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学者姓名：赵永席
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Abstract ：
Plant polyphenol-based coordination polymers (CPs) with ultra-small particle size and tailorable compositions are highly desired in biomedical applications, but their synthesis is still challenging due to the sophisticated coordination assembly process and unavoidable self-oxidation polymerization of polyphenol. Herein, a general ligand covalent-modification mediated coordination assembly strategy is proposed for the synthesis of water-dispersible CPs with tunable metal species (e.g., Gd, Cu, Ni, Zn, Fe) and ultra-small diameter (8.6-37.8 nm) using nontoxic plant polyphenol (e.g., tannic acid, gallic acid) as a polymerizable ligand. Polyphenol molecules react with formaldehyde firstly, which can effectively retard the oxidation induced self-polymerization of polyphenol and lead to the formation of metal ions containing CPs colloidal nanoparticles. These ultrafine nanoparticles with stably chelated metal ions are highly water dispersible and thus advantageous for bioimaging. As an example, ultra-small Gd contained CPs exhibit higher longitudinal relaxivity (r(1) = 25.5 L mmol(-1) s(-1)) value with low r(2)/r(1) (1.19) than clinically used Magnevist (Gd-DTPA, r(1) = 3.7 L mmol(-1) s(-1)). Due to the enhanced permeability and retention effect, they can be further used as a positive contrast agent for T-1-weighted MR imaging of tumour. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Keyword ：
Nanoparticle Contrast agent Coordination polymer Plant polyphenol Self-assembly
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| GB/T 7714 | Qin, Jing , Liang, Guohai , Feng, Bingxi et al. Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T-1-weighted magnetic resonance imaging [J]. | CHINESE CHEMICAL LETTERS , 2021 , 32 (2) : 842-848 . |
| MLA | Qin, Jing et al. "Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T-1-weighted magnetic resonance imaging" . | CHINESE CHEMICAL LETTERS 32 . 2 (2021) : 842-848 . |
| APA | Qin, Jing , Liang, Guohai , Feng, Bingxi , Wang, Gen , Wu, Na , Deng, Yonghui et al. Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T-1-weighted magnetic resonance imaging . | CHINESE CHEMICAL LETTERS , 2021 , 32 (2) , 842-848 . |
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Abstract ：
Aptamers have drawn great attention in the field of biological research and disease diagnosis for the remarkable advantages as recognition elements. They show unique superiority for facile selection, desirable thermal stability, flexible engineering, and low immunogenicity, complementing the use of conventional antibodies. Aptamer-functionalized microdevices offer promising properties for bioanalysis applications because of the compact sizes, minimal reaction volume, high throughput, operational feasibility, and controlled preciseness. In this review, we first introduce the innovative technologies in the selection of aptamers with microdevices and then highlight some advanced applications of aptamer-functionalized microdevices in bioanalysis field for diverse targets. Aptamer-functionalized microfluidic devices, microarrays, and paper-based and other interface-based microdevices are all bioanalysis platforms with huge potential in the near future. Finally, the major challenges of these microdevices applied in bioanalysis are discussed and future perspectives are also envisioned.
Keyword ：
microarray bioanalysis paper strip nanomaterial microfluidics aptamer
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| GB/T 7714 | Xue Jing , Chen Feng , Bai Min et al. Aptamer-Functionalized Microdevices for Bioanalysis. [J]. | ACS applied materials & interfaces , 2021 , 13 (8) : 9402-9411 . |
| MLA | Xue Jing et al. "Aptamer-Functionalized Microdevices for Bioanalysis." . | ACS applied materials & interfaces 13 . 8 (2021) : 9402-9411 . |
| APA | Xue Jing , Chen Feng , Bai Min , Cao Xiaowen , Fu Wenhao , Zhang Jin et al. Aptamer-Functionalized Microdevices for Bioanalysis. . | ACS applied materials & interfaces , 2021 , 13 (8) , 9402-9411 . |
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Abstract ：
Iron-polyphenol nanoparticles are usually prepared with nontoxic plant polyphenols as a main building block, which are an emerging photothermal agent for photothermal therapy. However, till now, few works have been made on the controllable synthesis of iron-polyphenol nanoparticles with tunable composition, as well as investigation of the relationship between material composition and photothermal property. In the present study, iron-polyphenol colloidal nanoparticles with tunable diameter (21–303 nm) and ion content (9.2–97.6 mg/g), as well as high colloidal stability are successfully synthesized using different polyphenols (such as tannic acid, epigallocatechin gallate, gallic acid, epicatechin and proanthocyanidin) as a ligand. In addition, photothermal performance is highly dependent on the organic ligand, iron content and particle size. Higher iron content and smaller diameter can contribute to higher photothermal performance. The iron-polyphenol nanoparticles with the optimal iron content and particle size are selected as a photothermal agent. They can effectively inhibit the tumour growth in vivo. The current work demonstrates a general synthesis strategy for iron-polyphenol colloidal nanoparticles with tailorable composition and clarifies the relationship between material composition and photothermal performance. Moreover, it is conductive to the rational design of polyphenol-based photothermal agents for theranostic applications. © 2021 Elsevier Inc.
