OBJECTIVE:　To　evaluate　the　contrast-enhanced　ultrasound(CEUS)　and　ultrasonic　elastography　(UE)　in　diagnosis　of　thyroid　nodules　by　a　binary　Logistic　regression　model.　METHODS:　A　total　149　cases　with　thyroid　nodules　were　examed　by　CEUS　and　UE　and　were　confirmed　by　surgical　pathology.　A　Logistic　model　was　obtained　on　the　basis　of　ultrasonographic　features.　Receiver　operator　characteris(ROC)　curve　was　constructed　to　assess　the　performance　of　the　Logistic　model.　RESULTS:　Four　ultrasonographic　features　including　calcification,　enhancement　degree,　biggest　perfusion　strength　and　elastic　score　were　finally　entered　into　the　Logistic　model.　The　percentage　of　correct　prediction　was　91.90%.　CONCLUSION:　Both　CEUS　and　UE　have　high　value　in　differential　diagnosis　of　thyroid　nodules　and　the　Logistic　regression　model　has　high　diagnostic　rate.