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Acoustic cavitation of encapsulated microbubble and its mechanical effect in soft tissue EI SCIE
期刊论文 | 2021 , 70 (15) | ACTA PHYSICA SINICA
WoS CC Cited Count: 1
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Abstract :

Ultrasound-induced cavitation in the viscoelastic biological tissues has attracted considerable attention due to its mechanical bio-effects, such as cell sonoporation, hemolysis, vascular disruption and tissue erosion. Cavitation can exert strong mechanical stresses on the surrounding tissues during the rapid bubble growth and collapse. The occurrence of cavitation needs the ultrasound exposure exceeding a certain acoustic pressure threshold, and the cavitation threshold is very high in most tissues, probably causing undesirable side-effects. Introducing artificial cavitation nuclei, e.g., microbubbles and nanodroplets stabilized with a shell such as albumin, lipids or polymers, into the targeted region can effectively reduce the cavitation threshold and significantly enhance the cavitation effects. However, neither the cavitation dynamics of an encapsulated microbubble nor the cavitation-induced stress field around the bubble in a soft tissue is quite clear. In this study, a comprehensive numerical model is developed to describe the dynamics of a lipid-shelled microbubble in vivo and quantify the cavitation-induced mechanical stress in the tissue. Considering the nonlinear changes of both shell viscosity and elasticity, a Gilmore model that has been considered as the most developed and realistic cavitation model is coupled with the Zener viscoelastic model for precisely describing tissue viscoelastic behavior with both creep recovery and stress relaxation of tissue. The developed model has an advantage of accurately describing the bubble behaviors in different biological tissues at high ultrasound intensities, especially for the bubble collapse. Furthermore, the spatiotemporal evolution of mechanical stress in the surrounding tissue generated by the cavitation bubble is investigated. Finally, the effects of encapsulated shell, elasticity modulus and viscosity of tissue as well as ultrasound amplitude are examined. The results show that the viscoelasticity of encapsulated shell and tissue both inhibit the bubble oscillations, and the tissue viscoelasticity has a larger inhibition effect. During the bubble oscillation, the compressive (negative) stress is generated in the tissue with the bubble growing and it continuously increases until it reaches a maximum value at a maximum radius, while the tensile (positive) stress is generated at the stage of bubble collapse and initial stage of bubble rebound due to the restoration of deformed tissue. The stress magnitude is greatest near the bubble wall and decreases rapidly with depth extending into the surrounding tissue. By contrast, the tensile stress decreases at a higher rate than the compressive stress. The encapsulated bubble presents a smaller stress in the tissue, but the decrease of the stress can be ignored at large acoustic pressures. Moreover, the stress decreases with the increase of tissue elasticity modulus, whereas it first increases and then decreases with tissue viscosity increasing, showing a maximum at 15 mPa.s. The increasing of the ultrasound amplitude enhances the bubble oscillations and consequently increases the stress in the tissue. This study is helpful in understanding the bubble dynamics and cavitation-induced mechanical stress of an encapsulated microbubble in soft tissue, which is essential for a safe and precise ultrasound therapy.

Keyword :

acoustic cavitation in soft tissue mechanical effect of cavitation encapsulated microbubble bubble dynamics

