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△D-二聚体与肺栓塞发生事件的相关性
期刊论文 | 2021 , 33 (4) , 517-520 | 西部医学
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Abstract :

目的 探讨患者△D-二聚体升高与肺栓塞(PE)的相关性.方法 采用回顾性病例对照研究,共纳入我院2017年6月~2018年7月行肺动脉血管造影检查(CTPA)的260例患者为研究对象,纳入患者均行CTPA,并且在CT-PA前1周内行两次D-二聚体监测(两次间隔时间>1 d).根据△D-二聚体结果分为△D-二聚体>0组与△D-二聚体≤0组.采用单因素及多因素Logistic回归模型分析△D-二聚体升高对PE发生的可能性.结果 本研究共收集△D-二聚体>0组150例与△D-二聚体≤0组110例;△D-二聚体在肺栓塞组的中位数为2960,在非肺栓塞组为5,差异有统计学意义(P<0.001);△D-二聚体>0组在PE中占41.3%,△D-二聚体≤0组在PE中占20.0%,差异有统计学意义(P<0.001).单因素Logistic回归分析显示:△D-二聚体>0发生PE的可能性是△D-二聚体≤0的2.755倍;多因素Logistic回归分析显示:△D-二聚体>0组发生PE的可能性是△D-二聚体≤0组的2.829倍.在非肿瘤患者中,△D-二聚体>0发生PE的可能性是△D-二聚体≤0的3.038倍;多因素Logistic回归显示:△D-二聚体>0组发生PE的风险是△D-二聚体≤0组的2.870倍,差异亦有统计学意义(P<0.05).结论 △D-二聚体>0与PE之间有较高的相关性,关注D-二聚体变化可提高PE的早期诊断率,尤其在非肿瘤患者中更显著.

Keyword :

D-二聚体 肺栓塞 肺动脉血管造影 相关性

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GB/T 7714 骆艳妮 , 王岗 , 王小闯 et al. △D-二聚体与肺栓塞发生事件的相关性 [J]. | 西部医学 , 2021 , 33 (4) : 517-520 .
MLA 骆艳妮 et al. "△D-二聚体与肺栓塞发生事件的相关性" . | 西部医学 33 . 4 (2021) : 517-520 .
APA 骆艳妮 , 王岗 , 王小闯 , 李佳媚 , 张静静 , 侯彦丽 . △D-二聚体与肺栓塞发生事件的相关性 . | 西部医学 , 2021 , 33 (4) , 517-520 .
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Effect of genetic liability to visceral adiposity on stroke and its subtypes: A Mendelian randomization study SCIE PubMed
期刊论文 | 2021 | INTERNATIONAL JOURNAL OF STROKE
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Abstract :

Background Observational studies have found an association between visceral adiposity and stroke. Aims The purpose of this study was to investigate the role and genetic effect of visceral adipose tissue accumulation on stroke and its subtypes. Methods In this two-sample Mendelian randomization study, genetic variants (221 single nucleotide polymorphisms; P < 5 x 10(-8)) using as instrumental variables for Mendelian randomization analysis was obtained from a genome-wide association study of visceral adipose tissue. The outcome datasets for stroke and its subtypes were obtained from the MEGASTROKE consortium (up to 67,162 cases and 453,702 controls). Mendelian randomization standard analysis (inverse variance weighted method) was conducted to investigate the effect of genetic liability to visceral adiposity on stroke and its subtypes. Sensitivity analyses (Mendelian randomization-Egger, weighted median, Mendelian randomization-pleiotropy residual sum and outlier) were also utilized to assess horizontal pleiotropy and remove outliers. Multi-variable Mendelian randomization analysis was employed to adjust potential confounders. Results In the standard Mendelian randomization analysis, genetically determined visceral adiposity (per 1 SD) was significantly associated with a higher risk of stroke (odds ratio (OR) 1.30; 95% confidence interval (CI) 1.21-1.41, P = 1.48x 10(-11)), ischemic stroke (OR 1.30; 95% CI 1.20-1.41, P = 4.01 x 10(-10)) and large artery stroke (OR 1.49; 95% CI 1.22-1.83, P = 1.16 x 10(-4)). The significant association was also found in sensitivity analysis and multi-variable Mendelian randomization analysis. Conclusions Genetic liability to visceral adiposity was significantly associated with an increased risk of stroke, ischemic stroke, and large artery stroke. The effect of genetic susceptibility to visceral adiposity on the stroke warrants further investigation.

