To　identify　HLA-B*15　subtypes　distribution　in　Han　population　in　Beijing,　People＇s　Republic　of　China,　826　unrelated　healthy　individuals　were　typed　using　the　polymerase　chain　reaction-sequence-based　typing　method.　Within　the　246　HLA-B*15　positive　individuals,　29　HLA-B*15　alleles　were　identified,　the　most　predominant　of　which　is　B*1501　(40.07%),　followed　by　B*1502　(12.87%),　B*1511　(12.87%),　B*1518　(9.19%)　and　B*1532　(3.31%).　The　distribution　of　HLA-B*15　subtype　frequencies　was　compared　between　the　Beijing　Han,　eight　other　Chinese　ethnic　minorities　and　six　Chinese　populations　covering　the　mainland　of　China,　Taiwan,　Hong　Kong　and　Singapore.　A　neighbor-joining　phylogenetic　tree　was　constructed　and　revealed　that　the　Beijing　Han　population　clustered　into　the　northern　populations　group　and　had　a　closer　relationship　with　northern　Han　and　Hui　than　with　southern　Han　or　other　ethnic　minorities.　These　results　thus　provide　useful　information　that　can　be　used　in　anthropology,　selection　for　bone　marrow　transplantation　as　well　as　in　disease-association　study,　such　as　in　carbamazepine　(CBZ)-induced　Stevens-Johnson　syndrome　and　toxic　epidermal　necrolysis.