Multifunctional　nanodrugs　with　the　integration　of　precise　diagnostic　and　effective　therapeutic　functions　have　shown　great　promise　in　improving　the　efficacy　of　cancer　therapy.　We　report　herein　a　simple　and　effective　approach　to　directly　assemble　an　anticancer　drug　(curcumin),　a　photodynamic　agent　(Ce6)　and　tumor　environment-sensitive　molecules　into　cross-linked　polyphosphazene　and　coat　on　superparamagnetic　Fe3O4　nanoclusters　to　form　discrete　nanoparticles　(termed　as　FHCPCe　NPs).　FHCPCe　NPs　have　high　physiological　stability　and　good　biocompatibility,　and　can　enhance　accumulation　in　tumor　tissue　via　the　enhanced　permeability　and　retention　effect.　Meanwhile,　the　FHCPCe　NPs　exhibit　an　effective　performance　of　dual-modality　magnetic　resonance　imaging　(MRI)　due　to　the　Fe3O4　cores　and　fluorescence　imaging　(FL)　in　the　xenografted　HeLa　tumor　because　of　the　fluorescence　of　Ce6.　Importantly,　under　the　conditions　of　supernormal　glutathione　levels　and　acidic　microenvironment　in　tumor　tissue,　curcumin　and　Ce6　can　be　effectively　released　by　the　degradation　of　FHCPCe　NPs.　Therefore,　excellent　anti-tumor　effects　both　in　vitro　and　in　vivo　have　been　achieved　by　synergistic　chemotherapy/photodynamic　therapy　(CT/PDT)　using　multifunctional　NPs.　Our　study　highlights　the　promise　of　developing　multifunctional　nanomaterials　for　accurate　multimodal　imaging-guided　highly　sensitive　therapy　of　cancer.