©　2018　Australasian　Society　for　the　Study　of　Brain　Impairment.　Background/Study　Concept:　Acute　lacunar　stroke　(Als)　plays　a　role　in　death/disability　worldwide.　Aphasia　refers　to　chronic　difficulty　with　communication　in　＞20%　of　patients　post　stroke.　We　describe　pathophysiological　features　of　white　matter　(WM)　abnormalities　and　their　relationship　between　WM　changes　and　aphasia　quotient　(AQ)　scores　in　Als.Methods:　Diffusion　tensor　imaging　data　were　acquired　in　37　Als　patients　and　28　healthy　controls.　Tract-based　spatial　statistics　(TBSS)　and　correlation　analyses　were　used.Results:　Consistent　with　the　hypothesis,　Als　had　decreased　fractional　anisotropy　(FA)　and　increased　mean　diffusivity,　axial　diffusivity　and　radial　diffusivity　in　the　genu,　body　and　splenium　of　the　corpus　callosum　(CC),　superior　longitudinal　fasciculus　(SLF)　and　corona　radiata　in　the　bilateral　hemisphere.　Reduced　FA　of　SLF　was　correlated　with　AQ　scores　in　Als　patients.Conclusion:　It　is　hoped　that　TBSS　could　shed　new　insights　into　aphasia　mechanisms　in　Als　to　help　promote　aging-related　disease　studies.