Keyword :

stroke Mendelian randomization stroke subtypes Visceral adiposity

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GB/T 7714 Yan, Bin , Yang, Jian , Qian, Li et al. Effect of genetic liability to visceral adiposity on stroke and its subtypes: A Mendelian randomization study [J]. | INTERNATIONAL JOURNAL OF STROKE , 2021 .
MLA Yan, Bin et al. "Effect of genetic liability to visceral adiposity on stroke and its subtypes: A Mendelian randomization study" . | INTERNATIONAL JOURNAL OF STROKE (2021) .
APA Yan, Bin , Yang, Jian , Qian, Li , Gao, Fengjie , Bai, Ling , Wang, Gang et al. Effect of genetic liability to visceral adiposity on stroke and its subtypes: A Mendelian randomization study . | INTERNATIONAL JOURNAL OF STROKE , 2021 .
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Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure SCIE PubMed
期刊论文 | 2021 , 11 (1) | SCIENTIFIC REPORTS
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Evidence indicates that glucose variation (GV) plays an important role in mortality of critically ill patients. We aimed to investigate the relationship between the coefficient of variation of 24-h venous blood glucose (24-hVBGCV) and mortality among patients with acute respiratory failure. The records of 1625 patients in the Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II) database were extracted. The 24-hVBGCV was calculated as the ratio of the standard deviation (SD) to the mean venous blood glucose level, expressed as a percentage. The outcomes included ICU mortality and in-hospital mortality. Participants were divided into three subgroups based on tertiles of 24-hVBGCV. Multivariable logistic regression models were used to evaluate the relationship between 24-hVBGCV and mortality. Sensitivity analyses were also performed in groups of patients with and without diabetes mellitus. Taking the lowest tertile as a reference, after adjustment for all the covariates, the highest tertile was significantly associated with ICU mortality [odds ratio (OR), 1.353; 95% confidence interval (CI), 1.018-1.797] and in-hospital mortality (OR, 1.319; 95% CI, 1.003-1.735), especially in the population without diabetes. The 24-hVBGCV may be associated with ICU and in-hospital mortality in patients with acute respiratory failure in the ICU, especially in those without diabetes.

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GB/T 7714 Zhang, Xiaoling , Zhang, Jingjing , Li, Jiamei et al. Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure [J]. | SCIENTIFIC REPORTS , 2021 , 11 (1) .
MLA Zhang, Xiaoling et al. "Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure" . | SCIENTIFIC REPORTS 11 . 1 (2021) .
APA Zhang, Xiaoling , Zhang, Jingjing , Li, Jiamei , Gao, Ya , Li, Ruohan , Jin, Xuting et al. Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure . | SCIENTIFIC REPORTS , 2021 , 11 (1) .
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The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study SCIE PubMed
期刊论文 | 2021 , 13 (5) , 7020-7034 | AGING-US
WoS CC Cited Count: 8
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Abstract :

Background: The inflammatory reaction is the main cause of acute respiratory distress syndrome and multiple organ failure in patients with Coronavirus disease 2019, especially those with severe and critical illness. Several studies suggested that high-dose vitamin C reduced inflammatory reaction associated with sepsis and acute respiratory distress syndrome. This study aimed to determine the efficacy and safety of high-dose vitamin C in Coronavirus disease 2019. Methods: We included 76 patients with Coronavirus disease 2019, classified into the high-dose vitamin C group (loading dose of 6g intravenous infusion per 12 hr on the first day, and 6g once for the following 4 days, n=46) and the standard therapy group (standard therapy alone, n=30). Results: The risk of 28-day mortality was reduced for the high-dose vitamin C versus the standard therapy group (HR=0.14, 95% CI, 0.03-0.72). Oxygen support status was improved more with high-dose vitamin C than standard therapy (63.9% vs 36.1%). No safety events were associated with high-dose vitamin C therapy. Conclusion: High-dose vitamin C may reduce the mortality and improve oxygen support status in patients with Coronavirus disease 2019 without adverse events.

