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< Page ,Total 25 >
The Evolution of Thrombus in Blood Vessels Irradiated by Laser Light With Different Laser Parameters EI
期刊论文 | 2021 , 42 (4) , 934-937 | Journal of Engineering Thermophysics
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Abstract :

At present, the most effective method for treating Port Wine Stain (PWS) is laser therapy. However, the complete clearance rate of PWS is still less than 20%, owing to the lack of the study on thermal response mechanism. Herein, the evolution of photocoagulation and thrombus formation in blood vessels was studied using dorsal skin chamber model irradiated by laser with different parameters, in order to promote the development of novel treatment strategies. The results showed that only photocoagulation occurred in blood vessels irradiated by Nd: YAG laser with a wavelength of 1064 nm. After the irradiation by 532 nm laser with long pulse duration, photocoagulation initially formed in the blood vessels, and then photocoagulation flowed away and thrombus adhered to blood vessel wall. The area of thrombus increases with time initially and then decreases. Besides, the thrombus existed in blood vessels for longer than 4 hours. After the irradiation by 532 nm laser with short pulse duration, the thrombus which was not adhered to blood vessels wall formed, and then flowed away. Since the thrombus that completely occludes the vessel lumen is the prerequisite for optimal clinical outcome, 532 nm laser with long pulse duration combined with antithrombotic drugs is promising to improve the efficacy of the laser treatment for PWS. © 2021, Science Press. All right reserved.

Keyword :

Blood vessels Blood Irradiation Ultrafast lasers Neodymium lasers Yttrium aluminum garnet

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GB/T 7714 Xing, Lin-Zhuang , Chen, Bin , Li, Dong . The Evolution of Thrombus in Blood Vessels Irradiated by Laser Light With Different Laser Parameters [J]. | Journal of Engineering Thermophysics , 2021 , 42 (4) : 934-937 .
MLA Xing, Lin-Zhuang 等. "The Evolution of Thrombus in Blood Vessels Irradiated by Laser Light With Different Laser Parameters" . | Journal of Engineering Thermophysics 42 . 4 (2021) : 934-937 .
APA Xing, Lin-Zhuang , Chen, Bin , Li, Dong . The Evolution of Thrombus in Blood Vessels Irradiated by Laser Light With Different Laser Parameters . | Journal of Engineering Thermophysics , 2021 , 42 (4) , 934-937 .
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Experimental investigation on the macroscopic spray and microscopic droplet diameter, velocity and temperature of R404A flashing spray EI SCIE
期刊论文 | 2021 , 177 | International Journal of Heat and Mass Transfer
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Abstract :

Two-phase flashing spray elicits wide interest in scientific and industrial fields. It can produce fine atomization with small size and low temperature droplets because of explosive atomization and strong evaporation. This study conducted an experimental investigation on the macroscopic spray and microscopic droplet diameter, velocity, and temperature through various measurement methods with a low saturation-temperature refrigerant R404A, which holds a special interest in laser dermatology. The spray presented a bowl spray configuration with rapid expansion at the nozzle exit. A core spray area near the nozzle field was revealed, in which the droplet Sauter mean diameter (D32) and temperature (Td) decreased rapidly while the droplet average velocity (V) exhibited an obvious acceleration with increasing axial distance. All the number distributions of droplet diameter and velocity presented Gaussian shapes. The cumulative distribution of droplet diameter followed the Rosin–Rammler correlation perfectly. The uniformity constant and characteristic droplet size were proposed for various axial and radial positions. The radial distributions of D32, V, and Td at various spray axial sections presented different profiles, among which the non-dimensional profiles of V showed a self-similar pattern. The two-dimensional thermal field presented a contractive pattern and a narrow spray width after the rapid expansion at the nozzle exit, which helped to control the spray cooling area more precisely compared with other expansion-like sprays with larger spray width. Experimental data could also provide validation data for the numerical simulation of flashing spray. © 2021

Keyword :

Cooling Spraying Spray nozzles Temperature Velocity Atomization Spray steelmaking Drops

