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A Plausible Role for Collectins in Skin Immune Homeostasis SCIE PubMed
期刊论文 | 2021 , 12 | FRONTIERS IN IMMUNOLOGY
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Abstract :

The skin is a complex organ that faces the external environment and participates in the innate immune system. Skin immune homeostasis is necessary to defend against external microorganisms and to recover from stress to the skin. This homeostasis depends on interactions among a variety of cells, cytokines, and the complement system. Collectins belong to the lectin pathway of the complement system, and have various roles in innate immune responses. Mannose-binding lectin (MBL), collectin kidney 1, and liver (CL-K1, CL-L1) activate the lectin pathway, while all have multiple functions, including recognition of pathogens, opsonization of phagocytosis, and modulation of cytokine-mediated inflammatory responses. Certain collectins are localized in the skin, and their expressions change during skin diseases. In this review, we summarize important advances in our understanding of how MBL, surfactant proteins A and D, CL-L1, and CL-K1 function in skin immune homeostasis. Based on the potential roles of collectins in skin diseases, we suggest therapeutic strategies for skin diseases through the targeting of collectins and relevant regulators.

Keyword :

collectins immunotherapy immune homeostasis skin immunity

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GB/T 7714 Wang, Tian , Li, Ke , Xiao, Shengxiang et al. A Plausible Role for Collectins in Skin Immune Homeostasis [J]. | FRONTIERS IN IMMUNOLOGY , 2021 , 12 .
MLA Wang, Tian et al. "A Plausible Role for Collectins in Skin Immune Homeostasis" . | FRONTIERS IN IMMUNOLOGY 12 (2021) .
APA Wang, Tian , Li, Ke , Xiao, Shengxiang , Xia, Yumin . A Plausible Role for Collectins in Skin Immune Homeostasis . | FRONTIERS IN IMMUNOLOGY , 2021 , 12 .
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TNF-Like Weak Inducer of Apoptosis Promotes Angiogenesis, Thereby Exacerbating Cutaneous Psoriatic Disease. PubMed SCIE
期刊论文 | 2021 , 141 (5) , 1356-1360 | The Journal of investigative dermatology
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GB/T 7714 Liu Wei , Zhang Dingwei , Luo Mai et al. TNF-Like Weak Inducer of Apoptosis Promotes Angiogenesis, Thereby Exacerbating Cutaneous Psoriatic Disease. [J]. | The Journal of investigative dermatology , 2021 , 141 (5) : 1356-1360 .
MLA Liu Wei et al. "TNF-Like Weak Inducer of Apoptosis Promotes Angiogenesis, Thereby Exacerbating Cutaneous Psoriatic Disease." . | The Journal of investigative dermatology 141 . 5 (2021) : 1356-1360 .
APA Liu Wei , Zhang Dingwei , Luo Mai , Jia Fangyan , Peng Lingling , Li Xiaoli et al. TNF-Like Weak Inducer of Apoptosis Promotes Angiogenesis, Thereby Exacerbating Cutaneous Psoriatic Disease. . | The Journal of investigative dermatology , 2021 , 141 (5) , 1356-1360 .
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The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies SCIE PubMed
期刊论文 | 2021 | CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ damage, especially the kidney, skin, and central nervous system. Anti-dsDNA antibodies play a pivotal role in SLE, and researchers have developed therapeutic strategies targeting these antibodies. Approaches to reduce anti-dsDNA antibodies via B cell targeted biologics against B cell surface antigens, B cell survival factors, or Bruton's tyrosine kinase have effectively eliminated B cells. However, their non-specific depletion hampers normal immune system functioning and limits the therapeutic benefits. Thus, scientists have attempted anti-dsDNA antibodies or lupus-specific strategies, such as the immature dendritic cell vaccine and immunoadsorption. Recently, synthetic mimic peptides (hCDR1, pCONs, DWEYS, FISLE-412, and ALW) that directly block anti-dsDNA autoantibodies have attracted attention, which could ameliorate lupus, decrease the serological autoantibody titer, reduce the deposition of renal autoantibodies, and improve pathological performance. These potent small peptide molecules are well tolerated, non-toxic, and non-immunogenic, which have demonstrated a benign safety profile and are expected to be hopeful candidates for SLE management. In this review, we clarify the role of anti-dsDNA antibodies in SLE, mainly focus on the current strategies targeting anti-dsDNA antibodies, and discuss their potential clinical value.