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GB/T 7714 Qin Dui , Zou Qing-Qin , Zhang-Yong et al. Acoustic cavitation of encapsulated microbubble and its mechanical effect in soft tissue [J]. | ACTA PHYSICA SINICA , 2021 , 70 (15) .
MLA Qin Dui et al. "Acoustic cavitation of encapsulated microbubble and its mechanical effect in soft tissue" . | ACTA PHYSICA SINICA 70 . 15 (2021) .
APA Qin Dui , Zou Qing-Qin , Zhang-Yong , Wang Wei , Wan Ming-Xi , Feng Yi . Acoustic cavitation of encapsulated microbubble and its mechanical effect in soft tissue . | ACTA PHYSICA SINICA , 2021 , 70 (15) .
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Study on the Application of Super-Resolution Ultrasound for Cerebral Vessel Imaging in Rhesus Monkeys SCIE PubMed
期刊论文 | 2021 , 12 | FRONTIERS IN NEUROLOGY
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Background: Ultrasound is ideal for displaying intracranial great vessels but not intracranial microvessels and terminal vessels. Even with contrast agents, the imaging effect is still unsatisfactory. In recent years, significant theoretical advances have been achieved in super-resolution imaging. The latest commonly used ultrafast plane-wave ultrasound Doppler imaging of the brain and microbubble-based super-resolution ultrasound imaging have been applied to the imaging of cerebral microvessels and blood flow in small animals such as mice but have not been applied to in vivo imaging of the cerebral microvessels in monkeys and larger animals. In China, preliminary research results have been obtained using super-resolution imaging in certain fields but rarely in fundamental and clinical experiments on large animals. In recent years, we have conducted a joint study with the Xi'an Jiaotong University to explore the application and performance of this new technique in the diagnosis of cerebrovascular diseases in large animals.Objective: To explore the characteristics and advantages of microbubble-based super-resolution ultrasound imaging of intracranial vessels in rhesus monkeys compared with conventional transcranial ultrasound.Methods: First, the effectiveness and feasibility of the super-resolution imaging technique were verified by modular simulation experiments. Then, the imaging parameters were adjusted based on in vitro experiments. Finally, two rhesus monkeys were used for in vivo experiments of intracranial microvessel imaging.Results: Compared with conventional plane-wave imaging, super-resolution imaging could measure the inner diameters of cerebral microvessels at a resolution of 1 mm or even 0.7 mm and extract blood flow information. In addition, it has a better signal-to-noise ratio (5.625 dB higher) and higher resolution (~30-fold higher). The results of the experiments with rhesus monkeys showed that microbubble-based super-resolution ultrasound imaging can achieve an optimal resolution at the micron level and an imaging depth >35 mm.Conclusion: Super-resolution imaging can realize the monitoring imaging of high-resolution and fast calculation of microbubbles in the process of tissue damage, providing an important experimental basis for the clinical application of non-invasive transcranial ultrasound.

Keyword :

cerebral vessel microbubbles ultrasound super-resolution imaging monkey

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GB/T 7714 Yan, Li , Bai, Chen , Zheng, Yu et al. Study on the Application of Super-Resolution Ultrasound for Cerebral Vessel Imaging in Rhesus Monkeys [J]. | FRONTIERS IN NEUROLOGY , 2021 , 12 .
MLA Yan, Li et al. "Study on the Application of Super-Resolution Ultrasound for Cerebral Vessel Imaging in Rhesus Monkeys" . | FRONTIERS IN NEUROLOGY 12 (2021) .
APA Yan, Li , Bai, Chen , Zheng, Yu , Zhou, Xiaodong , Wan, Mingxi , Zong, Yujin et al. Study on the Application of Super-Resolution Ultrasound for Cerebral Vessel Imaging in Rhesus Monkeys . | FRONTIERS IN NEUROLOGY , 2021 , 12 .
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Enhanced HIFU Theranostics with Dual-Frequency-Ring Focused Ultrasound and Activatable Perfluoropentane-Loaded Polymer Nanoparticles SCIE PubMed
期刊论文 | 2021 , 12 (11) | MICROMACHINES
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High-intensity focused ultrasound (HIFU) has been widely used in tumor ablation in clinical settings. Meanwhile, there is great potential to increase the therapeutic efficiency of temporary cavitation due to enhanced thermal effects and combined mechanical effects from nonlinear vibration and collapse of the microbubbles. In this study, dual-frequency (1.1 and 5 MHz) HIFU was used to produce acoustic droplet vaporization (ADV) microbubbles from activatable perfluoropentane-loaded polymer nanoparticles (PFP@Polymer NPs), which increased the therapeutic outcome of the HIFU and helped realize tumor theranostics with ultrasound contrast imaging. Combined with PFP@Polymer NPs, dual-frequency HIFU changed the shape of the damage lesion and reduced the acoustic intensity threshold of thermal damage significantly, from 216.86 to 62.38 W/cm(2). It produced a nearly 20 & DEG;C temperature increase in half the irradiation time and exhibited a higher tumor inhibition rate (84.5% & PLUSMN; 3.4%) at a low acoustic intensity (1.1 MHz: 23.77 W/cm(2); 5 MHz: 0.35 W/cm(2)) in vitro than the single-frequency HIFU (60.2% & PLUSMN; 11.9%). Moreover, compared with the traditional PFP@BSA NDs, PFP@Polymer NPs showed higher anti-tumor efficacy (81.13% vs. 69.34%; * p < 0.05) and better contrast-enhanced ultrasound (CEUS) imaging ability (gray value of 57.53 vs. 30.67; **** p < 0.0001), probably benefitting from its uniform and stable structure. It showed potential as a highly efficient tumor theranostics approach based on dual-frequency HIFU and activatable PFP@Polymer NPs.

