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ASSOCIATION OF SERUM UROMODULIN AND GENETIC VARIANTS WITH BLOOD PRESSURE CHANGES, AND HYPERTENSION IN CHINESE ADULTS: RESULTS FROM TWO PROSPECTIVE COHORTS SCIE
期刊论文 | 2021 , 39 , E112-E112 | JOURNAL OF HYPERTENSION
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GB/T 7714 Du, Mingfei , Wang, Yang , Gao, Wei -Hua et al. ASSOCIATION OF SERUM UROMODULIN AND GENETIC VARIANTS WITH BLOOD PRESSURE CHANGES, AND HYPERTENSION IN CHINESE ADULTS: RESULTS FROM TWO PROSPECTIVE COHORTS [J]. | JOURNAL OF HYPERTENSION , 2021 , 39 : E112-E112 .
MLA Du, Mingfei et al. "ASSOCIATION OF SERUM UROMODULIN AND GENETIC VARIANTS WITH BLOOD PRESSURE CHANGES, AND HYPERTENSION IN CHINESE ADULTS: RESULTS FROM TWO PROSPECTIVE COHORTS" . | JOURNAL OF HYPERTENSION 39 (2021) : E112-E112 .
APA Du, Mingfei , Wang, Yang , Gao, Wei -Hua , Sun, Yue , Zhang, Xiao -Yu , Zou, Ting et al. ASSOCIATION OF SERUM UROMODULIN AND GENETIC VARIANTS WITH BLOOD PRESSURE CHANGES, AND HYPERTENSION IN CHINESE ADULTS: RESULTS FROM TWO PROSPECTIVE COHORTS . | JOURNAL OF HYPERTENSION , 2021 , 39 , E112-E112 .
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Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults SCIE
期刊论文 | 2021 | JOURNAL OF CLINICAL HYPERTENSION
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Corin, a transmembrane serine protease that can cleave pro-atrial natriuretic peptide (Pro-ANP) into smaller bioactive molecule atrial natriuretic peptide, has been shown to be involved in the pathophysiology of hypertension, cardiac hypertrophy. We sought to examine the associations of corin genetic variations with salt sensitivity, blood pressure (BP) changes and hypertension incidence. We studied participants of the original Baoji Salt-Sensitive cohort, recruited from 124 families from seven Chinese villages in 2004 who sequentially received a usual baseline salt diet, a 7-day low salt diet (3 g/day) and a 7-day high salt diet (18 g/day), respectively. They were followed up for 8 years (in 2009, 2012) to evaluate the development of hypertension. Corin SNP rs3749584 was significantly associated with diastolic BP (DBP) and mean arterial pressure (MAP) response to low-salt diet, while rs4695253, rs17654278 were associated with pulse pressure (PP) response to low-salt diet. SNPs rs4695253, rs12509275, rs2351783, rs2271036, rs2271037 were significantly associated with systolic BP (SBP), DBP, and MAP responses to high-salt diet. In addition, SNPs rs12641823, rs6834933, rs2271036, and rs22710367 were significantly associated with the longitudinal changes in SBP, DBP, MAP, or PP over 8 years of follow-up. SNP rs73814824 was significantly associated with the incidence of hypertension over 8 years. Gene-based analysis showed that corin gene was significantly associated with longitudinal BP changes and hypertension incidence after 8-year follow-up. This study suggests that corin may play a role in salt sensitivity, BP progression, and development of hypertension.

