This　manuscript　has　provided　an　overview　of　the　development　of　TiNi　alloys　and　their　applications　in　biomedicine.　The　microstructures　and　properties　of　TiNi　alloys　are　first　introduced.　The　breakthroughs　in　the　manufacturing　and　applications　in　biomedicine　of　TiNi　alloys　in　recent　years　have　been　achieved　by　scientists　and　are　presented　in　the　present　paper.　It　is　well　known　that　the　properties　of　TiNi　alloys　are　affected　by　the　modification　methods　on　the　surface　of　bulk　TiNi　alloys.　The　main　preparation　technologies　of　TiNi　alloy　coatings　are　evaluated,　with　particular　attention　to　several　spray　technologies.　Then,　the　biocompatibility,　strong　anticorrosion　and　antiwear　properties,　and　mechanism　of　TiNi　alloys　are　also　described　in　detail.　Several　advanced　manufacturing　processes　of　＇TiNi　alloys　are　also　briefly　outlined　such　as　selective　laser　melting　and　spark　plasma　sintering.　The　performance　of　TiNi　alloy　coatings　prepared　by　thermal　spraying　techniques　are　fully　qualified　for　medical　applications.　Thermal　spraying　techniques　have　great　prospects　in　reducing　the　cost　and　improving　the　quality　of　TiNi　alloy　medical　products.