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Surface air discharge used for biomedicine: the positive correlation among gaseous NO3, aqueous O-2(-)/ONOO- and biological effects EI SCIE
期刊论文 | 2021 , 54 (49) | JOURNAL OF PHYSICS D-APPLIED PHYSICS
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Abstract :

Surface air discharge has been extensively reported to have strong antibacterial and anticancer effects, and these biological effects are more or less attributed to the short-lived aqueous reactive species produced by the air plasma. Insight into the generation mechanism for short-lived species is a key bottleneck in elucidating the antimicrobial and anticancer effects. Although the numerical study has predicted that the dissolution of gaseous NO3 plays a crucial role, but so far without experimental validation. In view of this, cavity ring-down spectroscopy is adopted in this paper to measure the NO3 spatial distribution between the surface air discharge and the solutions to be treated, and the concentrations of short-lived species in the solutions after plasma treatment are also measured for different discharge modes. A simplified chemical pathway for the conversion of gaseous NO3 to aqueous ONOOaq-/ONOOHaq and O-2aq(-) is proposed. Moreover, the inactivation effects for Escherichia coli and A549 lung cancer cells treated by the plasma-activated solutions are measured for different concentrations of short-lived species, and the key species for sterilization and anticancer are identified by chemical scavengers. Finally, a positive correlation chain is found among the inactivation effect, the concentrations of aqueous ONOOaq-/ONOOHaq and O-2aq(-), and the density of gaseous NO3, implying that NO3 might be very important for the production of aqueous short-lived reactive species as well as the biological effects induced by plasma-activated solutions.

Keyword :

surface air discharge biological effects CRDS discharge mode reactive species plasma-activated solution

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GB/T 7714 Wang, Wei , Liu, Zhijie , Chen, Jinkun et al. Surface air discharge used for biomedicine: the positive correlation among gaseous NO3, aqueous O-2(-)/ONOO- and biological effects [J]. | JOURNAL OF PHYSICS D-APPLIED PHYSICS , 2021 , 54 (49) .
MLA Wang, Wei et al. "Surface air discharge used for biomedicine: the positive correlation among gaseous NO3, aqueous O-2(-)/ONOO- and biological effects" . | JOURNAL OF PHYSICS D-APPLIED PHYSICS 54 . 49 (2021) .
APA Wang, Wei , Liu, Zhijie , Chen, Jinkun , Yao, Zhiqian , Zhang, Huaiyan , Xi, Wang et al. Surface air discharge used for biomedicine: the positive correlation among gaseous NO3, aqueous O-2(-)/ONOO- and biological effects . | JOURNAL OF PHYSICS D-APPLIED PHYSICS , 2021 , 54 (49) .
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The bactericidal effects of plasma-activated saline prepared by the combination of surface discharge plasma and plasma jet EI SCIE
期刊论文 | 2021 , 54 (38) | JOURNAL OF PHYSICS D-APPLIED PHYSICS
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Abstract :

Plasma-activated water (PAW), as a derivative of cold atmospheric pressure plasma, can inactivate bacteria and greatly expand the application of plasma technology. Commonly used PAW is activated by a plasma device, plasma jet, or surface discharge plasma. PAW prepared by some methods, such as a plasma jet with low frequency, exhibits little bactericidal effect and cannot be applied for use in disinfection or sterilization. Therefore, developing strategies to improve the bactericidal effects of PAW is necessary. Here, the air was first activated by a surface discharge device with a ceramic dielectric under two modes-the ozone mode and nitrogen oxide mode-and then incorporated with helium as the working gas for the plasma jet, which was used to prepare the plasma-activated saline (PAS). The concentrations of long-lived NO2 (-) and NO3 (-) and the short-lived O-1(2) in the PAS activated by the nitrogen oxide mode and plasma jet were highest. The amount of ONOO- in the PAS activated by the combination was lower than the amount in the PAS activated only by the plasma jet. The PAS activated by the combination of nitrogen oxide mode and plasma jet exhibited the strongest bactericidal effect, which was consistent with the intracellular reactive oxygen species levels. The scavenger analysis demonstrated that O-1(2) and ONOO- play essential roles in bacterial inactivation. These results indicate a new strategy for the preparation of PAW with strong bactericidal ability for application in environmental disinfection.