Keyword :

corin blood pressure salt sensitivity gene polymorphism salt

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GB/T 7714 Zou, Ting , Yao, Shi , Du, Ming-Fei et al. Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults [J]. | JOURNAL OF CLINICAL HYPERTENSION , 2021 .
MLA Zou, Ting et al. "Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults" . | JOURNAL OF CLINICAL HYPERTENSION (2021) .
APA Zou, Ting , Yao, Shi , Du, Ming-Fei , Mu, Jian-Jun , Chu, Chao , Hu, Gui-Lin et al. Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults . | JOURNAL OF CLINICAL HYPERTENSION , 2021 .
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An Intronic Risk SNP rs12454712 for Central Obesity Acts As an Allele-Specific Enhancer To Regulate BCL2 Expression SCIE PubMed
期刊论文 | 2021 , 70 (8) , 1679-1688 | DIABETES
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Genome-wide association studies (GWAS) have reproducibly associated the single nucleotide polymorphism (SNP) rs12454712 with waist-to-hip ratio adjusted for BMI (WHRadjBMI), but the functional role underlying this intronic variant is unknown. Integrative genomic and epigenomic analyses supported rs12454712 as a functional independent variant. We further demonstrated that rs12454712 acted as an allele-specific enhancer regulating expression of its located gene BCL2 by using dual-luciferase reporter assays and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9. Specifically, the rs12454712-C allele can bind transcription factor ZNF329, which efficiently elevates the enhancer activity and increases BCL2 expression. Knocking down Bcl2 in 3T3-L1 cells led to the downregulation of adipogenic differentiation marker genes and increased cell apoptosis. A significant negative correlation between BCL2 expression in subcutaneous adipose tissues and obesity was observed. Our findings illustrate the molecular mechanisms behind the intronic SNP rs12454712 for central obesity, which would be a potential and promising target for developing appropriate therapies.

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GB/T 7714 Dong, Shan-Shan , Zhu, Dong-Li , Zhou, Xiao-Rong et al. An Intronic Risk SNP rs12454712 for Central Obesity Acts As an Allele-Specific Enhancer To Regulate BCL2 Expression [J]. | DIABETES , 2021 , 70 (8) : 1679-1688 .
MLA Dong, Shan-Shan et al. "An Intronic Risk SNP rs12454712 for Central Obesity Acts As an Allele-Specific Enhancer To Regulate BCL2 Expression" . | DIABETES 70 . 8 (2021) : 1679-1688 .
APA Dong, Shan-Shan , Zhu, Dong-Li , Zhou, Xiao-Rong , Rong, Yu , Zeng, Mengqi , Chen, Jia-Bin et al. An Intronic Risk SNP rs12454712 for Central Obesity Acts As an Allele-Specific Enhancer To Regulate BCL2 Expression . | DIABETES , 2021 , 70 (8) , 1679-1688 .
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Genomic insights into the formation of human populations in East Asia SCIE PubMed
期刊论文 | 2021 , 591 (7850) , 413-+ | NATURE
Wang, Chuan-Chao | Yeh, Hui-Yuan | Popov, Alexander N. | Zhang, Hu-Qin | Matsumura, Hirofumi | Sirak, Kendra | Cheronet, Olivia | Kovalev, Alexey | Rohland, Nadin | Kim, Alexander M. | Mallick, Swapan | Bernardos, Rebecca | Tumen, Dashtseveg | Zhao, Jing | Liu, Yi-Chang | Liu, Jiun-Yu | Mah, Matthew | Wang, Ke | Zhang, Zhao | Adamski, Nicole | Broomandkhoshbacht, Nasreen | Callan, Kimberly | Candilio, Francesca | Carlson, Kellie Sara Duffett | Culleton, Brendan J. | Eccles, Laurie | Freilich, Suzanne | Keating, Denise | Lawson, Ann Marie | Mandl, Kirsten | Michel, Megan | Oppenheimer, Jonas | Ozdogan, Kadir Toykan | Stewardson, Kristin | Wen, Shaoqing | Yan, Shi | Zalzala, Fatma | Chuang, Richard | Huang, Ching-Jung | Looh, Hana | Shiung, Chung-Ching | Nikitin, Yuri G. | Tabarev, Andrei V. | Tishkin, Alexey A. | Lin, Song | Sun, Zhou-Yong | Wu, Xiao-Ming | Yang, Tie-Lin | Hu, Xi | Chen, Liang | Du, Hua | Bayarsaikhan, Jamsranjav | Mijiddorj, Enkhbayar | Erdenebaatar, Diimaajav | Iderkhangai, Tumur-Ochir | Myagmar, Erdene | Kanzawa-Kiriyama, Hideaki | Nishino, Masato | Shinoda, Ken-ichi | Shubina, Olga A. | Guo, Jianxin | Cai, Wangwei | Deng, Qiongying | Kang, Longli | Li, Dawei | Li, Dongna | Lin, Rong | Nini | Shrestha, Rukesh | Wang, Ling-Xiang | Wei, Lanhai | Xie, Guangmao | Yao, Hongbing | Zhang, Manfei | He, Guanglin | Yang, Xiaomin | Hu, Rong | Robbeets, Martine | Schiffels, Stephan | Kennett, Douglas J. | Jin, Li | Li, Hui | Krause, Johannes | Pinhasi, Ron | Reich, David
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Abstract :

