OF BIOPRINTING 7 . 3 (2021) : 86-96 .
APA Mao, Mao , Liang, Hongtao , He, Jiankang , Kasimu, Ayiguli , Zhang, Yanning , Wang, Ling et al. Coaxial Electrohydrodynamic Bioprinting of Pre-vascularized Cell-laden Constructs for Tissue Engineering . | INTERNATIONAL JOURNAL OF BIOPRINTING , 2021 , 7 (3) , 86-96 .
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Additively-manufactured poly-ether-ether-ketone (PEEK) lattice scaffolds with uniform microporous architectures for enhanced cellular response and soft tissue adhesion EI SCIE Scopus
期刊论文 | 2020 , 191 | MATERIALS & DESIGN | IF: 7.991
WoS CC Cited Count: 9 SCOPUS Cited Count: 9
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Abstract :

Additively-manufactured PEEK orthopedic implants have recently gained extensive attention due to their prominent characteristics such as good biocompatibility, low radiographic artifacts and similar elastic modulus to native bones. However, the inherent drawback associated with PEEK implants was their biologically inert surface which caused unsatisfactory cellular response and poor adhesion between the implants and surrounding soft tissues. Here we developed a sulfonation-treatment strategy to create microporous architectures onto the filaments of the additively-manufactured PEEK lattice scaffolds. The sulfonation time in the range of 30-45 s was found to facilitate the formation of uniform microscale pores throughout the printed PEEK lattice scaffolds and simultaneously have slight effect on their composition and mechanical properties. Biological results showed that the presence of microscale pores on the additively-manufactured PEEK lattice scaffolds significantly improved the spreading, proliferation and calcium deposition of bone-specific cells in comparison with the untreated PEEK lattice scaffolds. In vivo experiments demonstrated that the sulfonation-treated micropores facilitated the adhesion of newly-regenerated soft tissues to form tight implant-tissue bonding interfaces. The presented method provides a promising approach to improve the surface bioactivity of additively-manufactured PEEK lattice scaffolds for enhanced cellular response and soft tissue adhesion. (C) 2020 The Authors. Published by Elsevier Ltd.

Keyword :

Microporous architectures Bioactivity Scaffold Sulfonation Additive manufacturing Polyetheretherketone

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GB/T 7714 Su, Yanwen , He, Jiankang , Jiang, Nan et al. Additively-manufactured poly-ether-ether-ketone (PEEK) lattice scaffolds with uniform microporous architectures for enhanced cellular response and soft tissue adhesion [J]. | MATERIALS & DESIGN , 2020 , 191 .
MLA Su, Yanwen et al. "Additively-manufactured poly-ether-ether-ketone (PEEK) lattice scaffolds with uniform microporous architectures for enhanced cellular response and soft tissue adhesion" . | MATERIALS & DESIGN 191 (2020) .
APA Su, Yanwen , He, Jiankang , Jiang, Nan , Zhang, Hao , Wang, Lei , Liu, Xi et al. Additively-manufactured poly-ether-ether-ketone (PEEK) lattice scaffolds with uniform microporous architectures for enhanced cellular response and soft tissue adhesion . | MATERIALS & DESIGN , 2020 , 191 .
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<i>In-situ</i> re-melting and re-solidification treatment of selective laser sintered polycaprolactone lattice scaffolds for improved filament quality and mechanical properties. EI PubMed SCIE Scopus
期刊论文 | 2020 , 12 (3) | Biofabrication | IF: 9.954
WoS CC Cited Count: 8 SCOPUS Cited Count: 7
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Selective laser sintering (SLS) is a promising additive manufacturing technique that produces biodegradable tissue-engineered scaffolds with highly porous architectures without additional supporting. However, SLS process inherently results in partially melted microstructures which significantly impair the mechanical properties of the resultant scaffolds for potential applications in tissue engineering and regenerative medicine. Here, a novel post-treatment strategy was developed to endow the SLS-fabricated polycaprolactone (PCL) scaffolds with dense morphology and enhanced mechanical properties by embedding them in dense NaCl microparticles for in-situ re-melting and re-solidification. The effects of re-melting temperature and dwelling time on the microstructures of the SLS-fabricated filaments were studied. The results demonstrated that the minimum requirements of re-melting temperature and dwelling time for sufficient treatment were 65 ○C and 5 minutes respectively and the size of the SLS-fabricated filaments was reduced from 683.3 ± 28.0 μm to 601.6 ± 17.4 μm. This method was also highly effective in treating three-dimensional (3D) PCL lattice scaffolds, which showed improved filament quality and mechanical properties after post-treatment. The treated PCL scaffolds with an initial compressive modulus and strength of 3027.8 ± 204.2 kPa and 208.8 ± 14.5 kPa can maintain their original shapes after implantation in vivo for 24 weeks. Extensive newly-grown tissues were found to gradually penetrate into the porous regions along the PCL filaments. Although degradation occurred, the mechanical properties of the implanted constructs stably maintained. The presented method provides an innovative, green and general post-treatment strategy to improve both the filament quality and mechanical properties of SLS-fabricated PCL scaffolds for various tissue engineering applications.