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GB/T 7714 Zhou, Zhi-Fu , Yin, Jing , Yang, Xiao-Yu et al. Experimental investigation on the macroscopic spray and microscopic droplet diameter, velocity and temperature of R404A flashing spray [J]. | International Journal of Heat and Mass Transfer , 2021 , 177 .
MLA Zhou, Zhi-Fu et al. "Experimental investigation on the macroscopic spray and microscopic droplet diameter, velocity and temperature of R404A flashing spray" . | International Journal of Heat and Mass Transfer 177 (2021) .
APA Zhou, Zhi-Fu , Yin, Jing , Yang, Xiao-Yu , Chen, Bin , Liu, Bing . Experimental investigation on the macroscopic spray and microscopic droplet diameter, velocity and temperature of R404A flashing spray . | International Journal of Heat and Mass Transfer , 2021 , 177 .
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A new mathematical model for accurate quantification of cryogen spray cooling in cutaneous laser surgery using realistic boundary conditions SCIE PubMed
期刊论文 | 2021 , 36 (8) , 1609-1617 | LASERS IN MEDICAL SCIENCE
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Abstract :

Laser dermatologic surgery is widely used for various skin diseases. Prior to the laser treatment, transient cryogen spray cooling (CSC) is employed to prevent unwanted thermal damage of skin tissue due to melanin absorption in the epidermis. Accurate quantification on the cooling effect of CSC is essential in the subsequent laser energy dosage prediction. Based on the existing experimental data, we present a new dynamic correlation in terms of non-dimensional heat convection coefficient as a function of the dimensionless time and dimensionless spatial location. The effects of transient spray cooling and the thermal properties of experimental substrate are included in the correlation. The heat transfer within the skin tissue is calculated by a heat conduction equation. Meanwhile, the dynamic correlation of heat convection coefficient is incorporated into the heat conduction equation as a convection boundary condition. Simulation results demonstrate that the correlation correctly reflects several important characteristics of CSC and the model predictions are in consistent with the experimental observations. Numerical results indicate that the CSC time duration should be short enough to maintain selective cooling in epidermis while long enough to avoid the non-uniform spatial cooling on skin surface. A shorter spray distance (for example z = 30 mm) is found to have better cooling effect than a longer spray distance (z = 60 mm). The dynamic correlation in terms of non-dimensional heat convection coefficient proposed in this study can be used in accurate quantification of the effect of CSC. Optimal cooling duration of 75-100 ms and short spray distance of 30 mm are recommended for CSC clinical application.

Keyword :

Heat convection coefficient Laser surgery CSC Port wine stain

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GB/T 7714 Wu, Wenjuan , Li, Dong , Chen, Bin et al. A new mathematical model for accurate quantification of cryogen spray cooling in cutaneous laser surgery using realistic boundary conditions [J]. | LASERS IN MEDICAL SCIENCE , 2021 , 36 (8) : 1609-1617 .
MLA Wu, Wenjuan et al. "A new mathematical model for accurate quantification of cryogen spray cooling in cutaneous laser surgery using realistic boundary conditions" . | LASERS IN MEDICAL SCIENCE 36 . 8 (2021) : 1609-1617 .
APA Wu, Wenjuan , Li, Dong , Chen, Bin , Wang, Guoxiang . A new mathematical model for accurate quantification of cryogen spray cooling in cutaneous laser surgery using realistic boundary conditions . | LASERS IN MEDICAL SCIENCE , 2021 , 36 (8) , 1609-1617 .
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Wavelength optimization for the laser treatment of port wine stains SCIE PubMed
期刊论文 | 2021 | LASERS IN MEDICAL SCIENCE
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Abstract :

Based on the well-known principle of selective photothermolysis, laser has been a promising way for the treatment of port wine stains (PWSs). The laser wavelengths used for PWS's clinical treatment include but are not limited to pulsed dye laser (PDL) in 585-600 nm, long-pulse 755-nm alexandrite, and 1064-nm Nd:YAG lasers. The objective of this study was to investigate the optimal wavelength for PWS's laser treatment. A two-scale mathematic model was constructed to simultaneously quantify macroscale laser energy attenuation in two-layered bulk skin and microscale local energy absorption on target blood vessels within Krogh unit. The effects of morphological parameters, including epidermal melanin content, epidermal thickness, dermal blood content, blood vessel depth, and diameter on laser energy deposition within target blood vessels, were investigated from the visible to near-infrared bands (500-1100 nm). The energy deposition ratio of target blood vessel to epidermal surface was proposed to determine the optimal laser wavelength for PWS with different skin morphological parameters. The bioheat transfer modeling and animal experiment are also conducted to prove our wavelength optimization. The optimal wavelengths for lightly pigmented skin with small and shallow target blood vessels are 580-610 nm in the visible band. This wavelength coincides with commercially used PDL. The optimal wavelength shifts to 940 nm as the epidermal pigmentation increases or the size and blood vessel depth increases. The optimal wavelength changes to 1005 nm as the epidermal pigmentation or the size and burying depth of target blood vessel further increases. Nine hundred forty nanometers can be selected as a general wavelength in PWS treatment to meet the need in most widely morphological structure. Lasers with wavelengths in the 580-610, 940, and 1005 nm regions are effective for treating PWS because of their high optical selectivity in blood over the epidermis.