Keyword ：
Flavonoids Particle size Synthesis (chemical) Iron Ligands Theranostics Nanoparticles
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| GB/T 7714 | Qin, Jing , Liang, Guohai , Cheng, Dong et al. Controllable synthesis of iron-polyphenol colloidal nanoparticles with composition-dependent photothermal performance [J]. | Journal of Colloid and Interface Science , 2021 , 593 : 172-181 . |
| MLA | Qin, Jing et al. "Controllable synthesis of iron-polyphenol colloidal nanoparticles with composition-dependent photothermal performance" . | Journal of Colloid and Interface Science 593 (2021) : 172-181 . |
| APA | Qin, Jing , Liang, Guohai , Cheng, Dong , Liu, Yining , Cheng, Xiaoran , Yang, Pengkun et al. Controllable synthesis of iron-polyphenol colloidal nanoparticles with composition-dependent photothermal performance . | Journal of Colloid and Interface Science , 2021 , 593 , 172-181 . |
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Abstract ：
Dynamic information of intracellular transcripts is essential to understand their functional roles. Routine RNA-sequencing (RNA-seq) methods only measure RNA species at a steady state and do not provide RNA dynamic information. Here, we develop addition-elimination mechanism-activated nucleotide transition sequencing (AENT-seq) for transcriptome-wide profiling of RNA dynamics. In AENT-seq, nascent transcripts are metabolically labeled with 4-thiouridine (4sU). The total RNA is treated with N2H4 center dot H2O under aqueous conditions. N2H4 center dot H2O is demonstrated to convert 4sU to 4-hydrazino cytosine (C*) based on an addition-elimination chemistry. C* is regarded as cytosine (C) during the DNA extension process. This 4sU-to-C transition marks nascent transcripts, so it enables sequencing analysis of RNA dynamics. We apply our AENT-seq to investigate transcript dynamic information of several genes involved in cancer progression and metastasis. This method uses a simple chemical reaction in aqueous solutions and will be rapidly disseminated with extensive applications.
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| GB/T 7714 | Su, Li , Chen, Feng , Yu, Huahang et al. Addition-Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling [J]. | ANALYTICAL CHEMISTRY , 2021 , 93 (41) : 13974-13980 . |
| MLA | Su, Li et al. "Addition-Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling" . | ANALYTICAL CHEMISTRY 93 . 41 (2021) : 13974-13980 . |
| APA | Su, Li , Chen, Feng , Yu, Huahang , Yan, Hao , Zhao, Fengjiao , Fan, Chunhai et al. Addition-Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling . | ANALYTICAL CHEMISTRY , 2021 , 93 (41) , 13974-13980 . |
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Abstract ：
Bacterial biofilms are responsible for many chronic infections because antibacterial agents exhibit poor penetration into the dense matrix barrier and cannot easily reach the internal bacteria. Herein, we reported pHresponsive nanocomposites (PDA@Kana-AgNPs) that could penetrate and disperse biofilms, which were synthesized by the combination of ultrasmall silver nanoparticles (AgNPs) and kanamycin, and then coating with polydopamine. Confocal fluorescence imaging indicated that PDA@Kana-AgNPs could respond to the acidic microenvironment of biofilms, leading to biofilm-triggered on- demand drug release in situ. The zone of inhibition test and Resazurin assay showed that the combination of kanamycin and AgNPs had greater antimicrobial activity against test strains (Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Escherichia coli BL21) than when applied separately. The crystal violet staining test demonstrated that biofilms were effectively dispersed by the proposed nanocomposites. Biocompatibility was also evaluated, which showed that PDA@Kana-AgNPs were non-toxic to mammalian cells. Therefore, the proposed pH-responsive nanocomposites held great potential for efficient antibiotics delivery and showed synergistic antibacterial and antibiofilm activities. This strategy could also be used to encapsulate a variety of antibiotics in combination with other drugs or materials, thereby showing therapeutic potential in preventing biofilm-related infections and realizing fluorescence imaging in situ.