Keyword :

high-intensity focused ultrasound (HIFU) perfluoropentane-loaded polymer nanoparticle (PFP@Polymer NP) dual frequency theranostics cavitation

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GB/T 7714 Chen, Junjie , Nan, Zhezhu , Zhao, Yubo et al. Enhanced HIFU Theranostics with Dual-Frequency-Ring Focused Ultrasound and Activatable Perfluoropentane-Loaded Polymer Nanoparticles [J]. | MICROMACHINES , 2021 , 12 (11) .
MLA Chen, Junjie et al. "Enhanced HIFU Theranostics with Dual-Frequency-Ring Focused Ultrasound and Activatable Perfluoropentane-Loaded Polymer Nanoparticles" . | MICROMACHINES 12 . 11 (2021) .
APA Chen, Junjie , Nan, Zhezhu , Zhao, Yubo , Zhang, Lei , Zhu, Hongrui , Wu, Daocheng et al. Enhanced HIFU Theranostics with Dual-Frequency-Ring Focused Ultrasound and Activatable Perfluoropentane-Loaded Polymer Nanoparticles . | MICROMACHINES , 2021 , 12 (11) .
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Effects of Vertical Glottal Duct Length on Intraglottal Pressures in the Convergent Glottis SCIE
期刊论文 | 2021 , 11 (10) | APPLIED SCIENCES-BASEL
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In a previous study, the vertical glottal duct length was examined for its influence on intraglottal pressures and other aerodynamic parameters in the uniform glottis [J Voice 32, 8-22 (2018)]. This study extends that work for convergent glottal angles, the shape of the glottis during the glottal opening phase of vocal fold vibration. The computational fluid dynamics code ANSYS Fluent 6.3 was used to obtain the pressure distributions and other aerodynamic parameters for laminar, incompressible, two-dimensional flow in a static vocal fold model. Four typical vertical glottal duct lengths (0.108, 0.308, 0.608, 0.908 cm) were selected for three minimal diameters (0.01, 0.04, 0.16 cm), three transglottal pressures (500, 1000, 1500 Pa), and three convergent glottal angles (-5 degrees, -10 degrees, -20 degrees). The results suggest that a longer vertical glottal duct length increases the intraglottal pressures, decreases the glottal entrance loss coefficient, increases the transglottal pressure coefficient, causes a lower gradient of both the intraglottal flow velocity and the wall shear stress along the glottal wall-especially for low flows and small glottal minimal diameters-and has little effect on the exit pressure coefficient and volume flow. The vertical glottal duct length in the convergent glottis has important effects on phonation and should be well specified when building computational and physical models of the vocal folds.

