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1989—2019年SCIE收录的法医物证学文献计量学分析 PubMed CSCD
期刊论文 | 2021 , 37 (2) , 192-205 | 法医学杂志
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Abstract :

目的 对Web of Science核心合集科学引文索引(Science Citation Index-Expanded,SCIE)数据库收录的1989—2019年中国大陆学者发表的法医物证学文献进行计量学分析,展现近30年来的研究成果,并预测未来的研究领域和方向.方法 应用Microsoft Office Excel 2019软件对文献总体情况、研究机构、作者、基金资助、作者关键词等数据进行分析,通过PlotDB、Gephi 0.9.2软件和文献解读,对我国法医物证学领域研究现况进行数据可视化展示.结果 近30年来,中国大陆学者发表的SCIE收录的法医物证学文献共1126篇,以论文为主,数量和质量均呈上升趋势,发表于Forensic Science International-Genetics的文献数量最多.60.83%的文献有基金资助,其中国家自然科学基金资助项目最多(498篇).现阶段的研究热点包括短串联重复序列、单核苷酸多态性、插入/缺失多态性、连锁遗传标记、线粒体DNA遗传标记、表观遗传标记、RNA遗传标记、芯片技术和组学研究方法.结论 我国法医物证学研究随着高校法医学科的推进和建设飞速发展,尤其是在国家自然科学基金委员会和中华人民共和国科学技术部的资助下,中国大陆学者发表的SCIE收录的法医物证学文献数量增长迅速,为国内法医物证学领域应用基础研究的发展和整体水平的提高做出了积极贡献.

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GB/T 7714 张星茹 , 贺永锋 , 张蕴盈 et al. 1989—2019年SCIE收录的法医物证学文献计量学分析 [J]. | 法医学杂志 , 2021 , 37 (2) : 192-205 .
MLA 张星茹 et al. "1989—2019年SCIE收录的法医物证学文献计量学分析" . | 法医学杂志 37 . 2 (2021) : 192-205 .
APA 张星茹 , 贺永锋 , 张蕴盈 , 刘裕哲 , 朱波峰 . 1989—2019年SCIE收录的法医物证学文献计量学分析 . | 法医学杂志 , 2021 , 37 (2) , 192-205 .
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Validation of a 6-Dye Short Tandem Repeat System: A Dry Kit With Lyophilized Amplification Reagent SCIE PubMed
期刊论文 | 2021 , 12 | FRONTIERS IN GENETICS
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Abstract :

The SureID (R) S6 system used a lyophilized pellet as the amplification reagent to enable multiplexing of sex-determining marker Amelogenin, 21 autosomal short tandem repeats (STRs), and one Y-STR. To assess the performance, reliability, and limitation of the dry amplification system, the validation studies including PCR condition, reproducibility, sizing and precision, analytical threshold calculation, sensitivity and stochastic threshold calculation, species specificity, stability, mixture, case sample, and population and concordance were conducted according to the Scientific Working Group on DNA Analysis Methods (SWGDAM) Validation Guidelines. Experimental data suggested that the optimal range of total input DNA was from 125 to 500 pg; the appropriate analytical threshold was 80 relative fluorescence units (RFUs) while the stochastic threshold was 260 RFUs; for the stability studies, SureID (R) S6 system could resist against less than 500 mu mol/L of hematin, 100 ng/mu l of humic acid, 4 mM of indigotin, 800 mM of tannic acid, and 800 mM of calcium ion. Population and concordance studies using 500 unrelated individuals showed that the combined probability of discrimination (CPD) and cumulative probability of exclusion (CPE) values were 0.999999999999 and 0.999999998416, respectively. The genotypes for the same sample were concordant with the previously validated HUAXIA (TM) Platinum kit. The validation results demonstrated that the SureID (R) S6 system could be used for forensic applifications.

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forensic science multiplex-short tandem repeat system lyophilized PCR reagent validation SureID (R) S6 system