Keyword :

Therapeutic peptide Target therapy B cell Anti-dsDNA antibody Systemic lupus erythematosus (SLE)

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GB/T 7714 Wang, Yaqi , Xiao, Shengxiang , Xia, Yumin et al. The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies [J]. | CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY , 2021 .
MLA Wang, Yaqi et al. "The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies" . | CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021) .
APA Wang, Yaqi , Xiao, Shengxiang , Xia, Yumin , Wang, Huixia . The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies . | CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY , 2021 .
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Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study SCIE PubMed
期刊论文 | 2021 , 11 (1) | SCIENTIFIC REPORTS
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Bullous pemphigoid (BP), the most frequent blistering dermatosis in the elderly, is associated with increased mortality. The severity of BP can be assessed by detecting the anti-BP180 immunoglobulin G (IgG) concentration, but the lab test is not available in many community clinics. BP patients are usually in a hypercoagulable state with increased levels of D-dimer and fibrin degradation products (FDPs). We aimed to evaluate the use of D-dimer and FDPs in assessing BP severity. We compared the levels of plasma D-dimer, plasma FDPs, eosinophil counts, eosinophil cationic protein, and serum anti-BP180 IgG concentration between 48 typical BP patients and 33 Herpes zoster (HZ) patients (control group). Correlational analyses were conducted to determine the relationships between the lab values and common BP severity markers. The plasma D-dimer and FDP levels were higher in BP patients than in HZ controls (D-dimer: 3297 +/- 2517 mu g/L vs. 569.70 +/- 412.40 mu g/L; FDP: 9.74 +/- 5.88 mg/L vs. 2.02 +/- 1.69 mg/L, respectively, P < 0.0001). Significant positive correlations were found between D-dimer/FDP levels and BP severity markers (i.e. anti-BP180 IgG concentration [D-dimer: r = 0.3928, P = 0.0058; FDP: r = 0.4379, P = 0.0019] and eosinophil counts [D-dimer: r = 0.3625, P = 0.0013; FDP: r = 0.2880, P = 0.0472]) in BP patients. We also found an association between FDP and urticaria/erythema lesions (r = 0.3016, P = 0.0372), but no other BPDAI components. In 19 BP patients with complete remission after systemic glucocorticoid treatment, D-dimer and FDP levels decreased post-therapy (D-dimer: 5559 +/- 7492 mu g/L vs. 1738 +/- 1478 mu g/L; P < 0.0001; FDP: 11.20 +/- 5.88 mg/L vs. 5.13 +/- 3.44 mg/L; P = 0.0003), whereas they did not in BP patients with treatment resistant. Plasma D-dimer and FDP are convenient markers to evaluate BP severity assistant on BPDAI and eosinophil counts. FDP is also helpful for inflammatory lesions in BP patients.

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GB/T 7714 Wang, Sijia , Lu, Mei , Zhao, Zijun et al. Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study [J]. | SCIENTIFIC REPORTS , 2021 , 11 (1) .
MLA Wang, Sijia et al. "Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study" . | SCIENTIFIC REPORTS 11 . 1 (2021) .
APA Wang, Sijia , Lu, Mei , Zhao, Zijun , Peng, Xueting , Li, Liang , Cheng, Chuantao et al. Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study . | SCIENTIFIC REPORTS , 2021 , 11 (1) .
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New repair strategy: Treatment of V-shaped divided nevus on eyelids with fish-mouth flap SCIE PubMed
期刊论文 | 2021 | DERMATOLOGIC THERAPY
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GB/T 7714 Gu, Hanjiang , Xia, Yumin , Tan, Xuanfeng . New repair strategy: Treatment of V-shaped divided nevus on eyelids with fish-mouth flap [J]. | DERMATOLOGIC THERAPY , 2021 .
MLA Gu, Hanjiang et al. "New repair strategy: Treatment of V-shaped divided nevus on eyelids with fish-mouth flap" . | DERMATOLOGIC THERAPY (2021) .
APA Gu, Hanjiang , Xia, Yumin , Tan, Xuanfeng . New repair strategy: Treatment of V-shaped divided nevus on eyelids with fish-mouth flap . | DERMATOLOGIC THERAPY , 2021 .
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Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis. PubMed SCIE
期刊论文 | 2021 , 138 | Cytokine
WoS CC Cited Count: 1
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Psoriasis is a common chronic inflammatory dermatitis in which various cytokines play a detrimental role. The cytokine tumor necrosis factor-related weak inducer of apoptosis (TWEAK) is involved in the pathogenesis of multiple inflammatory disorders. However, the potential role of TWEAK in various subtypes of psoriasis has not been studied in depth. To investigate whether the levels of TWEAK are associated with clinical traits and the levels of some known psoriasis-related cytokines, such as interleukin (IL)-17A, IL-22, interferon (IFN)-γ, and IL-36γ, 20 patients with psoriasis vulgaris (PV), 8 patients with pustular psoriasis (PP), 8 patients with erythrodermic psoriasis (EP), and 20 healthy controls (HCs) were recruited into this study. The levels of serum cytokines were detected by commercial enzyme-linked immunosorbent assay kits. The average levels of TWEAK, IL-17A, IL-22, IFN-γ, and IL-36γ were significantly higher in the psoriasis groups than in the HC group. Furthermore, there was a statistically significant correlation between TWEAK and IL-17A/IFN-γ in PV and IL-36γ in EP, but there was no correlation between TWEAK and IL-22 in any subtype of psoriasis. This study suggests that TWEAK may have a role in the pathogenesis of PV, PP, and EP via synergy with IL-17A, IFN-γ, or IL-36γ, but not with IL-22.