Keyword ：
Aminoglycoside antibiotics pH-responsive Antibacterial activity Biofilms dispersion
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| GB/T 7714 | Li, Xizhe , Li, Bingyu , Liu, Ruirui et al. Development of pH-responsive nanocomposites with remarkably synergistic antibiofilm activities based on ultrasmall silver nanoparticles in combination with aminoglycoside antibiotics [J]. | COLLOIDS AND SURFACES B-BIOINTERFACES , 2021 , 208 . |
| MLA | Li, Xizhe et al. "Development of pH-responsive nanocomposites with remarkably synergistic antibiofilm activities based on ultrasmall silver nanoparticles in combination with aminoglycoside antibiotics" . | COLLOIDS AND SURFACES B-BIOINTERFACES 208 (2021) . |
| APA | Li, Xizhe , Li, Bingyu , Liu, Ruirui , Dong, Yanhua , Zhao, Yongxi , Wu, Yayan . Development of pH-responsive nanocomposites with remarkably synergistic antibiofilm activities based on ultrasmall silver nanoparticles in combination with aminoglycoside antibiotics . | COLLOIDS AND SURFACES B-BIOINTERFACES , 2021 , 208 . |
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Abstract ：
Cellular oxidative thymines, 5-hydroxymethyluracil (5hmU) and 5-formyluracil (5fU), are found in the genomes of a diverse range of organisms, the distribution of which profoundly influence biological processes and living systems. However, the distribution of cellular oxidative thymines has not been explored because of lacking both specific bioorthogonal labeling and sensitivity methods for single-cell analysis. Herein, we report a bioorthogonal chemical signature enabling amplified visualization of cellular oxidative thymines in single cells. The synthesized ATP-gamma-alkyne, an ATP analogue with bioorthogonal tag modified on gamma-phosphate can be specifically linked to cellular 5hmU by chemoenzymatic labeling. DNA with 5-alkynephosphomethyluracil were then clicked with azide (N-3)-modified 5hmU-primer. Identification of 5fU is based on selective reduction from 5fU to 5hmU, subsequent chemoenzymatic labeling of the newly generated 5hmU, and cross-linking with N-3-modified 5fU-primer via click chemistry. Then, all of the 5hmU and 5fU sites are encoded with respective circularized barcodes. These barcodes are simultaneously amplified for multiplexed single-molecule imaging. The above two kinds of barcodes can be simultaneously amplified for differentiated visualization of 5hmU and 5fU in single cells. We find these two kinds of cellular oxidative thymines are spatially organized in a cell-type-dependent style with cell-to-cell heterogeneity. We also investigate their multilevel subcellular information and explore their dynamic changes during cell cycles. Further, using DNA sequencing instead of fluorescence imaging, our proposed bioorthogonal chemical signature holds great potential to offer the sequence information of these oxidative thymines in cells and may provide a reliable chemical biology approach for studying the whole-genome oxidative thymines profiles and insights into their functional role and dynamics in biology.