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GB/T 7714 Li, Shuanglin , Lin, Jinfeng , Hao, Honglei et al. Validation of a 6-Dye Short Tandem Repeat System: A Dry Kit With Lyophilized Amplification Reagent [J]. | FRONTIERS IN GENETICS , 2021 , 12 .
MLA Li, Shuanglin et al. "Validation of a 6-Dye Short Tandem Repeat System: A Dry Kit With Lyophilized Amplification Reagent" . | FRONTIERS IN GENETICS 12 (2021) .
APA Li, Shuanglin , Lin, Jinfeng , Hao, Honglei , Jin, Haiying , Song, Danlu , Zhu, Bofeng . Validation of a 6-Dye Short Tandem Repeat System: A Dry Kit With Lyophilized Amplification Reagent . | FRONTIERS IN GENETICS , 2021 , 12 .
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Comprehensive Insights Into Forensic Features and Genetic Background of Chinese Northwest Hui Group Using Six Distinct Categories of 231 Molecular Markers SCIE PubMed
期刊论文 | 2021 , 12 | FRONTIERS IN GENETICS
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The Hui minority is predominantly composed of Chinese-speaking Islamic adherents distributed throughout China, of which the individuals are mainly concentrated in Northwest China. In the present study, we employed the length and sequence polymorphisms-based typing system of 231 molecular markers, i.e., amelogenin, 22 phenotypic-informative single nucleotide polymorphisms (PISNPs), 94 identity-informative single nucleotide polymorphisms (IISNPs), 24 Y-chromosomal short tandem repeats (Y-STRs), 56 ancestry-informative single nucleotide polymorphisms (AISNPs), 7 X-chromosomal short tandem repeats (X-STRs), and 27 autosomal short tandem repeats (A-STRs), into 90 unrelated male individuals from the Chinese Northwest Hui group to comprehensively explore its forensic characteristics and genetic background. Total of 451 length-based and 652 sequence-based distinct alleles were identified from 58 short tandem repeats (STRs) in 90 unrelated Northwest Hui individuals, denoting that the sequence-based genetic markers could pronouncedly provide more genetic information than length-based markers. The forensic characteristics and efficiencies of STRs and IISNPs were estimated, both of which externalized high polymorphisms in the Northwest Hui group and could be further utilized in forensic investigations. No significant departure from the Hardy-Weinberg equilibrium (HWE) expectation was observed after the Bonferroni correction. Additionally, four group sets of reference population data were exploited to dissect the genetic background of the Northwest Hui group separately from different perspectives, which contained 26 populations for 93 IISNPs, 58 populations for 17 Y-STRs, 26 populations for 55 AISNPs (raw data), and 109 populations for 55 AISNPs (allele frequencies). As a result, the analyses based on the Y-STRs indicated that the Northwest Hui group primarily exhibited intimate genetic relationships with reference Hui groups from Chinese different regions except for the Sichuan Hui group and secondarily displayed close genetic relationships with populations from Central and West Asia, as well as several Chinese groups. However, the AISNP analyses demonstrated that the Northwest Hui group shared more intimate relationships with current East Asian populations apart from reference Hui group, harboring the large proportion of ancestral component contributed by East Asia.

Keyword :

MPS population genentics forensics Chinese Hui minority molecular markers

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GB/T 7714 Chen, Chong , Jin, Xiaoye , Zhang, Xingru et al. Comprehensive Insights Into Forensic Features and Genetic Background of Chinese Northwest Hui Group Using Six Distinct Categories of 231 Molecular Markers [J]. | FRONTIERS IN GENETICS , 2021 , 12 .
MLA Chen, Chong et al. "Comprehensive Insights Into Forensic Features and Genetic Background of Chinese Northwest Hui Group Using Six Distinct Categories of 231 Molecular Markers" . | FRONTIERS IN GENETICS 12 (2021) .
APA Chen, Chong , Jin, Xiaoye , Zhang, Xingru , Zhang, Wenqing , Guo, Yuxin , Tao, Ruiyang et al. Comprehensive Insights Into Forensic Features and Genetic Background of Chinese Northwest Hui Group Using Six Distinct Categories of 231 Molecular Markers . | FRONTIERS IN GENETICS , 2021 , 12 .
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Fine-Scale Genetic Structure and Natural Selection Signatures of Southwestern Hans Inferred From Patterns of Genome-Wide Allele, Haplotype, and Haplogroup Lineages SCIE PubMed
期刊论文 | 2021 , 12 | FRONTIERS IN GENETICS
WoS CC Cited Count: 6
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The evolutionary and admixture history of Han Chinese have been widely discussed via traditional autosomal and uniparental genetic markers [e.g., short tandem repeats, low-density single nucleotide polymorphisms). However, their fine-scale genetic landscapes (admixture scenarios and natural selection signatures) based on the high-density allele/haplotype sharing patterns have not been deeply characterized. Here, we collected and generated genome-wide data of 50 Han Chinese individuals from four populations in Guizhou Province, one of the most ethnolinguistically diverse regions, and merged it with over 3,000 publicly available modern and ancient Eurasians to describe the genetic origin and population admixture history of Guizhou Hans and their neighbors. PCA and ADMIXTURE results showed that the studied four populations were homogeneous and grouped closely to central East Asians. Genetic homogeneity within Guizhou populations was further confirmed via the observed strong genetic affinity with inland Hmong-Mien people through the observed genetic clade in Fst and outgroup f(3)/f(4)-statistics. qpGraph-based phylogenies and f(4)-based demographic models illuminated that Guizhou Hans were well fitted via the admixture of ancient Yellow River Millet farmers related to Lajia people and southern Yangtze River farmers related to Hanben people. Further ChromoPainter-based chromosome painting profiles and GLOBETROTTER-based admixture signatures confirmed the two best source matches for southwestern Hans, respectively, from northern Shaanxi Hans and southern indigenes with variable mixture proportions in the historical period. Further three-way admixture models revealed larger genetic contributions from coastal southern East Asians into Guizhou Hans compared with the proposed inland ancient source from mainland Southeast Asia. We also identified candidate loci (e.g., MTUS2, NOTCH4, EDAR, ADH1B, and ABCG2) with strong natural selection signatures in Guizhou Hans via iHS, nSL, and ihh, which were associated with the susceptibility of the multiple complex diseases, morphology formation, alcohol and lipid metabolism. Generally, we provided a case and ideal strategy to reconstruct the detailed demographic evolutionary history of Guizhou Hans, which provided new insights into the fine-scale genomic formation of one ethnolinguistically specific targeted population from the comprehensive perspectives of the shared unlinked alleles, linked haplotypes, and paternal and maternal lineages.