The deep population history of East Asia remains poorly understood owing to a lack of ancient DNA data and sparse sampling of present-day people(1,2). Here we report genome-wide data from 166 East Asian individuals dating to between 6000 BC and AD 1000 and 46 present-day groups. Hunter-gatherers from Japan, the Amur River Basin, and people of Neolithic and Iron Age Taiwan and the Tibetan Plateau are linked by a deeply splitting lineage that probably reflects a coastal migration during the Late Pleistocene epoch. We also follow expansions during the subsequent Holocene epoch from four regions. First, hunter-gatherers from Mongolia and the Amur River Basin have ancestry shared by individuals who speak Mongolic and Tungusic languages, but do not carry ancestry characteristic of farmers from the West Liao River region (around 3000 BC), which contradicts theories that the expansion of these farmers spread the Mongolic and Tungusic proto-languages. Second, farmers from the Yellow River Basin (around 3000 BC) probably spread Sino-Tibetan languages, as their ancestry dispersed both to Tibet-where it forms approximately 84% of the gene pool in some groups-and to the Central Plain, where it has contributed around 59-84% to modern Han Chinese groups. Third, people from Taiwan from around 1300 BC to AD 800 derived approximately 75% of their ancestry from a lineage that is widespread in modern individuals who speak Austronesian, Tai-Kadai and Austroasiatic languages, and that we hypothesize derives from farmers of the Yangtze River Valley. Ancient people from Taiwan also derived about 25% of their ancestry from a northern lineage that is related to, but different from, farmers of the Yellow River Basin, which suggests an additional north-to-south expansion. Fourth, ancestry from Yamnaya Steppe pastoralists arrived in western Mongolia after around 3000 BC but was displaced by previously established lineages even while it persisted in western China, as would be expected if this ancestry was associated with the spread of proto-Tocharian Indo-European languages. Two later gene flows affected western Mongolia: migrants after around 2000 BC with Yamnaya and European farmer ancestry, and episodic influences of later groups with ancestry from Turan.

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GB/T 7714 Wang, Chuan-Chao , Yeh, Hui-Yuan , Popov, Alexander N. et al. Genomic insights into the formation of human populations in East Asia [J]. | NATURE , 2021 , 591 (7850) : 413-+ .
MLA Wang, Chuan-Chao et al. "Genomic insights into the formation of human populations in East Asia" . | NATURE 591 . 7850 (2021) : 413-+ .
APA Wang, Chuan-Chao , Yeh, Hui-Yuan , Popov, Alexander N. , Zhang, Hu-Qin , Matsumura, Hirofumi , Sirak, Kendra et al. Genomic insights into the formation of human populations in East Asia . | NATURE , 2021 , 591 (7850) , 413-+ .
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A transcriptome-wide association study identifies novel susceptibility genes for psoriasis. PubMed
期刊论文 | 2021 | Human molecular genetics
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Although more than 80 psoriasis genetic risk loci have been reported through genome-wide association studies (GWASs), the genetic mechanism of psoriasis remains unclear. To identify novel candidate genes associated with psoriasis and reveal the potential effects of genetic factors in the development of psoriasis, we conducted a transcriptome-wide association study (TWAS) based on summary statistics from GWAS of psoriasis (5175 cases and 447 089 controls) and gene expression levels from six tissues datasets (blood and skin). We identified 11 conditionally independent genes for psoriasis after Bonferroni corrections, such as the most significant genes UBLCP1 (PYFS = 2.98 × 10-16), and LCE3C (PSNSE = 9.72 × 10-12, PSSE = 6.24 × 10-12). The omnibus test identified additional 5 genes associated with psoriasis via the joint association model from multiple reference tissues. Among the 16 identified genes, 5 genes (CTSW, E1F1AD, KLRC3, FIBP, and EFEMP2) were regarded as novel genes for psoriasis. We evaluated the 16 candidate genes by querying public databases and identified 11 differentially expressed genes and 8 genes proved by the knockout mice models. Through GO enrichment analyses, we found that TWAS genes were enriched in the known GO terms associated with skin development, such as cornified envelope (P = 4.80 × 10-8) and peptide cross-linking (P = 1.50 × 10-7). Taken together, our results detected multiple novel candidate genes for psoriasis, providing clues for understanding the genetic mechanism of psoriasis.