Keyword :

Port wine stains Wavelength optimization Laser Selective photothermolysis 940-nm laser

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GB/T 7714 Li, D. , Wu, W. J. , Li, K. et al. Wavelength optimization for the laser treatment of port wine stains [J]. | LASERS IN MEDICAL SCIENCE , 2021 .
MLA Li, D. et al. "Wavelength optimization for the laser treatment of port wine stains" . | LASERS IN MEDICAL SCIENCE (2021) .
APA Li, D. , Wu, W. J. , Li, K. , Zhang, H. , Chen, B. , Ying, Z. X. et al. Wavelength optimization for the laser treatment of port wine stains . | LASERS IN MEDICAL SCIENCE , 2021 .
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Theoretical and in vivo investigations of morphology and concentration of gold nanoparticles for laser surgery SCIE PubMed
期刊论文 | 2021 | LASERS IN SURGERY AND MEDICINE
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Abstract :

Background and Objective Precise control of the thermal damage is critical during thermal therapy with the assistance of gold nanoparticles, which depends on the laser parameters and characteristics of gold nanoparticles. However, the current understanding of the relationship between the gold nanoparticles/incident laser light and the efficiency of photothermal therapy is limited, which should be studied systematically. Materials and Methods In this study, theoretical simulations were conducted to investigate the influence of laser wavelength, the size and shape of gold nanoparticles, and the distance of the particle in complex nanostructures on the optical properties and temperature distribution after laser irradiation, aiming to achieve maximum photothermal conversion efficiency and therapeutic effect during the laser treatment of port wine stains. Thereafter, gold nanoparticles were prepared and in vivo experiments were conducted to evaluate the effect on thermal damage of blood vessels. Results For the laser wavelength at 532 nm, gold nanospheres with diameters of 20 nm are ideal in terms of temperature rise. The optimized particle distance is 5 nm and the corresponding concentration is 0.26 mg/ml. For Nd:YAG laser at 1064 nm, gold nanorods with an aspect ratio of 6.3 and an effective radius of 12.7 nm are the most effective photothermal agents. The optimized particle distance is 4 nm, yielding the optimal concentration of 0.017 mg/ml. In vivo results demonstrated that using gold nanoparticles following our simulations as photothermal agents can greatly enhance the thermal damage of diseased blood vessels, reducing the laser energy and laser pulses required for the obvious thermal response of blood vessels. Conclusion For different laser wavelengths used in clinics in the near future, theoretical models presented in this study can be employed to obtain the morphology of single gold nanoparticle and the concentration of nanoparticles solutions, thereby obtaining the optimal photothermal conversion and enhanced thermal damage assisted by gold nanoparticles.

Keyword :

photothermal conversion laser surgery dorsal skin chamber gold nanoparticles port wine stain

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GB/T 7714 Xing, Linzhuang , Li, Dong , Chen, Bin et al. Theoretical and in vivo investigations of morphology and concentration of gold nanoparticles for laser surgery [J]. | LASERS IN SURGERY AND MEDICINE , 2021 .
MLA Xing, Linzhuang et al. "Theoretical and in vivo investigations of morphology and concentration of gold nanoparticles for laser surgery" . | LASERS IN SURGERY AND MEDICINE (2021) .
APA Xing, Linzhuang , Li, Dong , Chen, Bin , Gan, Hongwan , Zhong, Yu . Theoretical and in vivo investigations of morphology and concentration of gold nanoparticles for laser surgery . | LASERS IN SURGERY AND MEDICINE , 2021 .
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Vascular damage mechanism and parameter optimization under alexandrite laser irradiation: a theoretical study SCIE PubMed
期刊论文 | 2021 | LASERS IN MEDICAL SCIENCE
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Abstract :

The 755-nm Alexandrite Laser has a good clinical effect in treating resistant port wine stain, without causing thermal damage of normal tissue and side effects such as purpura. However, little is known about the mechanism of vascular damage induced by 755-nm laser irradiation, which restricts the optimization of laser parameters. In this work, the thermal damage model and the pressure damage model were used to study the damage mechanism of 755-nm laser irradiation on vessels, and the incident energy density and pulse width required for vascular damage were determined according to the damage mode. Under the irradiation of 755-nm laser, the vascular injury pattern was the co-occurrence of vessel rupture and vessel constriction, and the energy density required for the treatment of vessels with a diameter of 200 mu m to reach the damage threshold was the lowest.