Keyword :

vertical glottal duct length vocal fold geometry convergent glottal angle intraglottal pressure

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GB/T 7714 Li, Sheng , Scherer, Ronald C. , Wan, Mingxi . Effects of Vertical Glottal Duct Length on Intraglottal Pressures in the Convergent Glottis [J]. | APPLIED SCIENCES-BASEL , 2021 , 11 (10) .
MLA Li, Sheng et al. "Effects of Vertical Glottal Duct Length on Intraglottal Pressures in the Convergent Glottis" . | APPLIED SCIENCES-BASEL 11 . 10 (2021) .
APA Li, Sheng , Scherer, Ronald C. , Wan, Mingxi . Effects of Vertical Glottal Duct Length on Intraglottal Pressures in the Convergent Glottis . | APPLIED SCIENCES-BASEL , 2021 , 11 (10) .
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A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy SCIE PubMed
期刊论文 | 2021 , 16 , 3105-3119 | INTERNATIONAL JOURNAL OF NANOMEDICINE
WoS CC Cited Count: 4
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Background: Photothermal therapy (PTT) has attracted considerable attention for cancer treatment as it is highly controllable and minimally invasive. Various multifunctional nano-systems have been fabricated in an "all-in-one" form to guide and enhance PTT by integrating imaging and therapeutic functions. However, the complex fabrication of nanosystems and their high cost limit its clinical translation. Materials and Methods: Herein, a high efficient "one-for-all" nanodroplet with a simple composition but owning multiple capabilities was developed to achieve ultrasound (US) imaging-guided and cavitation-enhanced PTT. Perfluoropentane (PFP) nanodroplet with a polypyrrole (PPy) shell (PFP@PPy nanodroplet) was synthesized via ultrasonic emulsification and in situ oxidative polymerization. After characterization of the morphology, its photothermal effect, phase transition performance, as well as its capabilities of enhancing US imaging and acoustic cavitation were examined. Moreover, the antitumor efficacy of the combined therapy with PTT and acoustic cavitation via the PFP@PPy nanodroplets was studied both in vitro and in vivo. Results: The nanodroplets exhibited good stability, high biocompatibility, broad optical absorption over the visible and near-infrared (NIR) range, excellent photothermal conversion with an efficiency of 60.1% and activatable liquid-gas phase transition performance. Upon NIR laser and US irradiation, the phase transition of PFP cores into microbubbles significantly enhanced US imaging and acoustic cavitation both in vitro and in vivo. More importantly, the acoustic cavitation enhanced significantly the antitumor efficacy of PTT as compared to PTT alone thanks to the cavitation-mediated cell destruction, which demonstrated a substantial increase in cell detachment, 81.1% cell death in vitro and 99.5% tumor inhibition in vivo. Conclusion: The PFP@PPy nanodroplet as a "one-for-all" theranostic agent achieved highly efficient US imaging-guided and cavitation-enhanced cancer therapy, and has considerable potential to provide cancer theranostics in the future.

Keyword :

acoustic cavitation ultrasound imaging theranostics one-for-all nanodroplet photothermal therapy