Keyword :

COVID-19 mortality coronavirus disease 2019 safety ascorbic acid

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GB/T 7714 Gao, Dengfeng , Xu, Min , Wang, Gang et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study [J]. | AGING-US , 2021 , 13 (5) : 7020-7034 .
MLA Gao, Dengfeng et al. "The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study" . | AGING-US 13 . 5 (2021) : 7020-7034 .
APA Gao, Dengfeng , Xu, Min , Wang, Gang , Lv, Jianrui , Ma, Xiaorong , Guo, Yonghong et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study . | AGING-US , 2021 , 13 (5) , 7020-7034 .
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Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients SCIE PubMed
期刊论文 | 2021 , 48 (5) , 679-685 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
WoS CC Cited Count: 1
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Diabetic nephropathy (DN) is the major cause of chronic kidney disease and end-stage renal disease. Previous studies have demonstrated that long-chain omega-3 polyunsaturated fatty acids (PUFAs) might have therapeutic potential in reducing proteinuria in DN. However, the local level of eicosanoids derived from PUFAs in the plasma of DN patients remains unclear. This work aims to study the eicosanoid profile difference in plasma of DN patients and type 2 diabetes (T2D) without DN. A total of 27 T2D patients with similar diabetic duration were recruited and divided into T2D+DN group and T2D+NDN (non-DN) group based on urinary albumin excretion (UAE) detection. Using LC-MS/MS-based metabolomics, DN patients showed increased level of lipoxygenase (LOX) metabolites (5-HETE and LTB4) and decreased levels of eicosanoids derived according to the cytochrome P450s (CYP450) metabolic pathway (5,6-DHET; 14,15-DHET and 9,10-diHOME). Receiver operating characteristics and logistic regression analysis revealed increased level LOX metabolites and decreased level of CYP450 metabolites were significantly correlated with the incidence of DN in T2D patients. LOX and CYP450 metabolites correlated with DN incidence in T2D patients, which might be treatment targets for DN in T2D patients.

Keyword :

diabetic nephropathy metabolomics eicosanoids lipoxygenase cytochrome P450s

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GB/T 7714 Peng, Liyuan , Sun, Bei , Liu, Yajin et al. Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients [J]. | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY , 2021 , 48 (5) : 679-685 .
MLA Peng, Liyuan et al. "Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients" . | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 48 . 5 (2021) : 679-685 .
APA Peng, Liyuan , Sun, Bei , Liu, Yajin , Huang, Jing , Chen, Guangzhi , Zhang, Xu et al. Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients . | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY , 2021 , 48 (5) , 679-685 .
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The relationship between serum lactate dehydrogenase level and mortality in critically ill patients SCIE PubMed
期刊论文 | 2021 , 15 (8) , 551-559 | BIOMARKERS IN MEDICINE
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Background: To assess the association between serum lactate dehydrogenase (LDH) levels and mortality in intensive care unit patients. Materials & methods: A total of 1981 patients in the eICU Collaborative Research Database were divided into four groups according to quartiles of LDH levels. Logistic regressions were performed. Results: Elevated LDH levels were significantly associated with higher mortality (intensive care unit mortality: Q2 vs Q1: 1.046 [0.622-1.758]; Q3 vs Q1: 1.667 [1.029-2.699]; and Q4 vs Q1: 1.760 [1.092-2.839]). Similar results persisted in patients with different acute physiology and chronic health evaluation IV scores, and with or without sepsis. Conclusion: The serum LDH level may aid in the early identification of mortality risk in critically ill patients.

Keyword :

mortality eICU Collaborative Research Database intensive care unit lactate dehydrogenase

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GB/T 7714 Su, Dan , Li, Jiamei , Ren, Jiajia et al. The relationship between serum lactate dehydrogenase level and mortality in critically ill patients [J]. | BIOMARKERS IN MEDICINE , 2021 , 15 (8) : 551-559 .
MLA Su, Dan et al. "The relationship between serum lactate dehydrogenase level and mortality in critically ill patients" . | BIOMARKERS IN MEDICINE 15 . 8 (2021) : 551-559 .
APA Su, Dan , Li, Jiamei , Ren, Jiajia , Gao, Ya , Li, Ruohan , Jin, Xuting et al. The relationship between serum lactate dehydrogenase level and mortality in critically ill patients . | BIOMARKERS IN MEDICINE , 2021 , 15 (8) , 551-559 .
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An evaluation on the association of vancomycin trough concentration with mortality in critically ill patients: A multicenter retrospective study SCIE PubMed
期刊论文 | 2021 , 14 (5) , 1780-1790 | CTS-CLINICAL AND TRANSLATIONAL SCIENCE
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To determine the impact of initial vancomycin trough concentration (VTC) on mortality in adult patients in the intensive care unit (ICU) undergoing vancomycin therapy. During their first ICU stay, patients with initial VTC records after vancomycin treatment were recruited from the eICU Collaborative Research Database to this multicenter retrospective cohort study, and classified into four groups according to VTC: less than 10, 10-15, 15-20, and greater than 20 mg/L. Multivariable logistic regression and sensitivity analyses were performed to explore the association of VTC, as a continuous and categorical variable, with mortality. This study enrolled 7220 patients from 335 different ICUs at 208 hospitals. Multivariable logistic regression models indicated that VTC was positively correlated with ICU (odds ratio [OR], 1.028, 95% confidence interval [CI], 1.019-1.037) and hospital (OR 1.028, 95% CI, 1.020-1.036) mortalities. Moreover, compared with VTC less than 10 mg/L, VTCs of 10-15, 15-20, and greater than 20 mg/L were associated with a higher risk of ICU mortality (OR, 1.330, 95% CI, 1.070-1.653; OR, 1.596, 95% CI, 1.265-2.015; abd OR, 1.875, 95% CI, 1.491-2.357, respectively), and VTCs of 15-20 and greater than 20 mg/L were also correlated with increased hospital mortality (OR, 1.482, 95% CI, 1.225-1.793; and OR, 1.831, 95% CI, 1.517-2.210, respectively). Similar results persisted in patients with different Acute Physiology and Chronic Health Evaluation scores, creatinine clearance levels, ages, and body mass indexes. Our findings indicated a potential relationship of initial VTC with ICU and hospital mortalities in patients in the ICU. However, due to the retrospective nature of this study, future prospective studies or randomized controlled trials are needed to validate those results.