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GB/T 7714 Zhu Dongli , Yao Shi , Wu Hao et al. A transcriptome-wide association study identifies novel susceptibility genes for psoriasis. [J]. | Human molecular genetics , 2021 .
MLA Zhu Dongli et al. "A transcriptome-wide association study identifies novel susceptibility genes for psoriasis." . | Human molecular genetics (2021) .
APA Zhu Dongli , Yao Shi , Wu Hao , Ke Xin , Zhou Xiaorong , Geng Songmei et al. A transcriptome-wide association study identifies novel susceptibility genes for psoriasis. . | Human molecular genetics , 2021 .
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Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. PubMed
期刊论文 | 2021 , 11 , 754206 | Frontiers in oncology
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Aberrant telomerase reverse transcriptase (TERT) expression is crucial for tumor survival and cancer cells escaping apoptosis. Multiple TERT-locus variants at 5p15 have been discovered in association with cancer risk, yet the underlying mechanisms and clinical impacts remain unclear. Here, our association studies showed that the TERT promoter variant rs2853669 confers a risk of prostate cancer (PCa) in different ethnic groups. Further functional investigation revealed that the allele-specific binding of MYC and E2F1 at TERT promoter variant rs2853669 associates with elevated level of TERT in PCa. Mechanistically, androgen stimulations promoted the binding of MYC to allele T of rs2853669, thereby activating TERT, whereas hormone deprivations enhanced E2F1 binding at allele C of rs2853669, thus upregulating TERT expression. Notably, E2F1 could cooperate with AR signaling to regulate MYC expression. Clinical data demonstrated synergistic effects of MYC/E2F1/TERT expression or with the TT and CC genotype of rs2853669 on PCa prognosis and severity. Strikingly, single-nucleotide editing assays showed that the CC genotype of rs2853669 obviously promotes epithelial-mesenchymal transition (EMT) and the development of castration-resistant PCa (CRPC), confirmed by unbiased global transcriptome profiling. Our findings thus provided compelling evidence for understanding the roles of noncoding variations coordinated with androgen signaling and oncogenic transcription factors in mis-regulating TERT expression and driving PCa.

Keyword :

