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Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis SCIE PubMed
期刊论文 | 2021 , 73 (8) , 1430-1440 | ARTHRITIS & RHEUMATOLOGY
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Abstract :

Objective Collectin 11 (CL-11) is a soluble C-type lectin, a mediator of innate immunity. Its role in autoimmune disorders is unknown. We undertook this study to determine the role of CL-11 in a mouse model of rheumatoid arthritis (RA). Methods A murine collagen-induced arthritis (CIA) model was used and combined two approaches, including gene deletion of Colec11 and treatment with recombinant CL-11 (rCL-11). Joint inflammation and tissue destruction, circulating levels of inflammatory cytokines, and adaptive immune responses were assessed in mice with CIA. Splenic CD11c+ cells were used to examine the influence of CL-11 on antigen-presenting cell (APC) function. Serum CL-11 levels in RA patients were also examined. Results Colec11(-/-) mice developed more severe arthritis than wild-type mice, as determined by disease incidence, clinical arthritis scores, and histopathology (P < 0.05). Disease severity was associated with significantly enhanced APC activation, Th1/Th17 responses, pathogenic IgG2a production and joint inflammation, as well as elevated circulating levels of inflammatory cytokines. In vitro analysis of CD11c+ cells revealed that CL-11 is critical for suppression of APC activation and function. Pharmacologic treatment of mice with rCL-11 reduced the severity of CIA in mice. Analysis of human blood samples revealed that serum CL-11 levels were lower in RA patients (n = 51) compared to healthy controls (n = 53). Reduction in serum CL-11 was inversely associated with the Disease Activity Score in 28 joints, erythrocyte sedimentation rate, and C-reactive protein level (P < 0.05). Conclusion Our findings demonstrate a novel role of CL-11 in protection against RA, suggesting that the underlying mechanism involves suppression of APC activation and subsequent T cell responses.

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GB/T 7714 Wang, Na , Wu, Weiju , Qiang, Cui et al. Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis [J]. | ARTHRITIS & RHEUMATOLOGY , 2021 , 73 (8) : 1430-1440 .
MLA Wang, Na et al. "Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis" . | ARTHRITIS & RHEUMATOLOGY 73 . 8 (2021) : 1430-1440 .
APA Wang, Na , Wu, Weiju , Qiang, Cui , Ma, Ning , Wu, Kunyi , Liu, Dan et al. Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis . | ARTHRITIS & RHEUMATOLOGY , 2021 , 73 (8) , 1430-1440 .
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Human CD3(+)CD56(+)NKT-like cells express a range of complement receptors and C3 activation has negative effects on these cell activity and effector function SCIE PubMed
期刊论文 | 2021 , 82 (9) , 625-633 | HUMAN IMMUNOLOGY
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CD3(+)CD56(+)NKT-like cells are a rare population of lymphocytes that serve important roles in various types of immune-related diseases, and particularly in cancer. The complement system regulates inflammatory and immune responses by interacting with complement receptors expressed on a range of immune cells. However, whether CD3(+)CD56(+)NKT-like cells are regulated by the complement system has still not been definitively determined. In the present study, the expression of complement receptors and regulators in gated CD3(+)CD56(+)NKT-like cells isolated from human peripheral blood was assessed using PCR and flow cytometry. The results showed that human CD3(+)CD56(+)NKT-like cells expressed a range of complement receptors and regulators, such as CR3, C3aR, C5aR, C5L2, CD46 and CD55. Furthermore, the presence of complement component 3 (C3), a key component in complement activation in culture supernatant, mitigated the activity, IFN-gamma production and killing function of CD3(+)CD56(+)NKT-like cells. The present study provides evidences supporting the relationship between complement activation and functional modulation of CD3(+)CD56(+)NKT-like cells, expanding our knowledge of the complement regulatory network, and also highlighting a potential target for treatment of numerous immune-related diseases, particularly NKT cell-based tumor adoptive immunotherapy. (C) 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Keyword :