Keyword :

admixture history genetic origin haplotype chunk Han Chinese nature selection allele-sharing

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GB/T 7714 Wang, Mengge , Yuan, Didi , Zou, Xing et al. Fine-Scale Genetic Structure and Natural Selection Signatures of Southwestern Hans Inferred From Patterns of Genome-Wide Allele, Haplotype, and Haplogroup Lineages [J]. | FRONTIERS IN GENETICS , 2021 , 12 .
MLA Wang, Mengge et al. "Fine-Scale Genetic Structure and Natural Selection Signatures of Southwestern Hans Inferred From Patterns of Genome-Wide Allele, Haplotype, and Haplogroup Lineages" . | FRONTIERS IN GENETICS 12 (2021) .
APA Wang, Mengge , Yuan, Didi , Zou, Xing , Wang, Zheng , Yeh, Hui-Yuan , Liu, Jing et al. Fine-Scale Genetic Structure and Natural Selection Signatures of Southwestern Hans Inferred From Patterns of Genome-Wide Allele, Haplotype, and Haplogroup Lineages . | FRONTIERS IN GENETICS , 2021 , 12 .
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Aptamer-mediated synthesis of multifunctional nano-hydroxyapatite for active tumour bioimaging and treatment SCIE PubMed
期刊论文 | 2021 , 54 (9) | CELL PROLIFERATION
WoS CC Cited Count: 2
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Objectives The nano-hydroxyapatite (nHAp) is widely used to develop imaging probes and drug carriers due to its excellent bioactivity and biocompatibility. However, traditional methods usually need cumbersome and stringent conditions such as high temperature and post-modification to prepare the functionalized nHAp, which do not benefit the particles to enter cells due to the increased particle size. Herein, a biomimetic synthesis strategy was explored to achieve the AS1411-targeted tumour dual-model bioimaging using DNA aptamer AS1411 as a template. Then, the imaging properties and the biocompatibility of the synthesized AS-nFAp:Gd/Tb were further investigated. Materials and methods The AS-nFAp:Gd/Tb was prepared under mild conditions through a one-pot procedure with AS1411 as a template. Besides, the anticancer drug DOX was loaded to AS-nFAp:Gd/Tb so as to achieve the establishment of a multifunctional nano-probe that integrated the tumour diagnosis and treatment. The AS-nFAp:Gd/Tb was characterized by transmission electron microscopy (TEM), energy disperse X-ray Spectroscopy (EDS) mapping, X-ray photoelectron spectroscopy (XPS) spectrum, X-ray diffraction (XRD), fourier-transformed infrared (FTIR) spectroscopy, capillary electrophoresis analyses, zeta potential and particle sizes. The in vitro magnetic resonance imaging (MRI) and fluorescence imaging were performed on an MRI system and a confocal laser scanning microscope, respectively. The potential of the prepared multifunctional nHAp for a targeted tumour therapy was investigated by a CCK-8 kit. And the animal experiments were conducted on the basis of the guidelines approved by the Animal Care and Use Committee of Sichuan University, China. Results In the presence of AS1411, the as-prepared AS-nFAp:Gd/Tb presented a needle-like morphology with good monodispersity and improved imaging performance. Furthermore, due to the specific binding between AS1411 and nucleolin up-expressed in cancer cells, the AS-nFAp:Gd/Tb possessed excellent AS1411-targeted fluorescence and MRI imaging properties. Moreover, after loading chemotherapy drug DOX, in vitro and in vivo studies showed that DOX@AS-nFAp:Gd/Tb could effectively deliver DOX to tumour tissues and exert a highly effective tumour inhibition without systemic toxicity compared with pure DOX. Conclusions The results indicated that the prepared multifunctional nHAp synthesized by a novel biomimetic strategy had outstanding capabilities of recognition and treatment for the tumour and had good biocompatibility; hence, it might have a potential clinical application in the future.

