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单纯性汗腺棘皮瘤的临床病理分析
期刊论文 | 2022 , 38 (1) , 39-42 | 中国麻风皮肤病杂志
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为总结单纯性汗腺棘皮瘤(hidroacanthoma simplex,HS)的临床及组织病理特点,回顾性分析我院2015年1月至2020年8月诊治的5例HS患者及CNKI中检索文献报道的16例HS患者资料.结果示21例患者平均年龄61.1岁(36~86岁),其中男8例,女13例,病程5个月至50年,皮损主要见于躯干、下肢(17/21),也可见于上肢(4/21),皮损表现为斑块,无自觉症状.组织病理表现为表皮内境界清楚的肿瘤细胞团块,肿瘤细胞呈立方形或卵圆形,部分细胞胞质内含有糖原,呈透明状,局部可见导管分化,真皮内无明显变化.免疫组化染色显示:EMA阳性,CEA在导管分化处阳性.16例患者行手术切除,随访无复发及恶变,5例患者具体治疗方式不详.

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GB/T 7714 王宁 , 黄英剑 , 段琪琪 et al. 单纯性汗腺棘皮瘤的临床病理分析 [J]. | 中国麻风皮肤病杂志 , 2022 , 38 (1) : 39-42 .
MLA 王宁 et al. "单纯性汗腺棘皮瘤的临床病理分析" . | 中国麻风皮肤病杂志 38 . 1 (2022) : 39-42 .
APA 王宁 , 黄英剑 , 段琪琪 , 宋刘梅 , 杨鹏举 , 王声榜 et al. 单纯性汗腺棘皮瘤的临床病理分析 . | 中国麻风皮肤病杂志 , 2022 , 38 (1) , 39-42 .
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皮肤性病学科研型研究生培养方式的思考与探讨
期刊论文 | 2021 , 43 (3) , 409-410 | 皮肤病与性病
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科研型研究生的培养是加强皮肤性病学人才队伍建设的重要环节.笔者从皮肤性病学科研型研究生的培养现状与问题入手,并从编制个性化培养方案、双轨提升科研和临床能力、关注研究生心理健康发展等角度对解决问题的策略和方案进行了深入的分析与探讨.

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GB/T 7714 丰硕 , 张梦迪 , 吴佳纹 et al. 皮肤性病学科研型研究生培养方式的思考与探讨 [J]. | 皮肤病与性病 , 2021 , 43 (3) : 409-410 .
MLA 丰硕 et al. "皮肤性病学科研型研究生培养方式的思考与探讨" . | 皮肤病与性病 43 . 3 (2021) : 409-410 .
APA 丰硕 , 张梦迪 , 吴佳纹 , 汪炜 , 郑焱 . 皮肤性病学科研型研究生培养方式的思考与探讨 . | 皮肤病与性病 , 2021 , 43 (3) , 409-410 .
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A superfacial ulcer on the scrotum SCIE
期刊论文 | 2021 , 141 (5) , S74-S74 | JOURNAL OF INVESTIGATIVE DERMATOLOGY
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GB/T 7714 Tuo, H. , Zheng, Y. , Zhang, J. et al. A superfacial ulcer on the scrotum [J]. | JOURNAL OF INVESTIGATIVE DERMATOLOGY , 2021 , 141 (5) : S74-S74 .
MLA Tuo, H. et al. "A superfacial ulcer on the scrotum" . | JOURNAL OF INVESTIGATIVE DERMATOLOGY 141 . 5 (2021) : S74-S74 .
APA Tuo, H. , Zheng, Y. , Zhang, J. , Feng, Y. . A superfacial ulcer on the scrotum . | JOURNAL OF INVESTIGATIVE DERMATOLOGY , 2021 , 141 (5) , S74-S74 .
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LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells SCIE PubMed
期刊论文 | 2021 , 81 (11) , 2918-2929 | CANCER RESEARCH
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The long noncoding RNA (lncRNA) SAMMSON is required for human melanoma cell growth and survival. However, whether SAMMSON regulates the response of mutant BRAF melanoma cells to RAF inhibitors remains unknown. In this work, we showed that SAMMSON is rapidly induced upon inhibition of ERK signaling, and SAMMSON overexpression conferred resistance to vemurafenib-induced cytotoxicity in melanoma cells. SOX10 mediated transcriptional induction of SAMMSON by vemurafenib, and SOX10 sumoylation at K55 was essential for this function. In addition, depletion of SAMMSON activated p53 signaling, which is dependent on the SAMMSON-interacting protein CARF. Depletion of SAMMSON sensitized mutant BRAF melanoma cells to RAF inhibitors in vitro and in vivo, while CARF knockdown reversed the enhanced sensitivity. In summary, these findings suggest that SAMMSON may function as a new mediator of adaptive resistance to RAF inhibitors in melanoma by modulating CARF-p53 signaling. Significance: This study highlights the role of a SAMMSON/CARF/p53 signaling axis in modulating the adaptive resistance of mutant BRAF melanoma to RAF inhibitors.