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GB/T 7714 Ren, Jiajia , Hou, Yanli , Li, Jiamei et al. An evaluation on the association of vancomycin trough concentration with mortality in critically ill patients: A multicenter retrospective study [J]. | CTS-CLINICAL AND TRANSLATIONAL SCIENCE , 2021 , 14 (5) : 1780-1790 .
MLA Ren, Jiajia et al. "An evaluation on the association of vancomycin trough concentration with mortality in critically ill patients: A multicenter retrospective study" . | CTS-CLINICAL AND TRANSLATIONAL SCIENCE 14 . 5 (2021) : 1780-1790 .
APA Ren, Jiajia , Hou, Yanli , Li, Jiamei , Gao, Ya , Li, Ruohan , Jin, Xuting et al. An evaluation on the association of vancomycin trough concentration with mortality in critically ill patients: A multicenter retrospective study . | CTS-CLINICAL AND TRANSLATIONAL SCIENCE , 2021 , 14 (5) , 1780-1790 .
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Increasing serum ammonia level is a risk factor for the prognosis of critically ill patients: A multicenter retrospective cohort study. PubMed SCIE
期刊论文 | 2021 , 62 , 218-222 | Journal of critical care
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To assess the association between serum ammonia level upon admission during the initial intensive care unit (ICU) stay and mortality.This retrospective cohort study included 2703 adult patients in eICU Collaborative Research Database. The ICU mortality within ammonia deciles were assessed. Logistic regression analyses were performed to analyze the relationship between ammonia and mortality.We defined three ammonia categories: <47, 47-111, and ≥111 μg/dL, corresponding to low, intermediate, and high ICU mortality. Increased ammonia was significantly associated with increased ICU mortality (per 10 μg/dL increase: odds ratio, 1.070 [95% confidence intervals, 1.05-1.09]; intermediate vs. low: 1.90 [1.41-2.56]; high vs. low: 4.38 [2.99-6.41]) and in-hospital mortality (1.06 [1.04-1.08]; 1.45 [1.13-1.87]; 3.41 [2.43-4.79]). Adding ammonia to the Acute Physiology and Chronic Health Evaluation (APACHE) IV score improved the area under the curve from 0.826 to 0.839 (P < 0.001) and from 0.806 to 0.813 (P = 0.001) for ICU and in-hospital mortality, respectively. Interaction and subgroup analyses demonstrated consistent results in patients with different APACHE IV scores, with or without hepatic diseases.Elevated serum ammonia level in critically ill patients upon admission was an early risk factor for higher ICU and in-hospital mortality.

Keyword :