AR signaling TERT MYC E2F1 prostate cancer rs2853669 crpc EMT

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GB/T 7714 Dong Xiaoming , Zhang Qin , Hao Jinglan et al. Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. [J]. | Frontiers in oncology , 2021 , 11 : 754206 .
MLA Dong Xiaoming et al. "Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC." . | Frontiers in oncology 11 (2021) : 754206 .
APA Dong Xiaoming , Zhang Qin , Hao Jinglan , Xie Qianwen , Xu Binbing , Zhang Peng et al. Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. . | Frontiers in oncology , 2021 , 11 , 754206 .
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Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance EI SCIE PubMed
期刊论文 | 2021 , 8 (11) | ADVANCED SCIENCE
WoS CC Cited Count: 1
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Mitochondrial epigenetics is rising as intriguing notion for its potential involvement in aging and diseases, while the details remain largely unexplored. Here it is shown that among the 13 mitochondrial DNA (mtDNA) encoded genes, NADH-dehydrogenase 6 (ND6) transcript is primarily decreased in obese and type 2 diabetes populations, which negatively correlates with its distinctive hypermethylation. Hepatic mtDNA sequencing in mice unveils that ND6 presents the highest methylation level, which dramatically increases under diabetic condition due to enhanced mitochondrial translocation of DNA methyltransferase 1 (DNMT1) promoted by free fatty acid through adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) activation. Hepatic knockdown of ND6 or overexpression of Dnmt1 similarly impairs mitochondrial function and induces systemic insulin resistance both in vivo and in vitro. Genetic or chemical targeting hepatic DNMT1 shows significant benefits against insulin resistance associated metabolic disorders. These findings highlight the pivotal role of ND6 epigenetic network in regulating mitochondrial function and onset of insulin resistance, shedding light on potential preventive and therapeutic strategies of insulin resistance and related metabolic disorders from a perspective of mitochondrial epigenetics.

Keyword :

mitochondrial dysfunction mitochondrial NADH&#8208 obesity and type 2 diabetes mellitus (T2DM) dehydrogenase 6 (ND6) insulin resistance DNA methyltransferase 1 (DNMT1)

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GB/T 7714 Cao, Ke , Lv, Weiqiang , Wang, Xueqiang et al. Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance [J]. | ADVANCED SCIENCE , 2021 , 8 (11) .
MLA Cao, Ke et al. "Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance" . | ADVANCED SCIENCE 8 . 11 (2021) .
APA Cao, Ke , Lv, Weiqiang , Wang, Xueqiang , Dong, Shanshan , Liu, Xuyun , Yang, Tielin et al. Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance . | ADVANCED SCIENCE , 2021 , 8 (11) .
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Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study SCIE SSCI PubMed
期刊论文 | 2021 , 13 (1) | GENOME MEDICINE
WoS CC Cited Count: 4
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BackgroundChildhood obesity is reported to be associated with the risk of many diseases in adulthood. However, observational studies cannot fully account for confounding factors. We aimed to systematically assess the causal associations between childhood body mass index (BMI) and various adult traits/diseases using two-sample Mendelian randomization (MR).MethodsAfter data filtering, 263 adult traits genetically correlated with childhood BMI (P<0.05) were subjected to MR analyses. Inverse-variance weighted, MR-Egger, weighted median, and weighted mode methods were used to estimate the causal effects. Multivariable MR analysis was performed to test whether the effects of childhood BMI on adult traits are independent from adult BMI.ResultsWe identified potential causal effects of childhood obesity on 60 adult traits (27 disease-related traits, 27 lifestyle factors, and 6 other traits). Higher childhood BMI was associated with a reduced overall health rating (=-0.10, 95% CI -0.13 to -0.07, P=6.26x10(-11)). Specifically, higher childhood BMI was associated with increased odds of coronary artery disease (OR=1.09, 95% CI 1.06 to 1.11, P=4.28x10(-11)), essential hypertension (OR=1.12, 95% CI 1.08 to 1.16, P=1.27x10(-11)), type 2 diabetes (OR=1.36, 95% CI 1.30 to 1.43, P=1.57x10(-34)), and arthrosis (OR=1.09, 95% CI 1.06 to 1.12, P=8.80x10(-9)). However, after accounting for adult BMI, the detrimental effects of childhood BMI on disease-related traits were no longer present (P>0.05). For dietary habits, different from conventional understanding, we found that higher childhood BMI was associated with low calorie density food intake. However, this association might be specific to the UK Biobank population.ConclusionsIn summary, we provided a phenome-wide view of the effects of childhood BMI on adult traits. Multivariable MR analysis suggested that the associations between childhood BMI and increased risks of diseases in adulthood are likely attributed to individuals remaining obese in later life. Therefore, ensuring that childhood obesity does not persist into later life might be useful for reducing the detrimental effects of childhood obesity on adult diseases.

