Tumor　necrosis　factor-ainduced　protein　8-like　2　(TIPE2)　has　an　essential　role　in　immune　homeostasis,　yet　the　relationship　between　TIPE2　expression　and　allograft　rejection　has　not　been　addressed.　Dependent　on　clinical　diagnosis,　96　kidney　transplant　recipients　were　divided　into　three　groups,　long-term　survival　group,　acute　rejection　group　(AR)　and　chronic　rejection　group　(CR).　Thirty-two　healthy　volunteers　were　used　as　a　control　group.　The　expression　of　TIPE2　in　peripheral　blood　mononuclear　cells　(PBMC)　and　kidney　biopsy　samples　was　performed　using　reverse　transcript-polymerase　chain　reaction,　immunohistochemistry　and　immunofluorescence.　The　expression　of　TIPE2　in　PBMC　of　CR　group　was　significantly　higher　than　that　of　the　healthy　control　(P＜0.001),　but　TIPE2　expression　in　AR　group　was　lower　than　that　of　control　individuals　(P＜0.05).　The　renal　expression　of　TIPE2　in　allograft　tissue　of　CR　was　significantly　lower　and　its　expression　in　AR　slightly　lower　than　in　normal　kidneys.　The　positive　correlation　between　TIPE2　expression　in　PBMCs　and　the　CR　of　allo-kidney　grafts　indicates　that　detection　of　TIPE2　in　the　blood　samples　may　be　used　as　one　of　the　diagnosis　molecular　markers　in　clinical　monitoring　kidney　chronic　rejection.