In　order　to　explore　a　novel　method　for　the　treatment　of　drug　abuse,　we　evaluated　the　effect　of　chronic　deep　brain　stimulation　(DBS)　of　the　rat　nucleus　accumbens　(NAc)　on　morphine　reinforcement,　using　a　DBS　apparatus　and　an　implant　method　we　developed.　Thirty-two　adult　rats　weighing　240-260　g　were　divided　into　three　groups,　which　included　a　DBS　group　(n　=　10,　administration　of　surgery,　morphine　and　DBS),　a　sham　DBS　group　(n　=　12,　administration　of　surgery　and　morphine)　and　a　control　group　(n　=　10,　administration　of　physiological　saline).　The　DBS　electrode　was　stereotaxically　implanted　into　the　core　of　unilateral　NAc　and　connected　to　an　implantable　pulse　generator.　Then,　they　were　fixed　to　the　rat　skull.　One　week　later,　the　rats　in　each　group　were　intraperitoneally　injected　with　morphine　at　an　increasing　dose　(10-60　mg/kg)　once　daily.　The　rats　in　the　DBS　group　were　administered　a　130-Hz　high-frequency　stimulation　(HFS)　once　daily.　A　900-second　conditioned　place　preference　(CPP)　paradigm　was　used　for　determining　the　effect　of　electrical　stimulation　on　morphine　reinforcement　in　rats.　The　data　showed　that　7-10　days　later,　the　preference　score　of　the　DBS　group　was　significantly　lower　than　that　of　the　sham　DBS　group.　The　results　suggest　that　chronic　HFS　of　the　rat　NAc　can　block　CPP　induced　by　morphine　and　attenuate　morphine　reinforcement.