Keyword :

nano-hydroxyapatite dual-model bioimaging drug carriers biomimetic synthesis AS1411

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GB/T 7714 Zhang, Wenqing , Zhou, Ronghui , Yang, Yuting et al. Aptamer-mediated synthesis of multifunctional nano-hydroxyapatite for active tumour bioimaging and treatment [J]. | CELL PROLIFERATION , 2021 , 54 (9) .
MLA Zhang, Wenqing et al. "Aptamer-mediated synthesis of multifunctional nano-hydroxyapatite for active tumour bioimaging and treatment" . | CELL PROLIFERATION 54 . 9 (2021) .
APA Zhang, Wenqing , Zhou, Ronghui , Yang, Yuting , Peng, Shuanglin , Xiao, Dexuan , Kong, Tingting et al. Aptamer-mediated synthesis of multifunctional nano-hydroxyapatite for active tumour bioimaging and treatment . | CELL PROLIFERATION , 2021 , 54 (9) .
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Developmental validations of a self-developed 39 AIM-InDel panel and its forensic efficiency evaluations in the Shaanxi Han population SCIE PubMed
期刊论文 | 2021 , 135 (4) , 1359-1367 | INTERNATIONAL JOURNAL OF LEGAL MEDICINE
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Most of insertion/deletion polymorphisms are diallelic molecular markers characterized as small amplicon sizes, high inter-population diversities, and low mutation rates, which make them the promising genetic markers in biogeographic ancestor inference field. The developmental validations of a 39 ancestry informative marker-insertion/deletion (AIM-InDel) panel and the genetic polymorphic investigations of this panel were performed in the Shaanxi Han population of China. The developmental validation included the optimizations of PCR-related indicators, repeatability, reproducibility, precision, accuracy, sensitivity, species specificity, stability of the panel, and the abilities in analyzing degraded, casework, and mixture samples, and the present results demonstrated that this 39 AIM-InDel panel was robust, sensitive, and accurate. For the population diversity analyses, the combined discrimination power value of 38 AIM-InDel loci except for rs36038238 locus was 0.999999999931257, indicating that this novel panel was highly polymorphic, biogeographic informative, and could be also used in individual identifications in the Shaanxi Han population.

Keyword :