Keyword :

Psoriasis TWEAK IFN-γ IL-17A IL-22 IL-36γ

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GB/T 7714 Wang Huixia , Wang Sijia , Li Liang et al. Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis. [J]. | Cytokine , 2021 , 138 .
MLA Wang Huixia et al. "Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis." . | Cytokine 138 (2021) .
APA Wang Huixia , Wang Sijia , Li Liang , Wang Xiuying , Liu Chengfei , Lu Mei et al. Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis. . | Cytokine , 2021 , 138 .
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Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells SCIE PubMed
期刊论文 | 2021 , 70 (5) , 553-568 | INFLAMMATION RESEARCH
WoS CC Cited Count: 1
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Background and aim As a proinflammatory cytokine, tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in the progression of renal fibrosis by binding to its receptor, fibroblast growth factor-inducible 14 (Fn14). However, the effect of Fn14 inhibition on tubular epithelial cell-mediated tubulointerstitial fibrosis remains unclear. This study aimed to elucidate the role of TWEAK/Fn14 interaction in the development of experimental tubulointerstitial fibrosis as well as the protective effect of Fn14 knockdown on proximal tubular epithelial cells. Methods A murine model of unilateral ureteral obstruction was constructed in both wild-type and Fn14-deficient BALB/c mice, followed by observation of the tubulointerstitial pathologies. Results Fn14 deficiency ameliorated the pathological changes, including inflammatory cell infiltration and cell proliferation, accompanied by reduced production of profibrotic factors and extracellular matrix deposition. In vitro experiments showed that TWEAK dose-dependently enhanced the expression of collagen I, fibronectin, and alpha-smooth muscle actin in proximal tubular epithelial cells. Interestingly, TWEAK also upregulated the expression levels of Notch1/Jagged1. Fn14 knockdown and Notch1/Jagged1 inhibition also mitigated the effect of TWEAK on these cells. Conclusions In conclusion, TWEAK/Fn14 signals contributed to tubulointerstitial fibrosis by acting on proximal tubular epithelial cells. Fn14 inhibition might be a therapeutic strategy for protecting against renal interstitial fibrosis.

Keyword :

Fn14 Tumor necrosis factor-like weak inducer of apoptosis Proximal tubular epithelial cell Fibroblast growth factor&#8211 Renal fibrosis inducible 14 TWEAK Unilateral ureteral obstruction

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GB/T 7714 Luo, Mai , Liu, Mengmeng , Liu, Wei et al. Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells [J]. | INFLAMMATION RESEARCH , 2021 , 70 (5) : 553-568 .
MLA Luo, Mai et al. "Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells" . | INFLAMMATION RESEARCH 70 . 5 (2021) : 553-568 .
APA Luo, Mai , Liu, Mengmeng , Liu, Wei , Cui, Xiao , Zhai, Siyue , Gu, Hanjiang et al. Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells . | INFLAMMATION RESEARCH , 2021 , 70 (5) , 553-568 .
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Successful Treatment of Vitiligo with Cold Atmospheric Plasma‒Activated Hydrogel. PubMed
期刊论文 | 2021 , 141 (11) , 2710-2719.e6 | The Journal of investigative dermatology
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Vitiligo shows insufficient response to current therapies largely owing to T-lymphocyte dysfunction, abnormal inflammatory activation, and excessive oxidative stress in lesions. Cold atmospheric plasma (CAP) possesses pleiotropic antioxidant and anti-inflammatory properties and may offer an improvement to current treatment options. In this study, the efficacy and safety of CAP were investigated in a mouse model of vitiligo and a randomized and controlled trial of patients with active focal vitiligo. Skin biopsies showed that topical treatment of vitiligo-like lesions on mouse dorsal skin by CAP restored the distribution of melanin. In addition, CAP treatment reduced the infiltration of CD11c+ dendritic cells, CD3+ T cells, and CD8+ T cells; inhibited the release of CXCL10 and cytokine IFN-γ; and enhanced cellular resistance to oxidative stress and excessive immune response by enhancing the expression of the transcription factor NRF2 and attenuating the activity of inducible nitric oxide synthase. In a randomized and controlled trial, CAP treatment achieved partial and complete repigmentation in 80% and 20% of vitiligo lesions, respectively, without hyperpigmentation in surrounding areas or other adverse events during the treatment period and its follow-up period. In conclusion, CAP offers a promising option for the management of vitiligo.