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| GB/T 7714 | Bai, Min , Cao, Xiaowen , Chen, Feng et al. Bioorthogonal Chemical Signature Enabling Amplified Visualization of Cellular Oxidative Thymines [J]. | ANALYTICAL CHEMISTRY , 2021 , 93 (30) : 10495-10501 . |
| MLA | Bai, Min et al. "Bioorthogonal Chemical Signature Enabling Amplified Visualization of Cellular Oxidative Thymines" . | ANALYTICAL CHEMISTRY 93 . 30 (2021) : 10495-10501 . |
| APA | Bai, Min , Cao, Xiaowen , Chen, Feng , Xue, Jing , Zhao, Yue , Zhao, Yongxi . Bioorthogonal Chemical Signature Enabling Amplified Visualization of Cellular Oxidative Thymines . | ANALYTICAL CHEMISTRY , 2021 , 93 (30) , 10495-10501 . |
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Abstract ：
Exploring spatial organization and relationship of diverse biomolecules within cellular nanoenvironments is important to elucidate the fundamental processes of life. However, it remains methodologically challenging. Herein, we report a molecular recognition mechanism cellular macromolecules-tethered DNA walking indexing (Cell-TALKING) to probe the nanoenvironments containing diverse chromatin modifications. As an example, we characterize the nanoenvironments of three DNA modifications around one histone posttranslational modification (PTM). These DNA modifications in fixed cells are labeled with respective DNA barcoding probes, and then the PTM site is tethered with a DNA walking probe. Cell-TALKING can continuously produce cleavage records of any barcoding probes nearby the walking probe. New 3'-OH ends are generated on the cleaved barcoding probes to induce DNA amplification for downstream detections. Combining fluorescence imaging, we identify various combinatorial chromatin modifications and investigate their dynamic changes during cell cycles. We also explore the nanoenvironments in different cancer cell lines and clinical specimens. In principle, using high-throughput sequencing instead of fluorescence imaging may allow the detection of complex cellular nanoenvironments containing tens of biomolecules such as transcription factors. Investigation of spatial organization and relationships of biomolecules in cellular nanoenvironments is necessary to understand essential biological processes, but methodologically challenging. Here, the authors report cellular macromolecules-tethered DNA walking indexing (Cell-TALKING) to probe the nanoenvironments of DNA modifications around histone post-translational modifications, and explore the nanoenvironments in different cancer cell lines and clinical specimens.
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| GB/T 7714 | Chen, Feng , Bai, Min , Cao, Xiaowen et al. Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications [J]. | NATURE COMMUNICATIONS , 2021 , 12 (1) . |
| MLA | Chen, Feng et al. "Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications" . | NATURE COMMUNICATIONS 12 . 1 (2021) . |
| APA | Chen, Feng , Bai, Min , Cao, Xiaowen , Xue, Jing , Zhao, Yue , Wu, Na et al. Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications . | NATURE COMMUNICATIONS , 2021 , 12 (1) . |
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Abstract ：
Spherical mesoporous tin dioxides are emerging sensing materials for fabrication of gas sensor applied in various fields. However, the synthesis of spherical mesoporous SnO2 with uniform shape and small diameter (i.e., <100 nm) is still challenging. Herein, spherical mesoporous SnO2 materials with tunable diameter (55 110 nm), large pore size (similar to 5.8 nm) and high specific surface area (80.9-185.6 m(2)/g) are synthesized via a self-template strategy by direct thermal decomposition of tin-polyphenol-formaldehyde polymers (TPFPs). Spherical TPFPs are synthesized via a sol-gel process using a low-cost, nontoxic and renewable natural polyphenol (i.e., tannic acid) as a ligand, formaldehyde as a cross-linking agent, tin ions as a metal source in alkaline conditions. Block copolymers can regulate the polymerization process and promote the formation of uniform spheres. The diameter of TPFPs and their derived spherical mesoporous SnO2 can be adjusted by changing the amount of block co-polymers. The gas sensors fabricated from spherical mesoporous SnO2 exhibit excellent sensitivity to ethanol (18.9@50 ppm), fast response and recovery time (4 s / 44 s), good repeatability and long-term stability. This work demonstrates a reliable method for synthesis of spherical mesoporous SnO2, which could be potentially applied in catalysis, sensing and energy storage.
