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学者姓名:徐峰

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< Page ,Total 43 >
Effect of gene mutation of plants on their mechano-sensibility: the mutant of EXO70H4 influences the buckling of Arabidopsis trichomes EI SCIE
期刊论文 | 2021 , 146 (16) , 5169-5176 | ANALYST
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Abstract :

With the development of molecular biology, more and more mutants of plants have been constructed, where gene mutants have been found to influence not only the biological processes but also biophysical behaviors of plant cells. Trichomes are an important appendage, which has been found to act as an active mechanosensory switch transducing mechanical signals into physiology changes, where the mechanical property of trichomes is vital for such functions. Up to now, over 40 different genes have been found with the function of regulating trichome cell morphogenesis; however, the effect of gene mutants on trichome mechanosensory function remains elusive. In this study, we found that EXO70H4, one of the most up-regulated genes in the mature trichome, not only affects the thickness of the trichome cell wall but also the mechanical property (i.e., the Young's modulus) of trichomes. Finite element method simulation results show that the buckling instability and stress concentration (e.g., exerted by insects) cannot occur on the base of the mutant exo70H4 trichome, which might further interrupt the mechanical signal transduction from branches to the base of trichomes. These results indicated that the mutant exo70H4 trichome might lack the ability to act as an active mechanosensory switch against chewing insect herbivores. Our findings provide new information about the effect of gene mutation (like crop mutants) on the mechano-sensibility and capability to resist the agricultural pests or lodging, which could be of great significance to the development of agriculture.

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GB/T 7714 Liu, Han , Liu, Shaobao , Huang, Guoyou et al. Effect of gene mutation of plants on their mechano-sensibility: the mutant of EXO70H4 influences the buckling of Arabidopsis trichomes [J]. | ANALYST , 2021 , 146 (16) : 5169-5176 .
MLA Liu, Han et al. "Effect of gene mutation of plants on their mechano-sensibility: the mutant of EXO70H4 influences the buckling of Arabidopsis trichomes" . | ANALYST 146 . 16 (2021) : 5169-5176 .
APA Liu, Han , Liu, Shaobao , Huang, Guoyou , Xu, Feng . Effect of gene mutation of plants on their mechano-sensibility: the mutant of EXO70H4 influences the buckling of Arabidopsis trichomes . | ANALYST , 2021 , 146 (16) , 5169-5176 .
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Torsional and translational vibrations of a eukaryotic nucleus, and the prospect of vibrational mechanotransduction and therapy EI SCIE
期刊论文 | 2021 , 155 | JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
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Abstract :

Certain eukaryotic cells are believed to sense and respond to vibrational stimuli that are too small even to be transduced by mechanosensitive ion channels. One possible mechanism of signal amplification and transduction is torsional and translational resonance of the nucleus, the stiffest and densest organelle in a eukaryotic cell. To explore this possibility, we developed a theoretical model that analyzes the natural frequencies of torsional and translational vibrations of the nucleus. The model predicts that the natural frequency for torsional vibration is dependent upon cytoskeletal contractility, while that for translational vibration is dependent upon cytoskeletal stiffness. Further analysis across many species and cell types suggests that, for most eukaryotic cells, torsional vibration is the dominant form of nuclear response to higher frequency stimuli, providing a new potential mechanism for frequency-based mechanotransduction.

Keyword :

Nuclear mechanotransduction Vibrational therapy Oncotripsy Cytoskeleton filament Mechanogenetics

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GB/T 7714 Liu, Shaobao , Yang, Haiqian , Wang, Ming et al. Torsional and translational vibrations of a eukaryotic nucleus, and the prospect of vibrational mechanotransduction and therapy [J]. | JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS , 2021 , 155 .
MLA Liu, Shaobao et al. "Torsional and translational vibrations of a eukaryotic nucleus, and the prospect of vibrational mechanotransduction and therapy" . | JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS 155 (2021) .
APA Liu, Shaobao , Yang, Haiqian , Wang, Ming , Tian, Jin , Hong, Yuan , Li, Yuan et al. Torsional and translational vibrations of a eukaryotic nucleus, and the prospect of vibrational mechanotransduction and therapy . | JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS , 2021 , 155 .
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Chemically Triggered Hydrogel Transformations through Covalent Adaptable Networks and Applications in Cell Culture SCIE
期刊论文 | 2021 , 10 (7) , 901-906 | ACS MACRO LETTERS
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In this article, we report a "smart" hydrogel system, which can be remodeled into multiple architectures through dynamic covalent adaptable networks. The topological changes in hydrogel structures yield dynamically tunable properties through the reformation of covalent chemical linkages via amine-thiol scrambling, thiol-thiol exchange, decoupling reaction, and disulfide formation. The stiffness of the hydrogels can be regulated via dynamic covalent bonding, with some hydrogels displaying selfhealing and shear thinning properties, as demonstrated by rheological measurements. Significantly, the dramatic structural transformations are achieved under neutral aqueous conditions at room temperature. These "smart" hydrogels show good biocompatibility, which can induce cell growth in two-dimensional cell culture and effectively serve as a scaffold for encapsulating and releasing human mesenchymal stem cells in three-dimensional cell culture. Thus, the developed "smart" hydrogel system holds great potential in biomedical applications such as tissue engineering and cell therapy.