Ancestry inference Developmental validation Shaanxi Han population InDel

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GB/T 7714 Zhang, Xingru , Shen, Chunmei , Jin, Xiaoye et al. Developmental validations of a self-developed 39 AIM-InDel panel and its forensic efficiency evaluations in the Shaanxi Han population [J]. | INTERNATIONAL JOURNAL OF LEGAL MEDICINE , 2021 , 135 (4) : 1359-1367 .
MLA Zhang, Xingru et al. "Developmental validations of a self-developed 39 AIM-InDel panel and its forensic efficiency evaluations in the Shaanxi Han population" . | INTERNATIONAL JOURNAL OF LEGAL MEDICINE 135 . 4 (2021) : 1359-1367 .
APA Zhang, Xingru , Shen, Chunmei , Jin, Xiaoye , Guo, Yuxin , Xie, Tong , Zhu, Bofeng . Developmental validations of a self-developed 39 AIM-InDel panel and its forensic efficiency evaluations in the Shaanxi Han population . | INTERNATIONAL JOURNAL OF LEGAL MEDICINE , 2021 , 135 (4) , 1359-1367 .
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The Polymorphism Analyses of Short Tandem Repeats as a Basis for Understanding the Genetic Characteristics of the Guanzhong Han Population SCIE PubMed
期刊论文 | 2021 , 2021 | BIOMED RESEARCH INTERNATIONAL
WoS CC Cited Count: 1
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The short tandem repeat (STR) loci are polymorphic markers in the combined DNA index system (CODIS) and non-CODIS STR loci. Due to the highly polymorphic characteristic of STR loci, they are popular and widely used in forensic DNA typing laboratories. In this study, 22 STR loci (1 CODIS, 21 non-CODIS STR loci) and an Amelogenin locus were genotyped and analyzed in 590 unrelated individuals of the Guanzhong Han population. None of the 22 STR loci deviated from the Hardy-Weinberg equilibrium, and all the loci were in the linkage equilibrium state. We observed 247 alleles, and the corresponding allelic frequencies ranged from 0.0008 to 0.3695 in the Guanzhong Han population. The combined power of discrimination and the cumulative exclusion probability was 0.999 999 999 999 999 999 999 999 999 346 36 and 0.999 999 999 709 74, respectively. The results including Nei's D-A genetic distance, multidimensional scaling analysis, and principal component analysis showed that the Guanzhong Han population has closer genetic affinities with Northern Han, Chengdu Han, and Xinjiang Hui groups from China based on allelic frequencies of 15 overlapped S'I'R loci from Guanzhong Han and 13 reference groups. The present results indicated that Microreader (TM) 23sp ID kit included highly polymorphic loci, and it could be well used for individual identification, paternity testing, and population genetics in the Guanzhong Han population.

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GB/T 7714 Mei, Shuyan , Liu, Yanfang , Zhao, Congying et al. The Polymorphism Analyses of Short Tandem Repeats as a Basis for Understanding the Genetic Characteristics of the Guanzhong Han Population [J]. | BIOMED RESEARCH INTERNATIONAL , 2021 , 2021 .
MLA Mei, Shuyan et al. "The Polymorphism Analyses of Short Tandem Repeats as a Basis for Understanding the Genetic Characteristics of the Guanzhong Han Population" . | BIOMED RESEARCH INTERNATIONAL 2021 (2021) .
APA Mei, Shuyan , Liu, Yanfang , Zhao, Congying , Xu, Hui , Li, Shuanglin , Zhu, Bofeng . The Polymorphism Analyses of Short Tandem Repeats as a Basis for Understanding the Genetic Characteristics of the Guanzhong Han Population . | BIOMED RESEARCH INTERNATIONAL , 2021 , 2021 .
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Genetic structure analyses and ancestral information inference of Chinese Kyrgyz group via a panel of 39 AIM-DIPs SCIE PubMed
期刊论文 | 2021 , 113 (4) , 2056-2064 | GENOMICS
WoS CC Cited Count: 1
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Ancestry informative markers have extensive uses and advantages in inferring ancestral origins and estimating ancestral genetic information components of admixed populations. With the characteristics of highly cultural exchange and the admixed genetic structure of the Kyrgyz group, it is essential to enrich the genetic data of the Kyrgyz group. In this study, we used a self-developed ancestry informative marker-deletion/insertion polymorphic (AIM-DIP) panel to explore ancestral components of Chinese Kyrgyz group and population genetic relationships between the Kyrgyz group and reference populations. Results showed that all AIM-DIP loci were conformed to Hardy-Weinberg equilibrium. There were 36 AIM-DIP loci that contributed significantly to genetic information inference. Multiple statistical analyses revealed that Chinese Kyrgyz group had a closer genetic relationship with Chinese Uyghur group. The ancestral components of the Kyrgyz group, being mostly composed of genetic components of European and East Asian populations, were more similar to the ancestral components of Chinese Uyghur group.

Keyword :