Mortality Intensive care unit Ammonia eICU collaborative research database

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GB/T 7714 Li Jiamei , Li Ruohan , Gao Ya et al. Increasing serum ammonia level is a risk factor for the prognosis of critically ill patients: A multicenter retrospective cohort study. [J]. | Journal of critical care , 2021 , 62 : 218-222 .
MLA Li Jiamei et al. "Increasing serum ammonia level is a risk factor for the prognosis of critically ill patients: A multicenter retrospective cohort study." . | Journal of critical care 62 (2021) : 218-222 .
APA Li Jiamei , Li Ruohan , Gao Ya , Jin Xuting , Zhang Jingjing , Ren Jiajia et al. Increasing serum ammonia level is a risk factor for the prognosis of critically ill patients: A multicenter retrospective cohort study. . | Journal of critical care , 2021 , 62 , 218-222 .
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红细胞分布宽度与危重症患者病死率的相关性研究 CSCD
期刊论文 | 2021 , 41 (2) , 111-116 | 中国急救医学
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目的 探讨危重症患者入重症监护室(intensive care unit,ICU)时红细胞分布宽度(red cell distribution width,RDW)与病死率的相关性.方法 采用回顾性队列研究,纳入美国重症监护数据库Ⅱ 版本2.6(Multiparameter Intelligent Monitoring in Intensive CareⅡversion 2.6,MIMIC-Ⅱv2.6)中单次入院且ICU住院时长>24 h,同时有RDW检测记录的成年患者.根据RDW预测病死率的最佳cut-off值(14.55%)将研究对象分为低RDW组(RDW<14.55%)及高RDW组(RDW≥14.55%),比较两组的病死率,进一步使用单因素及多因素Logistic回归和Cox回归分析评估RDW与病死率的关系.结果 本研究最终共有13822例患者入组.高RDW组的医院病死率、ICU病死率、28 d病死率及1年病死率均高于低RDW组(分别为19.73%vs.8.42%,15.04%vs.6.65%,22.68%vs.9.12%,36.22%vs.14.45%,均P<0.001).RDW作为连续变量,多因素分析结果 显示,RDW越高,医院病死率(OR=1.227,95%CI 1.190~1.265)、ICU病死率(OR=1.180,95%CI 1.141~1.220)、28 d病死率(HR=1.161,95%CI 1.138~1.185)和1年病死率(HR=1.177,95%CI 1.159~1.195)越高.分组后回归分析结果 显示,与低水平RDW组相比,高水平RDW组患者的医院病死率增加0.912倍(OR=1.912,95%CI 1.683~2.172),ICU病死率增加0.673倍(OR=1.673,95%CI 1.452~1.928),28 d病死率增加0.850倍(HR=1.850,95%CI 1.675~2.043),1年病死率增加1.045倍(HR=2.045,95%CI 1.891~2.212),且存在统计学意义(P<0.001).结论 入ICU首次RDW增高是危重症患者死亡的危险因素.

Keyword :

重症监护室(ICU) 病死率 红细胞分布宽度(RDW)

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GB/T 7714 侯彦丽 , 金旭婷 , 李佳媚 et al. 红细胞分布宽度与危重症患者病死率的相关性研究 [J]. | 中国急救医学 , 2021 , 41 (2) : 111-116 .
MLA 侯彦丽 et al. "红细胞分布宽度与危重症患者病死率的相关性研究" . | 中国急救医学 41 . 2 (2021) : 111-116 .
APA 侯彦丽 , 金旭婷 , 李佳媚 , 张静静 , 骆艳妮 , 王小闯 et al. 红细胞分布宽度与危重症患者病死率的相关性研究 . | 中国急救医学 , 2021 , 41 (2) , 111-116 .
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Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy SCIE PubMed CSCD
期刊论文 | 2021 , 8 (1) | MILITARY MEDICAL RESEARCH
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Trauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhage. Previous studies on TIC have mainly focused on hemorrhagic coagulopathy caused by the hypocoagulable phenotype of TIC, while recent studies have found that trauma-induced hypercoagulopathy can occur in as many as 22.2-85.1% of trauma patients, in whom it can increase the risk of thrombotic events and mortality by 2- to 4-fold. Therefore, the Chinese People's Liberation Army Professional Committee of Critical Care Medicine and the Chinese Society of Thrombosis, Hemostasis and Critical Care, Chinese Medicine Education Association jointly formulated this Chinese Expert Consensus comprising 15 recommendations for the definition, pathophysiological mechanism, assessment, prevention, and treatment of trauma-induced hypercoagulopathy.

Keyword :

Thrombosis Diagnosis Trauma Treatment Coagulation dysfunction

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GB/T 7714 Song, Jing-Chun , Yang, Li-Kun , Zhao, Wei et al. Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy [J]. | MILITARY MEDICAL RESEARCH , 2021 , 8 (1) .
MLA Song, Jing-Chun et al. "Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy" . | MILITARY MEDICAL RESEARCH 8 . 1 (2021) .
APA Song, Jing-Chun , Yang, Li-Kun , Zhao, Wei , Zhu, Feng , Wang, Gang , Chen, Yao-Peng et al. Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy . | MILITARY MEDICAL RESEARCH , 2021 , 8 (1) .
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