Keyword :

reactive species surface discharge plasma plasma-activated saline plasma jet cold atmospheric-pressure plasma Escherichia coli

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GB/T 7714 Wang, Zifeng , Qi, Yu , Guo, Li et al. The bactericidal effects of plasma-activated saline prepared by the combination of surface discharge plasma and plasma jet [J]. | JOURNAL OF PHYSICS D-APPLIED PHYSICS , 2021 , 54 (38) .
MLA Wang, Zifeng et al. "The bactericidal effects of plasma-activated saline prepared by the combination of surface discharge plasma and plasma jet" . | JOURNAL OF PHYSICS D-APPLIED PHYSICS 54 . 38 (2021) .
APA Wang, Zifeng , Qi, Yu , Guo, Li , Huang, Lingling , Yao, Zhiqian , Yang, Lu et al. The bactericidal effects of plasma-activated saline prepared by the combination of surface discharge plasma and plasma jet . | JOURNAL OF PHYSICS D-APPLIED PHYSICS , 2021 , 54 (38) .
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Plasma-surface interaction: dynamic evolution of interfacial pattern modes during transformation process from dielectric to metallic substrate EI SCIE
期刊论文 | 2021 , 54 (39) | JOURNAL OF PHYSICS D-APPLIED PHYSICS
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Abstract :

Plasma-surface interaction is a complex system involving the codependency between the plasma and the substrate, especially for substrate's with different permittivities. Therefore, a better understanding of the dynamic evolution of interactions with different substrates is essential for optimizing the required changes of specific substrates. In this work, we report two modes of interfacial pattern formation by a pulsed helium plasma jet interacting with indium tin oxide (ITO) glass and a metal substrate, and we mainly focus on the dynamic evolution process for interfacial pattern modes during a transformation process from ITO glass to metal substrate. Pattern morphology, current-voltage characteristics, intensified charge coupled device images, and reactive species distribution are used to examine the evolution mechanism of the plasma-jet-substrate interaction. Results show that, for the ITO glass substrate, a circular interfacial pattern with plenty of streamer channels is generated while, for the metal substrate, a constricted solid spot interfacial pattern is formed; these two pattern mode transformations are realized from the glass dielectric to the metal substrate. Furthermore, during the transformation process from the dielectric to metal substrate, the pattern area is gradually decreased, while the discharge intensity, emission intensity, and local electric field gradually become stronger. Importantly, by observing the dynamic behavior of the interfacial pattern, the ionization wave on the substrate surface is stopped from spreading toward the metal direction and a bright touch point appears at the interface between the dielectric and the metal, while the surface ionization wave still spreads and has no influence on the other direction besides the metal direction. Additionally, the evolution mechanism of pattern mode transformation is discussed, which may be attributed to the difference in the substrate conductivity leading to the different distribution of the local electric field. This study is beneficial to deep insights into the nature of the plasma-surface interaction.

Keyword :

interfacial pattern plasma-surface interaction plasma jet ionization wave

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GB/T 7714 Liu, Zhijie , Wang, Wei , Pang, Bolun et al. Plasma-surface interaction: dynamic evolution of interfacial pattern modes during transformation process from dielectric to metallic substrate [J]. | JOURNAL OF PHYSICS D-APPLIED PHYSICS , 2021 , 54 (39) .
MLA Liu, Zhijie et al. "Plasma-surface interaction: dynamic evolution of interfacial pattern modes during transformation process from dielectric to metallic substrate" . | JOURNAL OF PHYSICS D-APPLIED PHYSICS 54 . 39 (2021) .
APA Liu, Zhijie , Wang, Wei , Pang, Bolun , Wang, Sitao , Gao, Yuting , Xu, Dehui et al. Plasma-surface interaction: dynamic evolution of interfacial pattern modes during transformation process from dielectric to metallic substrate . | JOURNAL OF PHYSICS D-APPLIED PHYSICS , 2021 , 54 (39) .
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Study on the anticancer effects of a 7 mu m sized helium plasma jet on micro-tumors EI SCIE
期刊论文 | 2021 , 54 (38) | JOURNAL OF PHYSICS D-APPLIED PHYSICS
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Abstract :