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GB/T 7714 Zhai Siyue , Xu Meifeng , Li Qiaosong et al. Successful Treatment of Vitiligo with Cold Atmospheric Plasma‒Activated Hydrogel. [J]. | The Journal of investigative dermatology , 2021 , 141 (11) : 2710-2719.e6 .
MLA Zhai Siyue et al. "Successful Treatment of Vitiligo with Cold Atmospheric Plasma‒Activated Hydrogel." . | The Journal of investigative dermatology 141 . 11 (2021) : 2710-2719.e6 .
APA Zhai Siyue , Xu Meifeng , Li Qiaosong , Guo Kun , Chen Hailan , Kong Michael G et al. Successful Treatment of Vitiligo with Cold Atmospheric Plasma‒Activated Hydrogel. . | The Journal of investigative dermatology , 2021 , 141 (11) , 2710-2719.e6 .
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TWEAK/Fn14信号调控干细胞增殖与分化的作用与机制
期刊论文 | 2020 , 10 (1) , 57-62 | 中华细胞与干细胞杂志(电子版)
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肿瘤坏死因子样弱凋亡诱导蛋白(TWEAK)是肿瘤坏死因子(TNF)超家族成员,通过作用于唯一受体成纤维细胞生长因子14(Fn14)调控细胞的增殖、分化和迁移等多种生命活动.近来研究表明,TWEAK/Fn14信号可以作用于多种干细胞,如肝干细胞、神经干细胞和间充质干细胞等,通过影响其增殖与分化的能力,干预组织的修复与再生.对该领域的研究进行综述,将有助于揭示TWEAK/Fn14信号调控干细胞增殖与分化的作用与机制,并为干细胞在疾病发生机制等基础研究、细胞治疗和组织工程等临床医学研究提供新的方向.

Keyword :

信号通路 分化 干细胞 TWEAK 增殖 Fn14

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GB/T 7714 延祝 , 夏育民 . TWEAK/Fn14信号调控干细胞增殖与分化的作用与机制 [J]. | 中华细胞与干细胞杂志(电子版) , 2020 , 10 (1) : 57-62 .
MLA 延祝 et al. "TWEAK/Fn14信号调控干细胞增殖与分化的作用与机制" . | 中华细胞与干细胞杂志(电子版) 10 . 1 (2020) : 57-62 .
APA 延祝 , 夏育民 . TWEAK/Fn14信号调控干细胞增殖与分化的作用与机制 . | 中华细胞与干细胞杂志(电子版) , 2020 , 10 (1) , 57-62 .
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银屑病的动物模型与细胞模型研究进展
期刊论文 | 2020 , 27 (3) , 204-206 | 皮肤性病诊疗学杂志
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银屑病的发病机制很复杂,目前尚未完全阐明.银屑病主要特征是表皮过度增生和明显的炎症浸润.在人类银屑病中观察到的特征也可在各种银屑病动物模型及体外模型中观察到,这些模型已广泛应用于银屑病的组织病理学、发病机制和对药物反应等研究.目前用于银屑病研究的模型主要包括动物模型和细胞模型,其中常用的动物模型有自发模型、转基因动物模型、药物诱导的模型(局部皮肤外用咪喹莫特)以及异体移植模型.这些模型虽然不能完全精确重现人类银屑病的发生及发展过程,但在揭示其可能的发病机制、新药测试等方面有重要价值.本文就银屑病的动物模型与细胞模型研究进展作一综述.

Keyword :

细胞模型 银屑病 动物模型

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GB/T 7714 彭玲玲 , 延祝 , 夏育民 . 银屑病的动物模型与细胞模型研究进展 [J]. | 皮肤性病诊疗学杂志 , 2020 , 27 (3) : 204-206 .
MLA 彭玲玲 et al. "银屑病的动物模型与细胞模型研究进展" . | 皮肤性病诊疗学杂志 27 . 3 (2020) : 204-206 .
APA 彭玲玲 , 延祝 , 夏育民 . 银屑病的动物模型与细胞模型研究进展 . | 皮肤性病诊疗学杂志 , 2020 , 27 (3) , 204-206 .
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