Keyword :

Mendelian randomization Adult outcome Causal Childhood BMI

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GB/T 7714 Dong, Shan-Shan , Zhang, Kun , Guo, Yan et al. Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study [J]. | GENOME MEDICINE , 2021 , 13 (1) .
MLA Dong, Shan-Shan et al. "Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study" . | GENOME MEDICINE 13 . 1 (2021) .
APA Dong, Shan-Shan , Zhang, Kun , Guo, Yan , Ding, Jing-Miao , Rong, Yu , Feng, Jun-Cheng et al. Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study . | GENOME MEDICINE , 2021 , 13 (1) .
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Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults SCIE PubMed
期刊论文 | 2021 , 39 (9) , 1817-1825 | JOURNAL OF HYPERTENSION
WoS CC Cited Count: 3
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Objective: Pregnancy-associated plasma protein-A2 (PAPP-A2) is the homolog of PAPP-A in the vertebrate genome and its role in protecting against salt-induced hypertension in salt-sensitive rats has been confirmed. We sought to examine the associations of plasma PAPP-A2 levels and its genetic variants with salt sensitivity, blood pressure (BP) changes and hypertension incidence in humans. Methods: Eighty participants (18-65 years old) sequentially consuming a usual diet, a 7-day low-salt diet (3.0 g/day) and a 7-day high-salt diet (18 g/day). In addition, we studied participants of the original Baoji Salt-Sensitive Study, recruited from 124 families in Northern China in 2004 who received the same salt intake intervention, and evaluated them for the development of hypertension over 14 years. Results: The plasma PAPPA2 levels significantly decreased with the change from baseline to a low-salt diet and decreased further when converting from the low-salt to high-salt diet. SNP rs12042763 in the PAPP-A2 gene was significantly associated with systolic BP responses to both low-salt and high-salt diet while SNP rs2861813 showed a significant association with the changes in SBP and pulse pressure at 14-year follow-up. Additionally, SNPs rs2294654 and rs718067 demonstrated a significant association with the incidence of hypertension over the 14-year follow-up. Finally, the gene-based analysis found that Pappa2 was significantly associated with longitudinal SBP changes and the incidence of hypertension over the 14-year follow-up. Conclusions: This study shows that dietary salt intake affects plasma PAPP-A2 levels and that PAPP-A2 may play a role in salt sensitivity, BP progression and development of hypertension in the Chinese populations.

Keyword :

salt pregnancy-associated plasma protein-A2 gene polymorphism blood pressure salt sensitivity

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GB/T 7714 Wang, Yang , Jia, Hao , Gao, Wei-Hua et al. Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults [J]. | JOURNAL OF HYPERTENSION , 2021 , 39 (9) : 1817-1825 .
MLA Wang, Yang et al. "Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults" . | JOURNAL OF HYPERTENSION 39 . 9 (2021) : 1817-1825 .
APA Wang, Yang , Jia, Hao , Gao, Wei-Hua , Zou, Ting , Yao, Shi , Du, Ming-Fei et al. Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults . | JOURNAL OF HYPERTENSION , 2021 , 39 (9) , 1817-1825 .
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Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults SCIE PubMed
期刊论文 | 2021 , 8 | FRONTIERS IN CARDIOVASCULAR MEDICINE
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Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk.Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension.Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 +/- 1.1 vs. 34.7 +/- 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972-0.984)] in Hanzhong Adolescent Hypertension Study cohort.Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension.

Keyword :

longitudinal change uromodulin (UMOD) blood pressure hypertension gene polymorphism

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GB/T 7714 Wang, Yang , Du, Ming-Fei , Yao, Shi et al. Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults [J]. | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2021 , 8 .
MLA Wang, Yang et al. "Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults" . | FRONTIERS IN CARDIOVASCULAR MEDICINE 8 (2021) .
APA Wang, Yang , Du, Ming-Fei , Yao, Shi , Zou, Ting , Zhang, Xiao-Yu , Hu, Gui-Lin et al. Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults . | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2021 , 8 .
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