As a promising technology for cancer therapy, cold atmospheric plasma has received extensive attention in recent years. However, previous studies pay more attention on how to achieve and amplify the anticancer range of plasma, while neglecting the clinical needs of precision medicine. Hence there is a lack of small-scale and fixed-point plasma technology for micro-tumor therapy. Here, a 7 mu m sized micro-plasma jet device was proposed, and its anticancer effects were evaluated based on three-dimensional (3D) bladder micro-tumor spheroids (T24 cell line) constructed in vitro. The experimental results showed that this micro-plasma jet device can effectively inactivate micro-tumors with diameters ranging from 50 to 300 mu m in a short time, and the anticancer effects on 3D T24 cells can still be maintained after irradiation. This work makes the highly precise and efficient inactivation of target micro-tumors possible through plasma technology in clinical therapy.

Keyword :

micro-plasma jet cold atmospheric plasma micro-tumor therapy 3D tumor spheroid plasma medicine

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GB/T 7714 Zhang, Hao , Zhang, Jishen , Xu, Shengduo et al. Study on the anticancer effects of a 7 mu m sized helium plasma jet on micro-tumors [J]. | JOURNAL OF PHYSICS D-APPLIED PHYSICS , 2021 , 54 (38) .
MLA Zhang, Hao et al. "Study on the anticancer effects of a 7 mu m sized helium plasma jet on micro-tumors" . | JOURNAL OF PHYSICS D-APPLIED PHYSICS 54 . 38 (2021) .
APA Zhang, Hao , Zhang, Jishen , Xu, Shengduo , Liu, Dingxin , Guo, Li , Li, Hua . Study on the anticancer effects of a 7 mu m sized helium plasma jet on micro-tumors . | JOURNAL OF PHYSICS D-APPLIED PHYSICS , 2021 , 54 (38) .
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Study on degradation of 252 kV circuit breaker's opening/closing coil under environmental factors EI
期刊论文 | 2021 , 41 (2) , 218-224 | Electric Power Automation Equipment
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Abstract :

Under long-term operating conditions, the performance of opening/closing coil of high voltage circuit breakers degrades due to the environmental factors such as temperature, humidity and salt spray. The damp heat test is used to simulate the effects of temperature and humidity on the opening/closing coil of 252 kV circuit breaker, and the alternating salt spray test is used to simulate the combined effects of temperature, humidity and salt spray on the opening/closing coil of 252 kV circuit breaker. The degradation of the opening/closing coil under the corresponding conditions and the change of the opening/closing coil currents are studied. The study results show that the degradation of 252 kV circuit breaker's opening/closing coil under hot and humid environment is a process of rapid change, which cannot be reflected by the opening/closing coil currents, and the degradation of 252 kV circuit breaker's opening/closing coil under salt spray environment is a nonlinear acceleration process. © 2021, Electric Power Automation Equipment Press. All right reserved.