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GB/T 7714 Han, Shujun , Yan, Yuwei , Ren, Yibo et al. LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells [J]. | CANCER RESEARCH , 2021 , 81 (11) : 2918-2929 .
MLA Han, Shujun et al. "LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells" . | CANCER RESEARCH 81 . 11 (2021) : 2918-2929 .
APA Han, Shujun , Yan, Yuwei , Ren, Yibo , Hu, Yiming , Wang, Yan , Chen, Lei et al. LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells . | CANCER RESEARCH , 2021 , 81 (11) , 2918-2929 .
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Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect SCIE PubMed
期刊论文 | 2021 | JOURNAL OF CELLULAR PHYSIOLOGY
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Kynureninase (KYNU) is a key enzyme in the tryptophan metabolism pathway with elevated expression in psoriatic lesions relative to normal skin. However, whether KYNU contributes to the pathogenesis of psoriasis remains unknown. We sought to investigate the role of KYNU in psoriasis and its possible regulation mechanism. In the results, KYNU is upregulated in psoriatic skin samples from patients or animal models compared with normal skin control which was assayed in psoriatic patient samples, IMQ-induced psoriasis-like skin inflammation in BABL/c mice and M5-stimulated keratinocyte cell lines by immunohistochemistry (IHC). KYNU knockdown had a trivial impact on keratinocyte proliferation, but significantly inhibited the production of inflammatory cytokines in HaCaT, HEK alpha, and HEKn cells by quantitative reverse-transcription polymerase chain reaction, enzyme-linked immunosorbent assay, and western blot analysis. The 3MODIFIER LETTER PRIME-untranslated region of KYNU contains a conserved target site of a skin-specific microRNA (miRNA), miR-203a, as predicted by TargetScan software. Furthermore, miR-203a exhibited an inversed expression kinetics to KYNU during the development of IMQ-induced psoriasis-like skin inflammation in BABL/c mice. Overexpression of miR-203 subsequently leading to the inhibition of KYNU, could significantly reduce the production of M5-induced, psoriasis-related inflammatory factors in keratinocytes. Finally, KYNU inhibitors could alleviate the pathological phenotypes in IMQ-mice. Our study supported the contributive role of KYNU in the development of psoriasis and provided preliminary evidence for KYNU as a potential therapeutic target in psoriasis.

Keyword :

psoriasis inflammation inhibitor miR-203a KYNU M5

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GB/T 7714 Wang, Min , Wang, Yuqian , Zhang, Mengdi et al. Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect [J]. | JOURNAL OF CELLULAR PHYSIOLOGY , 2021 .
MLA Wang, Min et al. "Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect" . | JOURNAL OF CELLULAR PHYSIOLOGY (2021) .
APA Wang, Min , Wang, Yuqian , Zhang, Mengdi , Duan, Qiqi , Chen, Caifeng , Sun, Qiong et al. Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect . | JOURNAL OF CELLULAR PHYSIOLOGY , 2021 .
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Clinical analysis of Hidroacanthoma simplex SCIE
期刊论文 | 2021 , 141 (5) , S113-S113 | JOURNAL OF INVESTIGATIVE DERMATOLOGY
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GB/T 7714 Wang, N. , Zheng, Y. . Clinical analysis of Hidroacanthoma simplex [J]. | JOURNAL OF INVESTIGATIVE DERMATOLOGY , 2021 , 141 (5) : S113-S113 .
MLA Wang, N. et al. "Clinical analysis of Hidroacanthoma simplex" . | JOURNAL OF INVESTIGATIVE DERMATOLOGY 141 . 5 (2021) : S113-S113 .
APA Wang, N. , Zheng, Y. . Clinical analysis of Hidroacanthoma simplex . | JOURNAL OF INVESTIGATIVE DERMATOLOGY , 2021 , 141 (5) , S113-S113 .
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基于全球疾病负担(GBD)大数据的中国银屑病流行病学负担分析 CSCD
期刊论文 | 2021 , 35 (4) , 386-392 | 中国皮肤性病学杂志
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目的 分析GBD 2017数据库中国银屑病数据,探讨中国银屑病疾病流行病学负担,为银屑病的防控提供理论依据.方法 检索GBD 2017数据库中国银屑病的患病数/率、发病数/率、DALYs/DALY率及中国和全球的社会人口学指数(SDI值),统计中国1990-2017年银屑病的流行趋势及年龄、时期、出生队列趋势,并研究银屑病发病率与SDI之间的关系.结果 2017年,中国银屑病患病率及发病率均位于全球偏低水平,患病人数为1990年的1.95倍,患病率、发病率及DALY率均持续上升.中国银屑病发病率年龄趋势呈中间高两头低形态,且男性高于女性.随着SDI值的增加,银屑病的发病率呈线性上升趋势.结论 1990-2017年间,中国银屑病疾病负担显著上升,且与社会发展程度呈正相关.积极研究银屑病准确的流行病学资料及与社会发展水平的关系,对于银屑病诊治、卫生政策制定具有重要意义.