CD3(+)CD56(+)NKT C3 Complement receptors Regulation

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GB/T 7714 Min, Xiao-Yun , Liu, Cheng-Fei , Cao, Bo et al. Human CD3(+)CD56(+)NKT-like cells express a range of complement receptors and C3 activation has negative effects on these cell activity and effector function [J]. | HUMAN IMMUNOLOGY , 2021 , 82 (9) : 625-633 .
MLA Min, Xiao-Yun et al. "Human CD3(+)CD56(+)NKT-like cells express a range of complement receptors and C3 activation has negative effects on these cell activity and effector function" . | HUMAN IMMUNOLOGY 82 . 9 (2021) : 625-633 .
APA Min, Xiao-Yun , Liu, Cheng-Fei , Cao, Bo , Zhang, Ting , Yang, Xiao , Ma, Ning et al. Human CD3(+)CD56(+)NKT-like cells express a range of complement receptors and C3 activation has negative effects on these cell activity and effector function . | HUMAN IMMUNOLOGY , 2021 , 82 (9) , 625-633 .
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Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis SCIE PubMed
期刊论文 | 2021 , 11 (1) | SCIENTIFIC REPORTS
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This study aimed to assess the association of coagulation-related indicators such as plasma fibrinogen (FIB), d-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) with the disease activity. Data from 105 RA patients and 102 age- and gender-matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide RA patients into low activity group (DAS28-CRP <= 2.7) and active group (DAS28-CRP > 2.7). Receiver operating characteristic (ROC) curve was applied to determine area under the curve (AUC). The association between plasma FIB, d-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Logistical regression analysis was used to identify the independent variables associated with RA disease activity. RA patients showed higher levels of plasma FIB, d-dimer, and FDP than the controls (P < 0.01). Plasma FIB, d-dimer, and FDP were also increased in active groups of RA patients than those in inactive groups (P < 0.001). ROC curve analyses revealed that the AUC of d-dimer was higher than erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF), and that of FDP was higher than RF in RA patients. In addition, the optimal cut-off value of plasma FIB, d-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 mu g/L, and 1.45 mg/L, respectively. Spearman analysis showed that plasma FIB, d-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. Logistical regression analysis showed that d-dimer (odds ratio 2.862, 95% confidence interval 1.851-5.426, P < 0.001) was an independent variable associated with RA disease activity. FIB, d-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. d-dimer may act as a novel inflammatory indice for indicating disease activity in RA patients.

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GB/T 7714 Xue, Li , Tao, Li , Li, Xueyi et al. Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis [J]. | SCIENTIFIC REPORTS , 2021 , 11 (1) .
MLA Xue, Li et al. "Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis" . | SCIENTIFIC REPORTS 11 . 1 (2021) .
APA Xue, Li , Tao, Li , Li, Xueyi , Wang, Yan , Wang, Biao , Zhang, Yanping et al. Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis . | SCIENTIFIC REPORTS , 2021 , 11 (1) .
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Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells SCIE PubMed
期刊论文 | 2021 , 70 (5) , 553-568 | INFLAMMATION RESEARCH
WoS CC Cited Count: 1
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Background and aim As a proinflammatory cytokine, tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in the progression of renal fibrosis by binding to its receptor, fibroblast growth factor-inducible 14 (Fn14). However, the effect of Fn14 inhibition on tubular epithelial cell-mediated tubulointerstitial fibrosis remains unclear. This study aimed to elucidate the role of TWEAK/Fn14 interaction in the development of experimental tubulointerstitial fibrosis as well as the protective effect of Fn14 knockdown on proximal tubular epithelial cells. Methods A murine model of unilateral ureteral obstruction was constructed in both wild-type and Fn14-deficient BALB/c mice, followed by observation of the tubulointerstitial pathologies. Results Fn14 deficiency ameliorated the pathological changes, including inflammatory cell infiltration and cell proliferation, accompanied by reduced production of profibrotic factors and extracellular matrix deposition. In vitro experiments showed that TWEAK dose-dependently enhanced the expression of collagen I, fibronectin, and alpha-smooth muscle actin in proximal tubular epithelial cells. Interestingly, TWEAK also upregulated the expression levels of Notch1/Jagged1. Fn14 knockdown and Notch1/Jagged1 inhibition also mitigated the effect of TWEAK on these cells. Conclusions In conclusion, TWEAK/Fn14 signals contributed to tubulointerstitial fibrosis by acting on proximal tubular epithelial cells. Fn14 inhibition might be a therapeutic strategy for protecting against renal interstitial fibrosis.