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GB/T 7714 Qin, Dui , Zhang, Lei , Zhu, Hongrui et al. A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy [J]. | INTERNATIONAL JOURNAL OF NANOMEDICINE , 2021 , 16 : 3105-3119 .
MLA Qin, Dui et al. "A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy" . | INTERNATIONAL JOURNAL OF NANOMEDICINE 16 (2021) : 3105-3119 .
APA Qin, Dui , Zhang, Lei , Zhu, Hongrui , Chen, Junjie , Wu, Daocheng , Bouakaz, Ayache et al. A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy . | INTERNATIONAL JOURNAL OF NANOMEDICINE , 2021 , 16 , 3105-3119 .
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Cascade-Amplifying Synergistic Therapy for Intracranial Glioma via Endogenous Reactive Oxygen Species-Triggered "All-in-One" Nanoplatform EI SCIE
期刊论文 | 2021 , 31 (46) | ADVANCED FUNCTIONAL MATERIALS
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Targeted delivery of drug-loaded nanoparticles to brain tumors is exceptionally difficult due to the blood-brain barrier (BBB). In addition, several chemotherapeutic drugs induce autophagy, which protects the cells from apoptosis and mitigates the therapeutic effect. A novel "all-in-one" nanoparticles (AMPTL) consisting of endogenous reactive oxygen species-cleavable thioketal linkers conjugated to paclitaxel (PTX) and autophagy inhibitor 3-methyladenine, and angiopep-2 peptide-modified DSPE-PEG(2K) is developed. AMPTL inhibits autophagy in the C6 glioma cells, as indicated by fewer autophagic vesicles, lower LC3-II expression and accumulation of SQSTM1/P62, and significantly upregulates p53 and the pro-apoptotic Bax and cleaved caspase-3 proteins. In addition, AMPTL treatment induces cell cycle arrest at the G2/M phase. Thus, inhibition of autophagy in the AMPTL-treated glioma cells sensitizes them to PTX-induced cell cycle arrest and apoptosis. Furthermore, focused pulse ultrasound and microbubbles enhances the delivery of AMPTL to intracranial glioma tissues by reversibly opening the BBB, which significantly inhibits xenograft growth and markedly improves survival rates of the tumor-bearing mice. Taken together, combining non-invasive BBB opening with autophagy inhibitors and chemotherapeutic drugs can achieve cascade-amplifying synergistic therapeutic effects against glioma.

Keyword :

endogenous ROS responsive smart nanoparticles blood brain barrier autophagy inhibition

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GB/T 7714 Wu, Pengying , Zhu, Mingting , Li, Yan et al. Cascade-Amplifying Synergistic Therapy for Intracranial Glioma via Endogenous Reactive Oxygen Species-Triggered "All-in-One" Nanoplatform [J]. | ADVANCED FUNCTIONAL MATERIALS , 2021 , 31 (46) .
MLA Wu, Pengying et al. "Cascade-Amplifying Synergistic Therapy for Intracranial Glioma via Endogenous Reactive Oxygen Species-Triggered "All-in-One" Nanoplatform" . | ADVANCED FUNCTIONAL MATERIALS 31 . 46 (2021) .
APA Wu, Pengying , Zhu, Mingting , Li, Yan , Ya, Zhen , Yang, Yabo , Yuan, Yuchen et al. Cascade-Amplifying Synergistic Therapy for Intracranial Glioma via Endogenous Reactive Oxygen Species-Triggered "All-in-One" Nanoplatform . | ADVANCED FUNCTIONAL MATERIALS , 2021 , 31 (46) .
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Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling EI SCIE Scopus
期刊论文 | 2020 , 148 | Mechanics of Materials | IF: 3.266
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Indentation type dynamic mechanical analysis (IT-DMA) is an attractive approach to characterizing viscoelastic properties of soft matter under both quasi-static and dynamic loadings. Frequency-dependent viscoelastic properties are usually characterized by storage and loss moduli whereas extracting inherent viscoelastic model parameters from dynamic loadings remains unsolved. In this study, closed-form solutions to dynamic oscillation loadings were first derived and adapted to a variety of excitations for arbitrary shape indenters. A uniform theoretical framework for ramp-hold-oscillation-relaxation/creep indentation tests are established and Kelvin-Voigt fractional derivative (KVFD) solutions are presented to predict the viscoelastic behavior for both quasi-static loadings (creep, relaxation) and dynamic loadings (sinusoidal displacement/force cycles at 5,10,15,20,30 Hz). Four gelatin-cream hydrogel samples were investigated under ramp-hold-oscillation-relaxation and ramp-hold-oscillation-creep testing conditions. Viscoelastic quantities of elasticity E0, fluidity α, and viscosity τ were extracted by fitting the experimental curves to KVFD predictions. The results show that KVFD models can accurately depict the viscoelastic behavior under both dynamic and quasi-static loadings with high goodness of fit (R2>0.936). To assess the proposed method, comparison of the viscoelastic quantities from different experimental protocols were conducted. Statistical results revealed viscoelastic parameters from different loading are in close agreement. For dynamic loadings, significant differences were found for [E0, α] estimates at different frequencies. For different experimental protocols, estimations were consistent in that E0 showed maximum value on Gel5Cream15 sample, and α was increased with increasing cream percentage. Moreover, viscoelastic quantities extracted from dynamic relaxation were correlated with those of the dynamic creep (r = 0.977, p 0, and r = 0.969, p 0, and r = 0.979, p © 2020 Elsevier Ltd