Keyword :

Alexandrite laser Port Wine Stains Parameter optimization Damage mechanism

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GB/T 7714 Li, Dong , Cheng, Lu , Chen, Bin et al. Vascular damage mechanism and parameter optimization under alexandrite laser irradiation: a theoretical study [J]. | LASERS IN MEDICAL SCIENCE , 2021 .
MLA Li, Dong et al. "Vascular damage mechanism and parameter optimization under alexandrite laser irradiation: a theoretical study" . | LASERS IN MEDICAL SCIENCE (2021) .
APA Li, Dong , Cheng, Lu , Chen, Bin , Jia, Hao . Vascular damage mechanism and parameter optimization under alexandrite laser irradiation: a theoretical study . | LASERS IN MEDICAL SCIENCE , 2021 .
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Extraction of the Structural Properties of Skin Tissue via Diffuse Reflectance Spectroscopy: An Inverse Methodology EI SCIE PubMed
期刊论文 | 2021 , 21 (11) | SENSORS
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Abstract :

For the laser treatment of vascular dermatosis, the blood vessel morphology and depth in skin tissue is essential to achieve personalized intelligent therapy. The morphology can be obtained from the laser speckle imaging, and vessel depth was extracted by an inverse methodology based on diffuse reflectance spectrum. With optimized spot size of 0.5 mm and known optical properties, the proposed method was experimentally validated via the spectral measurement of microcapillary with known size and depth embedded in an epoxy resin-based skin phantom. Results prove that vessel depth can be extracted with an average relative error of 5%, thereby providing the foundation for a personalized, precise, and intelligent laser treatment of vascular dermatosis.

Keyword :

diffuse reflectance spectroscopy skin phantom inverse methodology laser speckle imaging vascular dermatosis

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GB/T 7714 Chen, Bin , Zhang, Yong , Gao, Shang et al. Extraction of the Structural Properties of Skin Tissue via Diffuse Reflectance Spectroscopy: An Inverse Methodology [J]. | SENSORS , 2021 , 21 (11) .
MLA Chen, Bin et al. "Extraction of the Structural Properties of Skin Tissue via Diffuse Reflectance Spectroscopy: An Inverse Methodology" . | SENSORS 21 . 11 (2021) .
APA Chen, Bin , Zhang, Yong , Gao, Shang , Li, Dong . Extraction of the Structural Properties of Skin Tissue via Diffuse Reflectance Spectroscopy: An Inverse Methodology . | SENSORS , 2021 , 21 (11) .
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Numerical investigation of multi-pulsed cryogen spray cooling for skin cold protection in laser lipolysis EI SCIE
期刊论文 | 2020 , 77 (7) , 730-742 | NUMERICAL HEAT TRANSFER PART A-APPLICATIONS
WoS CC Cited Count: 1
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Abstract :

Noninvasive laser lipolysis exhibits a considerable potential in the treatment of obesity, but laser absorption by water may lead to dermal thermal damage. A novel multi-pulsed cryogen spray (MCS) method for external laser lipolysis was proposed to protect normal skin tissues. Numerical simulations on the basis of multilayer uniform skin model and Pennes biological heat transfer equation were conducted to investigate the cooling performance after continuous and R134a MCS in conjunction with 1210/1064 nm laser irradiation. Continuous spray cannot meet the requirement of laser lipolysis. Under the same accumulative spray duration, the cooling depth and temperature of MCS were much larger than that of continuous spray. With the pulse duration of 10 ms, the pulse delay of 2500 ms, the number of pulses of 10, and the duty cycle of 0.004, the cooling depth of the R134a MCS can reach to 5000 mu m, and the minimum temperature in the spray center of 1 mm below the skin tissue reduced to 11 degrees C. These conditions can effectively provide cold protection for skin undergoing external laser with the wavelength of 1210/1064 nm, the pulse width of 100 ms, and the energy density of 80 J/cm(2), which can reach the dissolution thickness of 3.4 mm.