Keyword :

Fn14 Tumor necrosis factor-like weak inducer of apoptosis Proximal tubular epithelial cell Fibroblast growth factor&#8211 Renal fibrosis inducible 14 TWEAK Unilateral ureteral obstruction

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GB/T 7714 Luo, Mai , Liu, Mengmeng , Liu, Wei et al. Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells [J]. | INFLAMMATION RESEARCH , 2021 , 70 (5) : 553-568 .
MLA Luo, Mai et al. "Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells" . | INFLAMMATION RESEARCH 70 . 5 (2021) : 553-568 .
APA Luo, Mai , Liu, Mengmeng , Liu, Wei , Cui, Xiao , Zhai, Siyue , Gu, Hanjiang et al. Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells . | INFLAMMATION RESEARCH , 2021 , 70 (5) , 553-568 .
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Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice SCIE PubMed
期刊论文 | 2020 , 40 (9) , 2070-2083 | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | IF: 8.311
WoS CC Cited Count: 3
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Objective: Emerging evidence suggests that C3aR (C3a anaphylatoxin receptor) signaling has protective roles in various inflammatory-related diseases. However, its role in atherosclerosis has been unknown. The purpose of the study was to investigate the possible protective role of C3aR in aortic atherosclerosis and explore molecular and cellular mechanisms involved in the protection. Approach and Results: C3ar(-/-)/Apoe(-/-)mice were generated by cross-breeding of atherosclerosis-proneApoe(-/-)mice andC3ar(-/-)mice.C3ar(-/-)/Apoe(-/-)mice andApoe(-/-)mice (as a control) underwent high-fat diet for 16 weeks were assessed for (1) atherosclerotic plaque burden, (2) aortic tissue inflammation, (3) recruitment of CD11b(+)leukocytes into atherosclerotic lesions, and (4) systemic inflammatory responses. Compared withApoe(-/-)mice,C3ar(-/-)/Apoe(-/-)mice developed more severe atherosclerosis. In addition,C3ar(-/-)/Apoe(-/-)mice have increased local production of proinflammatory mediators (eg, CCL2 [chemokine (C-C motif) ligand 2], TNF [tumor necrosis factor]-alpha) and infiltration of monocyte/macrophage in aortic tissue, and their lesional macrophages displayed an M1-like phenotype. Local pathological changes were associated with enhanced systemic inflammatory responses (ie, elevated plasma levels of CCL2 and TNF-alpha, increased circulating inflammatory cells). In vitro analyses using peritoneal macrophages showed that C3a stimulation resulted in upregulation of M2-associated signaling and molecules, but suppression of M1-associated signaling and molecules, supporting the roles of C3a/C3aR axis in mediating anti-inflammatory response and promoting M2 macrophage polarization. Conclusions: Our findings demonstrate a protective role for C3aR in the development of atherosclerosis and suggest that C3aR confers the protection through C3a/C3aR axis-mediated negative regulation of proinflammatory responses and modulation of macrophage toward the anti-inflammatory phenotype.