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GB/T 7714 Chang, Le , Wang, Cong , Han, Shuang et al. Chemically Triggered Hydrogel Transformations through Covalent Adaptable Networks and Applications in Cell Culture [J]. | ACS MACRO LETTERS , 2021 , 10 (7) : 901-906 .
MLA Chang, Le et al. "Chemically Triggered Hydrogel Transformations through Covalent Adaptable Networks and Applications in Cell Culture" . | ACS MACRO LETTERS 10 . 7 (2021) : 901-906 .
APA Chang, Le , Wang, Cong , Han, Shuang , Sun, Xiaolong , Xu, Feng . Chemically Triggered Hydrogel Transformations through Covalent Adaptable Networks and Applications in Cell Culture . | ACS MACRO LETTERS , 2021 , 10 (7) , 901-906 .
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Cancer Physical Hallmarks as New Targets for Improved Immunotherapy SCIE PubMed
期刊论文 | 2021 , 31 (7) , 520-524 | TRENDS IN CELL BIOLOGY
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A low response rate is the major challenge for existing cancer immunotherapies. Physical cues in the tumor microenvironment (TME) have been recognized as new hallmarks of cancer, which may synergistically contribute to low immunotherapy response. Recent evidence indicates that the physical hallmarks of cancer hold great potential as new targets for improved immunotherapy.

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GB/T 7714 Guo, Hui , Zhang, Tian , Yu, Yang et al. Cancer Physical Hallmarks as New Targets for Improved Immunotherapy [J]. | TRENDS IN CELL BIOLOGY , 2021 , 31 (7) : 520-524 .
MLA Guo, Hui et al. "Cancer Physical Hallmarks as New Targets for Improved Immunotherapy" . | TRENDS IN CELL BIOLOGY 31 . 7 (2021) : 520-524 .
APA Guo, Hui , Zhang, Tian , Yu, Yang , Xu, Feng . Cancer Physical Hallmarks as New Targets for Improved Immunotherapy . | TRENDS IN CELL BIOLOGY , 2021 , 31 (7) , 520-524 .
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A fast and ultrasensitive ELISA based on rolling circle amplification EI SCIE PubMed
期刊论文 | 2021 , 146 (9) , 2871-2877 | ANALYST
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A highly sensitive ELISA is critical for early diagnosis and biomarker discovery of various diseases. Although various ELISA technologies have been developed with high sensitivity, they are limited by poor repeatability, high cost, the dependence on complex equipment and/or a prolonged reaction time. To this end, we developed a fast and ultrasensitive ELISA (termed RELISA) based on rolling circle amplification (RCA) and enzymatic signal amplification. The RELISA is established on the traditional ELISA, with only one more RCA step that can be accomplished within 10 minutes. The prolonged single strand DNA (ssDNA) from RCA is able to enrich abundant horseradish peroxidase conjugate (HRP) modified detection probes. Consequently, the intensive HRP is able to catalyze TMB-H2O2 to produce significantly enhanced colorimetric signals. With CEACAM-7 as a model biomarker, the RELISA achieves the limit of detection as low as 2.82 pg mL(-1), which is similar to 50 times higher than that of the traditional ELISA. Therefore, we envision that the developed RELISA would be a powerful tool for the early diagnosis of various major diseases.