Keyword ：
Colloidal sphere Mesoporous material Self-template synthesis Gas sensing Tin dioxide
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| GB/T 7714 | Feng, Bingxi , Feng, Youyou , Qin, Jing et al. Self-template synthesis of spherical mesoporous tin dioxide from tin-polyphenol-formaldehyde polymers for conductometric ethanol gas sensing [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2021 , 341 . |
| MLA | Feng, Bingxi et al. "Self-template synthesis of spherical mesoporous tin dioxide from tin-polyphenol-formaldehyde polymers for conductometric ethanol gas sensing" . | SENSORS AND ACTUATORS B-CHEMICAL 341 (2021) . |
| APA | Feng, Bingxi , Feng, Youyou , Qin, Jing , Wang, Zheng , Zhang, Yalong , Du, Fei et al. Self-template synthesis of spherical mesoporous tin dioxide from tin-polyphenol-formaldehyde polymers for conductometric ethanol gas sensing . | SENSORS AND ACTUATORS B-CHEMICAL , 2021 , 341 . |
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Abstract ：
Nanozyme has been regarded as one of the antibacterial agents to kill bacteria via a Fenton-like reaction in the presence of H2O2. However, it still suffers drawbacks such as insufficient catalytic activity in near-neutral conditions and the requirement of high H2O2 levels, which would minimize the side effects to healthy tissues. Herein, a mesoporous ceria hollow sphere/enzyme nanoreactor is constructed by loading glucose oxidase in the mesoporous ceria hollow sphere nanozyme. Due to the mesoporous framework, large internal voids, and high specific surface area, the obtained nanoreactor can effectively convert the nontoxic glucose into highly toxic hydroxyl radicals via a cascade catalytic reaction. Moreover, the generated glucose acid can decrease the localized pH value, further boosting the peroxidase-like catalytic performance of mesoporous ceria. The generated hydroxyl radicals could damage severely the cell structure of the bacteria and prevent biofilm formation. Moreover, the in vivo experiments demonstrate that the nanoreactor can efficiently eliminate 99.9% of bacteria in the wound tissues and prevent persistent inflammation without damage to normal tissues in mice. This work provides a rational design of a nanoreactor with enhanced catalytic activity, which can covert glucose to hydroxyl radicals and exhibits potential applications in antibacterial therapy.
Keyword ：
hollow sphere ceria antibacterial therapy mesoporous material catalysis
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| GB/T 7714 | Qin, Jing , Feng, Youyou , Cheng, Dong et al. Construction of a Mesoporous Ceria Hollow Sphere/Enzyme Nanoreactor for Enhanced Cascade Catalytic Antibacterial Therapy [J]. | ACS APPLIED MATERIALS & INTERFACES , 2021 , 13 (34) : 40302-40314 . |
| MLA | Qin, Jing et al. "Construction of a Mesoporous Ceria Hollow Sphere/Enzyme Nanoreactor for Enhanced Cascade Catalytic Antibacterial Therapy" . | ACS APPLIED MATERIALS & INTERFACES 13 . 34 (2021) : 40302-40314 . |
| APA | Qin, Jing , Feng, Youyou , Cheng, Dong , Liu, Biwu , Wang, Zheng , Zhao, Yongxi et al. Construction of a Mesoporous Ceria Hollow Sphere/Enzyme Nanoreactor for Enhanced Cascade Catalytic Antibacterial Therapy . | ACS APPLIED MATERIALS & INTERFACES , 2021 , 13 (34) , 40302-40314 . |
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Abstract ：
5-Hydroxymethyluracil (5hmU) is found in the genomes of a diverse range of organisms as another kind of 5-hydroxymethylpyrimidine, with the exception of 5-hydroxymethylcytosine (5hmC). The biological function of 5hmU has not been well explored due to lacking both specific 5hmU recognition and singlecell analysis methods. Here we report differentiated visualization of single-cell 5hmU and 5hmC with microfluidic hydrogel encoding (sc5hmU/ShmC-microgel). Single cells and their genomic DNA after cell lysis can be encapsulated in individual agarose microgels. The 5hmU sites are then specifically labeled with thiophosphate for the first time, followed by labeling 5hmC with azide glucose. These labeled bases are each encoded into respective DNA barcode primers by chemical cross-linking. In situ amplification is triggered for single-molecule fluorescence visualization of single-cell 5hmU and 5hmC. On the basis of the scShmU/5hmC-microgel, we reveal cell typespecific molecular signatures of these two bases with remarkable single-cell heterogeneity. Utilizing machine learning algorithms to decode four-dimensional signatures of 5hmU/5hmC, we visualize the discrimination of nontumorigenic, carcinoma and highly invasive breast cell lines. This strategy provides a new route to analyze and decode single-cell DNA epigenetic modifications.
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| GB/T 7714 | Chen, Feng , Xue, Jing , Zhang, Jin et al. Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding [J]. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2020 , 142 (6) : 2889-2896 . |
| MLA | Chen, Feng et al. "Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding" . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 142 . 6 (2020) : 2889-2896 . |
| APA | Chen, Feng , Xue, Jing , Zhang, Jin , Bai, Min , Yu, Xu , Fan, Chunhai et al. Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2020 , 142 (6) , 2889-2896 . |
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