The　mixed　aqueous　solutions　of　anionic　surfactant　sodium　dodecyl　sulfate　with　polymer　polyacrylamide　of　various　kinds,　i.e.,　cationic,　anionic,　nonionic,　and　zwitterion,　were　firstly　tested　to　study　their　synergistic　effect　on　drag　reduction　performance.　The　optimal　combination　of　sodium　dodecyl　sulfate　with　anionic　polyacrylamide　was　confirmed　due　to　their　strong　hydrophobic　interaction　and　electrostatic　repulsion　caused　by　the　same　charge.　The　surface　tension,　conductivity,　and　viscosity　of　pure　surfactant　solution　and　mixed　solutions　at　different　surfactant　concentrations　with　anionic　polymer　of　certain　concentration　were　tested,　and　their　drag　reduction　behavior　in　pipe　flow　was　also　investigated　experimentally.　It　turns　out　that　drag　reduction　performance　acquired　from　the　combination　of　anionic　surfactant　and　anionic　polyacrylamide　is　better　than　either　of　the　single　additive,　especially　under　high　shear　rate.　For　the　mixtures,　the　degree　of　drag　reduction　is　strongly　dependent　on　the　concentration　of　SDS　and　more　pronounced　in　the　high　Reynolds　number　range.　The　best　drag　reduction　performance　is　obtained　for　the　SDS　concentration　around　the　polymer　saturation　point.　Our　work　should　be　of　value　for　the　drag　reduction　in　the　application　such　as　shale　gas　fracturing　and　various　fluid　transports.