Keyword :

Viscoelasticity Dynamic loads Solution mining Hydrogels Indentation Fits and tolerances Creep Curve fitting Creep testing

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GB/T 7714 Zhang, Hongmei , Lu, Tongqing , Zhang, Qingzhe et al. Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling [J]. | Mechanics of Materials , 2020 , 148 .
MLA Zhang, Hongmei et al. "Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling" . | Mechanics of Materials 148 (2020) .
APA Zhang, Hongmei , Lu, Tongqing , Zhang, Qingzhe , Zhou, Yan , Zhu, Hongrui , Harms, Joseph et al. Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling . | Mechanics of Materials , 2020 , 148 .
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Decreased clot debris size and increased efficiency of acoustic vortex assisted high intensity focused ultrasound thrombolysis EI SCIE Scopus
期刊论文 | 2020 , 128 (9) | JOURNAL OF APPLIED PHYSICS | IF: 2.546
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High intensity focused ultrasound (HIFU) thrombolysis is a non-pharmacological, non-invasive treatment option for the restoration of blood flow through occluded vessels. This study demonstrated that the combination of an acoustic vortex with HIFU thrombolysis can decrease the size of clot debris, while simultaneously increasing the thrombolysis efficiency. The detected stable and inertial cavitation doses were lower in acoustic vortex assisted HIFU thrombolysis than in HIFU thrombolysis alone or in HIFU thrombolysis combined with regular focused ultrasound. Additionally, optical images indicated that these positive effects can be attributed to the aggregation of the generated clot debris and cavitation microbubbles in the focal region. This effectively enhances the interaction between the microbubbles and the clot, as well as its debris. Furthermore, the proposed method was effective under a flow velocity of up to 6cm/s. This study demonstrated that the combination of an acoustic vortex and HIFU may provide a safer and more efficient thrombolysis approach by decreasing the debris size and by increasing the efficiency.

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GB/T 7714 Guo, Shifang , Wang, Xin , Guo, Xuyan et al. Decreased clot debris size and increased efficiency of acoustic vortex assisted high intensity focused ultrasound thrombolysis [J]. | JOURNAL OF APPLIED PHYSICS , 2020 , 128 (9) .
MLA Guo, Shifang et al. "Decreased clot debris size and increased efficiency of acoustic vortex assisted high intensity focused ultrasound thrombolysis" . | JOURNAL OF APPLIED PHYSICS 128 . 9 (2020) .
APA Guo, Shifang , Wang, Xin , Guo, Xuyan , Ya, Zhen , Wu, Pengying , Bouakaz, Ayache et al. Decreased clot debris size and increased efficiency of acoustic vortex assisted high intensity focused ultrasound thrombolysis . | JOURNAL OF APPLIED PHYSICS , 2020 , 128 (9) .
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Manipulation of Nanodroplets via a Nonuniform Focused Acoustic Vortex EI SCIE
期刊论文 | 2020 , 13 (3) | PHYSICAL REVIEW APPLIED | IF: 4.985
WoS CC Cited Count: 8
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Techniques for the manipulation of nanodroplets are central to many miniaturized systems in chemical and biological research and applications. In this study, we demonstrate that the dispersed nanodroplets composed of perfluorocarbon can be manipulated to form a micron-sized elliptical aggregation via a nonuniform focused acoustic vortex, and the aggregation location can be further flexibly regulated. In addition, it is unveiled theoretically and experimentally that the fundamental mechanism for the elliptical aggregation is the nonuniform distribution of the pressure, which makes the acoustic radiation forces acting on the dispersed nanodroplets converge at a certain point. Moreover, the required acoustic droplet vaporization threshold for the nanodroplets is significantly lowered, while the generated microbubbles remain similar in size after aggregation. The findings of this study provide an alternative field of opportunities for targeted drug delivery and imaging using nanodroplet emulsions.