Keyword :

Selective laser sintering (SLS) Post-treatment Filament quality Polycaprolactone (PCL) Mechanical properties

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GB/T 7714 Meng Zijie , He Jiankang , Cai Zhihao et al. <i>In-situ</i> re-melting and re-solidification treatment of selective laser sintered polycaprolactone lattice scaffolds for improved filament quality and mechanical properties. [J]. | Biofabrication , 2020 , 12 (3) .
MLA Meng Zijie et al. "<i>In-situ</i> re-melting and re-solidification treatment of selective laser sintered polycaprolactone lattice scaffolds for improved filament quality and mechanical properties." . | Biofabrication 12 . 3 (2020) .
APA Meng Zijie , He Jiankang , Cai Zhihao , Zhang Mingkun , Zhang Juliang , Ling Rui et al. <i>In-situ</i> re-melting and re-solidification treatment of selective laser sintered polycaprolactone lattice scaffolds for improved filament quality and mechanical properties. . | Biofabrication , 2020 , 12 (3) .
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Multi-directional cellular alignment in 3D guided by electrohydrodynamically-printed microlattices SCIE Scopus PubMed
期刊论文 | 2020 , 101 , 141-151 | ACTA BIOMATERIALIA | IF: 8.947
WoS CC Cited Count: 12 SCOPUS Cited Count: 13
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Abstract :

Recapitulating aligned cellular architectures of native tissues in vitro is important to engineer artificial tissue analogs with desired biological functions. Here a novel strategy is presented to direct three-dimensional (3D) cellular alignment by embedding cell/collagen hydrogel into the predefined electrohydrodynamically-printed microlattices. The cell/collagen hydrogel, originally filled within the printed microlattices uniformly, was found to gradually develop into densely-populated and highly-aligned bands along the longitudinal direction of the printed microlattices. The cellular alignment was highly dependent on the height, spacing and orientation of the microlattices. The presented method was applicable to multiple cell types including primary cardiomyocytes and the gaps formed between the aligned bands and the lateral walls of the microlattice facilitated the subsequent seeding and rapid alignment of other cell types which enables to engineer anisotropic multicellular tissue constructs. The engineered cardiac patches expressed mature cardiomyocyte-specific phenotypes and exhibited synchronous contractive activities. Multilayer cellular alignment with varied orientation in 3D collagen hydrogel was successfully achieved by using electrohydrodynamically-printed microlattices with layer-specific orientations. This exploration offers a promising way to engineer complex 3D tissue constructs with predefined cellular alignments. Statement of significance Fabrication of biomimetic highly-aligned complex cellular architectures has a great significance to recapitulate the unique mechanical and physiological functions of the engineered tissues (e.g., heart tissue, neuron, muscle). Here, we introduced a novel strategy to direct 3D cellular alignment by embedding cell/collagen hydrogel into the predefined electrohydrodynamically-printed microlattices without any external stimuli. The microscopical study of the dynamic alignment process of cells and collagen fibers contributed to exploring the mechanism of autonomous formation of highly-aligned cellular bands. Multilayer cellular alignment with varied orientation in 3D collagen hydrogel was successfully achieved by using the microlattices with layer-specific orientations, which showed a promising way to engineer complex 3D tissue constructs with predefined cellular alignments. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Keyword :

Collagen hydrogel Electrohydrodynamic printing Microlattice Cardiac patch Cellular alignment

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GB/T 7714 Mao, Mao , He, Jiankang , Li, Zhi et al. Multi-directional cellular alignment in 3D guided by electrohydrodynamically-printed microlattices [J]. | ACTA BIOMATERIALIA , 2020 , 101 : 141-151 .
MLA Mao, Mao et al. "Multi-directional cellular alignment in 3D guided by electrohydrodynamically-printed microlattices" . | ACTA BIOMATERIALIA 101 (2020) : 141-151 .
APA Mao, Mao , He, Jiankang , Li, Zhi , Han, Kang , Li, Dichen . Multi-directional cellular alignment in 3D guided by electrohydrodynamically-printed microlattices . | ACTA BIOMATERIALIA , 2020 , 101 , 141-151 .
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