Keyword :

中国 负担 银屑病 GBD 2017

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GB/T 7714 李慧贤 , 胡丽 , 郑焱 et al. 基于全球疾病负担(GBD)大数据的中国银屑病流行病学负担分析 [J]. | 中国皮肤性病学杂志 , 2021 , 35 (4) : 386-392 .
MLA 李慧贤 et al. "基于全球疾病负担(GBD)大数据的中国银屑病流行病学负担分析" . | 中国皮肤性病学杂志 35 . 4 (2021) : 386-392 .
APA 李慧贤 , 胡丽 , 郑焱 , 张键 , 刘文丽 , 高田原 et al. 基于全球疾病负担(GBD)大数据的中国银屑病流行病学负担分析 . | 中国皮肤性病学杂志 , 2021 , 35 (4) , 386-392 .
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八年制教育模式下皮肤病学医学生的优劣势分析
期刊论文 | 2021 , 13 (24) , 111-114 | 中国继续医学教育
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八年制医学教育模式是皮肤病学教学体系的新生事物.教育部门及高校对其投入大量精力物力,力求为培养皮肤科新一代有潜力的高层次人才奠定基础.挖掘其优势与不足,对于培养新型皮肤科医生,具有应用价值和指导意义.充分利用综合高校优势或前期理工科学院合作培养模式、同时开展器官-系统整合模块教学、PBL、数字化新媒体教学、双语教学等新型教育模式有利于加强对人体各系统的疾病的综合理解并培养具有国际视野的医工交叉复合型皮肤病学人才.综合分析其招生模式、课程体系结构、培养目标定位、质量控制标准与职业发展,为改进皮肤病学八年制教育模式提供参考.

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GB/T 7714 王子阳 , 张梦迪 , 汪炜 et al. 八年制教育模式下皮肤病学医学生的优劣势分析 [J]. | 中国继续医学教育 , 2021 , 13 (24) : 111-114 .
MLA 王子阳 et al. "八年制教育模式下皮肤病学医学生的优劣势分析" . | 中国继续医学教育 13 . 24 (2021) : 111-114 .
APA 王子阳 , 张梦迪 , 汪炜 , 郑焱 . 八年制教育模式下皮肤病学医学生的优劣势分析 . | 中国继续医学教育 , 2021 , 13 (24) , 111-114 .
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Clinical efficacy analysis of narrow spectrum intense pulsed light in the treatment of acne-related erythema in Chinese patients CPCI-S SCIE
会议论文 | 2020 , 140 (7) , S98-S98 | Virtual Conference of the Society-for-Investigative-Dermatology (SID )
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GB/T 7714 Yang, Y. , Zheng, Y. . Clinical efficacy analysis of narrow spectrum intense pulsed light in the treatment of acne-related erythema in Chinese patients [C] . 2020 : S98-S98 .
MLA Yang, Y. et al. "Clinical efficacy analysis of narrow spectrum intense pulsed light in the treatment of acne-related erythema in Chinese patients" . (2020) : S98-S98 .
APA Yang, Y. , Zheng, Y. . Clinical efficacy analysis of narrow spectrum intense pulsed light in the treatment of acne-related erythema in Chinese patients . (2020) : S98-S98 .
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A novel mutation of COL7A1 in a Chinese family with dystrophic epidermolysis bullosa pruriginosa CPCI-S SCIE
会议论文 | 2020 , 140 (7) , S31-S31 | Virtual Conference of the Society-for-Investigative-Dermatology (SID )
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GB/T 7714 Tuo, H. , Zheng, Y. . A novel mutation of COL7A1 in a Chinese family with dystrophic epidermolysis bullosa pruriginosa [C] . 2020 : S31-S31 .
MLA Tuo, H. et al. "A novel mutation of COL7A1 in a Chinese family with dystrophic epidermolysis bullosa pruriginosa" . (2020) : S31-S31 .
APA Tuo, H. , Zheng, Y. . A novel mutation of COL7A1 in a Chinese family with dystrophic epidermolysis bullosa pruriginosa . (2020) : S31-S31 .
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