An　integrated　design　optimization　method　for　3D　parameterized　turbine　vane　with　non-axisymmetric　endwall　is　proposed,　by　coupling　an　adaptive　range　differential　evolution　(ARDE)　algorithm,　3D　parameterization　method　for　both　blade　profile　and　non-axisymmetric　endwall　and　RANS　solver　technique.　Using　this　method,　3D　aerodynamic　design　optimization　of　a　turbine　cascade　with　low　aspect　ratio　is　carried　out.　The　effects　of　3D　blade　parameterization　and　endwall　contouring　of　optimal　design　on　aerodynamic　performance　are　analyzed　in　detail.　Thereby　the　correctness　and　effectiveness　of　proposed　design　optimization　method　is　demonstrated.　©　2016,　Science　Press.　All　right　reserved.