We　proposed　that　high　efficiency　high-intensity　focused　ultrasound　(HIFU)　could　be　achieved　by　using　a　splitting　transducer　with　various　frequencies　and　focusing　patterns,　and　explored　the　feasibility　of　using　ultrafast　active　cavitation　imaging　(UACI),　pulse　inversion　(PI)　sub-harmonic　cavitation　imaging　and　bubble　wavelet　transform　imaging　for　monitoring　of　cavitation　during　HIFU,　as　well　as　the　ultrasonic　B-mode　images,　differential　integrated　backscatter　(IBS)　images,　Nakagami　images　and　elastography　for　monitoring　HIFU-induced　lesion.　The　use　of　HIFU　splitting　transducer　had　the　potential　to　increase　the　size　of　the　thermal　lesion　in　a　shorter　duration　and　may　improve　the　ablation　efficiency　of　HIFU　and　would　shorten　the　exposure　duration　significantly.　The　spatial-temporal　evolution　of　residual　cavitation　bubbles　at　the　tissue-water　interface　was　obtained　by　UACI　and　the　results　showed　that　the　UACI　had　a　frame　rate　high　enough　to　capture　the　transient　behavior　of　the　cavitation　bubbles.　The　experiments　demonstrated　that　comparing　with　normal　sub-harmonic　and　PI　harmonic　images,　PI　sub-harmonic　images　had　higher　sensitivity　and　CTR,　which　was　conducive　to　showing　cavitation　bubbles.　The　CTR　would　be　further　improved　by　combining　PI　ultrafast　plane　wave　transmitting　with　cavitation　bubble　wavelet　transform.