Keyword :

macrophages complement C3a receptor inflammation atherosclerosis

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GB/T 7714 Wei, Lin-Lin , Ma, Ning , Wu, Kun-Yi et al. Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice [J]. | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY , 2020 , 40 (9) : 2070-2083 .
MLA Wei, Lin-Lin et al. "Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice" . | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 40 . 9 (2020) : 2070-2083 .
APA Wei, Lin-Lin , Ma, Ning , Wu, Kun-Yi , Wang, Jia-Xing , Diao, Teng-Yue , Zhao, Shu-Juan et al. Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice . | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY , 2020 , 40 (9) , 2070-2083 .
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血清淀粉样蛋白A在急性附睾炎中的诊断价值研究
期刊论文 | 2020 , 17 (16) , 2344-2346,2349 | 检验医学与临床
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Abstract :

目的 探讨血清淀粉样蛋白A(SAA)在急性附睾炎中的诊断价值.方法 选取2018年3月至2019年9月商洛市中心医院收治的67例拟诊断为急性附睾炎患者(急性附睾炎组)作为研究对象,另选取同期在该院体检健康成年男性58例作为对照组,两组SAA、血白细胞计数(WBC)、尿WBC及C-反应蛋白(CRP)水平进行检测并比较各指标水平及其阳性率,分析SAA与CRP、血WBC及尿WBC相关性,利用受试者工作特征曲线(ROC曲线)分析SAA对急性附睾炎的诊断效能,以及比较急性附睾炎组治疗前及治疗7 d后各指标水平.结果 急性附睾炎组SAA、CRP、血WBC及尿WBC水平与对照组比较,差异均有统计学意义(P<0.05).急性附睾炎组SAA与CRP、血WBC及尿WBC水平呈正相关(r=0.792、0.816、0.429,P<0.05).急性附睾炎组SAA、CRP、血WBC及尿WBC的阳性率分别92.54%、74.17%、85.33%和61.49%.以SAA为变量绘制急性附睾炎的ROC曲线,ROC曲线下面积为0.932(P<0.05),95%可信区间为0.915~0.948.急性附睾炎治疗前SAA、CRP及血WBC水平与其治疗7 d后各指标水平比较,均明显下降,差异有统计学意义(P<0.05).结论 SAA检测对急性附睾炎患者的诊断具有重要应用价值.

Keyword :

白细胞计数 血清淀粉样蛋白 急性附睾炎 C-反应蛋白

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GB/T 7714 赵璇 , 李可 , 茹伯战 . 血清淀粉样蛋白A在急性附睾炎中的诊断价值研究 [J]. | 检验医学与临床 , 2020 , 17 (16) : 2344-2346,2349 .
MLA 赵璇 et al. "血清淀粉样蛋白A在急性附睾炎中的诊断价值研究" . | 检验医学与临床 17 . 16 (2020) : 2344-2346,2349 .
APA 赵璇 , 李可 , 茹伯战 . 血清淀粉样蛋白A在急性附睾炎中的诊断价值研究 . | 检验医学与临床 , 2020 , 17 (16) , 2344-2346,2349 .
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New insights on the mechanisms of C5aR1 (CD88) involved in human urinary tract infection CPCI-S SCIE
会议论文 | 2019 , 49 , 1123-1124 | 17th International Congress of Immunology of the International-Union-of-Immunological-Societies (IUIS)
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GB/T 7714 Song, Y. , Chen, L. , Li, K. . New insights on the mechanisms of C5aR1 (CD88) involved in human urinary tract infection [C] . 2019 : 1123-1124 .
MLA Song, Y. et al. "New insights on the mechanisms of C5aR1 (CD88) involved in human urinary tract infection" . (2019) : 1123-1124 .
APA Song, Y. , Chen, L. , Li, K. . New insights on the mechanisms of C5aR1 (CD88) involved in human urinary tract infection . (2019) : 1123-1124 .
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Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy EI Scopus SCIE
期刊论文 | 2019 , 29 (1) | Advanced Functional Materials | IF: 16.836
WoS CC Cited Count: 60 SCOPUS Cited Count: 56
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© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Long blood circulation in vivo remains a challenge to dual-drug-loaded nanocarriers for synergistic chemotherapy. Herein, a novel strategy to prepare lollipop-like dual-drug-loaded nanoparticles (DOX–PDA–gossypol NPs) is developed based on the self-assembly of gossypol, doxorubicin (DOX), and polydopamine (PDA) via π–π stacking. Dopamine polymerizes to PDA and fills the gaps between the gossypol and DOX molecules to form the super compact long-circulating nanoparticles. The DOX–PDA–gossypol NPs show a suitable particle size of 59.6 ± 9.6 nm, high drug loading of 91%, superb stability, high maximum-tolerated dose (MTD) of over 60 mg kg-1, and negligible toxicity. These NPs also exhibit pH-dependent drug release and low combination index (0.23). Notably, they show dramatically ultralong blood circulation (>192 h) with elimination half times 458-fold and 258-fold longer than that of free DOX and free gossypol, respectively. These values are markedly higher than most of the reported results. Therefore, the DOX–PDA–gossypol NPs have a high tumor accumulation of 12% remaining on the 8th day postinjection. This characteristic contributes to the excellent tumor comprehensive synergistic therapeutic efficacy (TIR > 90%) with low administration dosage and is benefitted for widening the drug therapeutic window. Thus, the proposed strategy has remarkable potential for tumor synergistic therapy.