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GB/T 7714 You, Minli , Peng, Ping , Xue, Zhenrui et al. A fast and ultrasensitive ELISA based on rolling circle amplification [J]. | ANALYST , 2021 , 146 (9) : 2871-2877 .
MLA You, Minli et al. "A fast and ultrasensitive ELISA based on rolling circle amplification" . | ANALYST 146 . 9 (2021) : 2871-2877 .
APA You, Minli , Peng, Ping , Xue, Zhenrui , Tong, Haoyang , He, Wanghong , Mao, Ping et al. A fast and ultrasensitive ELISA based on rolling circle amplification . | ANALYST , 2021 , 146 (9) , 2871-2877 .
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Construction of cancer-on-a-chip for drug screening SCIE PubMed
期刊论文 | 2021 , 26 (8) , 1875-1890 | DRUG DISCOVERY TODAY
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Cancer-on-a-chip has recently emerged and attracted wide attention in the field of anticancer drug screening. Compared with traditional cancer models, it enables the faithful recapitulation of the native cancer microenvironment in a high-throughput and cost-effective manner. Moreover, the application of cancer-on-a-chip usually simplifies the process of drug loading and cellular characterization. Therefore, it is considered a promising tool for drug screening in both drug development and personal drug administration. Here, we review recent advances in cancer-on-a-chip assisted drug screening, with a special focus on the concrete process of constructing the microfluidic chip. It is thought that cancer-on-a-chip will strongly promote the development of drug screening by serving as a reliable and convenient cancer model.

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GB/T 7714 Liu, Yan , Yang, Qingzhen , Zhang, Hui et al. Construction of cancer-on-a-chip for drug screening [J]. | DRUG DISCOVERY TODAY , 2021 , 26 (8) : 1875-1890 .
MLA Liu, Yan et al. "Construction of cancer-on-a-chip for drug screening" . | DRUG DISCOVERY TODAY 26 . 8 (2021) : 1875-1890 .
APA Liu, Yan , Yang, Qingzhen , Zhang, Hui , Han, Shuang , Liu, Na , Ren, Hui et al. Construction of cancer-on-a-chip for drug screening . | DRUG DISCOVERY TODAY , 2021 , 26 (8) , 1875-1890 .
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侧流试纸孔径优化数值模型 CSCD
期刊论文 | 2021 , 42 (5) , 1257-1262 | 工程热物理学报
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纸基微流控芯片由于成本低、比表面积大以及良好的生物兼容性等优势在即时检测领域得到快速发展,但是纸基孔隙结构对于检测性能的影响规律和机制尚不清晰.本文针对侧流试纸这一典型纸基微流控芯片,通过将硝酸纤维素膜多孔结构简化为毛细平板通道,首次建立了耦合毛细流动和反应输运过程的数值模型,研究了样品液滴流速以及硝酸纤维素膜比表面积对检测信号生成的竞争机制.研究结果表明,样品液滴流速的增加以及更大的膜比表面积均可增强检测信号,且硝酸纤维素膜孔径存在最优值以提高检测灵敏度,为硝酸纤维素膜材料的微观设计优化指明了方向.

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GB/T 7714 贾朋朋 , 冯上升 , 徐峰 . 侧流试纸孔径优化数值模型 [J]. | 工程热物理学报 , 2021 , 42 (5) : 1257-1262 .
MLA 贾朋朋 et al. "侧流试纸孔径优化数值模型" . | 工程热物理学报 42 . 5 (2021) : 1257-1262 .
APA 贾朋朋 , 冯上升 , 徐峰 . 侧流试纸孔径优化数值模型 . | 工程热物理学报 , 2021 , 42 (5) , 1257-1262 .
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Design of organ-on-a-chip to improve cell capture efficiency EI SCIE
期刊论文 | 2021 , 209 | INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
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Organ-on-a-chip has emerged as a powerful platform with widespread applications in biomedical fields. In this platform, living cells are cultured in microfluidic chips to mimic the functions of native organ units in vitro . One important step for organ-on-a-chip is to capture cells, thus some microstructures are usually integrated in the chip to trap cells when the suspension is ejected into chip. To predict and evaluate the cell capture efficiency, we developed an Euler-Lagrange numerical model to simulate the dynamic process of cell capture. In this model, the Stokes equation was employed to solve the flow field with cells considered as spherical particles. The capture efficiency was quantified in terms of the number of trapped cells and the uniformity. Employing this model, the performance of three different designed chips was studied by numerical simulations and compared with experiments. This numerical model could be used to optimize the design of organ-on-a-chip.