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GB/T 7714 Guo, Shifang , Guo, Xuyan , Wang, Xin et al. Manipulation of Nanodroplets via a Nonuniform Focused Acoustic Vortex [J]. | PHYSICAL REVIEW APPLIED , 2020 , 13 (3) .
MLA Guo, Shifang et al. "Manipulation of Nanodroplets via a Nonuniform Focused Acoustic Vortex" . | PHYSICAL REVIEW APPLIED 13 . 3 (2020) .
APA Guo, Shifang , Guo, Xuyan , Wang, Xin , Du, Xuan , Wu, Pengying , Bouakaz, Ayache et al. Manipulation of Nanodroplets via a Nonuniform Focused Acoustic Vortex . | PHYSICAL REVIEW APPLIED , 2020 , 13 (3) .
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Enhanced Hemispherical-array Passive Acoustic Mapping utilizing Dual Apodization with Cross-correlation EI Scopus
会议论文 | 2020 , 2020-September | 2020 IEEE International Ultrasonics Symposium, IUS 2020
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Hemispherical-array passive acoustic mapping (PAM) has been proposed to monitor transcranial ultrasound treatments in real time by enabling three-dimensional (3D) mapping of cavitation activity in the brain. The traditional hemispherical-array PAM is implemented based on delay-and-sum processing, resulting in low resolution and high-level interference due to the low-frequency limit and the interaction between sound sources. Inspired by our previous work, in this study we apply dual apodization with cross-correlation (DAX) technique in hemispherical-array PAM to achieve better image quality with reduced interference artifacts. The proposed algorithm first designs two complementary receive apodizations, and then measures the similarity between two beamformed signals with the cross-correlation coefficient, finally weights the combined signal with the correlation coefficient. The algorithm is tested through numerical simulations, where a 30-cm and 256-element hemispherical array is used to receive the signal from each element (Gaussian-windowed sinusoidal signal at 600 kHz) in three different source configurations without and with noise. The image enhancement is assessed with signal-to-interference ratio (SIR). The obtained results on simulated data indicate that in the noise-free (noisy) case, the proposed algorithm improves the SIR by 12.0 dB (19.5 dB), 14.3 dB (20.4 dB), and 11.8 dB (18.4 dB) in single-, multi-, and random-source configurations. The proposed hemispherical-array PAM algorithm presented in this study has the potential to provide high-quality 3D cavitation image during transcranial ultrasound treatment. © 2020 IEEE.

Keyword :

Brain mapping Image enhancement Acoustic noise Ultrasonic applications Cavitation Mapping Pulse amplitude modulation Brain

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GB/T 7714 Lu, Shukuan , Zhao, Yan , Li, Renyan et al. Enhanced Hemispherical-array Passive Acoustic Mapping utilizing Dual Apodization with Cross-correlation [C] . 2020 .
MLA Lu, Shukuan et al. "Enhanced Hemispherical-array Passive Acoustic Mapping utilizing Dual Apodization with Cross-correlation" . (2020) .
APA Lu, Shukuan , Zhao, Yan , Li, Renyan , Wang, Diya , Yu, Xianbo , Zhang, Bo et al. Enhanced Hemispherical-array Passive Acoustic Mapping utilizing Dual Apodization with Cross-correlation . (2020) .
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