Keyword :

self-assembly synergistic therapy tumor ultralong circulating nanoparticles π–π stacking

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GB/T 7714 Wang, Ya , Wu, Youshen , Li, Ke et al. Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy [J]. | Advanced Functional Materials , 2019 , 29 (1) .
MLA Wang, Ya et al. "Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy" . | Advanced Functional Materials 29 . 1 (2019) .
APA Wang, Ya , Wu, Youshen , Li, Ke , Shen, Shihong , Liu, Zeying , Wu, Daocheng . Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy . | Advanced Functional Materials , 2019 , 29 (1) .
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Novel role for collectin-11 in modulation of dendritic cell maturation and function CPCI-S SCIE
会议论文 | 2018 , 102 , 202-202 | 27th International Complement Workshop (ICW) | IF: 3.064
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Cytokine secretion Dendritic cells Phenotypic maturation/activation Collectin-11

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GB/T 7714 Qiang, Cui , Wu, Weiju , Li, Ke et al. Novel role for collectin-11 in modulation of dendritic cell maturation and function [C] . 2018 : 202-202 .
MLA Qiang, Cui et al. "Novel role for collectin-11 in modulation of dendritic cell maturation and function" . (2018) : 202-202 .
APA Qiang, Cui , Wu, Weiju , Li, Ke , Zhou, Wuding . Novel role for collectin-11 in modulation of dendritic cell maturation and function . (2018) : 202-202 .
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C5aR1 promotes acute cystitis induced by uropathogenic Escherichia coli in mice CPCI-S SCIE
会议论文 | 2018 , 102 , 233-233 | 27th International Complement Workshop (ICW) | IF: 3.064
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Keyword :

Cystitis Inflammation C5a/C5aR1 axis

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GB/T 7714 Zhao, Guoxiu , Wu, Kunyi , Zhang, Ting et al. C5aR1 promotes acute cystitis induced by uropathogenic Escherichia coli in mice [C] . 2018 : 233-233 .
MLA Zhao, Guoxiu et al. "C5aR1 promotes acute cystitis induced by uropathogenic Escherichia coli in mice" . (2018) : 233-233 .
APA Zhao, Guoxiu , Wu, Kunyi , Zhang, Ting , Zhou, Wuding , Li, Ke . C5aR1 promotes acute cystitis induced by uropathogenic Escherichia coli in mice . (2018) : 233-233 .
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