Keyword :

Timing circuits Electric circuit breakers Temperature Electric network analysis

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GB/T 7714 Chu, Feihang , Huang, Hu , Peng, Zaixing et al. Study on degradation of 252 kV circuit breaker's opening/closing coil under environmental factors [J]. | Electric Power Automation Equipment , 2021 , 41 (2) : 218-224 .
MLA Chu, Feihang et al. "Study on degradation of 252 kV circuit breaker's opening/closing coil under environmental factors" . | Electric Power Automation Equipment 41 . 2 (2021) : 218-224 .
APA Chu, Feihang , Huang, Hu , Peng, Zaixing , Liu, Dingxin . Study on degradation of 252 kV circuit breaker's opening/closing coil under environmental factors . | Electric Power Automation Equipment , 2021 , 41 (2) , 218-224 .
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Antitumor effects of hyperthermia with plasma-treated solutions on 3D bladder tumor spheroids EI SCIE
期刊论文 | 2021 , 18 (10) | PLASMA PROCESSES AND POLYMERS
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As a form of cold atmospheric plasma application, plasma-treated solutions have shown promise in tumor therapy. Especially for the treatment of intracavitary tumors, plasma-treated solutions combined with traditional perfusion therapy have strong application potential. Here, we assessed the antitumor effects of the plasma-treated medium combined with hyperthermia on three-dimensional bladder tumor spheroids in vitro. We found that the combined treatment of plasma-treated medium and hyperthermia (43 degrees C) presented better antitumor effects than a single treatment. Further research showed that synchronous hyperthermia can promote the penetration of plasma-generated reactive oxygen species from the plasma-treated medium into cancer cells. Our results suggest that hyperthermic perfusion therapy using plasma-treated solutions may serve as a novel and valuable therapeutic strategy for bladder cancer.

Keyword :

hyperthermia reactive oxygen species cold atmospheric plasma intravesical perfusion plasma-treated medium

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GB/T 7714 Zhang, Hao , Zhang, Jishen , Xu, Shengduo et al. Antitumor effects of hyperthermia with plasma-treated solutions on 3D bladder tumor spheroids [J]. | PLASMA PROCESSES AND POLYMERS , 2021 , 18 (10) .
MLA Zhang, Hao et al. "Antitumor effects of hyperthermia with plasma-treated solutions on 3D bladder tumor spheroids" . | PLASMA PROCESSES AND POLYMERS 18 . 10 (2021) .
APA Zhang, Hao , Zhang, Jishen , Xu, Shengduo , Wang, Zifeng , Xu, Dehui , Guo, Li et al. Antitumor effects of hyperthermia with plasma-treated solutions on 3D bladder tumor spheroids . | PLASMA PROCESSES AND POLYMERS , 2021 , 18 (10) .
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Comparison of the Anticancer Effects of Pulsed Electric Field and He + O-2 Plasma Jet EI SCIE
期刊论文 | 2021 , 41 (4) , 973-987 | PLASMA CHEMISTRY AND PLASMA PROCESSING
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Abstract :

Cold atmospheric plasma (CAP) and pulsed electric field (PEF) technologies have received extensive attention for their potential beneficial effects in cancer therapy. As two emerging anticancer technologies, both CAP and PEF are related to high voltage electricity, so it is useful to compare their anticancer effects and underlying mechanism to further promote their clinical application. Here, based on three-dimensional (3D) multicellular tumor spheroids, the cytotoxicity of a He + O-2 plasma jet or pulsed electric field on cancer cells was tested. It was found that the anticancer effects of the PEF mainly occurred within the first four hours of treatment, while the anticancer effects of the plasma jet were maintained for at least 24 h after irradiation. The PEF was shown to destroy the integrity of the cell membrane and selectively kill cancer cells in the S and G(2)/M phases, and the apoptosis was observed in the entire region of the 3D tumor spheroids. In contrast, the He + O-2 plasma jet was shown to induce apoptosis by increasing cellular oxidative stress, and the apoptosis was observed only on the outermost layer of the 3D tumor spheroids.

