To　meet　the　requirements　for　vibration　detection　sensor　in　intelligent　manufacturing　and　overcome　shortcomings　in　the　existing　accelerometers　including　unsatisfactory　performances,　higher　cost　and　bulky　volume,　a　multi-flexure　piezoresistive　accelerometer　is　developed　based　on　micro-electro-mechanical　system　(MEMS)　technology.　The　proposed　accelerometer　introduces　two　tiny　beams　into　the　conventional　quad-beam　structure,　which　enhances　the　accelerometer＇s　natural　frequency　without　decreasing　the　sensitivity.　The　product　of　natural　frequency　and　sensitivity　is　regarded　as　the　evaluation　factor　to　determine　the　sensor　structural　dimensions,　considering　the　constraints　form　analytical　optimization　and　manufacturing　process.　The　sensor　chip　is　fabricated　by　silicon　etching,　boron　implantation,　Al　sputtering　and　anodic　bonding.　The　experimental　results　show　that　the　developed　accelerometer　possesses　a　sensitivity　of　0.544　mV　per　gravity　acceleration,　a　full　scale　accuracy　of　1.76%　and　natural　frequency　of　13.61　kHz,　and　can　accurately　acquire　the　acceleration　signal　with　different　frequencies.　Compared　with　the　conventional　quad-beam　sensor,　the　comprehensive　property　of　the　proposed　multi-flexure　accelerometer　is　improved　by　85%.