With　the　continuous　advance　of　biomedical　technology　and　the　rapid　development　of　minimally　invasive　surgery,　implantation　of　medical　devices　on　the　demand　for　fine　metal　materials　is　increasing.　Medical　wire,　cardiac　pacemaker　wire,　functional　electrical　stimulation　device,　dental　appliance,　cochlear　implant　device　and　other　medical　devices,　according　to　its　implant　size　and　function,　require　the　use　of　fine　wire　whose　diameter　ranging　from　50　μm　to　500　μm　for　processing.　Traditional　medical　wire　materials　such　as　316　stainless　steel,　NiTi　shape　memory　alloy,　TC4,　etc.　all　contain　toxic　elements　such　as　Cr　and　Ni.　When　these　medical　wire　materials　are　implanted　into　the　human　body,　more　or　less　they　will　be　corroded　and　worn,　causing　the　precipitation　of　toxic　elements,　which　will　easily　cause　an　inflammatory　reaction　and　cause　a　great　hazard.　Therefore,　in　recent　years,　researchers　have　continuously　tried　to　improve　the　performance　of　medical　wire　materials　by　selecting　suitable　substitute　elements　and　optimizing　the　preparation　process.　And　they　have　achieved　fruitful　results,　while　maintaining　high　strength　and　low　mold　while　eliminating　the　harm　caused　by　toxic　elements.　A　number　of　new　medical　wire　materials　have　appeared:　Fe-17Cr-14Mn-2Mo-(0.45-0.7)N　medical　austenitic　stainless　steel,　Ti-22Nb-Fe　alloy,　new　beta　titanium　alloy　and　so　on.　Smaller　size　not　only　requires　the　performance　of　the　material　itself,　but　also　a　highly　reliable　welding　technology,　especially　for　the　welding　technology　of　dissimilar　materials　which　commonly　used　in　medical　devices.　The　difficulty　lies　in　the　fact　that　the　chemical　composition　of　the　diffe-rent　kinds　of　wires　makes　the　welding　process　easy　to　form　brittle　compounds,　thereby　deteriorating　the　joint　performance　and　reducing　the　wel-ding　reliability.　In　recent　years,　researchers　have　compared　various　welding　methods　such　as　solid-phase　connection,　brazed　joint,　and　fusion-welded　joint.　It　is　found　that　the　micro-laser　welding　method　has　high　energy　density,　narrow　weld　seam,　small　heat-affected　zone,　small　welding　deformation,　and　high　temperature　retention.　Short　time,　less　amount　of　molten　metal,　good　beam　direction,　and　precision　machining　are　the　best　results　when　welding　dissimilar　metal　wires.　At　the　same　time,　through　the　optimization　of　process　parameters,　the　filling　of　the　transition　layer,　the　design　of　the　fixture,　the　analysis　of　the　joint　failure　form,　and　the　discussion　of　the　welding　connection　mechanism,　the　researchers　mainly　focused　on　316LVM　(low-carbon　vaccum　melting)　stainless　steel　wire　and　TiNi　shape　memory　alloy　wire.　Micro-laser　welding　of　dissimilar　metal　materials　have　been　systematically　studied,　and　some　research　results　have　been　obtained,　which　can　greatly　improve　the　reliability　of　dissimilar　wire　solder　joints.　This　paper　systematically　combs　the　development　and　application　of　medical　metal　wire　materials.　Aiming　at　the　difficulties　in　welding　dissimilar　fine　metal　wire　materials,　the　research　progress　of　welding　technology　of　dissimilar　metal　wire　materials　is　introduced　from　three　aspects:　welding　method,　process　research　and　connection　mechanism.　The　future　research　direction　of　this　field　is　summarized　and　forecasted,　which　can　help　to　prepare　high　reliability　biomedical　heterogeneous　metal　welded　joint.　©　2019,　Materials　Review　Magazine.　All　right　reserved.