Parametric　perfusion　imaging　(PPI)　obtained　from　dynamic　CEUS　images　can　depict　the　microvascular　hemodynamic　distribution.　CEUS　with　plane　wave　imaging　(PWI)　is　a　choice　for　accurate　PPI.　However,　the　limitation　of　disruption　rate　of　microbubbles　(DRM)　can＇t　be　overcome　in　PWI　completely　because　peak　negative　pressure　(PNP)　in　PWI　attenuates　linearly　with　imaging　depth.　The　objective　of　this　study　was　to　illustrate　the　feasibility　and　limitation　of　PWI-based　PPI　through　comparing　perfusion　features　of　conventional　focused　wave　imaging　(FWI)　and　PWI　after　clarifying　the　DRM　of　PWI.　To　compare　perfusion　features　of　FWI　and　PWI,　transducer　was　first　excited　under　the　same　acoustic　parameters,　especially　a　similar　PNP　in　＂focal＂　region;　and　five　separate　in　vivo　same　injections　were　performed　on　a　rabbit　kidney.　Raw　data　of　PWI　and　FWI　were　recorded　by　Sonix-DAQ　and　Touch.　Three　pairs　of　time-intensity　curves　(TICs)　were　then　extracted　from　dynamic　PWI　and　FWI　in　＂pre-focal＂,　＂focal＂,　and　＂post-focal＂　regions,　respectively.　Perfusion　parameters　were　estimated　from　the　denoised　and　fitted　TICs,　including　peak　value　(PV),　area　under　curve　(AUC),　half　transit　time　(HTT),　and　wash　in　ratio　(WIR).　Available　infusion　time　and　DRM　were　finally　quantified　by　changes　in　HTT　and　AUC,　respectively.　Due　to　the　differences　in　the　scanning　modes　and　PNP　distributions,　the　perfusion　features　in　PWI　differed　from　those　in　FWI.　Because　PNPs　of　PWI　were　higher　than　these　of　FWI　in　the　＂pre-　and　post-focal＂　regions,　PV　and　AUC　in　PWI　were　lower　and　DRM　in　PWI　was　higher　than　these　parameters　in　FWI.　Compared　with　FWI　in　the　＂focal＂　region　under　the　same　PNP,　all　parameters　in　PWI　were　larger　due　to　the　few　insonation　times　for　microbubbles　in　PWI,　and　DRM　in　PWI　was　lower.　Although　the　low　DRM　in　PWI　was　limited　by　the　relative　location　between　the　imaging　object　and　PNP　distribution,　the　average　WIR,　HTT,　and　AUC　in　PWI　were　66.67%,　20.51%,　and　4.96%　higher　than　those　in　FWI,　respectively.　So　PWI-based　PPI　with　the　long　infusion　time　and　limited　low　DRM　is　feasible,　which　can　provide　sufficient　perfusion　details　and　information　for　PPI.