Keyword :

Cancer therapy Pulsed electric field 3D multicellular tumor spheroids Reactive oxygen species Plasma jet

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GB/T 7714 Zhang, Hao , Zhang, Jishen , Xu, Shengduo et al. Comparison of the Anticancer Effects of Pulsed Electric Field and He + O-2 Plasma Jet [J]. | PLASMA CHEMISTRY AND PLASMA PROCESSING , 2021 , 41 (4) : 973-987 .
MLA Zhang, Hao et al. "Comparison of the Anticancer Effects of Pulsed Electric Field and He + O-2 Plasma Jet" . | PLASMA CHEMISTRY AND PLASMA PROCESSING 41 . 4 (2021) : 973-987 .
APA Zhang, Hao , Zhang, Jishen , Xu, Shengduo , Liu, Yifan , Sun, Bowen , Wang, Zifeng et al. Comparison of the Anticancer Effects of Pulsed Electric Field and He + O-2 Plasma Jet . | PLASMA CHEMISTRY AND PLASMA PROCESSING , 2021 , 41 (4) , 973-987 .
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Effects of H2O and O-2 Impurities on the Trichel Pulses Characteristics of the Negative Point-Plane Corona Discharge in SF6 EI SCIE
期刊论文 | 2021 , 41 (4) , 1101-1119 | PLASMA CHEMISTRY AND PLASMA PROCESSING
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The results of numerical simulation of the effects of H2O and O-2 impurities on the Trichel pulses characteristics in the negative point-plane corona discharge in SF6 gas at 0.4 MPa is presented in this paper. The H2O and O-2 contents varied from 200 ppm to 10,000 ppm. The continuity equations for three charged species along with Poisson's equation were solved simultaneously to obtain the Trichel pulses characteristics in SF6/H2O mixtures and SF6/O-2 mixtures. The reduced ionization coefficient, the reduced attachment coefficient, the electron mobility and the electron diffusion coefficient for SF6/H2O and SF6/O-2 mixtures were determined by solving the two-term Boltzmann equation. The effects of H2O and O-2 on the current pulses, the distributions of the charged species and the reduced electric field at the instants of the first and second peak pulse, the time-dependent total number of the three charged species in the gap and the reduced electric field at the discharge tip were investigated to determine the sensitivities of the Trichel pulses characteristics of the SF6 to the H2O and O-2 impurities.

Keyword :

Negative corona discharge Effects of H2O and O-2 Point-plane electrodes Numerical simulation Trichel pulses characteristics

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GB/T 7714 Gao, Qingqing , Wang, Xiaohua , Adamiak, Kazimierz et al. Effects of H2O and O-2 Impurities on the Trichel Pulses Characteristics of the Negative Point-Plane Corona Discharge in SF6 [J]. | PLASMA CHEMISTRY AND PLASMA PROCESSING , 2021 , 41 (4) : 1101-1119 .
MLA Gao, Qingqing et al. "Effects of H2O and O-2 Impurities on the Trichel Pulses Characteristics of the Negative Point-Plane Corona Discharge in SF6" . | PLASMA CHEMISTRY AND PLASMA PROCESSING 41 . 4 (2021) : 1101-1119 .
APA Gao, Qingqing , Wang, Xiaohua , Adamiak, Kazimierz , Yang, Aijun , Liu, Dingxin , Niu, Chunping et al. Effects of H2O and O-2 Impurities on the Trichel Pulses Characteristics of the Negative Point-Plane Corona Discharge in SF6 . | PLASMA CHEMISTRY AND PLASMA PROCESSING , 2021 , 41 (4) , 1101-1119 .
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Detection of decomposition products of SF6/air gas mixture by electron attachment mass spectrometry SCIE
期刊论文 | 2021 | HIGH VOLTAGE
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Sulphur hexafluoride (SF6) is widely used in gas insulation, and its decomposition products can be used to diagnose potential insulation failures. Quick and accurate detection of decomposition products can help to understand equipment-operating conditions in time. In this study, the decomposition products of SF6/air gas mixtures under different pulsed discharge voltages were studied. It was found that the main products were SOF2, SO2F2, SO2, CF4 and SOF4, and the yields of SOF2, SO2F2, SO2 and SOF4 increased with the number of discharge pulse. The productive rate of SOF2, SO2 and SOF4 were positively correlated with the discharge voltage, and when the discharge voltage increased from 5 to 15 kV, their yields after 50,000 discharges increased by 49%, 120% and 1100%, respectively. The productive rate of SOF2 and SO2 were positively correlated with the proportion of air in the gas mixtures while that of SOF4 was opposite. When the proportion of air increases from 0% to 90%, their yields after 50,000 discharges became 270%, 3169% and 10% of the originals, respectively. In addition, the productive rate of SO2F2 was not affected by discharge voltage and the proportion of air in the gas mixtures. SO2F2, SOF2, SOF4 and SO2 can be used as the basis for judging the discharge failures and the discharge degree of power equipment.

