With　the　rapid　development　of　renewable　energy　systems　and　Microgrid,　more　and　more　DC　grids　of　different　voltage　level　need　to　be　connected　by　the　high　voltage　and　high　power　DC-DC　converter.　The　traditional　topology　of　high　voltage　and　high　power　DC-DC　converter　was　Phase　Shifted　Full　Bridge　cascaded　Modules　(PSFBM).　Due　to　the　inefficiency　and　difficulty　on　manufacturing　high　frequency　transformer　of　PSFBM,　a　non-isolated　topology,　Multilevel　Modular　Capacitor-Clamped　DC-DC　Converter　(MMCCC),　was　proposed　as　an　alternative.　However,　the　MMCCC　also　has　some　inherent　disadvantages,　especially,　a　large　number　of　switching　devices　and　no　voltage　regulation　which　limit　its　application　in　the　connection　of　DC　grids　requiring　high　efficiency　and　accurate　control.　In　this　paper,　a　novel　non-isolated　high　voltage　and　high　power　ZCS　DC-DC　converter　based　on　serial　capacitors　is　proposed.　By　energy　transferring　circuit　to　transfer　the　energy　between　adjacent　serial　capacitors,　it　can　realize　the　bidirectional　DC-DC　conversion　with　less　switching　devices.　Furthermore,　by　a　control　system　with　independent　voltage　control　of　each　serial　capacitor,　It　can　improve　the　flexibility　and　accuracy　of　output　voltage　and　also　can　realize　a　higher　input　or　output　voltage　without　limitation　in　theory.　In　this　paper,　the　operation　principle　and　design　consideration　of　the　novel　topology　were　presented　in　detail,　and　a　simulation　with　ten　serial　capacitors　was　also　built　to　validated　the　effectiveness　of　the　novel　topology.　Finally,　a　1kW　test　equipment　with　250V　input　voltage　and　1000V　output　voltage　was　developed　in　laboratory　to　verify　the　simulation　result.