Keyword :

Microfluidics Fluid-structure interaction Tissue-on-a-chip Particulate flow Numerical simulation

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GB/T 7714 Yang, Qingzhen , Ju, Dapeng , Liu, Yan et al. Design of organ-on-a-chip to improve cell capture efficiency [J]. | INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES , 2021 , 209 .
MLA Yang, Qingzhen et al. "Design of organ-on-a-chip to improve cell capture efficiency" . | INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES 209 (2021) .
APA Yang, Qingzhen , Ju, Dapeng , Liu, Yan , Lv, Xuemeng , Xiao, Zhanfeng , Gao, Bin et al. Design of organ-on-a-chip to improve cell capture efficiency . | INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES , 2021 , 209 .
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The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis EI SCIE PubMed
期刊论文 | 2021 , 10 (8) | ADVANCED HEALTHCARE MATERIALS
WoS CC Cited Count: 1
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Abstract :

Natural extracellular matrix (ECM) mostly has a fibrous structure that supports and mechanically interacts with local residing cells to guide their behaviors. The effect of ECM elasticity on cell behaviors has been extensively investigated, while less attention has been paid to the effect of matrix fiber-network plasticity at microscale, although plastic remodeling of fibrous matrix is a common phenomenon in fibrosis. Here, a significant decrease is found in plasticity of native fibrotic tissues, which is associated with an increase in matrix crosslinking. To explore the role of plasticity in fibrosis development, a set of 3D collagen nanofibrous matrix with constant modulus but tunable plasticity is constructed by adjusting the crosslinking degree. Using plasticity-controlled 3D culture models, it is demonstrated that the decrease of matrix plasticity promotes fibroblast activation and spreading. Further, a coarse-grained molecular dynamic model is developed to simulate the cell-matrix interaction at microscale. Combining with molecular experiments, it is revealed that the enhanced fibroblast activation is mediated through cytoskeletal tension and nuclear translocation of Yes-associated protein. Taken together, the results clarify the effects of crosslinking-induced plasticity changes of nanofibrous matrix on the development of fibrotic diseases and highlight plasticity as an important mechanical cue in understanding cell-matrix interactions.

Keyword :

nanofibrous matrix fiber networks cell traction fibrosis mechanical plasticity

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GB/T 7714 Jia, Yuanbo , Wang, Yanzhong , Niu, Lele et al. The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis [J]. | ADVANCED HEALTHCARE MATERIALS , 2021 , 10 (8) .
MLA Jia, Yuanbo et al. "The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis" . | ADVANCED HEALTHCARE MATERIALS 10 . 8 (2021) .
APA Jia, Yuanbo , Wang, Yanzhong , Niu, Lele , Zhang, Hang , Tian, Jin , Gao, Dengfeng et al. The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis . | ADVANCED HEALTHCARE MATERIALS , 2021 , 10 (8) .
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A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health-Related Biomarkers SCIE PubMed
期刊论文 | 2021 | ADVANCED SCIENCE
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Detection of biomarkers associated with body conditions provides in-depth healthcare information and benefits to disease management, where the key challenge is to develop a minimally invasive platform with the ability to directly detect multiple biomarkers in body fluid. Dermal tattoo biosensor holds the potential to simultaneously detect multiple health-related biomarkers in skin interstitial fluid because of the features of minimal invasion, easy operation, and equipment-free result reading. Herein, a colorimetric dermal tattoo biosensor fabricated by a four-area segmented microneedle patch is developed for multiplexed detection of health-related biomarkers. The biosensor exhibits color changes in response to the change of biomarker concentration (i.e., pH, glucose, uric acid, and temperature), which can be directly read by naked eyes or captured by a camera for semi-quantitative measurement. It is demonstrated that the colorimetric dermal tattoo biosensor can simultaneously detect multiple biomarkers in vitro, ex vivo, and in vivo, and monitor the changes of the biomarker concentration for at least 4 days, showing its great potential for long-term health monitoring.

Keyword :

microneedle patch skin interstitial fluid wearable biosensors health monitoring point-of-care testing

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GB/T 7714 He, Rongyan , Liu, Hao , Fang, Tianshu et al. A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health-Related Biomarkers [J]. | ADVANCED SCIENCE , 2021 .
MLA He, Rongyan et al. "A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health-Related Biomarkers" . | ADVANCED SCIENCE (2021) .
APA He, Rongyan , Liu, Hao , Fang, Tianshu , Niu, Yan , Zhang, Huiqing , Han, Fei et al. A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health-Related Biomarkers . | ADVANCED SCIENCE , 2021 .
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