Ancestral components AIM-DIP Ancestry informative markers Kyrgyz

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GB/T 7714 Zhang, Wenqing , Jin, Xiaoye , Wang, Yijie et al. Genetic structure analyses and ancestral information inference of Chinese Kyrgyz group via a panel of 39 AIM-DIPs [J]. | GENOMICS , 2021 , 113 (4) : 2056-2064 .
MLA Zhang, Wenqing et al. "Genetic structure analyses and ancestral information inference of Chinese Kyrgyz group via a panel of 39 AIM-DIPs" . | GENOMICS 113 . 4 (2021) : 2056-2064 .
APA Zhang, Wenqing , Jin, Xiaoye , Wang, Yijie , Chen, Chong , Zhu, Bofeng . Genetic structure analyses and ancestral information inference of Chinese Kyrgyz group via a panel of 39 AIM-DIPs . | GENOMICS , 2021 , 113 (4) , 2056-2064 .
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Haplotype diversity and phylogenetic relationship analysis of Chinese Yulin Han population using 59 Y-STR loci of two novel Y-STR typing systems SCIE PubMed
期刊论文 | 2021 , 50 | LEGAL MEDICINE
WoS CC Cited Count: 1
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To investigate the genetic polymorphisms of 59 Y-chromosomal short tandem repeat (Y-STR) loci in the Yulin Han population, 229 unrelated healthy male individuals were analyzed using AGCU Y37 kit and AGCU Y-SUPP Plus kit. A total of 227 different haplotypes were obtained at the 59 Y-STR loci. Among them, 225 haplotypes were unique and 2 haplotypes occurred twice. The overall haplotypic diversity and discrimination capacity were 0.9999 and 0.9913, respectively. The phylogenetic relationships between the studied Yulin Han population and 17 previously reported reference populations were evaluated via multidimensional scaling and Neighbor-Joining analyses based on the haplotypic frequencies of ?YHRD Maximal Loci?. Phylogenetic analysis revealed that Yulin Han population was closely related to Chinese Han and Hunan Yao populations. These results demonstrated that the 59 Y-STR loci were useful for forensic applications and population genetic studies.

Keyword :

Genetic polymorphism Haplotype Y-STR Yulin Han population

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GB/T 7714 Zhou, Yongsong , Fang, Yating , Jin, Xiaoye et al. Haplotype diversity and phylogenetic relationship analysis of Chinese Yulin Han population using 59 Y-STR loci of two novel Y-STR typing systems [J]. | LEGAL MEDICINE , 2021 , 50 .
MLA Zhou, Yongsong et al. "Haplotype diversity and phylogenetic relationship analysis of Chinese Yulin Han population using 59 Y-STR loci of two novel Y-STR typing systems" . | LEGAL MEDICINE 50 (2021) .
APA Zhou, Yongsong , Fang, Yating , Jin, Xiaoye , Cui, Wei , Lan, Qiong , Xie, Tong et al. Haplotype diversity and phylogenetic relationship analysis of Chinese Yulin Han population using 59 Y-STR loci of two novel Y-STR typing systems . | LEGAL MEDICINE , 2021 , 50 .
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A Novel Panel of 43 Insertion/Deletion Loci for Human Identifications of Forensic Degraded DNA Samples: Development and Validation SCIE PubMed
期刊论文 | 2021 , 12 | FRONTIERS IN GENETICS
WoS CC Cited Count: 3
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Insertion/deletion polymorphism is a promising genetic marker in the forensic genetic fields, especially in the forensic application of degraded sample at crime scene. In this research, a novel five-dye multiplex amplification panel containing 43 highly polymorphic Insertion/deletion (InDel) loci and one Amelogenin gene locus is designed and constructed in-house for the individual identification in East Asian populations. The amplicon sizes of 43 InDel loci are less than 200 bp, which help to ensure that full allele profiles can be obtained from degraded DNA sample. A series of optimizations and developmental validations including optimization of PCR conditions, detection efficiency of the degraded and casework samples, sensitivity, reproducibility, precision, tolerance for inhibitors, species specificity and DNA mixtures are performed according to the Scientific Working Group on DNA Analysis Methods (SWGDAM) guideline. The results of the internal validation demonstrated that this novel InDel panel was a reliable, sensitive and accurate system with good tolerances to different inhibitors, and performed the considerable detection efficiency for the degraded or mixed samples, which could be used in the forensic applications.

Keyword :

Chinese Hui group degraded DNA developmental validation InDel individual identification

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GB/T 7714 Jin, Rui , Cui, Wei , Fang, Yating et al. A Novel Panel of 43 Insertion/Deletion Loci for Human Identifications of Forensic Degraded DNA Samples: Development and Validation [J]. | FRONTIERS IN GENETICS , 2021 , 12 .
MLA Jin, Rui et al. "A Novel Panel of 43 Insertion/Deletion Loci for Human Identifications of Forensic Degraded DNA Samples: Development and Validation" . | FRONTIERS IN GENETICS 12 (2021) .
APA Jin, Rui , Cui, Wei , Fang, Yating , Jin, Xiaoye , Wang, Hongdan , Lan, Qiong et al. A Novel Panel of 43 Insertion/Deletion Loci for Human Identifications of Forensic Degraded DNA Samples: Development and Validation . | FRONTIERS IN GENETICS , 2021 , 12 .
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