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GB/T 7714 Xin, Hui , Chen, Bin , Zhou, Zhifu et al. Numerical investigation of multi-pulsed cryogen spray cooling for skin cold protection in laser lipolysis [J]. | NUMERICAL HEAT TRANSFER PART A-APPLICATIONS , 2020 , 77 (7) : 730-742 .
MLA Xin, Hui et al. "Numerical investigation of multi-pulsed cryogen spray cooling for skin cold protection in laser lipolysis" . | NUMERICAL HEAT TRANSFER PART A-APPLICATIONS 77 . 7 (2020) : 730-742 .
APA Xin, Hui , Chen, Bin , Zhou, Zhifu , Li, Dong , Tian, Jiameng . Numerical investigation of multi-pulsed cryogen spray cooling for skin cold protection in laser lipolysis . | NUMERICAL HEAT TRANSFER PART A-APPLICATIONS , 2020 , 77 (7) , 730-742 .
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Influence Research of Experimental Conditions on Multi-pulsed Spraying Cooling Heat Transfer Characteristics EI CSCD
期刊论文 | 2020 , 41 (9) , 2220-2224 | Journal of Engineering Thermophysics | IF: 1.402
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Abstract :

High-energy laser lipolysis assisted with multi-pulsed cryogen spray cooling is a promising fat dissolution technology, which can not only effectively dissolve subcutaneous fat, but also protect epidermis and dermis from frostbite. Research on the influence of multi-pulsed cryogen spray cooling on the heat transfer characteristics is needed to provide theoretical guidance for selecting clinical treatment parameters. The influence of spray pressure, spray distance, nozzle diameter and length on the surface heat transfer characteristics of multi-pulsed cryogen R134a spray cooling was studied by epoxy resin phantom. Under longer pulse duration (30 ms), the greater the spray pressure, the better the heat transfer effect. However, the influence of spray pressure on phantom heat transfer is little under short pulse duration (10 ms). The optimal spray distance is 4 cm and 6 cm for short and long pulse duration, respectively. The larger the nozzle diameter, the bigger the optimal spray distance with increased the lowest temperature in the phantom and worse cooling effect. The longer the nozzle length, the better the cooling effect. © 2020, Science Press. All right reserved.

Keyword :

Cryogenic liquids Clinical research Cooling Phantoms Spray steelmaking Epoxy resins High energy lasers Spray nozzles

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GB/T 7714 Xin, Hui , Chen, Bin , Zhou, Zhi-Fu . Influence Research of Experimental Conditions on Multi-pulsed Spraying Cooling Heat Transfer Characteristics [J]. | Journal of Engineering Thermophysics , 2020 , 41 (9) : 2220-2224 .
MLA Xin, Hui et al. "Influence Research of Experimental Conditions on Multi-pulsed Spraying Cooling Heat Transfer Characteristics" . | Journal of Engineering Thermophysics 41 . 9 (2020) : 2220-2224 .
APA Xin, Hui , Chen, Bin , Zhou, Zhi-Fu . Influence Research of Experimental Conditions on Multi-pulsed Spraying Cooling Heat Transfer Characteristics . | Journal of Engineering Thermophysics , 2020 , 41 (9) , 2220-2224 .
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Experimental Study on Heat Transfer of Cryogen Spray Cooling Coupled Air Jet EI CSCD
期刊论文 | 2020 , 41 (6) , 1452-1456 | Journal of Engineering Thermophysics | IF: 1.402
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In this paper, a refrigerant-coupled air cooling method for laser treatment of Ota sinus surgery was proposed. The effect of the angle between refrigerant and air nozzles as well as air pressure on the cooling performance was studied with epoxy resin as the cooling substrate. It is found that the cooling effect can be improved by the air-assisted cryogen spray. When air pressure is small, the cooling effect increases with the increase of the angle. When the angle between the air and the refrigerant nozzles is constant, however, the temperature recovery rate will gradually accelerate with the increase of pressure, and the minimum temperature that can be reached will also increase, which is not conducive to cooling. © 2020, Science Press. All right reserved.

Keyword :

Nozzles Atmospheric pressure Cooling Refrigerants Pressure effects Epoxy resins Laser surgery

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GB/T 7714 Guo, Xiao-Xing , Zhou, Zhi-Fu , Chen, Bin . Experimental Study on Heat Transfer of Cryogen Spray Cooling Coupled Air Jet [J]. | Journal of Engineering Thermophysics , 2020 , 41 (6) : 1452-1456 .
MLA Guo, Xiao-Xing et al. "Experimental Study on Heat Transfer of Cryogen Spray Cooling Coupled Air Jet" . | Journal of Engineering Thermophysics 41 . 6 (2020) : 1452-1456 .
APA Guo, Xiao-Xing , Zhou, Zhi-Fu , Chen, Bin . Experimental Study on Heat Transfer of Cryogen Spray Cooling Coupled Air Jet . | Journal of Engineering Thermophysics , 2020 , 41 (6) , 1452-1456 .
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