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GB/T 7714 Yuan, Huan , Wang, Xiaonan , Yang, Aijun et al. Detection of decomposition products of SF6/air gas mixture by electron attachment mass spectrometry [J]. | HIGH VOLTAGE , 2021 .
MLA Yuan, Huan et al. "Detection of decomposition products of SF6/air gas mixture by electron attachment mass spectrometry" . | HIGH VOLTAGE (2021) .
APA Yuan, Huan , Wang, Xiaonan , Yang, Aijun , Liu, Dingxin , Wang, Xiaohua , Rong, Mingzhe . Detection of decomposition products of SF6/air gas mixture by electron attachment mass spectrometry . | HIGH VOLTAGE , 2021 .
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An integrated device for preparation of plasma-activated media with bactericidal properties: An in vitro and in vivo study SCIE
期刊论文 | 2021 | CONTRIBUTIONS TO PLASMA PHYSICS
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Plasma-activated media (PAM), the product of cold atmospheric plasma (CAP) acting on aqueous media, has similarly strong biological activity and some unique advantages compared with CAP for biomedical targets. However, no reliable PAM-preparing device with high safety for medical uses has yet been developed, limiting the advancement of PAM clinical trials. Herein, an integrated device for PAM preparation with a maximum yield of 4.8 L/hr is reported in detail. A large-area CAP is generated by the plasma-generating module based on the surface dielectric barrier discharge. Several sensors and controllers are applied in this device to stabilize the discharge environment and PAM consistency. In the in vitro experiments, PAM prepared in this device exhibits the bactericidal property of up to 6 logs reduction against various clinical pathogens with multi-drug resistance. The high bactericidal effect of PAM can be preserved for similar to 10 min. After constructing the mice model by cecal ligation and puncture, it is found that the abdominal injection of PAM can effectively relieve sepsis-induced systemic toxicity and maintain homeostasis, which is mainly attributed to the anti-infective efficacy of PAM. The third-party testing confirms that the soaking bactericidal rates of PAM to S. aureus and E. coli are respectively higher than 99.99% and 99.999%, while the acute oral toxicity, skin irritation, and oral genotoxicity of PAM are negligible. This study provides a practical approach for preparing PAM with high reliability, which shows an excellent prospect of clinical applications and commercialization.

Keyword :

bactericidal effect toxicological security reactive species plasma-activated media in vivo study

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GB/T 7714 Wang, Zifeng , Xu, Shengduo , Liu, Dingxin et al. An integrated device for preparation of plasma-activated media with bactericidal properties: An in vitro and in vivo study [J]. | CONTRIBUTIONS TO PLASMA PHYSICS , 2021 .
MLA Wang, Zifeng et al. "An integrated device for preparation of plasma-activated media with bactericidal properties: An in vitro and in vivo study" . | CONTRIBUTIONS TO PLASMA PHYSICS (2021) .
APA Wang, Zifeng , Xu, Shengduo , Liu, Dingxin , Wang, Cong , Chen, Jinkun , Zhang, Jingye et al. An integrated device for preparation of plasma-activated media with bactericidal properties: An in vitro and in vivo study . | CONTRIBUTIONS TO PLASMA PHYSICS , 2021 .
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